format-version: 1.2

[Term]
id: http://ontology.neuinfo.org/NIF/BiomaterialEntities/NIF-GrossAnatomy.owl#birnlex_1373
name: Caudate nucleus
namespace: http
def: "Subcortical nucleus of telecephalic origin consisting of an elongated gray mass lying lateral to and bordering the lateral ventricle.  It is divided into a head, body and tail in some species." []
is_a: CARO:0000055  ! multi-tissue structure

[Term]
id: http://purl.obolibrary.org/obo/VO_0000001
name: vaccine
namespace: http
def: "A vaccine is a processed (manufactured) material that has the function to modulate immune responses in a host organism (e.g., human) against a particular target(s) (e.g. a pathogen) in order to prevent or treat disease." []
is_a: snap:MaterialEntity 
relationship: OBI:0000312 OBI:0000719 ! vaccine preparation

[Term]
id: http://purl.obolibrary.org/obo/VO_0000002
name: vaccination
namespace: http
def: "Vaccination is: an ‘administering substance in vivo’ that involves in adding vaccine into a host (e.g., human, mouse) in vivo with the intend to invoke a protective immune response." []
is_a: OBI:0600007  ! administering substance in vivo

[Term]
id: http://usefulinc.com/ns/doap#Project
namespace: http

[Term]
id: http://usefulinc.com/ns/doap#SVNRepository
namespace: http

[Term]
id: http://usefulinc.com/ns/doap#Version
namespace: http

[Term]
id: CARO:0000043
name: portion of tissue
def: "Anatomical structure, that consists of similar cells and intercellular matrix, aggregated according to genetically determined spatial relationships." []
is_a: OBI:0100015  ! anatomical entity

[Term]
id: CARO:0000055
name: multi-tissue structure
def: "Anatomical structure that has as its parts two or more portions of tissue of at least two different types and which through specific morphogenetic processes forms a single distinct structural unit demarcated by bona-fide boundaries from other distinct structural units of different types." []
is_a: OBI:0100015  ! anatomical entity

[Term]
id: CARO:0000066
name: epithelium
def: "Portion of tissue, that consists of one or more layers of epithelial cells connected to each other by cell junctions and which is underlain by a basal lamina." []
is_a: CARO:0000043  ! portion of tissue

[Term]
id: CHEBI:16670
name: peptide
def: "Amide derived from two or more amino carboxylic acid molecules (the same or different) by formation of a covalent bond from the carbonyl carbon of one to the nitrogen atom of another with formal loss of water. The term is usually applied to structures formed from alpha-amino acids, but it includes those derived from any amino carboxylic acid." []
is_a: CHEBI:23367  ! molecular entity

[Term]
id: CHEBI:16991
name: deoxyribonucleic acids
def: "High molecular weight, linear polymers, composed of nucleotides containing deoxyribose and linked by phosphodiester bonds; DNA contain the genetic information of organisms." []
is_a: CHEBI:23367  ! molecular entity

[Term]
id: CHEBI:17137
name: hydrogensulfite
def: "A sulfur oxoanion that has formula HO3S." []
is_a: CHEBI:23367  ! molecular entity

[Term]
id: CHEBI:17234
name: glucose
is_a: CHEBI:23367  ! molecular entity

[Term]
id: CHEBI:17709
name: 5'-adenylyl sulfate
def: "An acyl sulfate that has formula C10H14N5O10PS." []
is_a: CHEBI:23367  ! molecular entity

[Term]
id: CHEBI:23367
name: molecular entity
def: "Any constitutionally or isotopically distinct atom, molecule, ion, ion pair, radical, radical ion, complex, conformer etc., identifiable as a separately distinguishable entity." []
is_a: snap:MaterialEntity 

[Term]
id: CHEBI:25078
name: luciferin
def: "A low-molecular-mass compound present in bioluminescent organisms that emits light when oxidized in presence of enzyme luciferase." []
is_a: CHEBI:23367  ! molecular entity

[Term]
id: CHEBI:26710
name: sodium chloride
def: "An inorganic chloride salt that has formula ClNa." []
is_a: CHEBI:23367  ! molecular entity

[Term]
id: CHEBI:28619
name: acrylamide
def: "An acrylamide that has formula C3H5NO." []
is_a: CHEBI:23367  ! molecular entity

[Term]
id: CHEBI:32142
name: sodium citrate dihydrate
is_a: CHEBI:23367  ! molecular entity

[Term]
id: CHEBI:33696
name: nucleic acid
def: "should be imported from chebi" []
is_a: CHEBI:23367  ! molecular entity

[Term]
id: CHEBI:33697
name: ribonucleic acids
def: "Naturally occurring polyribonucleotides." []
is_a: CHEBI:23367  ! molecular entity

[Term]
id: CHEBI:33709
name: amino acids
def: "Carboxylic acids containing one or more amino groups." []
is_a: CHEBI:23367  ! molecular entity

[Term]
id: CHEBI:37586
name: sodium phosphates
is_a: CHEBI:23367  ! molecular entity

[Term]
id: CHEBI:42191
name: ethylenediaminetetraacetic acid
def: "A tetracarboxylic acid that has formula C10H16N2O8." []
is_a: CHEBI:23367  ! molecular entity

[Term]
id: CHEBI:4705
name: double-stranded DNA
is_a: CHEBI:16991  ! deoxyribonucleic acids

[Term]
id: CHEBI:472552
name: 5-bromo-2-deoxyuridine
is_a: CHEBI:23367  ! molecular entity

[Term]
id: CHEBI:50076
name: chromium-51
def: "A synthetic radioactive isotope of chromium having a half-life of 27.7 days and decaying by electron capture with emission of gamma rays (0.32 MeV); it is used to label red blood cells for measurement of mass or volume, survival time, and sequestration studies, for the diagnosis of gastrointestinal bleeding, and to label platelets to study their survival." []
is_a: CHEBI:23367  ! molecular entity

[Term]
id: CHEBI:53526
name: tritiated thymidine
def: "Thymidine linked to the radioisotope tritium. Used to label DNA in the study of cellular and viral DNA synthesis.." []
is_a: CHEBI:23367  ! molecular entity

[Term]
id: CHEBI:9754
name: tris
def: "A compound widely used as a biological buffer substance in the pH range 7--9; pKa = 8.3 at 20 degreeC; pKa = 7.82 at 37 degreeC." []
is_a: CHEBI:23367  ! molecular entity

[Term]
id: CL:0000000
name: cell
def: "Anatomical structure that has as its parts a maximally connected cell compartment surrounded by a plasma membrane." []
is_a: snap:MaterialEntity 

[Term]
id: CL:0000057
name: fibroblast
def: "A connective tissue cell which secretes an extracellular matrix rich in collagen and other macromolecules." []
is_a: CL:0000000  ! cell

[Term]
id: CL:0000066
name: epithelial cell
def: "A cell that is usually found in a two-dimensional sheet with a free surface." []
is_a: CL:0000000  ! cell

[Term]
id: CL:0000084
name: T cell
def: "A type of lymphocyte whose defining characteristic is the expression of a T cell receptor complex." []
is_a: CL:0000542  ! lymphocyte

[Term]
id: CL:0000097
name: mast cell
def: "A cell that is found in almost all tissues containing numerous basophilic granules and capable of releasing large amounts of histamine and heparin upon activation." []
is_a: CL:0000000  ! cell

[Term]
id: CL:0000182
name: hepatocyte
def: "The main structural component of the liver. They are specialized epithelial cells that are organized into interconnected plates called lobules." []
is_a: CL:0000066  ! epithelial cell

[Term]
id: CL:0000235
name: macrophage
def: "A mononuclear phagocyte present in variety of tissues, typically differentiated from monocytes, capable of phagocytosing a variety of extracellular particulate material, including immune complexes, microorganisms, and dead cells." []
is_a: CL:0000000  ! cell

[Term]
id: CL:0000236
name: B cell
def: "A lymphocyte of B lineage with the phenotype CD19-positive and surface immunoglobulin-positive." []
is_a: CL:0000542  ! lymphocyte

[Term]
id: CL:0000451
name: dendritic cell
def: "A cell of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation." []
is_a: CL:0000000  ! cell

[Term]
id: CL:0000542
name: lymphocyte
def: "A cell of the B cell, T cell, or natural killer cell lineage." []
is_a: CL:0000842  ! mononuclear cell

[Term]
id: CL:0000624
name: CD4-positive, alpha-beta T cell
def: "A mature alpha-beta T cell that expresses an alpha-beta T cell receptor and the CD4 coreceptor." []
is_a: CL:0000789  ! alpha-beta T cell

[Term]
id: CL:0000625
name: CD8-positive, alpha-beta T cell
def: "A T cell expressing an alpha-beta T cell receptor and the CD8 coreceptor." []
is_a: CL:0000789  ! alpha-beta T cell

[Term]
id: CL:0000767
name: basophil
def: "Any of the immature or mature forms of a granular leukocyte that in its mature form has an irregularly shaped, pale-staining nucleus that is partially constricted into two lobes, and with cytoplasm that contains coarse, bluish-black granules of variable size. Basophils contain vasoactive amines such as histamine and serotonin, which are released on appropriate stimulation." []
is_a: CL:0000000  ! cell

[Term]
id: CL:0000786
name: plasma cell
def: "A terminally differentiated, post-mitotic, antibody secreting cell of the B cell lineage with the phenotype CD138-positive, surface immunonoglobulin-negative, and MHC Class II-negative. Plasma cells are oval or round with extensive rough endoplasmic reticulum, a well-developed Golgi apparatus, and a round nucleus having a characteristic cartwheel heterochromatin pattern and are devoted to producing large amounts of immunoglobulin." []
is_a: CL:0000236  ! B cell

[Term]
id: CL:0000789
name: alpha-beta T cell
def: "A T cell that expresses an alpha-beta T cell receptor complex." []
is_a: CL:0000084  ! T cell

[Term]
id: CL:0000794
name: CD8-positive, alpha-beta cytotoxic T cell
def: "A CD8-positive, alpha-beta T cell that is capable of killing target cells in an antigen specific manner with the phenotype perforin-positive and granzyme B-positive." []
is_a: CL:0000625  ! CD8-positive, alpha-beta T cell

[Term]
id: CL:0000814
name: mature NK T cell
def: "A mature alpha-beta T cell of a distinct lineage that bears natural killer markers and a T cell receptor specific for a limited set of ligands. NK T cells have activation and regulatory roles particularly early in an immune response." []
is_a: CL:0000789  ! alpha-beta T cell

[Term]
id: CL:0000842
name: mononuclear cell
def: "A leukocyte with a single non-segmented nucleus in the mature form." []
is_a: CL:0000000  ! cell

[Term]
id: ENVO:00001998
name: soil
def: "Any material within 2 m from the Earth's surface that is in contact with the atmosphere, with the exclusion of living organisms, areas with continuous ice not covered by other material, and water bodies deeper than 2 m." []
is_a: snap:MaterialEntity 

[Term]
id: ENVO:00002257
name: podzol
def: "Podzols are soils with a typically ash-grey upper subsurface horizon, bleached by loss of organic matter and iron oxides, on top of a dark accumulation horizon with brown, reddish or black illuviated humus and/or reddish Fe compounds. Podzols occur in humid areas in the boreal and temperate zones and locally also in the tropics." []
is_a: ENVO:00001998  ! soil

[Term]
id: FMA:49184
name: Mouth
is_a: CARO:0000055  ! multi-tissue structure

[Term]
id: FMA:5034
name: Lymph node
is_a: OBI:0100015  ! anatomical entity

[Term]
id: FMA:7196
name: Spleen
is_a: OBI:0100015  ! anatomical entity

[Term]
id: FMA:9669
name: Body substance
def: "Material anatomical entity in a gaseous, liquid, semisolid or solid state,  with or without the admixture of cells and biological macromolecules; produced by anatomical structures or derived from inhaled and ingested substances that have been modified by anatomical structures as they pass through the body. Examples: saliva, semen, cerebrospinal fluid, inhaled air, urine, feces, blood, plasma, lymph." []
is_a: OBI:0100015  ! anatomical entity

[Term]
id: FMA:9670
name: Blood
def: "Body substance which consists of plasma and blood cells" []
is_a: FMA:9669  ! Body substance

[Term]
id: GO:0001816
name: cytokine production
def: "The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." []
is_a: GO:0008150  ! biological_process

[Term]
id: GO:0001913
name: T cell mediated cytotoxicity
def: "The directed killing of a target cell by a T cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors." []
is_a: GO:0008150  ! biological_process

[Term]
id: GO:0002250
name: adaptive immune response
def: "An immune response based on directed amplification of specific receptors for antigen produced through a somatic diversification process, and allowing for enhanced response to subsequent exposures to the same antigen (immunological memory)." []
is_a: GO:0006955  ! immune response

[Term]
id: GO:0002367
name: cytokine production during immune response
def: "The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus during an immune response, resulting in an increase in its intracellular or extracellular levels." []
is_a: GO:0001816  ! cytokine production

[Term]
id: GO:0002390
name: platelet activating factor production
def: "The synthesis or release of platelet activating factor following a stimulus, resulting in an increase in its intracellular or extracellular levels." []
is_a: GO:0001816  ! cytokine production

[Term]
id: GO:0002534
name: cytokine production during acute inflammatory response
def: "The synthesis or release of a cytokine following a inflammatory stimulus during an acute inflammatory response, resulting in an increase in its intracellular or extracellular levels." []
is_a: GO:0001816  ! cytokine production

[Term]
id: GO:0003674
name: molecular_function
def: "Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. A given gene product may exhibit one or more molecular functions." []
is_a: snap:Function 

[Term]
id: GO:0003824
name: catalytic activity
def: "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." []
is_a: GO:0003674  ! molecular_function

[Term]
id: GO:0003964
name: RNA-directed DNA polymerase activity
def: "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." []
is_a: GO:0003824  ! catalytic activity

[Term]
id: GO:0005575
name: cellular_component
def: "The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together." []
is_a: snap:MaterialEntity 

[Term]
id: GO:0006006
name: glucose metabolic process
def: "The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides." []
is_a: GO:0008150  ! biological_process

[Term]
id: GO:0006955
name: immune response
def: "Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat." []
is_a: GO:0050896  ! response to stimulus

[Term]
id: GO:0007596
name: blood coagulation
def: "The sequential process by which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers." []
is_a: GO:0008150  ! biological_process

[Term]
id: GO:0008150
name: biological_process
def: "Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end." []
is_a: span:ProcessualEntity 

[Term]
id: GO:0008283
name: cell proliferation
def: "The multiplication or reproduction of cells, resulting in the expansion of a cell population." []
is_a: GO:0008150  ! biological_process

[Term]
id: GO:0010467
name: gene expression
def: "The process by which a gene's sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Some protein processing events may be included when they are required to form an active form of a product from an inactive precursor form." []
is_a: GO:0008150  ! biological_process

[Term]
id: GO:0010573
name: vascular endothelial growth factor production
def: "The appearance of vascular endothelial growth factor production due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." []
is_a: GO:0001816  ! cytokine production

[Term]
id: GO:0019815
name: B cell receptor complex
def: "An immunoglobulin complex that is present in the plasma membrane of B cells and that in its canonical form is composed of two identical immunoglobulin heavy chains and two identical immunoglobulin light chains and a signaling subunit, a heterodimer of the Ig-alpha and Ig-beta proteins." []
is_a: OBI:1110022  ! adaptive immune receptor

[Term]
id: GO:0032601
name: connective tissue growth factor production
def: "The appearance of connective tissue growth factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." []
is_a: GO:0001816  ! cytokine production

[Term]
id: GO:0032602
name: chemokine production
def: "The appearance of a chemokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." []
is_a: GO:0001816  ! cytokine production

[Term]
id: GO:0032604
name: granulocyte macrophage colony-stimulating factor production
def: "The appearance of granulocyte macrophage colony-stimulating factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." []
is_a: GO:0001816  ! cytokine production

[Term]
id: GO:0032605
name: hepatocyte growth factor production
def: "The appearance of hepatocyte growth factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." []
is_a: GO:0001816  ! cytokine production

[Term]
id: GO:0032606
name: type I interferon production
def: "The appearance of type I interferon due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families." []
is_a: GO:0001816  ! cytokine production

[Term]
id: GO:0032609
name: interferon-gamma production
def: "The appearance of interferon-gamma due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Interferon-gamma is also known as type II interferon." []
is_a: GO:0001816  ! cytokine production

[Term]
id: GO:0032611
name: interleukin-1 beta production
def: "The appearance of interleukin-1 beta due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." []
is_a: GO:0032612  ! interleukin-1 production

[Term]
id: GO:0032612
name: interleukin-1 production
def: "The appearance of interleukin-1 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." []
is_a: GO:0001816  ! cytokine production

[Term]
id: GO:0032613
name: interleukin-10 production
def: "The appearance of interleukin-10 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." []
is_a: GO:0001816  ! cytokine production

[Term]
id: GO:0032614
name: interleukin-11 production
def: "The appearance of interleukin-11 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." []
is_a: GO:0001816  ! cytokine production

[Term]
id: GO:0032615
name: interleukin-12 production
def: "The appearance of interleukin-12 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." []
is_a: GO:0001816  ! cytokine production

[Term]
id: GO:0032616
name: interleukin-13 production
def: "The appearance of interleukin-13 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." []
is_a: GO:0001816  ! cytokine production

[Term]
id: GO:0032617
name: interleukin-14 production
def: "The appearance of interleukin-14 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." []
is_a: GO:0001816  ! cytokine production

[Term]
id: GO:0032618
name: interleukin-15 production
def: "The appearance of interleukin-15 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." []
is_a: GO:0001816  ! cytokine production

[Term]
id: GO:0032619
name: interleukin-16 production
def: "The appearance of interleukin-16 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." []
is_a: GO:0001816  ! cytokine production

[Term]
id: GO:0032620
name: interleukin-17 production
def: "The appearance of interleukin-17 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." []
is_a: GO:0001816  ! cytokine production

[Term]
id: GO:0032621
name: interleukin-18 production
def: "The appearance of interleukin-18 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." []
is_a: GO:0001816  ! cytokine production

[Term]
id: GO:0032622
name: interleukin-19 production
def: "The appearance of interleukin-19 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." []
is_a: GO:0001816  ! cytokine production

[Term]
id: GO:0032623
name: interleukin-2 production
def: "The appearance of interleukin-2 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." []
is_a: GO:0001816  ! cytokine production

[Term]
id: GO:0032624
name: interleukin-20 production
def: "The appearance of interleukin-20 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." []
is_a: GO:0001816  ! cytokine production

[Term]
id: GO:0032625
name: interleukin-21 production
def: "The appearance of interleukin-21 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." []
is_a: GO:0001816  ! cytokine production

[Term]
id: GO:0032626
name: interleukin-22 production
def: "The appearance of interleukin-22 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." []
is_a: GO:0001816  ! cytokine production

[Term]
id: GO:0032627
name: interleukin-23 production
def: "The appearance of interleukin-23 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." []
is_a: GO:0001816  ! cytokine production

[Term]
id: GO:0032628
name: interleukin-24 production
def: "The appearance of interleukin-24 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." []
is_a: GO:0001816  ! cytokine production

[Term]
id: GO:0032629
name: interleukin-25 production
def: "The appearance of interleukin-25 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." []
is_a: GO:0001816  ! cytokine production

[Term]
id: GO:0032630
name: interleukin-26 production
def: "The appearance of interleukin-26 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." []
is_a: GO:0001816  ! cytokine production

[Term]
id: GO:0032631
name: interleukin-27 production
def: "The appearance of interleukin-27 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." []
is_a: GO:0001816  ! cytokine production

[Term]
id: GO:0032632
name: interleukin-3 production
def: "The appearance of interleukin-3 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." []
is_a: GO:0001816  ! cytokine production

[Term]
id: GO:0032633
name: interleukin-4 production
def: "The appearance of interleukin-4 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." []
is_a: GO:0001816  ! cytokine production

[Term]
id: GO:0032634
name: interleukin-5 production
def: "The appearance of interleukin-5 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." []
is_a: GO:0001816  ! cytokine production

[Term]
id: GO:0032635
name: interleukin-6 production
def: "The appearance of interleukin-6 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." []
is_a: GO:0001816  ! cytokine production

[Term]
id: GO:0032636
name: interleukin-7 production
def: "The appearance of interleukin-7 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." []
is_a: GO:0001816  ! cytokine production

[Term]
id: GO:0032637
name: interleukin-8 production
def: "The appearance of interleukin-8 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." []
is_a: GO:0001816  ! cytokine production

[Term]
id: GO:0032638
name: interleukin-9 production
def: "The appearance of interleukin-9 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." []
is_a: GO:0001816  ! cytokine production

[Term]
id: GO:0032639
name: TRAIL production
def: "The appearance of TRAIL due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." []
is_a: GO:0001816  ! cytokine production

[Term]
id: GO:0032640
name: tumor necrosis factor production
def: "The appearance of tumor necrosis factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." []
is_a: GO:0001816  ! cytokine production

[Term]
id: GO:0032641
name: lymphotoxin A production
def: "The appearance of lymphotoxin A due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." []
is_a: GO:0001816  ! cytokine production

[Term]
id: GO:0032905
name: transforming growth factor-beta1 production
def: "The appearance of transforming growth factor-beta1 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." []
is_a: GO:0001816  ! cytokine production

[Term]
id: GO:0032906
name: transforming growth factor-beta2 production
def: "The appearance of transforming growth factor-beta2 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." []
is_a: GO:0001816  ! cytokine production

[Term]
id: GO:0032907
name: transforming growth factor-beta3 production
def: "The appearance of transforming growth factor-beta3 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." []
is_a: GO:0001816  ! cytokine production

[Term]
id: GO:0034061
name: DNA polymerase activity
def: "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a nucleic acid template and primer." []
is_a: GO:0003824  ! catalytic activity

[Term]
id: GO:0034343
name: type III interferon production
def: "The appearance of type III interferon due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Type III interferons are members of the interferon-lambda gene family." []
is_a: GO:0001816  ! cytokine production

[Term]
id: GO:0042098
name: T cell proliferation
def: "The expansion of a T cell population by cell division. Follows T cell activation." []
is_a: GO:0008283  ! cell proliferation

[Term]
id: GO:0042101
name: T cell receptor complex
def: "A protein complex that contains a disulfide-linked heterodimer of T cell receptor (TCR) chains, which are members of the immunoglobulin superfamily, and mediates antigen recognition, ultimately resulting in T cell activation. The TCR heterodimer is associated with the CD3 complex, which consists of the nonpolymorphic polypeptides gamma, delta, epsilon, zeta, and, in some cases, eta (an RNA splice variant of zeta) or Fc epsilon chains." []
is_a: OBI:1110022  ! adaptive immune receptor

[Term]
id: GO:0042571
name: immunoglobulin complex, circulating
def: "An immunoglobulin complex that is secreted into extracellular space and found in mucosal areas or other tissues or circulating in the blood or lymph. In its canonical form, a circulating immunoglobulin complex is composed of two identical heavy chains and two identical light chains, held together by disulfide bonds. Some forms of are polymers of the basic structure and contain additional components such as J-chain and the secretory component." []
synonym: "antibody" EXACT []
is_a: OBI:1110022  ! adaptive immune receptor

[Term]
id: GO:0042575
name: DNA polymerase complex
def: "A protein complex that possesses DNA polymerase activity and is involved in template directed synthesis of DNA." []
is_a: GO:0043234  ! protein complex
is_a: OBI:0000427  ! enzyme
relationship: OBI:0000306 GO:0034061 ! DNA polymerase activity

[Term]
id: GO:0042611
name: MHC protein complex
def: "A transmembrane protein complex composed of an MHC alpha chain and, in most cases, either an MHC class II beta chain or an invariant beta2-microglobin chain, and with or without a bound peptide, lipid, or polysaccharide antigen." []
is_a: GO:0043234  ! protein complex

[Term]
id: GO:0043227
name: membrane-bounded organelle
def: "Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." []
is_a: GO:0005575  ! cellular_component

[Term]
id: GO:0043234
name: protein complex
def: "Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or carbohydrate groups." []
is_a: snap:MaterialEntity 

[Term]
id: GO:0050896
name: response to stimulus
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus." []
is_a: GO:0008150  ! biological_process

[Term]
id: HP:0000855
name: Insulin resistance
is_a: snap:Disposition 

[Term]
id: IAO:0000001

[Instance]
id: IAO:0000002
instance_of: IAO:0000078 

[Term]
id: IAO:0000003

[Term]
id: IAO:0000005

[Term]
id: IAO:0000006

[Term]
id: IAO:0000010

[Term]
id: IAO:0000027

[Term]
id: IAO:0000030

[Term]
id: IAO:0000032

[Term]
id: IAO:0000033

[Term]
id: IAO:0000037

[Term]
id: IAO:0000038

[Typedef]
id: IAO:0000039

[Term]
id: IAO:0000055

[Term]
id: IAO:0000078

[Term]
id: IAO:0000088

[Term]
id: IAO:0000098

[Term]
id: IAO:0000100

[Term]
id: IAO:0000101

[Term]
id: IAO:0000104

[Term]
id: IAO:0000109

[Instance]
id: IAO:0000120
instance_of: IAO:0000078 

[Instance]
id: IAO:0000121
instance_of: IAO:0000078 
instance_of: owl:Thing 

[Instance]
id: IAO:0000122
instance_of: IAO:0000078 

[Instance]
id: IAO:0000123
instance_of: IAO:0000078 

[Instance]
id: IAO:0000124
instance_of: IAO:0000078 

[Instance]
id: IAO:0000125
instance_of: IAO:0000078 
instance_of: owl:Thing 

[Typedef]
id: IAO:0000136

[Term]
id: IAO:0000178
is_a: snap:MaterialEntity 

[Term]
id: IAO:0000179

[Term]
id: IAO:0000183

[Term]
id: IAO:0000184

[Term]
id: IAO:0000186
is_a: IAO:0000178 

[Typedef]
id: IAO:0000221

[Typedef]
id: IAO:0000222
inverse_of_on_instance_level: OBI:1110112 

[Term]
id: IAO:0000306

[Term]
id: NCBITaxon:10026
name: Cricetinae
is_a: NCBITaxon:337677  ! Cricetidae

[Term]
id: NCBITaxon:10043
name: Phodopus
is_a: NCBITaxon:10026  ! Cricetinae

[Term]
id: NCBITaxon:10044
name: Phodopus sungorus
is_a: NCBITaxon:10043  ! Phodopus

[Term]
id: NCBITaxon:10066
name: Muridae
is_a: NCBITaxon:337687  ! Muroidea

[Term]
id: NCBITaxon:10088
name: Mus
is_a: NCBITaxon:39107  ! Murinae

[Term]
id: NCBITaxon:10090
name: Mus musculus
is_a: NCBITaxon:10088  ! Mus

[Term]
id: NCBITaxon:10114
name: Rattus
is_a: NCBITaxon:39107  ! Murinae

[Term]
id: NCBITaxon:10116
name: Rattus norvegicus
is_a: NCBITaxon:10114  ! Rattus

[Term]
id: NCBITaxon:10239
name: Viruses
is_a: OBI:0100026  ! organism

[Term]
id: NCBITaxon:102804
name: Asteroideae
is_a: NCBITaxon:4210  ! Asteraceae

[Term]
id: NCBITaxon:102814
name: Heliantheae
is_a: NCBITaxon:102804  ! Asteroideae

[Term]
id: NCBITaxon:102816
name: Mutisieae
is_a: NCBITaxon:219102  ! Mutisioideae

[Term]
id: NCBITaxon:104431
name: Obtectomera
is_a: NCBITaxon:37567  ! Ditrysia

[Term]
id: NCBITaxon:1060
name: Rhodobacter
is_a: NCBITaxon:31989  ! Rhodobacteraceae

[Term]
id: NCBITaxon:106178
name: canis group
is_a: NCBITaxon:943  ! Ehrlichia

[Term]
id: NCBITaxon:106179
name: phagocytophilum group
is_a: NCBITaxon:768  ! Anaplasma

[Term]
id: NCBITaxon:1063
name: Rhodobacter sphaeroides
is_a: NCBITaxon:1060  ! Rhodobacter

[Term]
id: NCBITaxon:106822
name: mitosporic Filobasidiales
is_a: NCBITaxon:90886  ! Filobasidiales

[Term]
id: NCBITaxon:107243
name: Thlaspi caerulescens
is_a: NCBITaxon:13287  ! Thlaspi

[Term]
id: NCBITaxon:107441
name: Cryptococcus [NCBITaxon:107441]
is_a: NCBITaxon:106822  ! mitosporic Filobasidiales

[Term]
id: NCBITaxon:1081
name: Rhodospirillum
is_a: NCBITaxon:41295  ! Rhodospirillaceae

[Term]
id: NCBITaxon:1085
name: Rhodospirillum rubrum
is_a: NCBITaxon:1081  ! Rhodospirillum

[Term]
id: NCBITaxon:1106
name: Chloroflexaceae
is_a: NCBITaxon:32064  ! Chloroflexales

[Term]
id: NCBITaxon:110618
name: Nectriaceae
is_a: NCBITaxon:5125  ! Hypocreales

[Term]
id: NCBITaxon:1107
name: Chloroflexus
is_a: NCBITaxon:1106  ! Chloroflexaceae

[Term]
id: NCBITaxon:1108
name: Chloroflexus aurantiacus
is_a: NCBITaxon:1107  ! Chloroflexus

[Term]
id: NCBITaxon:11118
name: Coronaviridae
is_a: NCBITaxon:76804  ! Nidovirales

[Term]
id: NCBITaxon:11119
name: Coronavirus
is_a: NCBITaxon:11118  ! Coronaviridae

[Term]
id: NCBITaxon:111520
name: Penaeoidea
is_a: NCBITaxon:6684  ! Dendrobranchiata

[Term]
id: NCBITaxon:111527
name: pseudomallei group
is_a: NCBITaxon:32008  ! Burkholderia

[Term]
id: NCBITaxon:1117
name: Cyanobacteria
is_a: NCBITaxon:2  ! Bacteria

[Term]
id: NCBITaxon:1118
name: Chroococcales
is_a: NCBITaxon:1117  ! Cyanobacteria

[Term]
id: NCBITaxon:1129
name: Synechococcus
is_a: NCBITaxon:1118  ! Chroococcales

[Term]
id: NCBITaxon:113509
name: Polytrichopsida
is_a: NCBITaxon:404260  ! Moss Superclass V

[Term]
id: NCBITaxon:113636
name: Populus tremula
is_a: NCBITaxon:3689  ! Populus

[Term]
id: NCBITaxon:1142
name: Synechocystis
is_a: NCBITaxon:1118  ! Chroococcales

[Term]
id: NCBITaxon:114277
name: spotted fever group
is_a: NCBITaxon:780  ! Rickettsia

[Term]
id: NCBITaxon:114292
name: typhus group
is_a: NCBITaxon:780  ! Rickettsia

[Term]
id: NCBITaxon:1143
name: Synechocystis sp.
is_a: NCBITaxon:1142  ! Synechocystis

[Term]
id: NCBITaxon:114524
name: Saccharomyces kudriavzevii
is_a: NCBITaxon:4930  ! Saccharomyces

[Term]
id: NCBITaxon:114525
name: Saccharomyces mikatae
is_a: NCBITaxon:4930  ! Saccharomyces

[Term]
id: NCBITaxon:114656
name: Funariidae
is_a: NCBITaxon:3214  ! Bryopsida

[Term]
id: NCBITaxon:1148
name: Synechocystis sp. PCC 6803
is_a: NCBITaxon:1142  ! Synechocystis

[Term]
id: NCBITaxon:1150
name: Oscillatoriales
is_a: NCBITaxon:1117  ! Cyanobacteria

[Term]
id: NCBITaxon:1161
name: Nostocales
is_a: NCBITaxon:1117  ! Cyanobacteria

[Term]
id: NCBITaxon:1162
name: Nostocaceae
is_a: NCBITaxon:1161  ! Nostocales

[Term]
id: NCBITaxon:1163
name: Anabaena
is_a: NCBITaxon:1162  ! Nostocaceae

[Term]
id: NCBITaxon:1172
name: Anabaena variabilis
is_a: NCBITaxon:1163  ! Anabaena

[Term]
id: NCBITaxon:117570
name: Teleostomi
is_a: NCBITaxon:7776  ! Gnathostomata

[Term]
id: NCBITaxon:117571
name: Euteleostomi
is_a: NCBITaxon:117570  ! Teleostomi

[Term]
id: NCBITaxon:1177
name: Nostoc
is_a: NCBITaxon:1162  ! Nostocaceae

[Term]
id: NCBITaxon:117747
name: Sphingobacteria
is_a: NCBITaxon:976  ! Bacteroidetes

[Term]
id: NCBITaxon:118267
name: mitosporic Saccharomycetales
is_a: NCBITaxon:4892  ! Saccharomycetales

[Term]
id: NCBITaxon:118781
name: Populus tomentosa
is_a: NCBITaxon:3689  ! Populus

[Term]
id: NCBITaxon:118882
name: Brucellaceae
is_a: NCBITaxon:356  ! Rhizobiales

[Term]
id: NCBITaxon:118883
name: Sulfolobaceae
is_a: NCBITaxon:2281  ! Sulfolobales

[Term]
id: NCBITaxon:118964
name: Deinococcales
is_a: NCBITaxon:188787  ! Deinococci

[Term]
id: NCBITaxon:118968
name: Coxiellaceae
is_a: NCBITaxon:118969  ! Legionellales

[Term]
id: NCBITaxon:118969
name: Legionellales
is_a: NCBITaxon:1236  ! Gammaproteobacteria

[Term]
id: NCBITaxon:119060
name: Burkholderiaceae
is_a: NCBITaxon:80840  ! Burkholderiales

[Term]
id: NCBITaxon:119065
name: unclassified Burkholderiales
is_a: NCBITaxon:80840  ! Burkholderiales

[Term]
id: NCBITaxon:119072
name: Thermoanaerobacter tengcongensis
is_a: NCBITaxon:1754  ! Thermoanaerobacter

[Term]
id: NCBITaxon:119089
name: Chromadorea
is_a: NCBITaxon:6231  ! Nematoda

[Term]
id: NCBITaxon:119258
name: Bombyciformes
is_a: NCBITaxon:37569  ! Bombycoidea

[Term]
id: NCBITaxon:119977
name: Acidithiobacillus
is_a: NCBITaxon:225058  ! Acidithiobacillaceae

[Term]
id: NCBITaxon:1205
name: Trichodesmium
is_a: NCBITaxon:1150  ! Oscillatoriales

[Term]
id: NCBITaxon:1206
name: Trichodesmium erythraeum
is_a: NCBITaxon:1205  ! Trichodesmium

[Term]
id: NCBITaxon:121759
name: Paracoccidioides brasiliensis
is_a: NCBITaxon:38946  ! Paracoccidioides

[Term]
id: NCBITaxon:1224
name: Proteobacteria
is_a: NCBITaxon:2  ! Bacteria

[Term]
id: NCBITaxon:123365
name: Neoteleostei
is_a: NCBITaxon:186839  ! Neognathi

[Term]
id: NCBITaxon:123366
name: Eurypterygii
is_a: NCBITaxon:123365  ! Neoteleostei

[Term]
id: NCBITaxon:123367
name: Ctenosquamata
is_a: NCBITaxon:123366  ! Eurypterygii

[Term]
id: NCBITaxon:123368
name: Acanthomorpha
is_a: NCBITaxon:123367  ! Ctenosquamata

[Term]
id: NCBITaxon:123369
name: Euacanthomorpha
is_a: NCBITaxon:123368  ! Acanthomorpha

[Term]
id: NCBITaxon:123370
name: Holacanthopterygii
is_a: NCBITaxon:123369  ! Euacanthomorpha

[Term]
id: NCBITaxon:1236
name: Gammaproteobacteria
is_a: NCBITaxon:1224  ! Proteobacteria

[Term]
id: NCBITaxon:1239
name: Firmicutes
is_a: NCBITaxon:2  ! Bacteria

[Term]
id: NCBITaxon:1243
name: Leuconostoc
is_a: NCBITaxon:81850  ! Leuconostocaceae

[Term]
id: NCBITaxon:1245
name: Leuconostoc mesenteroides
is_a: NCBITaxon:1243  ! Leuconostoc

[Term]
id: NCBITaxon:1247
name: Oenococcus oeni
is_a: NCBITaxon:46254  ! Oenococcus

[Term]
id: NCBITaxon:1253
name: Pediococcus
is_a: NCBITaxon:33958  ! Lactobacillaceae

[Term]
id: NCBITaxon:1255
name: Pediococcus pentosaceus
is_a: NCBITaxon:1253  ! Pediococcus

[Term]
id: NCBITaxon:1279
name: Staphylococcus
is_a: NCBITaxon:90964  ! Staphylococcaceae

[Term]
id: NCBITaxon:1280
name: Staphylococcus aureus
is_a: NCBITaxon:1279  ! Staphylococcus

[Term]
id: NCBITaxon:129213
name: Polytrichum juniperinum
is_a: NCBITaxon:3212  ! Polytrichum

[Term]
id: NCBITaxon:1297
name: Deinococcus-Thermus
is_a: NCBITaxon:2  ! Bacteria

[Term]
id: NCBITaxon:1298
name: Deinococcus
is_a: NCBITaxon:183710  ! Deinococcaceae

[Term]
id: NCBITaxon:1299
name: Deinococcus radiodurans
is_a: NCBITaxon:1298  ! Deinococcus

[Term]
id: NCBITaxon:129947
name: Euacanthopterygii
is_a: NCBITaxon:32455  ! Acanthopterygii

[Term]
id: NCBITaxon:1300
name: Streptococcaceae
is_a: NCBITaxon:186826  ! Lactobacillales

[Term]
id: NCBITaxon:1301
name: Streptococcus
is_a: NCBITaxon:1300  ! Streptococcaceae

[Term]
id: NCBITaxon:1302
name: Streptococcus gordonii
is_a: NCBITaxon:1301  ! Streptococcus

[Term]
id: NCBITaxon:1307
name: Streptococcus suis
is_a: NCBITaxon:1301  ! Streptococcus

[Term]
id: NCBITaxon:1309
name: Streptococcus mutans
is_a: NCBITaxon:1301  ! Streptococcus

[Term]
id: NCBITaxon:1311
name: Streptococcus agalactiae
is_a: NCBITaxon:1301  ! Streptococcus

[Term]
id: NCBITaxon:131221
name: Streptophytina
is_a: NCBITaxon:35493  ! Streptophyta

[Term]
id: NCBITaxon:1313
name: Streptococcus pneumoniae
is_a: NCBITaxon:1301  ! Streptococcus

[Term]
id: NCBITaxon:13134
name: Magnetospirillum
is_a: NCBITaxon:41295  ! Rhodospirillaceae

[Term]
id: NCBITaxon:1314
name: Streptococcus pyogenes
is_a: NCBITaxon:1301  ! Streptococcus

[Term]
id: NCBITaxon:13287
name: Thlaspi
is_a: NCBITaxon:3700  ! Brassicaceae

[Term]
id: NCBITaxon:13373
name: Burkholderia mallei
is_a: NCBITaxon:32008  ! Burkholderia

[Term]
id: NCBITaxon:133894
name: Penaeus
is_a: NCBITaxon:6685  ! Penaeidae

[Term]
id: NCBITaxon:13442
name: Coffea
is_a: NCBITaxon:169640  ! Coffeeae

[Term]
id: NCBITaxon:13443
name: Coffea arabica
is_a: NCBITaxon:13442  ! Coffea

[Term]
id: NCBITaxon:134537
name: Burkholderia fungorum
is_a: NCBITaxon:32008  ! Burkholderia

[Term]
id: NCBITaxon:1350
name: Enterococcus
is_a: NCBITaxon:81852  ! Enterococcaceae

[Term]
id: NCBITaxon:1351
name: Enterococcus faecalis
is_a: NCBITaxon:1350  ! Enterococcus

[Term]
id: NCBITaxon:1352
name: Enterococcus faecium
is_a: NCBITaxon:1350  ! Enterococcus

[Term]
id: NCBITaxon:13546
name: Gerbera
is_a: NCBITaxon:102816  ! Mutisieae

[Term]
id: NCBITaxon:135614
name: Xanthomonadales
is_a: NCBITaxon:1236  ! Gammaproteobacteria

[Term]
id: NCBITaxon:135621
name: Pseudomonadaceae
is_a: NCBITaxon:72274  ! Pseudomonadales

[Term]
id: NCBITaxon:135622
name: Alteromonadales
is_a: NCBITaxon:1236  ! Gammaproteobacteria

[Term]
id: NCBITaxon:135623
name: Vibrionales
is_a: NCBITaxon:1236  ! Gammaproteobacteria

[Term]
id: NCBITaxon:135625
name: Pasteurellales
is_a: NCBITaxon:1236  ! Gammaproteobacteria

[Term]
id: NCBITaxon:1357
name: Lactococcus
is_a: NCBITaxon:1300  ! Streptococcaceae

[Term]
id: NCBITaxon:1358
name: Lactococcus lactis
is_a: NCBITaxon:1357  ! Lactococcus

[Term]
id: NCBITaxon:136
name: Spirochaetales
is_a: NCBITaxon:203692  ! Spirochaetes (class)

[Term]
id: NCBITaxon:136841
name: Pseudomonas aeruginosa group
is_a: NCBITaxon:286  ! Pseudomonas

[Term]
id: NCBITaxon:136843
name: Pseudomonas fluorescens group
is_a: NCBITaxon:286  ! Pseudomonas

[Term]
id: NCBITaxon:136845
name: Pseudomonas putida group
is_a: NCBITaxon:286  ! Pseudomonas

[Term]
id: NCBITaxon:137
name: Spirochaetaceae
is_a: NCBITaxon:136  ! Spirochaetales

[Term]
id: NCBITaxon:138
name: Borrelia
is_a: NCBITaxon:137  ! Spirochaetaceae

[Term]
id: NCBITaxon:13819
name: Pteridaceae
is_a: NCBITaxon:3268  ! Filicales

[Term]
id: NCBITaxon:1385
name: Bacillales
is_a: NCBITaxon:91061  ! Bacilli

[Term]
id: NCBITaxon:1386
name: Bacillus
is_a: NCBITaxon:186817  ! Bacillaceae

[Term]
id: NCBITaxon:139
name: Borrelia burgdorferi
is_a: NCBITaxon:64895  ! Borrelia burgdorferi group

[Term]
id: NCBITaxon:1392
name: Bacillus anthracis
is_a: NCBITaxon:86661  ! Bacillus cereus group

[Term]
id: NCBITaxon:139271
name: Pinus [NCBITaxon:139271]
is_a: NCBITaxon:3337  ! Pinus

[Term]
id: NCBITaxon:1396
name: Bacillus cereus
is_a: NCBITaxon:86661  ! Bacillus cereus group

[Term]
id: NCBITaxon:1423
name: Bacillus subtilis
is_a: NCBITaxon:1386  ! Bacillus

[Term]
id: NCBITaxon:142796
name: Mycetozoa
is_a: NCBITaxon:2759  ! Eukaryota

[Term]
id: NCBITaxon:145260
name: Methanothermobacter
is_a: NCBITaxon:2159  ! Methanobacteriaceae

[Term]
id: NCBITaxon:145262
name: Methanothermobacter thermautotrophicus
is_a: NCBITaxon:145260  ! Methanothermobacter

[Term]
id: NCBITaxon:147367
name: Ehrhartoideae
is_a: NCBITaxon:359160  ! BEP clade

[Term]
id: NCBITaxon:147368
name: Pooideae
is_a: NCBITaxon:359160  ! BEP clade

[Term]
id: NCBITaxon:147369
name: Panicoideae
is_a: NCBITaxon:147370  ! PACCAD clade

[Term]
id: NCBITaxon:147370
name: PACCAD clade
is_a: NCBITaxon:4479  ! Poaceae

[Term]
id: NCBITaxon:147380
name: Oryzeae
is_a: NCBITaxon:147367  ! Ehrhartoideae

[Term]
id: NCBITaxon:147387
name: Poeae
is_a: NCBITaxon:147368  ! Pooideae

[Term]
id: NCBITaxon:147389
name: Triticeae
is_a: NCBITaxon:147368  ! Pooideae

[Term]
id: NCBITaxon:147429
name: Andropogoneae
is_a: NCBITaxon:147369  ! Panicoideae

[Term]
id: NCBITaxon:147537
name: Saccharomycotina
is_a: NCBITaxon:4890  ! Ascomycota

[Term]
id: NCBITaxon:147538
name: Pezizomycotina
is_a: NCBITaxon:4890  ! Ascomycota

[Term]
id: NCBITaxon:147543
name: Dothideomycetes et Chaetothyriomycetes incertae sedis
is_a: NCBITaxon:147538  ! Pezizomycotina

[Term]
id: NCBITaxon:147545
name: Eurotiomycetes
is_a: NCBITaxon:147538  ! Pezizomycotina

[Term]
id: NCBITaxon:147550
name: Sordariomycetes
is_a: NCBITaxon:147538  ! Pezizomycotina

[Term]
id: NCBITaxon:147551
name: Sordariomycetes incertae sedis
is_a: NCBITaxon:147550  ! Sordariomycetes

[Term]
id: NCBITaxon:147554
name: Schizosaccharomycetes
is_a: NCBITaxon:4890  ! Ascomycota

[Term]
id: NCBITaxon:148303
name: Magnaporthe
is_a: NCBITaxon:81093  ! Magnaporthaceae

[Term]
id: NCBITaxon:148305
name: Magnaporthe grisea
is_a: NCBITaxon:148303  ! Magnaporthe

[Term]
id: NCBITaxon:1485
name: Clostridium
is_a: NCBITaxon:31979  ! Clostridiaceae

[Term]
id: NCBITaxon:1488
name: Clostridium acetobutylicum
is_a: NCBITaxon:1485  ! Clostridium

[Term]
id: NCBITaxon:1491
name: Clostridium botulinum
is_a: NCBITaxon:1485  ! Clostridium

[Term]
id: NCBITaxon:1509
name: Clostridium sporogenes
is_a: NCBITaxon:1485  ! Clostridium

[Term]
id: NCBITaxon:1515
name: Clostridium thermocellum
is_a: NCBITaxon:1485  ! Clostridium

[Term]
id: NCBITaxon:1525
name: Moorella thermoacetica
is_a: NCBITaxon:44260  ! Moorella

[Term]
id: NCBITaxon:155616
name: Tremellomycetidae
is_a: NCBITaxon:165804  ! Heterobasidiomycetes

[Term]
id: NCBITaxon:155619
name: Homobasidiomycetes
is_a: NCBITaxon:5302  ! Hymenomycetes

[Term]
id: NCBITaxon:155892
name: Caulobacter vibrioides
is_a: NCBITaxon:75  ! Caulobacter

[Term]
id: NCBITaxon:156152
name: Plantaginaceae
is_a: NCBITaxon:4143  ! Lamiales

[Term]
id: NCBITaxon:156439
name: Group 2 species
is_a: NCBITaxon:11119  ! Coronavirus

[Term]
id: NCBITaxon:157
name: Treponema
is_a: NCBITaxon:137  ! Spirochaetaceae

[Term]
id: NCBITaxon:1578
name: Lactobacillus
is_a: NCBITaxon:33958  ! Lactobacillaceae

[Term]
id: NCBITaxon:158
name: Treponema denticola
is_a: NCBITaxon:157  ! Treponema

[Term]
id: NCBITaxon:159033
name: Citrus aurantiifolia
is_a: NCBITaxon:2706  ! Citrus

[Term]
id: NCBITaxon:1596
name: Lactobacillus gasseri
is_a: NCBITaxon:1578  ! Lactobacillus

[Term]
id: NCBITaxon:1599
name: Lactobacillus sakei
is_a: NCBITaxon:1578  ! Lactobacillus

[Term]
id: NCBITaxon:160
name: Treponema pallidum
is_a: NCBITaxon:157  ! Treponema

[Term]
id: NCBITaxon:1624
name: Lactobacillus salivarius
is_a: NCBITaxon:1578  ! Lactobacillus

[Term]
id: NCBITaxon:1637
name: Listeria
is_a: NCBITaxon:186820  ! Listeriaceae

[Term]
id: NCBITaxon:163735
name: Phaseoleae
is_a: NCBITaxon:3814  ! Papilionoideae

[Term]
id: NCBITaxon:163742
name: Trifolieae
is_a: NCBITaxon:3814  ! Papilionoideae

[Term]
id: NCBITaxon:163743
name: Vicieae
is_a: NCBITaxon:3814  ! Papilionoideae

[Term]
id: NCBITaxon:163747
name: Loteae
is_a: NCBITaxon:3814  ! Papilionoideae

[Term]
id: NCBITaxon:1639
name: Listeria monocytogenes
is_a: NCBITaxon:1637  ! Listeria

[Term]
id: NCBITaxon:1642
name: Listeria innocua
is_a: NCBITaxon:1637  ! Listeria

[Term]
id: NCBITaxon:1653
name: Corynebacteriaceae
is_a: NCBITaxon:85007  ! Corynebacterineae

[Term]
id: NCBITaxon:1654
name: Actinomyces
is_a: NCBITaxon:2049  ! Actinomycetaceae

[Term]
id: NCBITaxon:1655
name: Actinomyces naeslundii
is_a: NCBITaxon:1654  ! Actinomyces

[Term]
id: NCBITaxon:165696
name: Novosphingobium
is_a: NCBITaxon:41297  ! Sphingomonadaceae

[Term]
id: NCBITaxon:165804
name: Heterobasidiomycetes
is_a: NCBITaxon:5302  ! Hymenomycetes

[Term]
id: NCBITaxon:1678
name: Bifidobacterium
is_a: NCBITaxon:31953  ! Bifidobacteriaceae

[Term]
id: NCBITaxon:169618
name: Ixoroideae
is_a: NCBITaxon:24966  ! Rubiaceae

[Term]
id: NCBITaxon:169640
name: Coffeeae
is_a: NCBITaxon:169618  ! Ixoroideae

[Term]
id: NCBITaxon:1716
name: Corynebacterium
is_a: NCBITaxon:1653  ! Corynebacteriaceae

[Term]
id: NCBITaxon:171638
name: Rosoideae
is_a: NCBITaxon:3745  ! Rosaceae

[Term]
id: NCBITaxon:1718
name: Corynebacterium glutamicum
is_a: NCBITaxon:1716  ! Corynebacterium

[Term]
id: NCBITaxon:175121
name: Passeroidea
is_a: NCBITaxon:9126  ! Passeriformes

[Term]
id: NCBITaxon:1754
name: Thermoanaerobacter
is_a: NCBITaxon:186814  ! Thermoanaerobacteriaceae

[Term]
id: NCBITaxon:1760
name: Actinobacteria (class)
is_a: NCBITaxon:201174  ! Actinobacteria

[Term]
id: NCBITaxon:1762
name: Mycobacteriaceae
is_a: NCBITaxon:85007  ! Corynebacterineae

[Term]
id: NCBITaxon:1763
name: Mycobacterium
is_a: NCBITaxon:1762  ! Mycobacteriaceae

[Term]
id: NCBITaxon:1769
name: Mycobacterium leprae
is_a: NCBITaxon:1763  ! Mycobacterium

[Term]
id: NCBITaxon:1773
name: Mycobacterium tuberculosis
is_a: NCBITaxon:77643  ! Mycobacterium tuberculosis complex

[Term]
id: NCBITaxon:18101
name: Gerbera hybrid cultivar
is_a: NCBITaxon:13546  ! Gerbera

[Term]
id: NCBITaxon:183710
name: Deinococcaceae
is_a: NCBITaxon:118964  ! Deinococcales

[Term]
id: NCBITaxon:183770
name: Enterogona
is_a: NCBITaxon:7713  ! Ascidiacea

[Term]
id: NCBITaxon:183924
name: Thermoprotei
is_a: NCBITaxon:28889  ! Crenarchaeota

[Term]
id: NCBITaxon:183925
name: Methanobacteria
is_a: NCBITaxon:28890  ! Euryarchaeota

[Term]
id: NCBITaxon:183963
name: Halobacteria
is_a: NCBITaxon:28890  ! Euryarchaeota

[Term]
id: NCBITaxon:183967
name: Thermoplasmata
is_a: NCBITaxon:28890  ! Euryarchaeota

[Term]
id: NCBITaxon:183968
name: Thermococci
is_a: NCBITaxon:28890  ! Euryarchaeota

[Term]
id: NCBITaxon:183980
name: Archaeoglobi
is_a: NCBITaxon:28890  ! Euryarchaeota

[Term]
id: NCBITaxon:184208
name: Psathyrellaceae
is_a: NCBITaxon:5338  ! Agaricales

[Term]
id: NCBITaxon:184431
name: Coprinopsis
is_a: NCBITaxon:184208  ! Psathyrellaceae

[Term]
id: NCBITaxon:186285
name: Drosophiliti
is_a: NCBITaxon:46879  ! Drosophilina

[Term]
id: NCBITaxon:186328
name: Entomoplasmatales
is_a: NCBITaxon:31969  ! Mollicutes

[Term]
id: NCBITaxon:186623
name: Actinopteri
is_a: NCBITaxon:7898  ! Actinopterygii

[Term]
id: NCBITaxon:186624
name: Elopocephala
is_a: NCBITaxon:32443  ! Teleostei

[Term]
id: NCBITaxon:186625
name: Clupeocephala
is_a: NCBITaxon:186624  ! Elopocephala

[Term]
id: NCBITaxon:186626
name: Otophysi
is_a: NCBITaxon:32519  ! Ostariophysi

[Term]
id: NCBITaxon:186627
name: Cypriniphysi
is_a: NCBITaxon:186626  ! Otophysi

[Term]
id: NCBITaxon:186634
name: Otocephala
is_a: NCBITaxon:186625  ! Clupeocephala

[Term]
id: NCBITaxon:186801
name: Clostridia
is_a: NCBITaxon:1239  ! Firmicutes

[Term]
id: NCBITaxon:186802
name: Clostridiales
is_a: NCBITaxon:186801  ! Clostridia

[Term]
id: NCBITaxon:186807
name: Peptococcaceae
is_a: NCBITaxon:186802  ! Clostridiales

[Term]
id: NCBITaxon:186814
name: Thermoanaerobacteriaceae
is_a: NCBITaxon:68295  ! Thermoanaerobacteriales

[Term]
id: NCBITaxon:186817
name: Bacillaceae
is_a: NCBITaxon:1385  ! Bacillales

[Term]
id: NCBITaxon:186820
name: Listeriaceae
is_a: NCBITaxon:1385  ! Bacillales

[Term]
id: NCBITaxon:186823
name: Alicyclobacillaceae
is_a: NCBITaxon:1385  ! Bacillales

[Term]
id: NCBITaxon:186826
name: Lactobacillales
is_a: NCBITaxon:91061  ! Bacilli

[Term]
id: NCBITaxon:186839
name: Neognathi
is_a: NCBITaxon:32447  ! Euteleostei

[Term]
id: NCBITaxon:186841
name: Salmonoidei
is_a: NCBITaxon:8006  ! Salmoniformes

[Term]
id: NCBITaxon:187619
name: Anurophorinae
is_a: NCBITaxon:36141  ! Isotomidae

[Term]
id: NCBITaxon:187622
name: Cryptopygus
is_a: NCBITaxon:187619  ! Anurophorinae

[Term]
id: NCBITaxon:187623
name: Cryptopygus antarcticus
is_a: NCBITaxon:187622  ! Cryptopygus

[Term]
id: NCBITaxon:187857
name: Aquificae (class)
is_a: NCBITaxon:200783  ! Aquificae

[Term]
id: NCBITaxon:188
name: Magnetospirillum magnetotacticum
is_a: NCBITaxon:13134  ! Magnetospirillum

[Term]
id: NCBITaxon:1883
name: Streptomyces
is_a: NCBITaxon:2062  ! Streptomycetaceae

[Term]
id: NCBITaxon:188708
name: Thermotogae (class)
is_a: NCBITaxon:200918  ! Thermotogae

[Term]
id: NCBITaxon:188709
name: Thermotogaceae
is_a: NCBITaxon:2419  ! Thermotogales

[Term]
id: NCBITaxon:188787
name: Deinococci
is_a: NCBITaxon:1297  ! Deinococcus-Thermus

[Term]
id: NCBITaxon:189478
name: Orbiliomycetes
is_a: NCBITaxon:147538  ! Pezizomycotina

[Term]
id: NCBITaxon:189479
name: Orbiliales
is_a: NCBITaxon:189478  ! Orbiliomycetes

[Term]
id: NCBITaxon:19013
name: Zinnia
is_a: NCBITaxon:102814  ! Heliantheae

[Term]
id: NCBITaxon:1902
name: Streptomyces coelicolor
is_a: NCBITaxon:1883  ! Streptomyces

[Term]
id: NCBITaxon:19205
name: Lepidium
is_a: NCBITaxon:3700  ! Brassicaceae

[Term]
id: NCBITaxon:194
name: Campylobacter
is_a: NCBITaxon:72294  ! Campylobacteraceae

[Term]
id: NCBITaxon:194924
name: Desulfovibrionaceae
is_a: NCBITaxon:213115  ! Desulfovibrionales

[Term]
id: NCBITaxon:195633
name: Pleuronichthys
is_a: NCBITaxon:8256  ! Pleuronectidae

[Term]
id: NCBITaxon:195635
name: Pleuronichthys verticalis
is_a: NCBITaxon:195633  ! Pleuronichthys

[Term]
id: NCBITaxon:196627
name: Corynebacterium glutamicum ATCC 13032
is_a: NCBITaxon:1718  ! Corynebacterium glutamicum

[Term]
id: NCBITaxon:197
name: Campylobacter jejuni
is_a: NCBITaxon:194  ! Campylobacter

[Term]
id: NCBITaxon:197562
name: Pancrustacea
is_a: NCBITaxon:197563  ! Mandibulata

[Term]
id: NCBITaxon:197563
name: Mandibulata
is_a: NCBITaxon:6656  ! Arthropoda

[Term]
id: NCBITaxon:2
name: Bacteria
is_a: OBI:0100026  ! organism

[Term]
id: NCBITaxon:200666
name: Sphingobacteriales
is_a: NCBITaxon:117747  ! Sphingobacteria

[Term]
id: NCBITaxon:200783
name: Aquificae
is_a: NCBITaxon:2  ! Bacteria

[Term]
id: NCBITaxon:200795
name: Chloroflexi
is_a: NCBITaxon:2  ! Bacteria

[Term]
id: NCBITaxon:200918
name: Thermotogae
is_a: NCBITaxon:2  ! Bacteria

[Term]
id: NCBITaxon:201174
name: Actinobacteria
is_a: NCBITaxon:2  ! Bacteria

[Term]
id: NCBITaxon:2021
name: Thermobifida fusca
is_a: NCBITaxon:83677  ! Thermobifida

[Term]
id: NCBITaxon:203490
name: Fusobacteria (class)
is_a: NCBITaxon:32066  ! Fusobacteria

[Term]
id: NCBITaxon:203491
name: Fusobacterales
is_a: NCBITaxon:203490  ! Fusobacteria (class)

[Term]
id: NCBITaxon:203492
name: Fusobacteriaceae
is_a: NCBITaxon:203491  ! Fusobacterales

[Term]
id: NCBITaxon:203691
name: Spirochaetes
is_a: NCBITaxon:2  ! Bacteria

[Term]
id: NCBITaxon:203692
name: Spirochaetes (class)
is_a: NCBITaxon:203691  ! Spirochaetes

[Term]
id: NCBITaxon:2037
name: Actinomycetales
is_a: NCBITaxon:85003  ! Actinobacteridae

[Term]
id: NCBITaxon:204428
name: Chlamydiae
is_a: NCBITaxon:51290  ! Chlamydiae/Verrucomicrobia group

[Term]
id: NCBITaxon:204429
name: Chlamydiae (class)
is_a: NCBITaxon:204428  ! Chlamydiae

[Term]
id: NCBITaxon:204441
name: Rhodospirillales
is_a: NCBITaxon:28211  ! Alphaproteobacteria

[Term]
id: NCBITaxon:204455
name: Rhodobacterales
is_a: NCBITaxon:28211  ! Alphaproteobacteria

[Term]
id: NCBITaxon:204457
name: Sphingomonadales
is_a: NCBITaxon:28211  ! Alphaproteobacteria

[Term]
id: NCBITaxon:204458
name: Caulobacterales
is_a: NCBITaxon:28211  ! Alphaproteobacteria

[Term]
id: NCBITaxon:204773
name: Herminiimonas arsenicoxydans
is_a: NCBITaxon:303379  ! Herminiimonas

[Term]
id: NCBITaxon:2049
name: Actinomycetaceae
is_a: NCBITaxon:85005  ! Actinomycineae

[Term]
id: NCBITaxon:2062
name: Streptomycetaceae
is_a: NCBITaxon:85011  ! Streptomycineae

[Term]
id: NCBITaxon:206350
name: Methylophilales
is_a: NCBITaxon:28216  ! Betaproteobacteria

[Term]
id: NCBITaxon:206351
name: Neisseriales
is_a: NCBITaxon:28216  ! Betaproteobacteria

[Term]
id: NCBITaxon:206389
name: Rhodocyclales
is_a: NCBITaxon:28216  ! Betaproteobacteria

[Term]
id: NCBITaxon:207598
name: Homo/Pan/Gorilla group
is_a: NCBITaxon:9604  ! Hominidae

[Term]
id: NCBITaxon:2085
name: Mycoplasmatales
is_a: NCBITaxon:31969  ! Mollicutes

[Term]
id: NCBITaxon:208557
name: Pasteuria nishizawae
is_a: NCBITaxon:86004  ! Pasteuria

[Term]
id: NCBITaxon:209
name: Helicobacter
is_a: NCBITaxon:72293  ! Helicobacteraceae

[Term]
id: NCBITaxon:2092
name: Mycoplasmataceae
is_a: NCBITaxon:2085  ! Mycoplasmatales

[Term]
id: NCBITaxon:2093
name: Mycoplasma
is_a: NCBITaxon:2092  ! Mycoplasmataceae

[Term]
id: NCBITaxon:2097
name: Mycoplasma genitalium
is_a: NCBITaxon:2093  ! Mycoplasma

[Term]
id: NCBITaxon:210
name: Helicobacter pylori
is_a: NCBITaxon:209  ! Helicobacter

[Term]
id: NCBITaxon:210007
name: Streptococcus mutans UA159
is_a: NCBITaxon:1309  ! Streptococcus mutans

[Term]
id: NCBITaxon:2104
name: Mycoplasma pneumoniae
is_a: NCBITaxon:2093  ! Mycoplasma

[Term]
id: NCBITaxon:2107
name: Mycoplasma pulmonis
is_a: NCBITaxon:2093  ! Mycoplasma

[Term]
id: NCBITaxon:2129
name: Ureaplasma
is_a: NCBITaxon:2092  ! Mycoplasmataceae

[Term]
id: NCBITaxon:2130
name: Ureaplasma urealyticum
is_a: NCBITaxon:2129  ! Ureaplasma

[Term]
id: NCBITaxon:213115
name: Desulfovibrionales
is_a: NCBITaxon:28221  ! Deltaproteobacteria

[Term]
id: NCBITaxon:213422
name: Geobacteraceae
is_a: NCBITaxon:69541  ! Desulfuromonadales

[Term]
id: NCBITaxon:213849
name: Campylobacterales
is_a: NCBITaxon:29547  ! Epsilonproteobacteria

[Term]
id: NCBITaxon:2151
name: Mesoplasma florum
is_a: NCBITaxon:46239  ! Mesoplasma

[Term]
id: NCBITaxon:2157
name: Archaea
is_a: OBI:0100026  ! organism

[Term]
id: NCBITaxon:2158
name: Methanobacteriales
is_a: NCBITaxon:183925  ! Methanobacteria

[Term]
id: NCBITaxon:2159
name: Methanobacteriaceae
is_a: NCBITaxon:2158  ! Methanobacteriales

[Term]
id: NCBITaxon:216193
name: Sylvia communis
is_a: NCBITaxon:43162  ! Sylvia

[Term]
id: NCBITaxon:216441
name: Lymnaeoidea
is_a: NCBITaxon:6520  ! Basommatophora

[Term]
id: NCBITaxon:216780
name: Antirrhineae
is_a: NCBITaxon:156152  ! Plantaginaceae

[Term]
id: NCBITaxon:216816
name: Bifidobacterium longum
is_a: NCBITaxon:1678  ! Bifidobacterium

[Term]
id: NCBITaxon:219102
name: Mutisioideae
is_a: NCBITaxon:4210  ! Asteraceae

[Term]
id: NCBITaxon:2206
name: Methanosarcinaceae
is_a: NCBITaxon:94695  ! Methanosarcinales

[Term]
id: NCBITaxon:2207
name: Methanosarcina
is_a: NCBITaxon:2206  ! Methanosarcinaceae

[Term]
id: NCBITaxon:2208
name: Methanosarcina barkeri
is_a: NCBITaxon:2207  ! Methanosarcina

[Term]
id: NCBITaxon:2209
name: Methanosarcina mazei
is_a: NCBITaxon:2207  ! Methanosarcina

[Term]
id: NCBITaxon:2225
name: Methanococcoides
is_a: NCBITaxon:2206  ! Methanosarcinaceae

[Term]
id: NCBITaxon:222543
name: Hypocreomycetidae
is_a: NCBITaxon:147550  ! Sordariomycetes

[Term]
id: NCBITaxon:222544
name: Sordariomycetidae
is_a: NCBITaxon:147550  ! Sordariomycetes

[Term]
id: NCBITaxon:2231
name: Archaeoglobales
is_a: NCBITaxon:183980  ! Archaeoglobi

[Term]
id: NCBITaxon:2232
name: Archaeoglobaceae
is_a: NCBITaxon:2231  ! Archaeoglobales

[Term]
id: NCBITaxon:2233
name: Archaeoglobus
is_a: NCBITaxon:2232  ! Archaeoglobaceae

[Term]
id: NCBITaxon:2234
name: Archaeoglobus fulgidus
is_a: NCBITaxon:2233  ! Archaeoglobus

[Term]
id: NCBITaxon:2235
name: Halobacteriales
is_a: NCBITaxon:183963  ! Halobacteria

[Term]
id: NCBITaxon:2236
name: Halobacteriaceae
is_a: NCBITaxon:2235  ! Halobacteriales

[Term]
id: NCBITaxon:2239
name: Halobacterium
is_a: NCBITaxon:2236  ! Halobacteriaceae

[Term]
id: NCBITaxon:2242
name: Halobacterium salinarum
is_a: NCBITaxon:2239  ! Halobacterium

[Term]
id: NCBITaxon:2243
name: Halobacterium sp.
is_a: NCBITaxon:2239  ! Halobacterium

[Term]
id: NCBITaxon:224471
name: Burkholderiales Genera incertae sedis
is_a: NCBITaxon:119065  ! unclassified Burkholderiales

[Term]
id: NCBITaxon:2246
name: Haloferax volcanii
is_a: NCBITaxon:2251  ! Haloferax

[Term]
id: NCBITaxon:224756
name: Methanomicrobia
is_a: NCBITaxon:28890  ! Euryarchaeota

[Term]
id: NCBITaxon:225057
name: Acidithiobacillales
is_a: NCBITaxon:1236  ! Gammaproteobacteria

[Term]
id: NCBITaxon:225058
name: Acidithiobacillaceae
is_a: NCBITaxon:225057  ! Acidithiobacillales

[Term]
id: NCBITaxon:2251
name: Haloferax
is_a: NCBITaxon:2236  ! Halobacteriaceae

[Term]
id: NCBITaxon:2258
name: Thermococcales
is_a: NCBITaxon:183968  ! Thermococci

[Term]
id: NCBITaxon:2259
name: Thermococcaceae
is_a: NCBITaxon:2258  ! Thermococcales

[Term]
id: NCBITaxon:2260
name: Pyrococcus
is_a: NCBITaxon:2259  ! Thermococcaceae

[Term]
id: NCBITaxon:2266
name: Thermoproteales
is_a: NCBITaxon:183924  ! Thermoprotei

[Term]
id: NCBITaxon:2267
name: Thermoproteaceae
is_a: NCBITaxon:2266  ! Thermoproteales

[Term]
id: NCBITaxon:2270
name: Thermoproteus
is_a: NCBITaxon:2267  ! Thermoproteaceae

[Term]
id: NCBITaxon:2271
name: Thermoproteus tenax
is_a: NCBITaxon:2270  ! Thermoproteus

[Term]
id: NCBITaxon:227290
name: Rhizobium/Agrobacterium group
is_a: NCBITaxon:82115  ! Rhizobiaceae

[Term]
id: NCBITaxon:227292
name: Sinorhizobium/Ensifer group
is_a: NCBITaxon:82115  ! Rhizobiaceae

[Term]
id: NCBITaxon:227331
name: Paxilineae
is_a: NCBITaxon:68889  ! Boletales

[Term]
id: NCBITaxon:227859
name: SARS coronavirus
is_a: NCBITaxon:156439  ! Group 2 species

[Term]
id: NCBITaxon:2281
name: Sulfolobales
is_a: NCBITaxon:183924  ! Thermoprotei

[Term]
id: NCBITaxon:2284
name: Sulfolobus
is_a: NCBITaxon:118883  ! Sulfolobaceae

[Term]
id: NCBITaxon:2285
name: Sulfolobus acidocaldarius
is_a: NCBITaxon:2284  ! Sulfolobus

[Term]
id: NCBITaxon:2287
name: Sulfolobus solfataricus
is_a: NCBITaxon:2284  ! Sulfolobus

[Term]
id: NCBITaxon:2301
name: Thermoplasmatales
is_a: NCBITaxon:183967  ! Thermoplasmata

[Term]
id: NCBITaxon:2302
name: Thermoplasma
is_a: NCBITaxon:46659  ! Thermoplasmataceae

[Term]
id: NCBITaxon:2303
name: Thermoplasma acidophilum
is_a: NCBITaxon:2302  ! Thermoplasma

[Term]
id: NCBITaxon:23216
name: Rubus
is_a: NCBITaxon:171638  ! Rosoideae

[Term]
id: NCBITaxon:232347
name: magnoliids
is_a: NCBITaxon:3398  ! Magnoliophyta

[Term]
id: NCBITaxon:2335
name: Thermotoga
is_a: NCBITaxon:188709  ! Thermotogaceae

[Term]
id: NCBITaxon:2336
name: Thermotoga maritima
is_a: NCBITaxon:2335  ! Thermotoga

[Term]
id: NCBITaxon:234
name: Brucella
is_a: NCBITaxon:118882  ! Brucellaceae

[Term]
id: NCBITaxon:235
name: Brucella abortus
is_a: NCBITaxon:234  ! Brucella

[Term]
id: NCBITaxon:23513
name: Rutaceae
is_a: NCBITaxon:41937  ! Sapindales

[Term]
id: NCBITaxon:2370
name: Xylella
is_a: NCBITaxon:32033  ! Xanthomonadaceae

[Term]
id: NCBITaxon:2371
name: Xylella fastidiosa
is_a: NCBITaxon:2370  ! Xylella

[Term]
id: NCBITaxon:238069
name: Saliceae
is_a: NCBITaxon:3688  ! Salicaceae

[Term]
id: NCBITaxon:241806
name: Moniliformopses
is_a: NCBITaxon:78536  ! Euphyllophyta

[Term]
id: NCBITaxon:2419
name: Thermotogales
is_a: NCBITaxon:188708  ! Thermotogae (class)

[Term]
id: NCBITaxon:24966
name: Rubiaceae
is_a: NCBITaxon:4055  ! Gentianales

[Term]
id: NCBITaxon:255725
name: Rubrobacterineae
is_a: NCBITaxon:84996  ! Rubrobacterales

[Term]
id: NCBITaxon:259537
name: Dechloromonas aromatica
is_a: NCBITaxon:73029  ! Dechloromonas

[Term]
id: NCBITaxon:262
name: Francisella
is_a: NCBITaxon:34064  ! Francisellaceae

[Term]
id: NCBITaxon:262014
name: Xenopus [NCBITaxon:262014]
is_a: NCBITaxon:8353  ! Xenopus

[Term]
id: NCBITaxon:263
name: Francisella tularensis
is_a: NCBITaxon:262  ! Francisella

[Term]
id: NCBITaxon:263510
name: Crocosphaera
is_a: NCBITaxon:1118  ! Chroococcales

[Term]
id: NCBITaxon:263511
name: Crocosphaera watsonii
is_a: NCBITaxon:263510  ! Crocosphaera

[Term]
id: NCBITaxon:264
name: Francisella tularensis subsp. novicida
is_a: NCBITaxon:263  ! Francisella tularensis

[Term]
id: NCBITaxon:266068
name: Rickettsia sibirica subgroup
is_a: NCBITaxon:114277  ! spotted fever group

[Term]
id: NCBITaxon:2706
name: Citrus
is_a: NCBITaxon:23513  ! Rutaceae

[Term]
id: NCBITaxon:2711
name: Citrus sinensis
is_a: NCBITaxon:2706  ! Citrus

[Term]
id: NCBITaxon:2713
name: Aquifex
is_a: NCBITaxon:64898  ! Aquificaceae

[Term]
id: NCBITaxon:272131
name: Nostoc punctiforme
is_a: NCBITaxon:1177  ! Nostoc

[Term]
id: NCBITaxon:27291
name: Saccharomyces paradoxus
is_a: NCBITaxon:4930  ! Saccharomyces

[Term]
id: NCBITaxon:27292
name: Saccharomyces pastorianus
is_a: NCBITaxon:4930  ! Saccharomyces

[Term]
id: NCBITaxon:2759
name: Eukaryota
is_a: OBI:0100026  ! organism

[Term]
id: NCBITaxon:27592
name: Bovinae
is_a: NCBITaxon:9895  ! Bovidae

[Term]
id: NCBITaxon:27772
name: Coregonus
is_a: NCBITaxon:8015  ! Salmonidae

[Term]
id: NCBITaxon:28067
name: Rubrivivax
is_a: NCBITaxon:224471  ! Burkholderiales Genera incertae sedis

[Term]
id: NCBITaxon:28068
name: Rubrivivax gelatinosus
is_a: NCBITaxon:28067  ! Rubrivivax

[Term]
id: NCBITaxon:28097
name: Ralstonia syzygii
is_a: NCBITaxon:48736  ! Ralstonia

[Term]
id: NCBITaxon:28105
name: Sinorhizobium
is_a: NCBITaxon:227292  ! Sinorhizobium/Ensifer group

[Term]
id: NCBITaxon:28211
name: Alphaproteobacteria
is_a: NCBITaxon:1224  ! Proteobacteria

[Term]
id: NCBITaxon:28216
name: Betaproteobacteria
is_a: NCBITaxon:1224  ! Proteobacteria

[Term]
id: NCBITaxon:28221
name: Deltaproteobacteria
is_a: NCBITaxon:68525  ! delta/epsilon subdivisions

[Term]
id: NCBITaxon:28231
name: Geobacter
is_a: NCBITaxon:213422  ! Geobacteraceae

[Term]
id: NCBITaxon:28232
name: Geobacter metallireducens
is_a: NCBITaxon:28231  ! Geobacter

[Term]
id: NCBITaxon:282459
name: Staphylococcus aureus subsp. aureus MSSA476
is_a: NCBITaxon:46170  ! Staphylococcus aureus subsp. aureus

[Term]
id: NCBITaxon:28450
name: Burkholderia pseudomallei
is_a: NCBITaxon:111527  ! pseudomallei group

[Term]
id: NCBITaxon:28568
name: Trichocomaceae
is_a: NCBITaxon:5042  ! Eurotiales

[Term]
id: NCBITaxon:286
name: Pseudomonas
is_a: NCBITaxon:135621  ! Pseudomonadaceae

[Term]
id: NCBITaxon:287
name: Pseudomonas aeruginosa
is_a: NCBITaxon:136841  ! Pseudomonas aeruginosa group

[Term]
id: NCBITaxon:2870
name: Phaeophyceae
is_a: NCBITaxon:33634  ! stramenopiles

[Term]
id: NCBITaxon:2877
name: Ectocarpales
is_a: NCBITaxon:2870  ! Phaeophyceae

[Term]
id: NCBITaxon:2878
name: Ectocarpaceae
is_a: NCBITaxon:2877  ! Ectocarpales

[Term]
id: NCBITaxon:2879
name: Ectocarpus
is_a: NCBITaxon:2878  ! Ectocarpaceae

[Term]
id: NCBITaxon:2880
name: Ectocarpus siliculosus
is_a: NCBITaxon:2879  ! Ectocarpus

[Term]
id: NCBITaxon:28889
name: Crenarchaeota
is_a: NCBITaxon:2157  ! Archaea

[Term]
id: NCBITaxon:28890
name: Euryarchaeota
is_a: NCBITaxon:2157  ! Archaea

[Term]
id: NCBITaxon:28901
name: Salmonella enterica
is_a: NCBITaxon:590  ! Salmonella

[Term]
id: NCBITaxon:292
name: Burkholderia cepacia
is_a: NCBITaxon:87882  ! Burkholderia cepacia complex

[Term]
id: NCBITaxon:292817
name: Cryptococcus gattii
is_a: NCBITaxon:107441  ! Cryptococcus [NCBITaxon:107441]

[Term]
id: NCBITaxon:29291
name: Methanococcoides burtonii
is_a: NCBITaxon:2225  ! Methanococcoides

[Term]
id: NCBITaxon:294
name: Pseudomonas fluorescens
is_a: NCBITaxon:136843  ! Pseudomonas fluorescens group

[Term]
id: NCBITaxon:29465
name: Veillonella
is_a: NCBITaxon:31977  ! Acidaminococcaceae

[Term]
id: NCBITaxon:29466
name: Veillonella parvula
is_a: NCBITaxon:29465  ! Veillonella

[Term]
id: NCBITaxon:29547
name: Epsilonproteobacteria
is_a: NCBITaxon:68525  ! delta/epsilon subdivisions

[Term]
id: NCBITaxon:29595
name: Ceratopteris
is_a: NCBITaxon:13819  ! Pteridaceae

[Term]
id: NCBITaxon:29596
name: Ceratopteris thalictroides
is_a: NCBITaxon:29595  ! Ceratopteris

[Term]
id: NCBITaxon:29760
name: Vitis vinifera
is_a: NCBITaxon:3603  ! Vitis

[Term]
id: NCBITaxon:29859
name: Hypocrea
is_a: NCBITaxon:5129  ! Hypocreaceae

[Term]
id: NCBITaxon:30001
name: Collembola
is_a: NCBITaxon:79744  ! Ellipura

[Term]
id: NCBITaxon:300275
name: Lachancea
is_a: NCBITaxon:4893  ! Saccharomycetaceae

[Term]
id: NCBITaxon:303
name: Pseudomonas putida
is_a: NCBITaxon:136845  ! Pseudomonas putida group

[Term]
id: NCBITaxon:30314
name: Mesobatrachia
is_a: NCBITaxon:8342  ! Anura

[Term]
id: NCBITaxon:30319
name: Pipoidea
is_a: NCBITaxon:30314  ! Mesobatrachia

[Term]
id: NCBITaxon:303379
name: Herminiimonas
is_a: NCBITaxon:75682  ! Oxalobacteraceae

[Term]
id: NCBITaxon:3041
name: Chlorophyta
is_a: NCBITaxon:33090  ! Viridiplantae

[Term]
id: NCBITaxon:3042
name: Chlamydomonadales
is_a: NCBITaxon:3166  ! Chlorophyceae

[Term]
id: NCBITaxon:305
name: Ralstonia solanacearum
is_a: NCBITaxon:48736  ! Ralstonia

[Term]
id: NCBITaxon:3051
name: Chlamydomonadaceae
is_a: NCBITaxon:3042  ! Chlamydomonadales

[Term]
id: NCBITaxon:3052
name: Chlamydomonas
is_a: NCBITaxon:3051  ! Chlamydomonadaceae

[Term]
id: NCBITaxon:3055
name: Chlamydomonas reinhardtii
is_a: NCBITaxon:3052  ! Chlamydomonas

[Term]
id: NCBITaxon:30727
name: Cyprinoidea
is_a: NCBITaxon:7952  ! Cypriniformes

[Term]
id: NCBITaxon:30942
name: Pleuronectoidei
is_a: NCBITaxon:8252  ! Pleuronectiformes

[Term]
id: NCBITaxon:31022
name: Tetraodontiformes
is_a: NCBITaxon:32485  ! Percomorpha

[Term]
id: NCBITaxon:31028
name: Tetraodontoidei
is_a: NCBITaxon:31022  ! Tetraodontiformes

[Term]
id: NCBITaxon:31031
name: Tetraodontidae
is_a: NCBITaxon:32517  ! Tetradontoidea

[Term]
id: NCBITaxon:31032
name: Takifugu
is_a: NCBITaxon:31031  ! Tetraodontidae

[Term]
id: NCBITaxon:31033
name: Takifugu rubripes
is_a: NCBITaxon:31032  ! Takifugu

[Term]
id: NCBITaxon:31244
name: Schistosomatoidea
is_a: NCBITaxon:6180  ! Strigeidida

[Term]
id: NCBITaxon:31245
name: Schistosomatidae
is_a: NCBITaxon:31244  ! Schistosomatoidea

[Term]
id: NCBITaxon:314145
name: Laurasiatheria
is_a: NCBITaxon:9347  ! Eutheria

[Term]
id: NCBITaxon:314146
name: Euarchontoglires
is_a: NCBITaxon:9347  ! Eutheria

[Term]
id: NCBITaxon:314147
name: Glires
is_a: NCBITaxon:314146  ! Euarchontoglires

[Term]
id: NCBITaxon:314293
name: Simiiformes
is_a: NCBITaxon:376913  ! Haplorrhini

[Term]
id: NCBITaxon:314294
name: Cercopithecoidea
is_a: NCBITaxon:9526  ! Catarrhini

[Term]
id: NCBITaxon:314295
name: Hominoidea
is_a: NCBITaxon:9526  ! Catarrhini

[Term]
id: NCBITaxon:3166
name: Chlorophyceae
is_a: NCBITaxon:3041  ! Chlorophyta

[Term]
id: NCBITaxon:316625
name: Saccharophagus
is_a: NCBITaxon:72275  ! Alteromonadaceae

[Term]
id: NCBITaxon:3193
name: Embryophyta
is_a: NCBITaxon:131221  ! Streptophytina

[Term]
id: NCBITaxon:31953
name: Bifidobacteriaceae
is_a: NCBITaxon:85004  ! Bifidobacteriales

[Term]
id: NCBITaxon:31969
name: Mollicutes
is_a: NCBITaxon:1239  ! Firmicutes

[Term]
id: NCBITaxon:31977
name: Acidaminococcaceae
is_a: NCBITaxon:186802  ! Clostridiales

[Term]
id: NCBITaxon:31979
name: Clostridiaceae
is_a: NCBITaxon:186802  ! Clostridiales

[Term]
id: NCBITaxon:31989
name: Rhodobacteraceae
is_a: NCBITaxon:204455  ! Rhodobacterales

[Term]
id: NCBITaxon:32008
name: Burkholderia
is_a: NCBITaxon:119060  ! Burkholderiaceae

[Term]
id: NCBITaxon:32011
name: Methylophilaceae
is_a: NCBITaxon:206350  ! Methylophilales

[Term]
id: NCBITaxon:32012
name: Thiomonas
is_a: NCBITaxon:224471  ! Burkholderiales Genera incertae sedis

[Term]
id: NCBITaxon:32033
name: Xanthomonadaceae
is_a: NCBITaxon:135614  ! Xanthomonadales

[Term]
id: NCBITaxon:32046
name: Synechococcus elongatus
is_a: NCBITaxon:1129  ! Synechococcus

[Term]
id: NCBITaxon:32061
name: Chloroflexi (class)
is_a: NCBITaxon:200795  ! Chloroflexi

[Term]
id: NCBITaxon:32064
name: Chloroflexales
is_a: NCBITaxon:32061  ! Chloroflexi (class)

[Term]
id: NCBITaxon:32066
name: Fusobacteria
is_a: NCBITaxon:2  ! Bacteria

[Term]
id: NCBITaxon:32069
name: Aquificales
is_a: NCBITaxon:187857  ! Aquificae (class)

[Term]
id: NCBITaxon:3208
name: Bryophyta
is_a: NCBITaxon:3193  ! Embryophyta

[Term]
id: NCBITaxon:3210
name: Polytrichales
is_a: NCBITaxon:113509  ! Polytrichopsida

[Term]
id: NCBITaxon:3211
name: Polytrichaceae
is_a: NCBITaxon:3210  ! Polytrichales

[Term]
id: NCBITaxon:3212
name: Polytrichum
is_a: NCBITaxon:3211  ! Polytrichaceae

[Term]
id: NCBITaxon:3214
name: Bryopsida
is_a: NCBITaxon:404260  ! Moss Superclass V

[Term]
id: NCBITaxon:3215
name: Funariales
is_a: NCBITaxon:114656  ! Funariidae

[Term]
id: NCBITaxon:3216
name: Funariaceae
is_a: NCBITaxon:3215  ! Funariales

[Term]
id: NCBITaxon:3217
name: Physcomitrella
is_a: NCBITaxon:3216  ! Funariaceae

[Term]
id: NCBITaxon:3218
name: Physcomitrella patens
is_a: NCBITaxon:3217  ! Physcomitrella

[Term]
id: NCBITaxon:32199
name: Buchnera
is_a: NCBITaxon:543  ! Enterobacteriaceae

[Term]
id: NCBITaxon:32247
name: Rubus idaeus
is_a: NCBITaxon:23216  ! Rubus

[Term]
id: NCBITaxon:32341
name: Sophophora
is_a: NCBITaxon:7215  ! Drosophila

[Term]
id: NCBITaxon:32346
name: melanogaster group
is_a: NCBITaxon:32341  ! Sophophora

[Term]
id: NCBITaxon:32351
name: melanogaster subgroup
is_a: NCBITaxon:32346  ! melanogaster group

[Term]
id: NCBITaxon:32355
name: obscura group
is_a: NCBITaxon:32341  ! Sophophora

[Term]
id: NCBITaxon:32358
name: pseudoobscura subgroup
is_a: NCBITaxon:32355  ! obscura group

[Term]
id: NCBITaxon:3242
name: Lycopodiophyta
is_a: NCBITaxon:58023  ! Tracheophyta

[Term]
id: NCBITaxon:3243
name: Isoetopsida
is_a: NCBITaxon:3242  ! Lycopodiophyta

[Term]
id: NCBITaxon:3244
name: Selaginellales
is_a: NCBITaxon:3243  ! Isoetopsida

[Term]
id: NCBITaxon:32443
name: Teleostei
is_a: NCBITaxon:41665  ! Neopterygii

[Term]
id: NCBITaxon:32447
name: Euteleostei
is_a: NCBITaxon:186625  ! Clupeocephala

[Term]
id: NCBITaxon:3245
name: Selaginellaceae
is_a: NCBITaxon:3244  ! Selaginellales

[Term]
id: NCBITaxon:32455
name: Acanthopterygii
is_a: NCBITaxon:123370  ! Holacanthopterygii

[Term]
id: NCBITaxon:3246
name: Selaginella
is_a: NCBITaxon:3245  ! Selaginellaceae

[Term]
id: NCBITaxon:32485
name: Percomorpha
is_a: NCBITaxon:129947  ! Euacanthopterygii

[Term]
id: NCBITaxon:32517
name: Tetradontoidea
is_a: NCBITaxon:31028  ! Tetraodontoidei

[Term]
id: NCBITaxon:32518
name: Paracanthopterygii
is_a: NCBITaxon:123370  ! Holacanthopterygii

[Term]
id: NCBITaxon:32519
name: Ostariophysi
is_a: NCBITaxon:186634  ! Otocephala

[Term]
id: NCBITaxon:32523
name: Tetrapoda
is_a: NCBITaxon:8287  ! Sarcopterygii

[Term]
id: NCBITaxon:32524
name: Amniota
is_a: NCBITaxon:32523  ! Tetrapoda

[Term]
id: NCBITaxon:32525
name: Theria
is_a: NCBITaxon:40674  ! Mammalia

[Term]
id: NCBITaxon:32561
name: Sauria
is_a: NCBITaxon:8457  ! Sauropsida

[Term]
id: NCBITaxon:3263
name: Filicophyta
is_a: NCBITaxon:241806  ! Moniliformopses

[Term]
id: NCBITaxon:3268
name: Filicales
is_a: NCBITaxon:3290  ! Filicopsida

[Term]
id: NCBITaxon:329
name: Ralstonia pickettii
is_a: NCBITaxon:48736  ! Ralstonia

[Term]
id: NCBITaxon:3290
name: Filicopsida
is_a: NCBITaxon:3263  ! Filicophyta

[Term]
id: NCBITaxon:33045
name: Bartonella grahamii
is_a: NCBITaxon:773  ! Bartonella

[Term]
id: NCBITaxon:33083
name: Dictyosteliida
is_a: NCBITaxon:142796  ! Mycetozoa

[Term]
id: NCBITaxon:33090
name: Viridiplantae
is_a: NCBITaxon:2759  ! Eukaryota

[Term]
id: NCBITaxon:3312
name: Coniferophyta
is_a: NCBITaxon:58024  ! Spermatophyta

[Term]
id: NCBITaxon:33125
name: Lepidium sativum
is_a: NCBITaxon:19205  ! Lepidium

[Term]
id: NCBITaxon:3313
name: Coniferales
is_a: NCBITaxon:58019  ! Coniferopsida

[Term]
id: NCBITaxon:33154
name: Fungi/Metazoa group
is_a: NCBITaxon:2759  ! Eukaryota

[Term]
id: NCBITaxon:33169
name: Eremothecium gossypii
is_a: NCBITaxon:33170  ! Eremothecium

[Term]
id: NCBITaxon:33170
name: Eremothecium
is_a: NCBITaxon:4893  ! Saccharomycetaceae

[Term]
id: NCBITaxon:33178
name: Aspergillus terreus
is_a: NCBITaxon:5052  ! Aspergillus

[Term]
id: NCBITaxon:3318
name: Pinaceae
is_a: NCBITaxon:3313  ! Coniferales

[Term]
id: NCBITaxon:33183
name: Onygenales
is_a: NCBITaxon:147545  ! Eurotiomycetes

[Term]
id: NCBITaxon:33208
name: Metazoa
is_a: NCBITaxon:33154  ! Fungi/Metazoa group

[Term]
id: NCBITaxon:33213
name: Bilateria
is_a: NCBITaxon:6072  ! Eumetazoa

[Term]
id: NCBITaxon:33214
name: Acoelomata
is_a: NCBITaxon:33213  ! Bilateria

[Term]
id: NCBITaxon:33217
name: Pseudocoelomata
is_a: NCBITaxon:33213  ! Bilateria

[Term]
id: NCBITaxon:3328
name: Picea
is_a: NCBITaxon:3318  ! Pinaceae

[Term]
id: NCBITaxon:33283
name: Tylenchina
is_a: NCBITaxon:6300  ! Tylenchida

[Term]
id: NCBITaxon:33284
name: Tylenchoidea
is_a: NCBITaxon:33283  ! Tylenchina

[Term]
id: NCBITaxon:33286
name: Heteroderinae
is_a: NCBITaxon:6301  ! Heteroderidae

[Term]
id: NCBITaxon:3330
name: Picea glauca
is_a: NCBITaxon:3328  ! Picea

[Term]
id: NCBITaxon:33316
name: Coelomata
is_a: NCBITaxon:33213  ! Bilateria

[Term]
id: NCBITaxon:33317
name: Protostomia
is_a: NCBITaxon:33316  ! Coelomata

[Term]
id: NCBITaxon:33340
name: Neoptera
is_a: NCBITaxon:7496  ! Pterygota

[Term]
id: NCBITaxon:3337
name: Pinus
is_a: NCBITaxon:3318  ! Pinaceae

[Term]
id: NCBITaxon:33392
name: Endopterygota
is_a: NCBITaxon:33340  ! Neoptera

[Term]
id: NCBITaxon:3347
name: Pinus radiata
is_a: NCBITaxon:139271  ! Pinus [NCBITaxon:139271]

[Term]
id: NCBITaxon:33511
name: Deuterostomia
is_a: NCBITaxon:33316  ! Coelomata

[Term]
id: NCBITaxon:33553
name: Sciurognathi
is_a: NCBITaxon:9989  ! Rodentia

[Term]
id: NCBITaxon:33554
name: Carnivora
is_a: NCBITaxon:314145  ! Laurasiatheria

[Term]
id: NCBITaxon:33630
name: Alveolata
is_a: NCBITaxon:2759  ! Eukaryota

[Term]
id: NCBITaxon:33634
name: stramenopiles
is_a: NCBITaxon:2759  ! Eukaryota

[Term]
id: NCBITaxon:33682
name: Euglenozoa
is_a: NCBITaxon:2759  ! Eukaryota

[Term]
id: NCBITaxon:337677
name: Cricetidae
is_a: NCBITaxon:337687  ! Muroidea

[Term]
id: NCBITaxon:337687
name: Muroidea
is_a: NCBITaxon:33553  ! Sciurognathi

[Term]
id: NCBITaxon:338
name: Xanthomonas
is_a: NCBITaxon:32033  ! Xanthomonadaceae

[Term]
id: NCBITaxon:338152
name: Felinae
is_a: NCBITaxon:9681  ! Felidae

[Term]
id: NCBITaxon:339
name: Xanthomonas campestris
is_a: NCBITaxon:338  ! Xanthomonas

[Term]
id: NCBITaxon:33903
name: Streptomyces avermitilis
is_a: NCBITaxon:1883  ! Streptomyces

[Term]
id: NCBITaxon:33925
name: Entomoplasmataceae
is_a: NCBITaxon:186328  ! Entomoplasmatales

[Term]
id: NCBITaxon:33958
name: Lactobacillaceae
is_a: NCBITaxon:186826  ! Lactobacillales

[Term]
id: NCBITaxon:3398
name: Magnoliophyta
is_a: NCBITaxon:58024  ! Spermatophyta

[Term]
id: NCBITaxon:33988
name: Rickettsieae
is_a: NCBITaxon:775  ! Rickettsiaceae

[Term]
id: NCBITaxon:340
name: Xanthomonas campestris pv. campestris
is_a: NCBITaxon:339  ! Xanthomonas campestris

[Term]
id: NCBITaxon:3400
name: Magnoliales
is_a: NCBITaxon:232347  ! magnoliids

[Term]
id: NCBITaxon:3401
name: Magnoliaceae
is_a: NCBITaxon:3400  ! Magnoliales

[Term]
id: NCBITaxon:34064
name: Francisellaceae
is_a: NCBITaxon:72273  ! Thiotrichales

[Term]
id: NCBITaxon:3413
name: Liriodendron
is_a: NCBITaxon:3401  ! Magnoliaceae

[Term]
id: NCBITaxon:3415
name: Liriodendron tulipifera
is_a: NCBITaxon:3413  ! Liriodendron

[Term]
id: NCBITaxon:34245
name: Zinnia elegans
is_a: NCBITaxon:19013  ! Zinnia

[Term]
id: NCBITaxon:34305
name: Lotus japonicus
is_a: NCBITaxon:3867  ! Lotus

[Term]
id: NCBITaxon:34346
name: Schizosaccharomycetales
is_a: NCBITaxon:147554  ! Schizosaccharomycetes

[Term]
id: NCBITaxon:34380
name: mitosporic Trichocomaceae
is_a: NCBITaxon:28568  ! Trichocomaceae

[Term]
id: NCBITaxon:34383
name: mitosporic Onygenales
is_a: NCBITaxon:33183  ! Onygenales

[Term]
id: NCBITaxon:34506
name: Strongyloides ratti
is_a: NCBITaxon:6247  ! Strongyloides

[Term]
id: NCBITaxon:34509
name: Heterodera
is_a: NCBITaxon:33286  ! Heteroderinae

[Term]
id: NCBITaxon:34735
name: Apoidea
is_a: NCBITaxon:7434  ! Aculeata

[Term]
id: NCBITaxon:3481
name: Cannabaceae
is_a: NCBITaxon:3744  ! Rosales

[Term]
id: NCBITaxon:3482
name: Cannabis
is_a: NCBITaxon:3481  ! Cannabaceae

[Term]
id: NCBITaxon:3483
name: Cannabis sativa
is_a: NCBITaxon:3482  ! Cannabis

[Term]
id: NCBITaxon:3502
name: Fagales
is_a: NCBITaxon:91835  ! eurosids I

[Term]
id: NCBITaxon:3504
name: Betula
is_a: NCBITaxon:3514  ! Betulaceae

[Term]
id: NCBITaxon:3505
name: Betula pendula
is_a: NCBITaxon:3504  ! Betula

[Term]
id: NCBITaxon:35082
name: Cryptosporidiidae
is_a: NCBITaxon:423054  ! Eimeriorina

[Term]
id: NCBITaxon:351
name: Azotobacter group
is_a: NCBITaxon:135621  ! Pseudomonadaceae

[Term]
id: NCBITaxon:3514
name: Betulaceae
is_a: NCBITaxon:3502  ! Fagales

[Term]
id: NCBITaxon:352
name: Azotobacter
is_a: NCBITaxon:351  ! Azotobacter group

[Term]
id: NCBITaxon:35278
name: ssRNA positive-strand viruses, no DNA stage
is_a: NCBITaxon:10239  ! Viruses

[Term]
id: NCBITaxon:354
name: Azotobacter vinelandii
is_a: NCBITaxon:352  ! Azotobacter

[Term]
id: NCBITaxon:35493
name: Streptophyta
is_a: NCBITaxon:33090  ! Viridiplantae

[Term]
id: NCBITaxon:35497
name: Suina
is_a: NCBITaxon:91561  ! Cetartiodactyla

[Term]
id: NCBITaxon:35500
name: Pecora
is_a: NCBITaxon:9845  ! Ruminantia

[Term]
id: NCBITaxon:35510
name: Equus subg. Equus
is_a: NCBITaxon:9789  ! Equus

[Term]
id: NCBITaxon:356
name: Rhizobiales
is_a: NCBITaxon:28211  ! Alphaproteobacteria

[Term]
id: NCBITaxon:357
name: Agrobacterium
is_a: NCBITaxon:227290  ! Rhizobium/Agrobacterium group

[Term]
id: NCBITaxon:35793
name: Rickettsia sibirica
is_a: NCBITaxon:266068  ! Rickettsia sibirica subgroup

[Term]
id: NCBITaxon:358
name: Agrobacterium tumefaciens
is_a: NCBITaxon:357  ! Agrobacterium

[Term]
id: NCBITaxon:359160
name: BEP clade
is_a: NCBITaxon:4479  ! Poaceae

[Term]
id: NCBITaxon:3602
name: Vitaceae
is_a: NCBITaxon:403667  ! Vitales

[Term]
id: NCBITaxon:3603
name: Vitis
is_a: NCBITaxon:3602  ! Vitaceae

[Term]
id: NCBITaxon:36141
name: Isotomidae
is_a: NCBITaxon:79707  ! Entomobryoidea

[Term]
id: NCBITaxon:36270
name: Sylviidae
is_a: NCBITaxon:9126  ! Passeriformes

[Term]
id: NCBITaxon:3646
name: Malpighiales
is_a: NCBITaxon:91835  ! eurosids I

[Term]
id: NCBITaxon:36629
name: Neosartorya
is_a: NCBITaxon:28568  ! Trichocomaceae

[Term]
id: NCBITaxon:36630
name: Neosartorya fischeri
is_a: NCBITaxon:60888  ! Neosartorya fischeri group

[Term]
id: NCBITaxon:36853
name: Desulfitobacterium
is_a: NCBITaxon:186807  ! Peptococcaceae

[Term]
id: NCBITaxon:3688
name: Salicaceae
is_a: NCBITaxon:3646  ! Malpighiales

[Term]
id: NCBITaxon:3689
name: Populus
is_a: NCBITaxon:238069  ! Saliceae

[Term]
id: NCBITaxon:3694
name: Populus trichocarpa
is_a: NCBITaxon:3689  ! Populus

[Term]
id: NCBITaxon:3695
name: Populus trichocarpa x Populus deltoides
is_a: NCBITaxon:3689  ! Populus

[Term]
id: NCBITaxon:3696
name: Populus deltoides
is_a: NCBITaxon:3689  ! Populus

[Term]
id: NCBITaxon:3699
name: Brassicales
is_a: NCBITaxon:91836  ! eurosids II

[Term]
id: NCBITaxon:3700
name: Brassicaceae
is_a: NCBITaxon:3699  ! Brassicales

[Term]
id: NCBITaxon:3701
name: Arabidopsis
is_a: NCBITaxon:3700  ! Brassicaceae

[Term]
id: NCBITaxon:3702
name: Arabidopsis thaliana
is_a: NCBITaxon:3701  ! Arabidopsis

[Term]
id: NCBITaxon:3705
name: Brassica
is_a: NCBITaxon:3700  ! Brassicaceae

[Term]
id: NCBITaxon:3707
name: Brassica juncea
is_a: NCBITaxon:3705  ! Brassica

[Term]
id: NCBITaxon:3708
name: Brassica napus
is_a: NCBITaxon:3705  ! Brassica

[Term]
id: NCBITaxon:3711
name: Brassica rapa
is_a: NCBITaxon:3705  ! Brassica

[Term]
id: NCBITaxon:3744
name: Rosales
is_a: NCBITaxon:91835  ! eurosids I

[Term]
id: NCBITaxon:3745
name: Rosaceae
is_a: NCBITaxon:3744  ! Rosales

[Term]
id: NCBITaxon:375013
name: Aedes/Ochlerotatus group
is_a: NCBITaxon:53550  ! Culicini

[Term]
id: NCBITaxon:37567
name: Ditrysia
is_a: NCBITaxon:41197  ! Heteroneura

[Term]
id: NCBITaxon:37569
name: Bombycoidea
is_a: NCBITaxon:104431  ! Obtectomera

[Term]
id: NCBITaxon:37570
name: Noctuoidea
is_a: NCBITaxon:104431  ! Obtectomera

[Term]
id: NCBITaxon:37611
name: Estrildidae
is_a: NCBITaxon:175121  ! Passeroidea

[Term]
id: NCBITaxon:37616
name: Viannia
is_a: NCBITaxon:5658  ! Leishmania

[Term]
id: NCBITaxon:37617
name: Leishmania braziliensis species complex
is_a: NCBITaxon:37616  ! Viannia

[Term]
id: NCBITaxon:376913
name: Haplorrhini
is_a: NCBITaxon:9443  ! Primates

[Term]
id: NCBITaxon:379
name: Rhizobium
is_a: NCBITaxon:227290  ! Rhizobium/Agrobacterium group

[Term]
id: NCBITaxon:379583
name: Feliformia
is_a: NCBITaxon:33554  ! Carnivora

[Term]
id: NCBITaxon:379584
name: Caniformia
is_a: NCBITaxon:33554  ! Carnivora

[Term]
id: NCBITaxon:3803
name: Fabaceae
is_a: NCBITaxon:72025  ! Fabales

[Term]
id: NCBITaxon:381
name: Mesorhizobium loti
is_a: NCBITaxon:68287  ! Mesorhizobium

[Term]
id: NCBITaxon:3814
name: Papilionoideae
is_a: NCBITaxon:3803  ! Fabaceae

[Term]
id: NCBITaxon:382
name: Sinorhizobium meliloti
is_a: NCBITaxon:28105  ! Sinorhizobium

[Term]
id: NCBITaxon:38323
name: Bartonella henselae
is_a: NCBITaxon:773  ! Bartonella

[Term]
id: NCBITaxon:384
name: Rhizobium leguminosarum
is_a: NCBITaxon:379  ! Rhizobium

[Term]
id: NCBITaxon:3846
name: Glycine
is_a: NCBITaxon:163735  ! Phaseoleae

[Term]
id: NCBITaxon:3847
name: Glycine max
is_a: NCBITaxon:3846  ! Glycine

[Term]
id: NCBITaxon:38568
name: Leishmania [NCBITaxon:38568]
is_a: NCBITaxon:5658  ! Leishmania

[Term]
id: NCBITaxon:38573
name: Leishmania infantum species complex
is_a: NCBITaxon:38568  ! Leishmania [NCBITaxon:38568]

[Term]
id: NCBITaxon:38574
name: Leishmania donovani species complex
is_a: NCBITaxon:38568  ! Leishmania [NCBITaxon:38568]

[Term]
id: NCBITaxon:38581
name: Leishmania major species complex
is_a: NCBITaxon:38568  ! Leishmania [NCBITaxon:38568]

[Term]
id: NCBITaxon:38582
name: Leishmania mexicana species complex
is_a: NCBITaxon:38568  ! Leishmania [NCBITaxon:38568]

[Term]
id: NCBITaxon:38609
name: Diprotodontia
is_a: NCBITaxon:9263  ! Metatheria

[Term]
id: NCBITaxon:3867
name: Lotus
is_a: NCBITaxon:163747  ! Loteae

[Term]
id: NCBITaxon:3877
name: Medicago
is_a: NCBITaxon:163742  ! Trifolieae

[Term]
id: NCBITaxon:3879
name: Medicago sativa
is_a: NCBITaxon:3877  ! Medicago

[Term]
id: NCBITaxon:3880
name: Medicago truncatula
is_a: NCBITaxon:3877  ! Medicago

[Term]
id: NCBITaxon:38820
name: Poales
is_a: NCBITaxon:4734  ! commelinids

[Term]
id: NCBITaxon:3887
name: Pisum
is_a: NCBITaxon:163743  ! Vicieae

[Term]
id: NCBITaxon:3888
name: Pisum sativum
is_a: NCBITaxon:3887  ! Pisum

[Term]
id: NCBITaxon:38946
name: Paracoccidioides
is_a: NCBITaxon:34383  ! mitosporic Onygenales

[Term]
id: NCBITaxon:3898
name: Trifolium
is_a: NCBITaxon:163742  ! Trifolieae

[Term]
id: NCBITaxon:3899
name: Trifolium repens
is_a: NCBITaxon:3898  ! Trifolium

[Term]
id: NCBITaxon:39107
name: Murinae
is_a: NCBITaxon:10066  ! Muridae

[Term]
id: NCBITaxon:39560
name: Cyprininae
is_a: NCBITaxon:7953  ! Cyprinidae

[Term]
id: NCBITaxon:39562
name: Rasborinae
is_a: NCBITaxon:7953  ! Cyprinidae

[Term]
id: NCBITaxon:39700
name: Trypanozoon
is_a: NCBITaxon:5690  ! Trypanosoma

[Term]
id: NCBITaxon:39946
name: Oryza sativa (indica cultivar-group)
is_a: NCBITaxon:4530  ! Oryza sativa

[Term]
id: NCBITaxon:39947
name: Oryza sativa (japonica cultivar-group)
is_a: NCBITaxon:4530  ! Oryza sativa

[Term]
id: NCBITaxon:4004
name: Linaceae
is_a: NCBITaxon:3646  ! Malpighiales

[Term]
id: NCBITaxon:4005
name: Linum
is_a: NCBITaxon:4004  ! Linaceae

[Term]
id: NCBITaxon:4006
name: Linum usitatissimum
is_a: NCBITaxon:4005  ! Linum

[Term]
id: NCBITaxon:400783
name: Thraupini
is_a: NCBITaxon:62155  ! Emberizinae

[Term]
id: NCBITaxon:40155
name: Estrildinae
is_a: NCBITaxon:37611  ! Estrildidae

[Term]
id: NCBITaxon:403667
name: Vitales
is_a: NCBITaxon:91827  ! core eudicotyledons

[Term]
id: NCBITaxon:404
name: Methylobacillus
is_a: NCBITaxon:32011  ! Methylophilaceae

[Term]
id: NCBITaxon:404260
name: Moss Superclass V
is_a: NCBITaxon:3208  ! Bryophyta

[Term]
id: NCBITaxon:405
name: Methylobacillus flagellatus
is_a: NCBITaxon:404  ! Methylobacillus

[Term]
id: NCBITaxon:4055
name: Gentianales
is_a: NCBITaxon:91888  ! lamiids

[Term]
id: NCBITaxon:40674
name: Mammalia
is_a: NCBITaxon:32524  ! Amniota

[Term]
id: NCBITaxon:4069
name: Solanales
is_a: NCBITaxon:91888  ! lamiids

[Term]
id: NCBITaxon:4070
name: Solanaceae
is_a: NCBITaxon:4069  ! Solanales

[Term]
id: NCBITaxon:4071
name: Capsicum
is_a: NCBITaxon:424564  ! Capsiceae

[Term]
id: NCBITaxon:4072
name: Capsicum annuum
is_a: NCBITaxon:4071  ! Capsicum

[Term]
id: NCBITaxon:4081
name: Solanum lycopersicum
is_a: NCBITaxon:49274  ! Lycopersicon

[Term]
id: NCBITaxon:4085
name: Nicotiana
is_a: NCBITaxon:424562  ! Nicotianeae

[Term]
id: NCBITaxon:4100
name: Nicotiana benthamiana
is_a: NCBITaxon:4085  ! Nicotiana

[Term]
id: NCBITaxon:41048
name: Neosartorya fennelliae
is_a: NCBITaxon:36629  ! Neosartorya

[Term]
id: NCBITaxon:4107
name: Solanum
is_a: NCBITaxon:424574  ! Solaneae

[Term]
id: NCBITaxon:4113
name: Solanum tuberosum
is_a: NCBITaxon:4107  ! Solanum

[Term]
id: NCBITaxon:41191
name: Glossata
is_a: NCBITaxon:7088  ! Lepidoptera

[Term]
id: NCBITaxon:41196
name: Neolepidoptera
is_a: NCBITaxon:41191  ! Glossata

[Term]
id: NCBITaxon:41197
name: Heteroneura
is_a: NCBITaxon:41196  ! Neolepidoptera

[Term]
id: NCBITaxon:41254
name: Mycosphaerella
is_a: NCBITaxon:93133  ! Mycosphaerellaceae

[Term]
id: NCBITaxon:41295
name: Rhodospirillaceae
is_a: NCBITaxon:204441  ! Rhodospirillales

[Term]
id: NCBITaxon:41297
name: Sphingomonadaceae
is_a: NCBITaxon:204457  ! Sphingomonadales

[Term]
id: NCBITaxon:4143
name: Lamiales
is_a: NCBITaxon:91888  ! lamiids

[Term]
id: NCBITaxon:4150
name: Antirrhinum
is_a: NCBITaxon:216780  ! Antirrhineae

[Term]
id: NCBITaxon:4151
name: Antirrhinum majus
is_a: NCBITaxon:4150  ! Antirrhinum

[Term]
id: NCBITaxon:41665
name: Neopterygii
is_a: NCBITaxon:186623  ! Actinopteri

[Term]
id: NCBITaxon:41666
name: Batrachia
is_a: NCBITaxon:8292  ! Amphibia

[Term]
id: NCBITaxon:41705
name: Protacanthopterygii
is_a: NCBITaxon:32447  ! Euteleostei

[Term]
id: NCBITaxon:418101
name: Plasmodium (Vinckeia)
is_a: NCBITaxon:5820  ! Plasmodium

[Term]
id: NCBITaxon:418107
name: Plasmodium (Laverania)
is_a: NCBITaxon:5820  ! Plasmodium

[Term]
id: NCBITaxon:41827
name: Culicoidea
is_a: NCBITaxon:43786  ! Culicimorpha

[Term]
id: NCBITaxon:41937
name: Sapindales
is_a: NCBITaxon:91836  ! eurosids II

[Term]
id: NCBITaxon:4209
name: Asterales
is_a: NCBITaxon:91882  ! campanulids

[Term]
id: NCBITaxon:4210
name: Asteraceae
is_a: NCBITaxon:4209  ! Asterales

[Term]
id: NCBITaxon:42255
name: Rubrobacter
is_a: NCBITaxon:84997  ! Rubrobacteraceae

[Term]
id: NCBITaxon:422676
name: Aconoidasida
is_a: NCBITaxon:5794  ! Apicomplexa

[Term]
id: NCBITaxon:423054
name: Eimeriorina
is_a: NCBITaxon:75739  ! Eucoccidiorida

[Term]
id: NCBITaxon:42374
name: Candida dubliniensis
is_a: NCBITaxon:5475  ! Candida

[Term]
id: NCBITaxon:424551
name: Solanoideae
is_a: NCBITaxon:4070  ! Solanaceae

[Term]
id: NCBITaxon:424554
name: Nicotianoideae
is_a: NCBITaxon:4070  ! Solanaceae

[Term]
id: NCBITaxon:424562
name: Nicotianeae
is_a: NCBITaxon:424554  ! Nicotianoideae

[Term]
id: NCBITaxon:424564
name: Capsiceae
is_a: NCBITaxon:424551  ! Solanoideae

[Term]
id: NCBITaxon:424574
name: Solaneae
is_a: NCBITaxon:424551  ! Solanoideae

[Term]
id: NCBITaxon:426114
name: Thiomonas sp. 3As
is_a: NCBITaxon:32012  ! Thiomonas

[Term]
id: NCBITaxon:42857
name: Moorella group
is_a: NCBITaxon:186814  ! Thermoanaerobacteriaceae

[Term]
id: NCBITaxon:431241
name: Trichoderma reesei QM6a
is_a: NCBITaxon:51453  ! Hypocrea jecorina

[Term]
id: NCBITaxon:43162
name: Sylvia
is_a: NCBITaxon:36270  ! Sylviidae

[Term]
id: NCBITaxon:436486
name: Dinosauria
is_a: NCBITaxon:8492  ! Archosauria

[Term]
id: NCBITaxon:436489
name: Saurischia
is_a: NCBITaxon:436486  ! Dinosauria

[Term]
id: NCBITaxon:436491
name: Theropoda
is_a: NCBITaxon:436489  ! Saurischia

[Term]
id: NCBITaxon:436492
name: Coelurosauria
is_a: NCBITaxon:436491  ! Theropoda

[Term]
id: NCBITaxon:43733
name: Muscomorpha
is_a: NCBITaxon:7203  ! Brachycera

[Term]
id: NCBITaxon:43738
name: Schizophora
is_a: NCBITaxon:43733  ! Muscomorpha

[Term]
id: NCBITaxon:43741
name: Acalyptratae
is_a: NCBITaxon:43738  ! Schizophora

[Term]
id: NCBITaxon:43746
name: Ephydroidea
is_a: NCBITaxon:43741  ! Acalyptratae

[Term]
id: NCBITaxon:43786
name: Culicimorpha
is_a: NCBITaxon:7148  ! Nematocera

[Term]
id: NCBITaxon:43816
name: Anophelinae
is_a: NCBITaxon:7157  ! Culicidae

[Term]
id: NCBITaxon:43817
name: Culicinae
is_a: NCBITaxon:7157  ! Culicidae

[Term]
id: NCBITaxon:43845
name: Drosophilinae
is_a: NCBITaxon:7214  ! Drosophilidae

[Term]
id: NCBITaxon:43988
name: Cyanothece
is_a: NCBITaxon:1118  ! Chroococcales

[Term]
id: NCBITaxon:43989
name: Cyanothece sp. ATCC 51142
is_a: NCBITaxon:43988  ! Cyanothece

[Term]
id: NCBITaxon:44260
name: Moorella
is_a: NCBITaxon:42857  ! Moorella group

[Term]
id: NCBITaxon:4447
name: Liliopsida
is_a: NCBITaxon:3398  ! Magnoliophyta

[Term]
id: NCBITaxon:44534
name: Cellia
is_a: NCBITaxon:7164  ! Anopheles

[Term]
id: NCBITaxon:44537
name: Pyretophorus
is_a: NCBITaxon:44534  ! Cellia

[Term]
id: NCBITaxon:44542
name: gambiae species complex
is_a: NCBITaxon:44537  ! Pyretophorus

[Term]
id: NCBITaxon:44689
name: Dictyostelium discoideum
is_a: NCBITaxon:5782  ! Dictyostelium

[Term]
id: NCBITaxon:4479
name: Poaceae
is_a: NCBITaxon:38820  ! Poales

[Term]
id: NCBITaxon:4512
name: Hordeum
is_a: NCBITaxon:147389  ! Triticeae

[Term]
id: NCBITaxon:4513
name: Hordeum vulgare
is_a: NCBITaxon:4512  ! Hordeum

[Term]
id: NCBITaxon:4520
name: Lolium
is_a: NCBITaxon:147387  ! Poeae

[Term]
id: NCBITaxon:4522
name: Lolium perenne
is_a: NCBITaxon:4520  ! Lolium

[Term]
id: NCBITaxon:4527
name: Oryza
is_a: NCBITaxon:147380  ! Oryzeae

[Term]
id: NCBITaxon:4530
name: Oryza sativa
is_a: NCBITaxon:4527  ! Oryza

[Term]
id: NCBITaxon:4564
name: Triticum
is_a: NCBITaxon:147389  ! Triticeae

[Term]
id: NCBITaxon:4565
name: Triticum aestivum
is_a: NCBITaxon:4564  ! Triticum

[Term]
id: NCBITaxon:4567
name: Triticum turgidum subsp. durum
is_a: NCBITaxon:4571  ! Triticum turgidum

[Term]
id: NCBITaxon:4571
name: Triticum turgidum
is_a: NCBITaxon:4564  ! Triticum

[Term]
id: NCBITaxon:4575
name: Zea
is_a: NCBITaxon:147429  ! Andropogoneae

[Term]
id: NCBITaxon:4577
name: Zea mays
is_a: NCBITaxon:4575  ! Zea

[Term]
id: NCBITaxon:4605
name: Festuca
is_a: NCBITaxon:147387  ! Poeae

[Term]
id: NCBITaxon:4606
name: Festuca arundinacea
is_a: NCBITaxon:4605  ! Festuca

[Term]
id: NCBITaxon:46170
name: Staphylococcus aureus subsp. aureus
is_a: NCBITaxon:1280  ! Staphylococcus aureus

[Term]
id: NCBITaxon:46239
name: Mesoplasma
is_a: NCBITaxon:33925  ! Entomoplasmataceae

[Term]
id: NCBITaxon:46254
name: Oenococcus
is_a: NCBITaxon:81850  ! Leuconostocaceae

[Term]
id: NCBITaxon:46659
name: Thermoplasmataceae
is_a: NCBITaxon:2301  ! Thermoplasmatales

[Term]
id: NCBITaxon:468
name: Moraxellaceae
is_a: NCBITaxon:72274  ! Pseudomonadales

[Term]
id: NCBITaxon:46877
name: Drosophilini
is_a: NCBITaxon:43845  ! Drosophilinae

[Term]
id: NCBITaxon:46879
name: Drosophilina
is_a: NCBITaxon:46877  ! Drosophilini

[Term]
id: NCBITaxon:469
name: Acinetobacter
is_a: NCBITaxon:468  ! Moraxellaceae

[Term]
id: NCBITaxon:470
name: Acinetobacter baumannii
is_a: NCBITaxon:469  ! Acinetobacter

[Term]
id: NCBITaxon:47021
name: Orbiliaceae
is_a: NCBITaxon:189479  ! Orbiliales

[Term]
id: NCBITaxon:47144
name: Tetraodon
is_a: NCBITaxon:31031  ! Tetraodontidae

[Term]
id: NCBITaxon:4734
name: commelinids
is_a: NCBITaxon:4447  ! Liliopsida

[Term]
id: NCBITaxon:4751
name: Fungi
is_a: NCBITaxon:33154  ! Fungi/Metazoa group

[Term]
id: NCBITaxon:47570
name: Schizotrypanum
is_a: NCBITaxon:5690  ! Trypanosoma

[Term]
id: NCBITaxon:47766
name: Agrotis
is_a: NCBITaxon:95179  ! Noctuinae

[Term]
id: NCBITaxon:47767
name: Agrotis segetum
is_a: NCBITaxon:47766  ! Agrotis

[Term]
id: NCBITaxon:481
name: Neisseriaceae
is_a: NCBITaxon:206351  ! Neisseriales

[Term]
id: NCBITaxon:482
name: Neisseria
is_a: NCBITaxon:481  ! Neisseriaceae

[Term]
id: NCBITaxon:485
name: Neisseria gonorrhoeae
is_a: NCBITaxon:482  ! Neisseria

[Term]
id: NCBITaxon:487
name: Neisseria meningitidis
is_a: NCBITaxon:482  ! Neisseria

[Term]
id: NCBITaxon:48736
name: Ralstonia
is_a: NCBITaxon:119060  ! Burkholderiaceae

[Term]
id: NCBITaxon:48881
name: Geospiza
is_a: NCBITaxon:400783  ! Thraupini

[Term]
id: NCBITaxon:48882
name: Geospiza conirostris
is_a: NCBITaxon:48881  ! Geospiza

[Term]
id: NCBITaxon:48883
name: Geospiza fortis
is_a: NCBITaxon:48881  ! Geospiza

[Term]
id: NCBITaxon:48885
name: Geospiza magnirostris
is_a: NCBITaxon:48881  ! Geospiza

[Term]
id: NCBITaxon:48886
name: Geospiza scandens
is_a: NCBITaxon:48881  ! Geospiza

[Term]
id: NCBITaxon:4890
name: Ascomycota
is_a: NCBITaxon:4751  ! Fungi

[Term]
id: NCBITaxon:4891
name: Saccharomycetes
is_a: NCBITaxon:147537  ! Saccharomycotina

[Term]
id: NCBITaxon:4892
name: Saccharomycetales
is_a: NCBITaxon:4891  ! Saccharomycetes

[Term]
id: NCBITaxon:4893
name: Saccharomycetaceae
is_a: NCBITaxon:4892  ! Saccharomycetales

[Term]
id: NCBITaxon:48935
name: Novosphingobium aromaticivorans
is_a: NCBITaxon:165696  ! Novosphingobium

[Term]
id: NCBITaxon:4894
name: Schizosaccharomycetaceae
is_a: NCBITaxon:34346  ! Schizosaccharomycetales

[Term]
id: NCBITaxon:4895
name: Schizosaccharomyces
is_a: NCBITaxon:4894  ! Schizosaccharomycetaceae

[Term]
id: NCBITaxon:4896
name: Schizosaccharomyces pombe
is_a: NCBITaxon:4895  ! Schizosaccharomyces

[Term]
id: NCBITaxon:4910
name: Kluyveromyces
is_a: NCBITaxon:4893  ! Saccharomycetaceae

[Term]
id: NCBITaxon:4914
name: Kluyveromyces waltii
is_a: NCBITaxon:4910  ! Kluyveromyces

[Term]
id: NCBITaxon:4919
name: Pichia
is_a: NCBITaxon:4893  ! Saccharomycetaceae

[Term]
id: NCBITaxon:4922
name: Pichia pastoris
is_a: NCBITaxon:4919  ! Pichia

[Term]
id: NCBITaxon:49274
name: Lycopersicon
is_a: NCBITaxon:4107  ! Solanum

[Term]
id: NCBITaxon:4930
name: Saccharomyces
is_a: NCBITaxon:4893  ! Saccharomycetaceae

[Term]
id: NCBITaxon:4931
name: Saccharomyces bayanus
is_a: NCBITaxon:4930  ! Saccharomyces

[Term]
id: NCBITaxon:49319
name: Rubrobacter xylanophilus
is_a: NCBITaxon:42255  ! Rubrobacter

[Term]
id: NCBITaxon:4932
name: Saccharomyces cerevisiae
is_a: NCBITaxon:4930  ! Saccharomyces

[Term]
id: NCBITaxon:49338
name: Desulfitobacterium hafniense
is_a: NCBITaxon:36853  ! Desulfitobacterium

[Term]
id: NCBITaxon:4934
name: Lachancea kluyveri
is_a: NCBITaxon:300275  ! Lachancea

[Term]
id: NCBITaxon:50339
name: Thermoplasma volcanium
is_a: NCBITaxon:2302  ! Thermoplasma

[Term]
id: NCBITaxon:5042
name: Eurotiales
is_a: NCBITaxon:147545  ! Eurotiomycetes

[Term]
id: NCBITaxon:5052
name: Aspergillus
is_a: NCBITaxon:34380  ! mitosporic Trichocomaceae

[Term]
id: NCBITaxon:50557
name: Insecta
is_a: NCBITaxon:6960  ! Hexapoda

[Term]
id: NCBITaxon:5057
name: Aspergillus clavatus
is_a: NCBITaxon:5052  ! Aspergillus

[Term]
id: NCBITaxon:506
name: Alcaligenaceae
is_a: NCBITaxon:80840  ! Burkholderiales

[Term]
id: NCBITaxon:5061
name: Aspergillus niger
is_a: NCBITaxon:5052  ! Aspergillus

[Term]
id: NCBITaxon:5085
name: Aspergillus fumigatus
is_a: NCBITaxon:5052  ! Aspergillus

[Term]
id: NCBITaxon:51029
name: Heterodera glycines
is_a: NCBITaxon:34509  ! Heterodera

[Term]
id: NCBITaxon:5125
name: Hypocreales
is_a: NCBITaxon:222543  ! Hypocreomycetidae

[Term]
id: NCBITaxon:5126
name: Gibberella
is_a: NCBITaxon:110618  ! Nectriaceae

[Term]
id: NCBITaxon:5129
name: Hypocreaceae
is_a: NCBITaxon:5125  ! Hypocreales

[Term]
id: NCBITaxon:51290
name: Chlamydiae/Verrucomicrobia group
is_a: NCBITaxon:2  ! Bacteria

[Term]
id: NCBITaxon:51291
name: Chlamydiales
is_a: NCBITaxon:204429  ! Chlamydiae (class)

[Term]
id: NCBITaxon:5139
name: Sordariales
is_a: NCBITaxon:222544  ! Sordariomycetidae

[Term]
id: NCBITaxon:5140
name: Neurospora
is_a: NCBITaxon:5148  ! Sordariaceae

[Term]
id: NCBITaxon:5141
name: Neurospora crassa
is_a: NCBITaxon:5140  ! Neurospora

[Term]
id: NCBITaxon:51453
name: Hypocrea jecorina
is_a: NCBITaxon:29859  ! Hypocrea

[Term]
id: NCBITaxon:5146
name: Sordaria
is_a: NCBITaxon:5148  ! Sordariaceae

[Term]
id: NCBITaxon:5147
name: Sordaria macrospora
is_a: NCBITaxon:5146  ! Sordaria

[Term]
id: NCBITaxon:5148
name: Sordariaceae
is_a: NCBITaxon:5139  ! Sordariales

[Term]
id: NCBITaxon:51511
name: Ciona savignyi
is_a: NCBITaxon:7718  ! Ciona

[Term]
id: NCBITaxon:517
name: Bordetella
is_a: NCBITaxon:506  ! Alcaligenaceae

[Term]
id: NCBITaxon:518
name: Bordetella bronchiseptica
is_a: NCBITaxon:517  ! Bordetella

[Term]
id: NCBITaxon:520
name: Bordetella pertussis
is_a: NCBITaxon:517  ! Bordetella

[Term]
id: NCBITaxon:5204
name: Basidiomycota
is_a: NCBITaxon:4751  ! Fungi

[Term]
id: NCBITaxon:52153
name: Festuca rubra
is_a: NCBITaxon:4605  ! Festuca

[Term]
id: NCBITaxon:5257
name: Ustilaginomycetes
is_a: NCBITaxon:5204  ! Basidiomycota

[Term]
id: NCBITaxon:5267
name: Ustilaginales
is_a: NCBITaxon:62909  ! Ustilaginomycetidae

[Term]
id: NCBITaxon:5268
name: Ustilaginaceae
is_a: NCBITaxon:5267  ! Ustilaginales

[Term]
id: NCBITaxon:5269
name: Ustilago
is_a: NCBITaxon:5268  ! Ustilaginaceae

[Term]
id: NCBITaxon:5270
name: Ustilago maydis
is_a: NCBITaxon:5269  ! Ustilago

[Term]
id: NCBITaxon:52713
name: Leymus
is_a: NCBITaxon:147389  ! Triticeae

[Term]
id: NCBITaxon:5302
name: Hymenomycetes
is_a: NCBITaxon:5204  ! Basidiomycota

[Term]
id: NCBITaxon:5303
name: Aphyllophorales
is_a: NCBITaxon:155619  ! Homobasidiomycetes

[Term]
id: NCBITaxon:5304
name: Corticiaceae
is_a: NCBITaxon:5303  ! Aphyllophorales

[Term]
id: NCBITaxon:5305
name: Phanerochaete
is_a: NCBITaxon:5304  ! Corticiaceae

[Term]
id: NCBITaxon:5306
name: Phanerochaete chrysosporium
is_a: NCBITaxon:5305  ! Phanerochaete

[Term]
id: NCBITaxon:5338
name: Agaricales
is_a: NCBITaxon:155619  ! Homobasidiomycetes

[Term]
id: NCBITaxon:53413
name: Xanthomonas axonopodis
is_a: NCBITaxon:338  ! Xanthomonas

[Term]
id: NCBITaxon:5346
name: Coprinopsis cinerea
is_a: NCBITaxon:184431  ! Coprinopsis

[Term]
id: NCBITaxon:53541
name: Stegomyia
is_a: NCBITaxon:7158  ! Aedes

[Term]
id: NCBITaxon:53550
name: Culicini
is_a: NCBITaxon:43817  ! Culicinae

[Term]
id: NCBITaxon:5394
name: Paxillaceae
is_a: NCBITaxon:227331  ! Paxilineae

[Term]
id: NCBITaxon:5395
name: Paxillus
is_a: NCBITaxon:5394  ! Paxillaceae

[Term]
id: NCBITaxon:53953
name: Pyrococcus horikoshii
is_a: NCBITaxon:2260  ! Pyrococcus

[Term]
id: NCBITaxon:54032
name: mitosporic Orbiliaceae
is_a: NCBITaxon:47021  ! Orbiliaceae

[Term]
id: NCBITaxon:54033
name: Monacrosporium
is_a: NCBITaxon:54032  ! mitosporic Orbiliaceae

[Term]
id: NCBITaxon:541
name: Zymomonas
is_a: NCBITaxon:41297  ! Sphingomonadaceae

[Term]
id: NCBITaxon:542
name: Zymomonas mobilis
is_a: NCBITaxon:541  ! Zymomonas

[Term]
id: NCBITaxon:543
name: Enterobacteriaceae
is_a: NCBITaxon:91347  ! Enterobacteriales

[Term]
id: NCBITaxon:54734
name: Mycosphaerella graminicola
is_a: NCBITaxon:41254  ! Mycosphaerella

[Term]
id: NCBITaxon:5475
name: Candida
is_a: NCBITaxon:118267  ! mitosporic Saccharomycetales

[Term]
id: NCBITaxon:5476
name: Candida albicans
is_a: NCBITaxon:5475  ! Candida

[Term]
id: NCBITaxon:5478
name: Candida glabrata
is_a: NCBITaxon:5475  ! Candida

[Term]
id: NCBITaxon:54921
name: Pinus resinosa
is_a: NCBITaxon:139271  ! Pinus [NCBITaxon:139271]

[Term]
id: NCBITaxon:5518
name: Gibberella zeae
is_a: NCBITaxon:5126  ! Gibberella

[Term]
id: NCBITaxon:55746
name: Panagrolaimoidea
is_a: NCBITaxon:6236  ! Rhabditida

[Term]
id: NCBITaxon:55879
name: Rhabditoidea
is_a: NCBITaxon:6236  ! Rhabditida

[Term]
id: NCBITaxon:55885
name: Peloderinae
is_a: NCBITaxon:6243  ! Rhabditidae

[Term]
id: NCBITaxon:561
name: Escherichia
is_a: NCBITaxon:543  ! Enterobacteriaceae

[Term]
id: NCBITaxon:562
name: Escherichia coli
is_a: NCBITaxon:561  ! Escherichia

[Term]
id: NCBITaxon:56364
name: Agrotis ipsilon
is_a: NCBITaxon:47766  ! Agrotis

[Term]
id: NCBITaxon:5653
name: Kinetoplastida
is_a: NCBITaxon:33682  ! Euglenozoa

[Term]
id: NCBITaxon:5654
name: Trypanosomatidae
is_a: NCBITaxon:5653  ! Kinetoplastida

[Term]
id: NCBITaxon:5658
name: Leishmania
is_a: NCBITaxon:5654  ! Trypanosomatidae

[Term]
id: NCBITaxon:5660
name: Leishmania braziliensis
is_a: NCBITaxon:37617  ! Leishmania braziliensis species complex

[Term]
id: NCBITaxon:5661
name: Leishmania donovani
is_a: NCBITaxon:38574  ! Leishmania donovani species complex

[Term]
id: NCBITaxon:5664
name: Leishmania major
is_a: NCBITaxon:38581  ! Leishmania major species complex

[Term]
id: NCBITaxon:5665
name: Leishmania mexicana
is_a: NCBITaxon:38582  ! Leishmania mexicana species complex

[Term]
id: NCBITaxon:5671
name: Leishmania infantum
is_a: NCBITaxon:38573  ! Leishmania infantum species complex

[Term]
id: NCBITaxon:5690
name: Trypanosoma
is_a: NCBITaxon:5654  ! Trypanosomatidae

[Term]
id: NCBITaxon:5691
name: Trypanosoma brucei
is_a: NCBITaxon:39700  ! Trypanozoon

[Term]
id: NCBITaxon:5693
name: Trypanosoma cruzi
is_a: NCBITaxon:47570  ! Schizotrypanum

[Term]
id: NCBITaxon:5782
name: Dictyostelium
is_a: NCBITaxon:33083  ! Dictyosteliida

[Term]
id: NCBITaxon:5794
name: Apicomplexa
is_a: NCBITaxon:33630  ! Alveolata

[Term]
id: NCBITaxon:5796
name: Coccidia
is_a: NCBITaxon:5794  ! Apicomplexa

[Term]
id: NCBITaxon:57975
name: Burkholderia thailandensis
is_a: NCBITaxon:111527  ! pseudomallei group

[Term]
id: NCBITaxon:58019
name: Coniferopsida
is_a: NCBITaxon:3312  ! Coniferophyta

[Term]
id: NCBITaxon:58023
name: Tracheophyta
is_a: NCBITaxon:3193  ! Embryophyta

[Term]
id: NCBITaxon:58024
name: Spermatophyta
is_a: NCBITaxon:78536  ! Euphyllophyta

[Term]
id: NCBITaxon:5806
name: Cryptosporidium
is_a: NCBITaxon:35082  ! Cryptosporidiidae

[Term]
id: NCBITaxon:5807
name: Cryptosporidium parvum
is_a: NCBITaxon:5806  ! Cryptosporidium

[Term]
id: NCBITaxon:5819
name: Haemosporida
is_a: NCBITaxon:422676  ! Aconoidasida

[Term]
id: NCBITaxon:5820
name: Plasmodium
is_a: NCBITaxon:5819  ! Haemosporida

[Term]
id: NCBITaxon:5821
name: Plasmodium berghei
is_a: NCBITaxon:418101  ! Plasmodium (Vinckeia)

[Term]
id: NCBITaxon:5833
name: Plasmodium falciparum
is_a: NCBITaxon:418107  ! Plasmodium (Laverania)

[Term]
id: NCBITaxon:590
name: Salmonella
is_a: NCBITaxon:543  ! Enterobacteriaceae

[Term]
id: NCBITaxon:592
name: Salmonella enteritidis
is_a: NCBITaxon:590  ! Salmonella

[Term]
id: NCBITaxon:59728
name: Taeniopygia
is_a: NCBITaxon:40155  ! Estrildinae

[Term]
id: NCBITaxon:59729
name: Taeniopygia guttata
is_a: NCBITaxon:59728  ! Taeniopygia

[Term]
id: NCBITaxon:59861
name: Coregonus clupeaformis
is_a: NCBITaxon:27772  ! Coregonus

[Term]
id: NCBITaxon:601
name: Salmonella typhi
is_a: NCBITaxon:590  ! Salmonella

[Term]
id: NCBITaxon:602
name: Salmonella typhimurium
is_a: NCBITaxon:590  ! Salmonella

[Term]
id: NCBITaxon:6072
name: Eumetazoa
is_a: NCBITaxon:33208  ! Metazoa

[Term]
id: NCBITaxon:60888
name: Neosartorya fischeri group
is_a: NCBITaxon:36629  ! Neosartorya

[Term]
id: NCBITaxon:6157
name: Platyhelminthes
is_a: NCBITaxon:33214  ! Acoelomata

[Term]
id: NCBITaxon:6178
name: Trematoda
is_a: NCBITaxon:6157  ! Platyhelminthes

[Term]
id: NCBITaxon:6179
name: Digenea
is_a: NCBITaxon:6178  ! Trematoda

[Term]
id: NCBITaxon:6180
name: Strigeidida
is_a: NCBITaxon:6179  ! Digenea

[Term]
id: NCBITaxon:6181
name: Schistosoma
is_a: NCBITaxon:31245  ! Schistosomatidae

[Term]
id: NCBITaxon:6182
name: Schistosoma japonicum
is_a: NCBITaxon:6181  ! Schistosoma

[Term]
id: NCBITaxon:6183
name: Schistosoma mansoni
is_a: NCBITaxon:6181  ! Schistosoma

[Term]
id: NCBITaxon:62155
name: Emberizinae
is_a: NCBITaxon:9133  ! Fringillidae

[Term]
id: NCBITaxon:6231
name: Nematoda
is_a: NCBITaxon:33217  ! Pseudocoelomata

[Term]
id: NCBITaxon:6236
name: Rhabditida
is_a: NCBITaxon:119089  ! Chromadorea

[Term]
id: NCBITaxon:6237
name: Caenorhabditis
is_a: NCBITaxon:55885  ! Peloderinae

[Term]
id: NCBITaxon:6238
name: Caenorhabditis briggsae
is_a: NCBITaxon:6237  ! Caenorhabditis

[Term]
id: NCBITaxon:6239
name: Caenorhabditis elegans
is_a: NCBITaxon:6237  ! Caenorhabditis

[Term]
id: NCBITaxon:6243
name: Rhabditidae
is_a: NCBITaxon:55879  ! Rhabditoidea

[Term]
id: NCBITaxon:6246
name: Strongyloididae
is_a: NCBITaxon:55746  ! Panagrolaimoidea

[Term]
id: NCBITaxon:6247
name: Strongyloides
is_a: NCBITaxon:6246  ! Strongyloididae

[Term]
id: NCBITaxon:6274
name: Spirurida
is_a: NCBITaxon:119089  ! Chromadorea

[Term]
id: NCBITaxon:6278
name: Brugia
is_a: NCBITaxon:6296  ! Onchocercidae

[Term]
id: NCBITaxon:6279
name: Brugia malayi
is_a: NCBITaxon:6278  ! Brugia

[Term]
id: NCBITaxon:629
name: Yersinia
is_a: NCBITaxon:543  ! Enterobacteriaceae

[Term]
id: NCBITaxon:62909
name: Ustilaginomycetidae
is_a: NCBITaxon:5257  ! Ustilaginomycetes

[Term]
id: NCBITaxon:6295
name: Filarioidea
is_a: NCBITaxon:6274  ! Spirurida

[Term]
id: NCBITaxon:6296
name: Onchocercidae
is_a: NCBITaxon:6295  ! Filarioidea

[Term]
id: NCBITaxon:6300
name: Tylenchida
is_a: NCBITaxon:119089  ! Chromadorea

[Term]
id: NCBITaxon:6301
name: Heteroderidae
is_a: NCBITaxon:33284  ! Tylenchoidea

[Term]
id: NCBITaxon:632
name: Yersinia pestis
is_a: NCBITaxon:629  ! Yersinia

[Term]
id: NCBITaxon:63363
name: Aquifex aeolicus
is_a: NCBITaxon:2713  ! Aquifex

[Term]
id: NCBITaxon:641
name: Vibrionaceae
is_a: NCBITaxon:135623  ! Vibrionales

[Term]
id: NCBITaxon:6447
name: Mollusca
is_a: NCBITaxon:33317  ! Protostomia

[Term]
id: NCBITaxon:6448
name: Gastropoda
is_a: NCBITaxon:6447  ! Mollusca

[Term]
id: NCBITaxon:64684
name: Buchnera sp.
is_a: NCBITaxon:32199  ! Buchnera

[Term]
id: NCBITaxon:64895
name: Borrelia burgdorferi group
is_a: NCBITaxon:138  ! Borrelia

[Term]
id: NCBITaxon:64898
name: Aquificaceae
is_a: NCBITaxon:32069  ! Aquificales

[Term]
id: NCBITaxon:6519
name: Pulmonata
is_a: NCBITaxon:6448  ! Gastropoda

[Term]
id: NCBITaxon:6520
name: Basommatophora
is_a: NCBITaxon:6519  ! Pulmonata

[Term]
id: NCBITaxon:6524
name: Planorbidae
is_a: NCBITaxon:216441  ! Lymnaeoidea

[Term]
id: NCBITaxon:6525
name: Biomphalaria
is_a: NCBITaxon:6524  ! Planorbidae

[Term]
id: NCBITaxon:6526
name: Biomphalaria glabrata
is_a: NCBITaxon:6525  ! Biomphalaria

[Term]
id: NCBITaxon:657
name: Photobacterium
is_a: NCBITaxon:641  ! Vibrionaceae

[Term]
id: NCBITaxon:662
name: Vibrio
is_a: NCBITaxon:641  ! Vibrionaceae

[Term]
id: NCBITaxon:6656
name: Arthropoda
is_a: NCBITaxon:88770  ! Panarthropoda

[Term]
id: NCBITaxon:6657
name: Crustacea
is_a: NCBITaxon:197562  ! Pancrustacea

[Term]
id: NCBITaxon:666
name: Vibrio cholerae
is_a: NCBITaxon:662  ! Vibrio

[Term]
id: NCBITaxon:6681
name: Malacostraca
is_a: NCBITaxon:6657  ! Crustacea

[Term]
id: NCBITaxon:6682
name: Eucarida
is_a: NCBITaxon:72041  ! Eumalacostraca

[Term]
id: NCBITaxon:6683
name: Decapoda
is_a: NCBITaxon:6682  ! Eucarida

[Term]
id: NCBITaxon:6684
name: Dendrobranchiata
is_a: NCBITaxon:6683  ! Decapoda

[Term]
id: NCBITaxon:6685
name: Penaeidae
is_a: NCBITaxon:111520  ! Penaeoidea

[Term]
id: NCBITaxon:6687
name: Penaeus monodon
is_a: NCBITaxon:133894  ! Penaeus

[Term]
id: NCBITaxon:68287
name: Mesorhizobium
is_a: NCBITaxon:69277  ! Phyllobacteriaceae

[Term]
id: NCBITaxon:68295
name: Thermoanaerobacteriales
is_a: NCBITaxon:186801  ! Clostridia

[Term]
id: NCBITaxon:68336
name: Bacteroidetes/Chlorobi group
is_a: NCBITaxon:2  ! Bacteria

[Term]
id: NCBITaxon:68525
name: delta/epsilon subdivisions
is_a: NCBITaxon:1224  ! Proteobacteria

[Term]
id: NCBITaxon:68889
name: Boletales
is_a: NCBITaxon:155619  ! Homobasidiomycetes

[Term]
id: NCBITaxon:69277
name: Phyllobacteriaceae
is_a: NCBITaxon:356  ! Rhizobiales

[Term]
id: NCBITaxon:69541
name: Desulfuromonadales
is_a: NCBITaxon:28221  ! Deltaproteobacteria

[Term]
id: NCBITaxon:6960
name: Hexapoda
is_a: NCBITaxon:197562  ! Pancrustacea

[Term]
id: NCBITaxon:7088
name: Lepidoptera
is_a: NCBITaxon:85604  ! Amphiesmenoptera

[Term]
id: NCBITaxon:7089
name: Bombycidae
is_a: NCBITaxon:119258  ! Bombyciformes

[Term]
id: NCBITaxon:7090
name: Bombyx
is_a: NCBITaxon:7089  ! Bombycidae

[Term]
id: NCBITaxon:7091
name: Bombyx mori
is_a: NCBITaxon:7090  ! Bombyx

[Term]
id: NCBITaxon:70987
name: Apinae
is_a: NCBITaxon:7458  ! Apidae

[Term]
id: NCBITaxon:7100
name: Noctuidae
is_a: NCBITaxon:37570  ! Noctuoidea

[Term]
id: NCBITaxon:71150
name: Paxillus involutus
is_a: NCBITaxon:5395  ! Paxillus

[Term]
id: NCBITaxon:712
name: Pasteurellaceae
is_a: NCBITaxon:135625  ! Pasteurellales

[Term]
id: NCBITaxon:71240
name: eudicotyledons
is_a: NCBITaxon:3398  ! Magnoliophyta

[Term]
id: NCBITaxon:71274
name: asterids
is_a: NCBITaxon:91827  ! core eudicotyledons

[Term]
id: NCBITaxon:71275
name: rosids
is_a: NCBITaxon:91827  ! core eudicotyledons

[Term]
id: NCBITaxon:713
name: Actinobacillus
is_a: NCBITaxon:712  ! Pasteurellaceae

[Term]
id: NCBITaxon:7147
name: Diptera
is_a: NCBITaxon:33392  ! Endopterygota

[Term]
id: NCBITaxon:7148
name: Nematocera
is_a: NCBITaxon:7147  ! Diptera

[Term]
id: NCBITaxon:715
name: Actinobacillus pleuropneumoniae
is_a: NCBITaxon:713  ! Actinobacillus

[Term]
id: NCBITaxon:7157
name: Culicidae
is_a: NCBITaxon:41827  ! Culicoidea

[Term]
id: NCBITaxon:7158
name: Aedes
is_a: NCBITaxon:375013  ! Aedes/Ochlerotatus group

[Term]
id: NCBITaxon:7159
name: Aedes aegypti
is_a: NCBITaxon:53541  ! Stegomyia

[Term]
id: NCBITaxon:7164
name: Anopheles
is_a: NCBITaxon:43816  ! Anophelinae

[Term]
id: NCBITaxon:7165
name: Anopheles gambiae
is_a: NCBITaxon:44542  ! gambiae species complex

[Term]
id: NCBITaxon:72025
name: Fabales
is_a: NCBITaxon:91835  ! eurosids I

[Term]
id: NCBITaxon:7203
name: Brachycera
is_a: NCBITaxon:7147  ! Diptera

[Term]
id: NCBITaxon:72041
name: Eumalacostraca
is_a: NCBITaxon:6681  ! Malacostraca

[Term]
id: NCBITaxon:7214
name: Drosophilidae
is_a: NCBITaxon:43746  ! Ephydroidea

[Term]
id: NCBITaxon:7215
name: Drosophila
is_a: NCBITaxon:186285  ! Drosophiliti

[Term]
id: NCBITaxon:7220
name: Drosophila erecta
is_a: NCBITaxon:32351  ! melanogaster subgroup

[Term]
id: NCBITaxon:7226
name: Drosophila mauritiana
is_a: NCBITaxon:32351  ! melanogaster subgroup

[Term]
id: NCBITaxon:7227
name: Drosophila melanogaster
is_a: NCBITaxon:32351  ! melanogaster subgroup

[Term]
id: NCBITaxon:72273
name: Thiotrichales
is_a: NCBITaxon:1236  ! Gammaproteobacteria

[Term]
id: NCBITaxon:72274
name: Pseudomonadales
is_a: NCBITaxon:1236  ! Gammaproteobacteria

[Term]
id: NCBITaxon:72275
name: Alteromonadaceae
is_a: NCBITaxon:135622  ! Alteromonadales

[Term]
id: NCBITaxon:72293
name: Helicobacteraceae
is_a: NCBITaxon:213849  ! Campylobacterales

[Term]
id: NCBITaxon:72294
name: Campylobacteraceae
is_a: NCBITaxon:213849  ! Campylobacterales

[Term]
id: NCBITaxon:7233
name: Drosophila orena
is_a: NCBITaxon:32351  ! melanogaster subgroup

[Term]
id: NCBITaxon:7237
name: Drosophila pseudoobscura
is_a: NCBITaxon:32358  ! pseudoobscura subgroup

[Term]
id: NCBITaxon:7238
name: Drosophila sechellia
is_a: NCBITaxon:32351  ! melanogaster subgroup

[Term]
id: NCBITaxon:724
name: Haemophilus
is_a: NCBITaxon:712  ! Pasteurellaceae

[Term]
id: NCBITaxon:7240
name: Drosophila simulans
is_a: NCBITaxon:32351  ! melanogaster subgroup

[Term]
id: NCBITaxon:7243
name: Drosophila teissieri
is_a: NCBITaxon:32351  ! melanogaster subgroup

[Term]
id: NCBITaxon:7245
name: Drosophila yakuba
is_a: NCBITaxon:32351  ! melanogaster subgroup

[Term]
id: NCBITaxon:727
name: Haemophilus influenzae
is_a: NCBITaxon:724  ! Haemophilus

[Term]
id: NCBITaxon:73029
name: Dechloromonas
is_a: NCBITaxon:75787  ! Rhodocyclaceae

[Term]
id: NCBITaxon:7399
name: Hymenoptera
is_a: NCBITaxon:33392  ! Endopterygota

[Term]
id: NCBITaxon:7400
name: Apocrita
is_a: NCBITaxon:7399  ! Hymenoptera

[Term]
id: NCBITaxon:74109
name: Photobacterium profundum
is_a: NCBITaxon:657  ! Photobacterium

[Term]
id: NCBITaxon:7434
name: Aculeata
is_a: NCBITaxon:7400  ! Apocrita

[Term]
id: NCBITaxon:74495
name: Monacrosporium haptotylum
is_a: NCBITaxon:54033  ! Monacrosporium

[Term]
id: NCBITaxon:745
name: Pasteurella
is_a: NCBITaxon:712  ! Pasteurellaceae

[Term]
id: NCBITaxon:7458
name: Apidae
is_a: NCBITaxon:34735  ! Apoidea

[Term]
id: NCBITaxon:7459
name: Apis
is_a: NCBITaxon:83321  ! Apini

[Term]
id: NCBITaxon:7460
name: Apis mellifera
is_a: NCBITaxon:7459  ! Apis

[Term]
id: NCBITaxon:747
name: Pasteurella multocida
is_a: NCBITaxon:745  ! Pasteurella

[Term]
id: NCBITaxon:7496
name: Pterygota
is_a: NCBITaxon:85512  ! Dicondylia

[Term]
id: NCBITaxon:74968
name: Ferroplasma
is_a: NCBITaxon:90142  ! Ferroplasmaceae

[Term]
id: NCBITaxon:75
name: Caulobacter
is_a: NCBITaxon:76892  ! Caulobacteraceae

[Term]
id: NCBITaxon:75682
name: Oxalobacteraceae
is_a: NCBITaxon:80840  ! Burkholderiales

[Term]
id: NCBITaxon:75702
name: Populus euphratica
is_a: NCBITaxon:3689  ! Populus

[Term]
id: NCBITaxon:75739
name: Eucoccidiorida
is_a: NCBITaxon:5796  ! Coccidia

[Term]
id: NCBITaxon:75787
name: Rhodocyclaceae
is_a: NCBITaxon:206389  ! Rhodocyclales

[Term]
id: NCBITaxon:766
name: Rickettsiales
is_a: NCBITaxon:28211  ! Alphaproteobacteria

[Term]
id: NCBITaxon:768
name: Anaplasma
is_a: NCBITaxon:942  ! Anaplasmataceae

[Term]
id: NCBITaxon:76804
name: Nidovirales
is_a: NCBITaxon:35278  ! ssRNA positive-strand viruses, no DNA stage

[Term]
id: NCBITaxon:76892
name: Caulobacteraceae
is_a: NCBITaxon:204458  ! Caulobacterales

[Term]
id: NCBITaxon:7711
name: Chordata
is_a: NCBITaxon:33511  ! Deuterostomia

[Term]
id: NCBITaxon:7712
name: Urochordata
is_a: NCBITaxon:7711  ! Chordata

[Term]
id: NCBITaxon:7713
name: Ascidiacea
is_a: NCBITaxon:7712  ! Urochordata

[Term]
id: NCBITaxon:7716
name: Phlebobranchia
is_a: NCBITaxon:183770  ! Enterogona

[Term]
id: NCBITaxon:7717
name: Cionidae
is_a: NCBITaxon:7716  ! Phlebobranchia

[Term]
id: NCBITaxon:7718
name: Ciona
is_a: NCBITaxon:7717  ! Cionidae

[Term]
id: NCBITaxon:7719
name: Ciona intestinalis
is_a: NCBITaxon:7718  ! Ciona

[Term]
id: NCBITaxon:772
name: Bartonellaceae
is_a: NCBITaxon:356  ! Rhizobiales

[Term]
id: NCBITaxon:7720
name: Stolidobranchia
is_a: NCBITaxon:7713  ! Ascidiacea

[Term]
id: NCBITaxon:7727
name: Pyuridae
is_a: NCBITaxon:7720  ! Stolidobranchia

[Term]
id: NCBITaxon:773
name: Bartonella
is_a: NCBITaxon:772  ! Bartonellaceae

[Term]
id: NCBITaxon:7732
name: Herdmania
is_a: NCBITaxon:7727  ! Pyuridae

[Term]
id: NCBITaxon:7733
name: Herdmania momus
is_a: NCBITaxon:7732  ! Herdmania

[Term]
id: NCBITaxon:7742
name: Vertebrata
is_a: NCBITaxon:89593  ! Craniata

[Term]
id: NCBITaxon:775
name: Rickettsiaceae
is_a: NCBITaxon:766  ! Rickettsiales

[Term]
id: NCBITaxon:776
name: Coxiella
is_a: NCBITaxon:118968  ! Coxiellaceae

[Term]
id: NCBITaxon:77643
name: Mycobacterium tuberculosis complex
is_a: NCBITaxon:1763  ! Mycobacterium

[Term]
id: NCBITaxon:777
name: Coxiella burnetii
is_a: NCBITaxon:776  ! Coxiella

[Term]
id: NCBITaxon:7776
name: Gnathostomata
is_a: NCBITaxon:7742  ! Vertebrata

[Term]
id: NCBITaxon:780
name: Rickettsia
is_a: NCBITaxon:33988  ! Rickettsieae

[Term]
id: NCBITaxon:781
name: Rickettsia conorii
is_a: NCBITaxon:114277  ! spotted fever group

[Term]
id: NCBITaxon:782
name: Rickettsia prowazekii
is_a: NCBITaxon:114292  ! typhus group

[Term]
id: NCBITaxon:783
name: Rickettsia rickettsii
is_a: NCBITaxon:114277  ! spotted fever group

[Term]
id: NCBITaxon:78536
name: Euphyllophyta
is_a: NCBITaxon:58023  ! Tracheophyta

[Term]
id: NCBITaxon:7898
name: Actinopterygii
is_a: NCBITaxon:117571  ! Euteleostomi

[Term]
id: NCBITaxon:7952
name: Cypriniformes
is_a: NCBITaxon:186627  ! Cypriniphysi

[Term]
id: NCBITaxon:7953
name: Cyprinidae
is_a: NCBITaxon:30727  ! Cyprinoidea

[Term]
id: NCBITaxon:7954
name: Danio
is_a: NCBITaxon:39562  ! Rasborinae

[Term]
id: NCBITaxon:7955
name: Danio rerio
is_a: NCBITaxon:7954  ! Danio

[Term]
id: NCBITaxon:7961
name: Cyprinus
is_a: NCBITaxon:39560  ! Cyprininae

[Term]
id: NCBITaxon:7962
name: Cyprinus carpio
is_a: NCBITaxon:7961  ! Cyprinus

[Term]
id: NCBITaxon:79704
name: Arthropleona
is_a: NCBITaxon:30001  ! Collembola

[Term]
id: NCBITaxon:79707
name: Entomobryoidea
is_a: NCBITaxon:79704  ! Arthropleona

[Term]
id: NCBITaxon:79744
name: Ellipura
is_a: NCBITaxon:6960  ! Hexapoda

[Term]
id: NCBITaxon:8006
name: Salmoniformes
is_a: NCBITaxon:41705  ! Protacanthopterygii

[Term]
id: NCBITaxon:8015
name: Salmonidae
is_a: NCBITaxon:186841  ! Salmonoidei

[Term]
id: NCBITaxon:8016
name: Oncorhynchus
is_a: NCBITaxon:8015  ! Salmonidae

[Term]
id: NCBITaxon:8022
name: Oncorhynchus mykiss
is_a: NCBITaxon:8016  ! Oncorhynchus

[Term]
id: NCBITaxon:8028
name: Salmo
is_a: NCBITaxon:8015  ! Salmonidae

[Term]
id: NCBITaxon:803
name: Bartonella quintana
is_a: NCBITaxon:773  ! Bartonella

[Term]
id: NCBITaxon:8030
name: Salmo salar
is_a: NCBITaxon:8028  ! Salmo

[Term]
id: NCBITaxon:8032
name: Salmo trutta
is_a: NCBITaxon:8028  ! Salmo

[Term]
id: NCBITaxon:8043
name: Gadiformes
is_a: NCBITaxon:32518  ! Paracanthopterygii

[Term]
id: NCBITaxon:8045
name: Gadidae
is_a: NCBITaxon:8043  ! Gadiformes

[Term]
id: NCBITaxon:8048
name: Gadus
is_a: NCBITaxon:8045  ! Gadidae

[Term]
id: NCBITaxon:8049
name: Gadus morhua
is_a: NCBITaxon:8048  ! Gadus

[Term]
id: NCBITaxon:80840
name: Burkholderiales
is_a: NCBITaxon:28216  ! Betaproteobacteria

[Term]
id: NCBITaxon:80863
name: Populus tremula x Populus alba
is_a: NCBITaxon:3689  ! Populus

[Term]
id: NCBITaxon:809
name: Chlamydiaceae
is_a: NCBITaxon:51291  ! Chlamydiales

[Term]
id: NCBITaxon:810
name: Chlamydia
is_a: NCBITaxon:809  ! Chlamydiaceae

[Term]
id: NCBITaxon:81093
name: Magnaporthaceae
is_a: NCBITaxon:147551  ! Sordariomycetes incertae sedis

[Term]
id: NCBITaxon:8111
name: Perciformes
is_a: NCBITaxon:32485  ! Percomorpha

[Term]
id: NCBITaxon:8112
name: Percoidei
is_a: NCBITaxon:8111  ! Perciformes

[Term]
id: NCBITaxon:813
name: Chlamydia trachomatis
is_a: NCBITaxon:810  ! Chlamydia

[Term]
id: NCBITaxon:8169
name: Sparidae
is_a: NCBITaxon:8112  ! Percoidei

[Term]
id: NCBITaxon:8174
name: Sparus
is_a: NCBITaxon:8169  ! Sparidae

[Term]
id: NCBITaxon:8175
name: Sparus aurata
is_a: NCBITaxon:8174  ! Sparus

[Term]
id: NCBITaxon:81850
name: Leuconostocaceae
is_a: NCBITaxon:186826  ! Lactobacillales

[Term]
id: NCBITaxon:81852
name: Enterococcaceae
is_a: NCBITaxon:186826  ! Lactobacillales

[Term]
id: NCBITaxon:82115
name: Rhizobiaceae
is_a: NCBITaxon:356  ! Rhizobiales

[Term]
id: NCBITaxon:8252
name: Pleuronectiformes
is_a: NCBITaxon:32485  ! Percomorpha

[Term]
id: NCBITaxon:8256
name: Pleuronectidae
is_a: NCBITaxon:30942  ! Pleuronectoidei

[Term]
id: NCBITaxon:8259
name: Platichthys
is_a: NCBITaxon:8256  ! Pleuronectidae

[Term]
id: NCBITaxon:8260
name: Platichthys flesus
is_a: NCBITaxon:8259  ! Platichthys

[Term]
id: NCBITaxon:8287
name: Sarcopterygii
is_a: NCBITaxon:117571  ! Euteleostomi

[Term]
id: NCBITaxon:8292
name: Amphibia
is_a: NCBITaxon:32523  ! Tetrapoda

[Term]
id: NCBITaxon:83321
name: Apini
is_a: NCBITaxon:70987  ! Apinae

[Term]
id: NCBITaxon:8342
name: Anura
is_a: NCBITaxon:41666  ! Batrachia

[Term]
id: NCBITaxon:8352
name: Pipidae
is_a: NCBITaxon:30319  ! Pipoidea

[Term]
id: NCBITaxon:8353
name: Xenopus
is_a: NCBITaxon:8360  ! Xenopodinae

[Term]
id: NCBITaxon:8355
name: Xenopus laevis
is_a: NCBITaxon:262014  ! Xenopus [NCBITaxon:262014]

[Term]
id: NCBITaxon:83553
name: Chlamydophila
is_a: NCBITaxon:809  ! Chlamydiaceae

[Term]
id: NCBITaxon:83558
name: Chlamydophila pneumoniae
is_a: NCBITaxon:83553  ! Chlamydophila

[Term]
id: NCBITaxon:8360
name: Xenopodinae
is_a: NCBITaxon:8352  ! Pipidae

[Term]
id: NCBITaxon:8363
name: Silurana
is_a: NCBITaxon:8353  ! Xenopus

[Term]
id: NCBITaxon:8364
name: Xenopus tropicalis
is_a: NCBITaxon:8363  ! Silurana

[Term]
id: NCBITaxon:83676
name: Nocardiopsaceae
is_a: NCBITaxon:85012  ! Streptosporangineae

[Term]
id: NCBITaxon:83677
name: Thermobifida
is_a: NCBITaxon:83676  ! Nocardiopsaceae

[Term]
id: NCBITaxon:8457
name: Sauropsida
is_a: NCBITaxon:32524  ! Amniota

[Term]
id: NCBITaxon:848
name: Fusobacterium
is_a: NCBITaxon:203492  ! Fusobacteriaceae

[Term]
id: NCBITaxon:8492
name: Archosauria
is_a: NCBITaxon:32561  ! Sauria

[Term]
id: NCBITaxon:84995
name: Rubrobacteridae
is_a: NCBITaxon:1760  ! Actinobacteria (class)

[Term]
id: NCBITaxon:84996
name: Rubrobacterales
is_a: NCBITaxon:84995  ! Rubrobacteridae

[Term]
id: NCBITaxon:84997
name: Rubrobacteraceae
is_a: NCBITaxon:255725  ! Rubrobacterineae

[Term]
id: NCBITaxon:85003
name: Actinobacteridae
is_a: NCBITaxon:1760  ! Actinobacteria (class)

[Term]
id: NCBITaxon:85004
name: Bifidobacteriales
is_a: NCBITaxon:85003  ! Actinobacteridae

[Term]
id: NCBITaxon:85005
name: Actinomycineae
is_a: NCBITaxon:2037  ! Actinomycetales

[Term]
id: NCBITaxon:85007
name: Corynebacterineae
is_a: NCBITaxon:2037  ! Actinomycetales

[Term]
id: NCBITaxon:85011
name: Streptomycineae
is_a: NCBITaxon:2037  ! Actinomycetales

[Term]
id: NCBITaxon:85012
name: Streptosporangineae
is_a: NCBITaxon:2037  ! Actinomycetales

[Term]
id: NCBITaxon:851
name: Fusobacterium nucleatum
is_a: NCBITaxon:848  ! Fusobacterium

[Term]
id: NCBITaxon:85512
name: Dicondylia
is_a: NCBITaxon:50557  ! Insecta

[Term]
id: NCBITaxon:85604
name: Amphiesmenoptera
is_a: NCBITaxon:33392  ! Endopterygota

[Term]
id: NCBITaxon:85681
name: Citrus clementina
is_a: NCBITaxon:2706  ! Citrus

[Term]
id: NCBITaxon:85692
name: Triticum turgidum subsp. dicoccoides
is_a: NCBITaxon:4571  ! Triticum turgidum

[Term]
id: NCBITaxon:85986
name: Paxillus filamentosus
is_a: NCBITaxon:5395  ! Paxillus

[Term]
id: NCBITaxon:86004
name: Pasteuria
is_a: NCBITaxon:186823  ! Alicyclobacillaceae

[Term]
id: NCBITaxon:86020
name: Leymus cinereus
is_a: NCBITaxon:52713  ! Leymus

[Term]
id: NCBITaxon:86021
name: Leymus triticoides
is_a: NCBITaxon:52713  ! Leymus

[Term]
id: NCBITaxon:86304
name: Saccharophagus degradans
is_a: NCBITaxon:316625  ! Saccharophagus

[Term]
id: NCBITaxon:86661
name: Bacillus cereus group
is_a: NCBITaxon:1386  ! Bacillus

[Term]
id: NCBITaxon:86665
name: Bacillus halodurans
is_a: NCBITaxon:1386  ! Bacillus

[Term]
id: NCBITaxon:87173
name: Geospiza difficilis
is_a: NCBITaxon:48881  ! Geospiza

[Term]
id: NCBITaxon:872
name: Desulfovibrio
is_a: NCBITaxon:194924  ! Desulfovibrionaceae

[Term]
id: NCBITaxon:876
name: Desulfovibrio desulfuricans
is_a: NCBITaxon:872  ! Desulfovibrio

[Term]
id: NCBITaxon:8782
name: Aves
is_a: NCBITaxon:436492  ! Coelurosauria

[Term]
id: NCBITaxon:87882
name: Burkholderia cepacia complex
is_a: NCBITaxon:32008  ! Burkholderia

[Term]
id: NCBITaxon:8825
name: Neognathae
is_a: NCBITaxon:8782  ! Aves

[Term]
id: NCBITaxon:88770
name: Panarthropoda
is_a: NCBITaxon:33317  ! Protostomia

[Term]
id: NCBITaxon:89373
name: Flexibacteraceae
is_a: NCBITaxon:200666  ! Sphingobacteriales

[Term]
id: NCBITaxon:89593
name: Craniata
is_a: NCBITaxon:7711  ! Chordata

[Term]
id: NCBITaxon:8976
name: Galliformes
is_a: NCBITaxon:8825  ! Neognathae

[Term]
id: NCBITaxon:9005
name: Phasianidae
is_a: NCBITaxon:8976  ! Galliformes

[Term]
id: NCBITaxon:90142
name: Ferroplasmaceae
is_a: NCBITaxon:2301  ! Thermoplasmatales

[Term]
id: NCBITaxon:9030
name: Gallus
is_a: NCBITaxon:9072  ! Phasianinae

[Term]
id: NCBITaxon:9031
name: Gallus gallus
is_a: NCBITaxon:9030  ! Gallus

[Term]
id: NCBITaxon:9072
name: Phasianinae
is_a: NCBITaxon:9005  ! Phasianidae

[Term]
id: NCBITaxon:90886
name: Filobasidiales
is_a: NCBITaxon:155616  ! Tremellomycetidae

[Term]
id: NCBITaxon:90964
name: Staphylococcaceae
is_a: NCBITaxon:1385  ! Bacillales

[Term]
id: NCBITaxon:91061
name: Bacilli
is_a: NCBITaxon:1239  ! Firmicutes

[Term]
id: NCBITaxon:9126
name: Passeriformes
is_a: NCBITaxon:8825  ! Neognathae

[Term]
id: NCBITaxon:9133
name: Fringillidae
is_a: NCBITaxon:175121  ! Passeroidea

[Term]
id: NCBITaxon:91347
name: Enterobacteriales
is_a: NCBITaxon:1236  ! Gammaproteobacteria

[Term]
id: NCBITaxon:91561
name: Cetartiodactyla
is_a: NCBITaxon:314145  ! Laurasiatheria

[Term]
id: NCBITaxon:91827
name: core eudicotyledons
is_a: NCBITaxon:71240  ! eudicotyledons

[Term]
id: NCBITaxon:91835
name: eurosids I
is_a: NCBITaxon:71275  ! rosids

[Term]
id: NCBITaxon:91836
name: eurosids II
is_a: NCBITaxon:71275  ! rosids

[Term]
id: NCBITaxon:91882
name: campanulids
is_a: NCBITaxon:71274  ! asterids

[Term]
id: NCBITaxon:91888
name: lamiids
is_a: NCBITaxon:71274  ! asterids

[Term]
id: NCBITaxon:920
name: Acidithiobacillus ferrooxidans
is_a: NCBITaxon:119977  ! Acidithiobacillus

[Term]
id: NCBITaxon:92181
name: Bartonella koehlerae
is_a: NCBITaxon:773  ! Bartonella

[Term]
id: NCBITaxon:9263
name: Metatheria
is_a: NCBITaxon:32525  ! Theria

[Term]
id: NCBITaxon:92829
name: Xanthomonas axonopodis pv. citri
is_a: NCBITaxon:53413  ! Xanthomonas axonopodis

[Term]
id: NCBITaxon:9307
name: Macropodidae
is_a: NCBITaxon:38609  ! Diprotodontia

[Term]
id: NCBITaxon:9312
name: Macropus
is_a: NCBITaxon:9307  ! Macropodidae

[Term]
id: NCBITaxon:93133
name: Mycosphaerellaceae
is_a: NCBITaxon:147543  ! Dothideomycetes et Chaetothyriomycetes incertae sedis

[Term]
id: NCBITaxon:9315
name: Macropus eugenii
is_a: NCBITaxon:9312  ! Macropus

[Term]
id: NCBITaxon:9347
name: Eutheria
is_a: NCBITaxon:32525  ! Theria

[Term]
id: NCBITaxon:942
name: Anaplasmataceae
is_a: NCBITaxon:766  ! Rickettsiales

[Term]
id: NCBITaxon:943
name: Ehrlichia
is_a: NCBITaxon:942  ! Anaplasmataceae

[Term]
id: NCBITaxon:944
name: Ehrlichia canis
is_a: NCBITaxon:106178  ! canis group

[Term]
id: NCBITaxon:9443
name: Primates
is_a: NCBITaxon:314146  ! Euarchontoglires

[Term]
id: NCBITaxon:94695
name: Methanosarcinales
is_a: NCBITaxon:224756  ! Methanomicrobia

[Term]
id: NCBITaxon:9479
name: Platyrrhini
is_a: NCBITaxon:314293  ! Simiiformes

[Term]
id: NCBITaxon:948
name: Anaplasma phagocytophilum
is_a: NCBITaxon:106179  ! phagocytophilum group

[Term]
id: NCBITaxon:9480
name: Callitrichinae
is_a: NCBITaxon:9498  ! Cebidae

[Term]
id: NCBITaxon:9481
name: Callithrix
is_a: NCBITaxon:9480  ! Callitrichinae

[Term]
id: NCBITaxon:9483
name: Callithrix jacchus
is_a: NCBITaxon:9481  ! Callithrix

[Term]
id: NCBITaxon:9498
name: Cebidae
is_a: NCBITaxon:9479  ! Platyrrhini

[Term]
id: NCBITaxon:95179
name: Noctuinae
is_a: NCBITaxon:7100  ! Noctuidae

[Term]
id: NCBITaxon:9526
name: Catarrhini
is_a: NCBITaxon:314293  ! Simiiformes

[Term]
id: NCBITaxon:9527
name: Cercopithecidae
is_a: NCBITaxon:314294  ! Cercopithecoidea

[Term]
id: NCBITaxon:9528
name: Cercopithecinae
is_a: NCBITaxon:9527  ! Cercopithecidae

[Term]
id: NCBITaxon:9539
name: Macaca
is_a: NCBITaxon:9528  ! Cercopithecinae

[Term]
id: NCBITaxon:9541
name: Macaca fascicularis
is_a: NCBITaxon:9539  ! Macaca

[Term]
id: NCBITaxon:9542
name: Macaca fuscata
is_a: NCBITaxon:9539  ! Macaca

[Term]
id: NCBITaxon:9544
name: Macaca mulatta
is_a: NCBITaxon:9539  ! Macaca

[Term]
id: NCBITaxon:9596
name: Pan
is_a: NCBITaxon:207598  ! Homo/Pan/Gorilla group

[Term]
id: NCBITaxon:9598
name: Pan troglodytes
is_a: NCBITaxon:9596  ! Pan

[Term]
id: NCBITaxon:9599
name: Pongo
is_a: NCBITaxon:9604  ! Hominidae

[Term]
id: NCBITaxon:9600
name: Pongo pygmaeus
is_a: NCBITaxon:9599  ! Pongo

[Term]
id: NCBITaxon:9604
name: Hominidae
is_a: NCBITaxon:314295  ! Hominoidea

[Term]
id: NCBITaxon:9605
name: Homo
is_a: NCBITaxon:207598  ! Homo/Pan/Gorilla group

[Term]
id: NCBITaxon:9606
name: Homo sapiens
synonym: "human being" EXACT []
is_a: NCBITaxon:9605  ! Homo

[Term]
id: NCBITaxon:9608
name: Canidae
is_a: NCBITaxon:379584  ! Caniformia

[Term]
id: NCBITaxon:9611
name: Canis
is_a: NCBITaxon:9608  ! Canidae

[Term]
id: NCBITaxon:9615
name: Canis familiaris
is_a: NCBITaxon:9611  ! Canis

[Term]
id: NCBITaxon:9625
name: Vulpes
is_a: NCBITaxon:9608  ! Canidae

[Term]
id: NCBITaxon:9627
name: Vulpes vulpes
is_a: NCBITaxon:9625  ! Vulpes

[Term]
id: NCBITaxon:9681
name: Felidae
is_a: NCBITaxon:379583  ! Feliformia

[Term]
id: NCBITaxon:9682
name: Felis
is_a: NCBITaxon:338152  ! Felinae

[Term]
id: NCBITaxon:9685
name: Felis catus
is_a: NCBITaxon:9682  ! Felis

[Term]
id: NCBITaxon:97393
name: Ferroplasma acidarmanus
is_a: NCBITaxon:74968  ! Ferroplasma

[Term]
id: NCBITaxon:976
name: Bacteroidetes
is_a: NCBITaxon:68336  ! Bacteroidetes/Chlorobi group

[Term]
id: NCBITaxon:978
name: Cytophaga
is_a: NCBITaxon:89373  ! Flexibacteraceae

[Term]
id: NCBITaxon:9787
name: Perissodactyla
is_a: NCBITaxon:314145  ! Laurasiatheria

[Term]
id: NCBITaxon:9788
name: Equidae
is_a: NCBITaxon:9787  ! Perissodactyla

[Term]
id: NCBITaxon:9789
name: Equus
is_a: NCBITaxon:9788  ! Equidae

[Term]
id: NCBITaxon:9796
name: Equus caballus
is_a: NCBITaxon:35510  ! Equus subg. Equus

[Term]
id: NCBITaxon:9821
name: Suidae
is_a: NCBITaxon:35497  ! Suina

[Term]
id: NCBITaxon:9822
name: Sus
is_a: NCBITaxon:9821  ! Suidae

[Term]
id: NCBITaxon:9823
name: Sus scrofa
is_a: NCBITaxon:9822  ! Sus

[Term]
id: NCBITaxon:9845
name: Ruminantia
is_a: NCBITaxon:91561  ! Cetartiodactyla

[Term]
id: NCBITaxon:985
name: Cytophaga hutchinsonii
is_a: NCBITaxon:978  ! Cytophaga

[Term]
id: NCBITaxon:98746
name: Festuca brevipila
is_a: NCBITaxon:4605  ! Festuca

[Term]
id: NCBITaxon:98754
name: Festuca rubra subsp. fallax
is_a: NCBITaxon:52153  ! Festuca rubra

[Term]
id: NCBITaxon:98755
name: Festuca rubra subsp. littoralis
is_a: NCBITaxon:52153  ! Festuca rubra

[Term]
id: NCBITaxon:9895
name: Bovidae
is_a: NCBITaxon:35500  ! Pecora

[Term]
id: NCBITaxon:9903
name: Bos
is_a: NCBITaxon:27592  ! Bovinae

[Term]
id: NCBITaxon:9913
name: Bos taurus
is_a: NCBITaxon:9903  ! Bos

[Term]
id: NCBITaxon:9915
name: Bos indicus
is_a: NCBITaxon:9903  ! Bos

[Term]
id: NCBITaxon:9935
name: Ovis
is_a: NCBITaxon:9963  ! Caprinae

[Term]
id: NCBITaxon:9940
name: Ovis aries
is_a: NCBITaxon:9935  ! Ovis

[Term]
id: NCBITaxon:9963
name: Caprinae
is_a: NCBITaxon:9895  ! Bovidae

[Term]
id: NCBITaxon:99883
name: Tetraodon nigroviridis
is_a: NCBITaxon:47144  ! Tetraodon

[Term]
id: NCBITaxon:9989
name: Rodentia
is_a: NCBITaxon:314147  ! Glires

[Term]
id: OBI:0000006
name: role of being consumer safety officer
def: "the role of a human being that is realized by enforcing regulations to ensure consumer safety" []
is_a: OBI:0000273  ! role of regulator of consumables and medical devices
disjoint_from: OBI:0000056  ! notified body role

[Term]
id: OBI:0000010
name: fluorescent reporter intensity
def: "The fluorescent reporter intensity is a datum that represents the output of a scanner measuring the intensity value for each fluorescent reporter." []
is_a: IAO:0000109 
disjoint_from: OBI:0000054  ! ratio of collected to emitted light
disjoint_from: OBI:0000101  ! measured expression level
disjoint_from: OBI:0000119  ! number of particles in subset
disjoint_from: OBI:0000125  ! number of lost events electronic
disjoint_from: OBI:0000172  ! parameter threshold
disjoint_from: OBI:0000269  ! number of lost events computer
disjoint_from: OBI:0000789  ! survival rate
disjoint_from: OBI:0000801  ! spike train datum

[Term]
id: OBI:0000011
name: planned process
def: "A processual entity that realizes a plan which is the concretization of a plan specification." []
is_a: span:ProcessualEntity 

[Term]
id: OBI:0000014
name: regulator role
def: "Regulator role is a regulatory role involved with making and/or enforcing relevant legislation and governmental orders" []
is_a: OBI:0000017  ! regulatory role
disjoint_from: OBI:0000016  ! regulation-assigned role

[Instance]
id: OBI:0000014_1
name: the regulator role of the FDA
instance_of: OBI:0000014  ! regulator role
instance_of: owl:Thing 
relationship: http://purl.org/obo/owl/OBO_REL#role_of OBI:0000245_11 ! U.S. Food and Drug Administration

[Term]
id: OBI:0000015
name: biological feature identification objective
def: "Biological_feature_identification_objective is an objective role carried out by the proposition defining the aim of a study designed to examine or characterize a particular biological feature." []
is_a: IAO:0000005 
disjoint_from: OBI:0000208  ! methodology testing objective
disjoint_from: OBI:0000441  ! assay objective
disjoint_from: OBI:0000456  ! material transformation objective
disjoint_from: OBI:0000684  ! specimen creation objective
disjoint_from: OBI:0000806  ! material maintenance objective
disjoint_from: OBI:0200166  ! data transformation objective

[Term]
id: OBI:0000016
name: regulation-assigned role
def: "Regulation-assigned role is a regulatory role defined by legislation or governmental orders" []
is_a: OBI:0000017  ! regulatory role
disjoint_from: OBI:0000014  ! regulator role

[Term]
id: OBI:0000017
name: regulatory role
def: "Regulatory role is a role which inheres in material entities and is realized in the processes of making, enforcing or being defined by legislation or orders issued by a governmental body." []
is_a: snap:Role 
disjoint_from: OBI:0000025  ! reference substance role
disjoint_from: OBI:0000029  ! centrifuge pellet role
disjoint_from: OBI:0000034  ! supernatant role
disjoint_from: OBI:0000040  ! drug role
disjoint_from: OBI:0000067  ! evaluant role
disjoint_from: OBI:0000086  ! reagent role
disjoint_from: OBI:0000091  ! detector reagent role
disjoint_from: OBI:0000093  ! patient role
disjoint_from: OBI:0000097  ! study subject role
disjoint_from: OBI:0000112  ! specimen role
disjoint_from: OBI:0000140  ! label role
disjoint_from: OBI:0000174  ! study group role
disjoint_from: OBI:0000204  ! nutrient role
disjoint_from: OBI:0000237  ! antigen role
disjoint_from: OBI:0000275  ! analyte role
disjoint_from: OBI:0000319  ! material to be added role
disjoint_from: OBI:0000405  ! primer role
disjoint_from: OBI:0000416  ! cloning insert role
disjoint_from: OBI:0000444  ! target of material addition role
disjoint_from: OBI:0000571  ! manufacturer role
disjoint_from: OBI:0000718  ! pathogen role
disjoint_from: OBI:0000720  ! adjuvent role
disjoint_from: OBI:0000725  ! host role
disjoint_from: OBI:0000847  ! test substance role
disjoint_from: OBI:0302731  ! buffer role
disjoint_from: OBI:0302732  ! solvent role
disjoint_from: OBI:0302733  ! solute role
disjoint_from: OBI:1110082  ! immunogen role
disjoint_from: OBI:1110083  ! host of immune response role
disjoint_from: OBI:1110086  ! restricting MHC role
disjoint_from: OBI:1110087  ! donor
disjoint_from: OBI:1110091  ! carrier role
disjoint_from: OBI:1110092  ! adjuvant role
disjoint_from: OBI:1110120  ! assay antigen role

[Term]
id: OBI:0000018
name: supplier role
def: "Supplier is a worker who provides reagents, subjects and other materials used in a study; this role generally occurs before the study, but could occur during the study" []
is_a: OBI:0000116  ! worker role

[Term]
id: OBI:0000020
name: contract research organization role
def: "Contract research organization is a worker role of carrying out the study according to the protocol document or study plan delivered by the PI, under the control of the study director.  This role cannot make decisions about the study execution" []
is_a: OBI:0000116  ! worker role

[Term]
id: OBI:0000021
name: list-mode data file
def: "A list-mode data file is a binary digital entity where events are stored sequentially, parameter by parameter." []
is_a: IAO:0000030 
disjoint_from: OBI:0000078  ! eMedical record
disjoint_from: OBI:0000083  ! electronic case report tabulation
disjoint_from: OBI:0000158  ! eSource document
disjoint_from: OBI:0000167  ! electronic case report form
disjoint_from: OBI:0000210  ! analytical cytology data file
disjoint_from: OBI:0000213  ! fluorescence compensation matrix
disjoint_from: OBI:0000682  ! study result
disjoint_from: OBI:0302840  ! curated
disjoint_from: OBI:0302874  ! edited information

[Term]
id: OBI:0000023
name: classified data set
def: "A classified data set is a data set that is produced as the output of a class prediction data transformation and consists of a data set with assigned class labels." []
synonym: "data set with assigned class labels" EXACT []
is_a: IAO:0000100 

[Term]
id: OBI:0000025
name: reference substance role
def: "a role inhering in a substance that is realized when  characteristics or responses elicited by the substance are used for comparison or reference." []
is_a: snap:Role 
disjoint_from: OBI:0000017  ! regulatory role
disjoint_from: OBI:0000029  ! centrifuge pellet role
disjoint_from: OBI:0000034  ! supernatant role
disjoint_from: OBI:0000040  ! drug role
disjoint_from: OBI:0000067  ! evaluant role
disjoint_from: OBI:0000086  ! reagent role
disjoint_from: OBI:0000091  ! detector reagent role
disjoint_from: OBI:0000093  ! patient role
disjoint_from: OBI:0000097  ! study subject role
disjoint_from: OBI:0000112  ! specimen role
disjoint_from: OBI:0000140  ! label role
disjoint_from: OBI:0000174  ! study group role
disjoint_from: OBI:0000204  ! nutrient role
disjoint_from: OBI:0000237  ! antigen role
disjoint_from: OBI:0000275  ! analyte role
disjoint_from: OBI:0000319  ! material to be added role
disjoint_from: OBI:0000405  ! primer role
disjoint_from: OBI:0000416  ! cloning insert role
disjoint_from: OBI:0000444  ! target of material addition role
disjoint_from: OBI:0000571  ! manufacturer role
disjoint_from: OBI:0000718  ! pathogen role
disjoint_from: OBI:0000720  ! adjuvent role
disjoint_from: OBI:0000725  ! host role
disjoint_from: OBI:0000847  ! test substance role
disjoint_from: OBI:0302731  ! buffer role
disjoint_from: OBI:0302732  ! solvent role
disjoint_from: OBI:0302733  ! solute role
disjoint_from: OBI:1110082  ! immunogen role
disjoint_from: OBI:1110083  ! host of immune response role
disjoint_from: OBI:1110086  ! restricting MHC role
disjoint_from: OBI:1110087  ! donor
disjoint_from: OBI:1110091  ! carrier role
disjoint_from: OBI:1110092  ! adjuvant role
disjoint_from: OBI:1110120  ! assay antigen role

[Term]
id: OBI:0000026
name: cytological stain role
def: "is a role of a stain that is realized when the stain is used to colour cells and or cellular components for the purposes of visualization" []
is_a: OBI:0000250  ! dye role
disjoint_from: OBI:0000110  ! pH indicator dye role
disjoint_from: OBI:0000221  ! vital dye role

[Term]
id: OBI:0000029
name: centrifuge pellet role
def: "pellet role is a role which inheres in a material entity and is realized by a material separation process using gravitational force generated by a centrifuge in which the material bearing the pellet role is the heavier or heaviest component of the output material.." []
is_a: snap:Role 
relationship: http://purl.org/obo/owl/OBO_REL#inheres_in snap:MaterialEntity
disjoint_from: OBI:0000017  ! regulatory role
disjoint_from: OBI:0000025  ! reference substance role
disjoint_from: OBI:0000034  ! supernatant role
disjoint_from: OBI:0000040  ! drug role
disjoint_from: OBI:0000067  ! evaluant role
disjoint_from: OBI:0000086  ! reagent role
disjoint_from: OBI:0000091  ! detector reagent role
disjoint_from: OBI:0000093  ! patient role
disjoint_from: OBI:0000097  ! study subject role
disjoint_from: OBI:0000112  ! specimen role
disjoint_from: OBI:0000140  ! label role
disjoint_from: OBI:0000174  ! study group role
disjoint_from: OBI:0000204  ! nutrient role
disjoint_from: OBI:0000237  ! antigen role
disjoint_from: OBI:0000275  ! analyte role
disjoint_from: OBI:0000319  ! material to be added role
disjoint_from: OBI:0000405  ! primer role
disjoint_from: OBI:0000416  ! cloning insert role
disjoint_from: OBI:0000444  ! target of material addition role
disjoint_from: OBI:0000571  ! manufacturer role
disjoint_from: OBI:0000718  ! pathogen role
disjoint_from: OBI:0000720  ! adjuvent role
disjoint_from: OBI:0000725  ! host role
disjoint_from: OBI:0000847  ! test substance role
disjoint_from: OBI:0302731  ! buffer role
disjoint_from: OBI:0302732  ! solvent role
disjoint_from: OBI:0302733  ! solute role
disjoint_from: OBI:1110082  ! immunogen role
disjoint_from: OBI:1110083  ! host of immune response role
disjoint_from: OBI:1110086  ! restricting MHC role
disjoint_from: OBI:1110087  ! donor
disjoint_from: OBI:1110091  ! carrier role
disjoint_from: OBI:1110092  ! adjuvant role
disjoint_from: OBI:1110120  ! assay antigen role

[Term]
id: OBI:0000032
name: clinical research coordinator role
def: "A clinical research coordinator is a worker role comprised of handling the administrative duties of a trial or study." []
is_a: OBI:0000116  ! worker role

[Term]
id: OBI:0000034
name: supernatant role
def: "supernatant role is a role which inheres in a material entity and is realized by a material separation process using gravitational force in which the material bearing the supernatant role is the liquid component of the output material." []
is_a: snap:Role 
relationship: OBI:0000300 OBI:0600014 ! material component separation
relationship: http://purl.org/obo/owl/OBO_REL#inheres_in snap:MaterialEntity
disjoint_from: OBI:0000017  ! regulatory role
disjoint_from: OBI:0000025  ! reference substance role
disjoint_from: OBI:0000029  ! centrifuge pellet role
disjoint_from: OBI:0000040  ! drug role
disjoint_from: OBI:0000067  ! evaluant role
disjoint_from: OBI:0000086  ! reagent role
disjoint_from: OBI:0000091  ! detector reagent role
disjoint_from: OBI:0000093  ! patient role
disjoint_from: OBI:0000097  ! study subject role
disjoint_from: OBI:0000112  ! specimen role
disjoint_from: OBI:0000140  ! label role
disjoint_from: OBI:0000174  ! study group role
disjoint_from: OBI:0000204  ! nutrient role
disjoint_from: OBI:0000237  ! antigen role
disjoint_from: OBI:0000275  ! analyte role
disjoint_from: OBI:0000319  ! material to be added role
disjoint_from: OBI:0000405  ! primer role
disjoint_from: OBI:0000416  ! cloning insert role
disjoint_from: OBI:0000444  ! target of material addition role
disjoint_from: OBI:0000571  ! manufacturer role
disjoint_from: OBI:0000718  ! pathogen role
disjoint_from: OBI:0000720  ! adjuvent role
disjoint_from: OBI:0000725  ! host role
disjoint_from: OBI:0000847  ! test substance role
disjoint_from: OBI:0302731  ! buffer role
disjoint_from: OBI:0302732  ! solvent role
disjoint_from: OBI:0302733  ! solute role
disjoint_from: OBI:1110082  ! immunogen role
disjoint_from: OBI:1110083  ! host of immune response role
disjoint_from: OBI:1110086  ! restricting MHC role
disjoint_from: OBI:1110087  ! donor
disjoint_from: OBI:1110091  ! carrier role
disjoint_from: OBI:1110092  ! adjuvant role
disjoint_from: OBI:1110120  ! assay antigen role

[Term]
id: OBI:0000038
name: chromatography column
def: "Column chromatography in chemistry is a tube (typically glass) used to purify individual chemical compounds from mixtures of compounds. It is often used for preparative applications on scales from micrograms up to kilograms." []
is_a: OBI:0000047  ! processed material
relationship: OBI:0000306 OBI:0000370 ! contain function

[Term]
id: OBI:0000040
name: drug role
def: "Drug role is a role borne by a molecular entity and is realized in a process of absorption by an organism  alters, or effects  (or is assumed to effect) a function(s) which inhere in an organism" []
is_a: snap:Role 
relationship: http://purl.org/obo/owl/OBO_REL#inheres_in CHEBI:23367 ! molecular entity
disjoint_from: OBI:0000017  ! regulatory role
disjoint_from: OBI:0000025  ! reference substance role
disjoint_from: OBI:0000029  ! centrifuge pellet role
disjoint_from: OBI:0000034  ! supernatant role
disjoint_from: OBI:0000067  ! evaluant role
disjoint_from: OBI:0000086  ! reagent role
disjoint_from: OBI:0000091  ! detector reagent role
disjoint_from: OBI:0000093  ! patient role
disjoint_from: OBI:0000097  ! study subject role
disjoint_from: OBI:0000112  ! specimen role
disjoint_from: OBI:0000140  ! label role
disjoint_from: OBI:0000174  ! study group role
disjoint_from: OBI:0000204  ! nutrient role
disjoint_from: OBI:0000237  ! antigen role
disjoint_from: OBI:0000275  ! analyte role
disjoint_from: OBI:0000319  ! material to be added role
disjoint_from: OBI:0000405  ! primer role
disjoint_from: OBI:0000416  ! cloning insert role
disjoint_from: OBI:0000444  ! target of material addition role
disjoint_from: OBI:0000571  ! manufacturer role
disjoint_from: OBI:0000718  ! pathogen role
disjoint_from: OBI:0000720  ! adjuvent role
disjoint_from: OBI:0000725  ! host role
disjoint_from: OBI:0000847  ! test substance role
disjoint_from: OBI:0302731  ! buffer role
disjoint_from: OBI:0302732  ! solvent role
disjoint_from: OBI:0302733  ! solute role
disjoint_from: OBI:1110082  ! immunogen role
disjoint_from: OBI:1110083  ! host of immune response role
disjoint_from: OBI:1110086  ! restricting MHC role
disjoint_from: OBI:1110087  ! donor
disjoint_from: OBI:1110091  ! carrier role
disjoint_from: OBI:1110092  ! adjuvant role
disjoint_from: OBI:1110120  ! assay antigen role

[Term]
id: OBI:0000041
name: pump valve switch
def: "A pump valve switch is a cardinal part of a liquid chromatography instrument that controls the flow." []
is_a: OBI:0000047  ! processed material
relationship: OBI:0000306 OBI:0000379 ! mechanical function

[Term]
id: OBI:0000043
name: xenotransplantation
def: "is the transplantation of living cells, tissues or \norgans from one species to another such as from pigs to humans" []
is_a: OBI:0000105  ! transplantation
disjoint_from: OBI:0000057  ! allotransplantation
disjoint_from: OBI:0000171  ! autotransplantation

[Term]
id: OBI:0000044
name: physical document
def: "A physical document is an object serving as a record of information by means of symbolic marks." []
is_a: OBI:0000047  ! processed material

[Term]
id: OBI:0000045
name: waiting
def: "not actively doing anything to a material for a duration of time." []
is_a: OBI:0600009  ! exposure of material to environment
disjoint_from: OBI:0600011  ! acclimatization

[Term]
id: OBI:0000047
name: processed material
def: "Is a material entity that is created or changed during material processing." []
is_a: snap:MaterialEntity 
intersection_of: snap:MaterialEntity 
intersection_of: OBI:0000312 OBI:0000094 ! material processing

[Term]
id: OBI:0000048
name: chromatography device
def: "A Chromatography device is a device that facilitates the separation of mixtures. The function of a chromatography device involves passing a mixture dissolved in a \"mobile phase\" through a stationary phase, which separates the analyte to be measured from other molecules in the mixture and allows it to be isolated." []
synonym: "chromatography instrument" EXACT []
is_a: OBI:0000832  ! measurement device
relationship: OBI:0000306 OBI:0000370 ! contain function
relationship: OBI:0000306 OBI:0000372 ! separation function
relationship: OBI:0000306 OBI:0000401 ! environment control function
relationship: OBI:0000306 OBI:0000453 ! measure function

[Term]
id: OBI:0000049
name: mass spectrometer
def: "A mass spectrometer is an instrument which is used to measure the mass to charge ratio of ions. All mass spectrometers consist of three basic parts: an ion source, a mass analyzer, and a detector system. The stages within the mass spectrometer are: 1. Production of ions from the sample 2. Separation of ions with different masses 3. Detection of the number of ions of each mass produced 4.Collection of data to generate the mass spectrum" []
is_a: OBI:0000047  ! processed material
relationship: http://purl.org/obo/owl/OBO_REL#bearer_of OBI:0000654 ! device setting

[Term]
id: OBI:0000050
name: platform
def: "A platform is an object_aggregate that is the set of instruments and software needed to perform a process. definition_source: OBI." []
is_a: OBI:0000047  ! processed material
relationship: OBI:0000304 OBI:0000245 ! organization
relationship: OBI:0000306 snap:Function
relationship: OBI:0000312 OBI:0000094 ! material processing
disjoint_from: OBI:0000146  ! supernatant collection system harvesting frame
disjoint_from: OBI:0000245  ! organization
disjoint_from: OBI:0000318  ! eluate
disjoint_from: OBI:0000390  ! thermostatic circulator
disjoint_from: OBI:0000420  ! trypsinized material
disjoint_from: OBI:0000432  ! polyacrylamide gel
disjoint_from: OBI:0000439  ! agarose gel
disjoint_from: OBI:0000576  ! scattered molecular aggregate
disjoint_from: OBI:0000651  ! urine specimen
disjoint_from: OBI:0000655  ! blood specimen
disjoint_from: OBI:0000680  ! whole organism preparation
disjoint_from: OBI:0000798  ! capsule shell
disjoint_from: OBI:0000814  ! guar gum
disjoint_from: OBI:0100014  ! chimera
disjoint_from: OBI:0100016  ! blood plasma
disjoint_from: OBI:0100017  ! blood serum specimen
disjoint_from: OBI:0100039  ! fragment derived from protein
disjoint_from: OBI:0100055  ! cell line cell
disjoint_from: OBI:0100056  ! immortalized cell line
disjoint_from: OBI:0100058  ! xenograft
disjoint_from: OBI:0100060  ! cell culture
disjoint_from: OBI:0100067  ! bronchial alveolar lavage
disjoint_from: OBI:0100069  ! polymer
disjoint_from: OBI:0100086  ! glucose in solution
disjoint_from: OBI:0302714  ! collection (of entities of organismal origin)
disjoint_from: OBI:0400102  ! waste tank
disjoint_from: OBI:1000023  ! cell culture supernatant
disjoint_from: OBI:1000024  ! cell pellet
disjoint_from: OBI:1000036  ! cell lysate
disjoint_from: OBI:1000042  ! peptide construct
disjoint_from: OBI:1000048  ! transgenic organism

[Term]
id: OBI:0000051
name: liquid chromatography mass spectrometry platform
def: "A liquid chromatography mass spectrometry platform is a platform that is the collection of instrument, software and reagents needed to perform a liquid chromatography mass spectrometry protocol. definition_source: OBI." []
is_a: OBI:0000047  ! processed material

[Term]
id: OBI:0000052
name: microarray platform
def: "A microarray platform is a platform that contains the instruments, software and reagents needed to perform a microarray protocol. definition_source: OBI." []
is_a: OBI:0000047  ! processed material

[Term]
id: OBI:0000054
name: ratio of collected to emitted light
def: "A ratio of collected to emitted light is a datum measuring the amount of light collected s compared to the total amount of emitted light in the detector component of a flow cytometer instrument. The datum has a qualitative role" []
is_a: IAO:0000109 
disjoint_from: OBI:0000010  ! fluorescent reporter intensity
disjoint_from: OBI:0000101  ! measured expression level
disjoint_from: OBI:0000119  ! number of particles in subset
disjoint_from: OBI:0000125  ! number of lost events electronic
disjoint_from: OBI:0000172  ! parameter threshold
disjoint_from: OBI:0000269  ! number of lost events computer
disjoint_from: OBI:0000789  ! survival rate
disjoint_from: OBI:0000801  ! spike train datum

[Term]
id: OBI:0000055
name: software optimization
def: "Software_optimization is a software_testing_objective role describing a study designed to identify the best software or parameters of the software." []
is_a: OBI:0000242  ! software testing objective

[Term]
id: OBI:0000056
name: notified body role
def: "Notified body is regulator of consumables and medical devices charged by the Competent Authority with verifying compliance of medical devices (not drugs) with the applicable Essential Requirements stated in the Medical Device Directive" []
is_a: OBI:0000273  ! role of regulator of consumables and medical devices
disjoint_from: OBI:0000006  ! role of being consumer safety officer

[Term]
id: OBI:0000057
name: allotransplantation
def: "is the transplantation of organs between members of the same species." []
is_a: OBI:0000105  ! transplantation
disjoint_from: OBI:0000043  ! xenotransplantation
disjoint_from: OBI:0000171  ! autotransplantation

[Term]
id: OBI:0000059
name: gamma counter
def: "A processed material which measures gamma radiation" []
is_a: OBI:0000832  ! measurement device
relationship: OBI:0000306 OBI:0000453 ! measure function

[Term]
id: OBI:0000060
name: trial monitor role
def: "Trial monitor is a responsible party involved in planning, overseeing the conduct of a study or study component, and interpreting data from a study" []
is_a: OBI:0000102  ! responsible party role

[Term]
id: OBI:0000064
name: positive reference substance role
def: "Reference substance is a reference role in which the characteristics or responses elicited by the substance playing the reference substance role are used to establish a \"100%\" response" []
is_a: OBI:0000025  ! reference substance role
disjoint_from: OBI:0000129  ! calibration substance role
disjoint_from: OBI:0000214  ! negative reference substance role
disjoint_from: OBI:0000409  ! nucleic acid template role

[Term]
id: OBI:0000065
name: polyethylene glycol p-(1,1,3,3-tetramethylbutyl)-phenyl ether
def: "triton X100 is a chemical entity which belongs to the group of The pluronics which are triblock copolymers of ethylene oxide and propylene oxide. Triton x-100 is_used_as detergent due to its non-ionic surfactant properties" []
is_a: CHEBI:23367  ! molecular entity
disjoint_from: OBI:0000817  ! fucoidan

[Term]
id: OBI:0000066
name: investigation
def: "a planned process that consists of parts: planning, study design execution, documentation and which produce conclusion(s)." []
relationship: OBI:0000299 IAO:0000144
relationship: OBO_REL:has_part OBI:0000340 ! documenting
relationship: OBO_REL:has_part OBI:0000471 ! study design execution

[Term]
id: OBI:0000067
name: evaluant role
def: "a role that inheres in an entity that is realized in an assay in which data is generated about the bearer of the evaluant role" []
is_a: snap:Role 
disjoint_from: OBI:0000017  ! regulatory role
disjoint_from: OBI:0000025  ! reference substance role
disjoint_from: OBI:0000029  ! centrifuge pellet role
disjoint_from: OBI:0000034  ! supernatant role
disjoint_from: OBI:0000040  ! drug role
disjoint_from: OBI:0000086  ! reagent role
disjoint_from: OBI:0000091  ! detector reagent role
disjoint_from: OBI:0000093  ! patient role
disjoint_from: OBI:0000097  ! study subject role
disjoint_from: OBI:0000112  ! specimen role
disjoint_from: OBI:0000140  ! label role
disjoint_from: OBI:0000174  ! study group role
disjoint_from: OBI:0000204  ! nutrient role
disjoint_from: OBI:0000237  ! antigen role
disjoint_from: OBI:0000275  ! analyte role
disjoint_from: OBI:0000319  ! material to be added role
disjoint_from: OBI:0000405  ! primer role
disjoint_from: OBI:0000416  ! cloning insert role
disjoint_from: OBI:0000444  ! target of material addition role
disjoint_from: OBI:0000571  ! manufacturer role
disjoint_from: OBI:0000718  ! pathogen role
disjoint_from: OBI:0000720  ! adjuvent role
disjoint_from: OBI:0000725  ! host role
disjoint_from: OBI:0000847  ! test substance role
disjoint_from: OBI:0302731  ! buffer role
disjoint_from: OBI:0302732  ! solvent role
disjoint_from: OBI:0302733  ! solute role
disjoint_from: OBI:1110082  ! immunogen role
disjoint_from: OBI:1110083  ! host of immune response role
disjoint_from: OBI:1110086  ! restricting MHC role
disjoint_from: OBI:1110087  ! donor
disjoint_from: OBI:1110091  ! carrier role
disjoint_from: OBI:1110092  ! adjuvant role
disjoint_from: OBI:1110120  ! assay antigen role

[Term]
id: OBI:0000068
name: reporting party role
def: "Reporting party role is a study personnel role played by a party who reports the outcome of a study component" []
is_a: OBI:0000202  ! investigation agent role

[Term]
id: OBI:0000070
name: assay
def: "A planned process with the objective to produce information about some evaluant" []
synonym: "measuring" EXACT []
synonym: "scientific observation" EXACT []
is_a: OBI:0000011  ! planned process
relationship: OBI:0000308 OBI:0000067 ! evaluant role
disjoint_from: OBI:0000339  ! planning
disjoint_from: OBI:0200000  ! data transformation

[Term]
id: OBI:0000071
name: quantitative confidence value
def: "A quantitative confidence value is a information content entity which is used to indicate the degree of uncertainty about a measurement." []
is_a: IAO:0000027 

[Term]
id: OBI:0000073
name: sample preparation for assay
def: "A sample_preparation_for_assay is a protocol_application including material_enrollments and biomaterial_transformations. definition_source: OBI." []
synonym: "study" EXACT []
is_a: OBI:0000094  ! material processing
relationship: OBI:0000417 OBI:0000456 ! material transformation objective

[Term]
id: OBI:0000075
name: diagnosis textual entity
def: "diagnosis is an assessment of a disease or injury, its likely prognosis and treatment." []
is_a: IAO:0000300 

[Term]
id: OBI:0000076
name: unplanned occurrence effecting an investigation
def: "a process which is external in origin to the investigation that has an impact on the outcome." []
is_a: span:ProcessualEntity 

[Term]
id: OBI:0000078
name: eMedical record
def: "An eMedical record is a digital document derived from a computer system used primarily for patient care in a clinical setting.  Not required to be compliant with requirements of 21 CFR Part 11." []
is_a: IAO:0000030 
disjoint_from: OBI:0000021  ! list-mode data file
disjoint_from: OBI:0000083  ! electronic case report tabulation
disjoint_from: OBI:0000158  ! eSource document
disjoint_from: OBI:0000167  ! electronic case report form
disjoint_from: OBI:0000210  ! analytical cytology data file
disjoint_from: OBI:0000213  ! fluorescence compensation matrix
disjoint_from: OBI:0000682  ! study result
disjoint_from: OBI:0302840  ! curated
disjoint_from: OBI:0302874  ! edited information

[Term]
id: OBI:0000079
name: culture medium role
def: "A culture medium role is a role that inheres in a material entity and is realized in the use of that material entity by an organism grown in vitro to provide all needed nourishment." []
is_a: OBI:0000162  ! complete nutrient role
disjoint_from: OBI:0000248  ! feed role

[Term]
id: OBI:0000083
name: electronic case report tabulation
def: "An electronic case report tabulation is a digital document containing tabular data about multiple trial participants which is part of a clinical regulatory submission.  An eCRT has the property that it can be audited and compliant with requirements of 21 CFR Part 11  and has format suited to review by regulators." []
is_a: IAO:0000030 
disjoint_from: OBI:0000021  ! list-mode data file
disjoint_from: OBI:0000078  ! eMedical record
disjoint_from: OBI:0000158  ! eSource document
disjoint_from: OBI:0000167  ! electronic case report form
disjoint_from: OBI:0000210  ! analytical cytology data file
disjoint_from: OBI:0000213  ! fluorescence compensation matrix
disjoint_from: OBI:0000682  ! study result
disjoint_from: OBI:0302840  ! curated
disjoint_from: OBI:0302874  ! edited information

[Term]
id: OBI:0000084
name: polystyrene tube
def: "a polystyrene tube is a test tube made of polystyrene" []
is_a: OBI:0000836  ! test tube

[Term]
id: OBI:0000086
name: reagent role
def: "Reagent role is a role played by a molecular entity used to produce a chemical reaction to detect, measure, or produce other substances" []
is_a: snap:Role 
disjoint_from: OBI:0000017  ! regulatory role
disjoint_from: OBI:0000025  ! reference substance role
disjoint_from: OBI:0000029  ! centrifuge pellet role
disjoint_from: OBI:0000034  ! supernatant role
disjoint_from: OBI:0000040  ! drug role
disjoint_from: OBI:0000067  ! evaluant role
disjoint_from: OBI:0000091  ! detector reagent role
disjoint_from: OBI:0000093  ! patient role
disjoint_from: OBI:0000097  ! study subject role
disjoint_from: OBI:0000112  ! specimen role
disjoint_from: OBI:0000140  ! label role
disjoint_from: OBI:0000174  ! study group role
disjoint_from: OBI:0000204  ! nutrient role
disjoint_from: OBI:0000237  ! antigen role
disjoint_from: OBI:0000275  ! analyte role
disjoint_from: OBI:0000319  ! material to be added role
disjoint_from: OBI:0000405  ! primer role
disjoint_from: OBI:0000416  ! cloning insert role
disjoint_from: OBI:0000444  ! target of material addition role
disjoint_from: OBI:0000571  ! manufacturer role
disjoint_from: OBI:0000718  ! pathogen role
disjoint_from: OBI:0000720  ! adjuvent role
disjoint_from: OBI:0000725  ! host role
disjoint_from: OBI:0000847  ! test substance role
disjoint_from: OBI:0302731  ! buffer role
disjoint_from: OBI:0302732  ! solvent role
disjoint_from: OBI:0302733  ! solute role
disjoint_from: OBI:1110082  ! immunogen role
disjoint_from: OBI:1110083  ! host of immune response role
disjoint_from: OBI:1110086  ! restricting MHC role
disjoint_from: OBI:1110087  ! donor
disjoint_from: OBI:1110091  ! carrier role
disjoint_from: OBI:1110092  ! adjuvant role
disjoint_from: OBI:1110120  ! assay antigen role

[Term]
id: OBI:0000089
name: role of regulator of chemical manufacturer
def: "A regulator of chemical manufacture is a regulator involved with making and enforcing legislation and governmental orders relevant to chemical manufacture" []
is_a: OBI:0000014  ! regulator role
disjoint_from: OBI:0000154  ! role of Institutional Review Board
disjoint_from: OBI:0000273  ! role of regulator of consumables and medical devices

[Term]
id: OBI:0000091
name: detector reagent role
def: "detector reagent role is a reagent role which inheres in a molecular entity and is realized by the process of recording or registering a stimulus." []
is_a: snap:Role 
disjoint_from: OBI:0000017  ! regulatory role
disjoint_from: OBI:0000025  ! reference substance role
disjoint_from: OBI:0000029  ! centrifuge pellet role
disjoint_from: OBI:0000034  ! supernatant role
disjoint_from: OBI:0000040  ! drug role
disjoint_from: OBI:0000067  ! evaluant role
disjoint_from: OBI:0000086  ! reagent role
disjoint_from: OBI:0000093  ! patient role
disjoint_from: OBI:0000097  ! study subject role
disjoint_from: OBI:0000112  ! specimen role
disjoint_from: OBI:0000140  ! label role
disjoint_from: OBI:0000174  ! study group role
disjoint_from: OBI:0000204  ! nutrient role
disjoint_from: OBI:0000237  ! antigen role
disjoint_from: OBI:0000275  ! analyte role
disjoint_from: OBI:0000319  ! material to be added role
disjoint_from: OBI:0000405  ! primer role
disjoint_from: OBI:0000416  ! cloning insert role
disjoint_from: OBI:0000444  ! target of material addition role
disjoint_from: OBI:0000571  ! manufacturer role
disjoint_from: OBI:0000718  ! pathogen role
disjoint_from: OBI:0000720  ! adjuvent role
disjoint_from: OBI:0000725  ! host role
disjoint_from: OBI:0000847  ! test substance role
disjoint_from: OBI:0302731  ! buffer role
disjoint_from: OBI:0302732  ! solvent role
disjoint_from: OBI:0302733  ! solute role
disjoint_from: OBI:1110082  ! immunogen role
disjoint_from: OBI:1110083  ! host of immune response role
disjoint_from: OBI:1110086  ! restricting MHC role
disjoint_from: OBI:1110087  ! donor
disjoint_from: OBI:1110091  ! carrier role
disjoint_from: OBI:1110092  ! adjuvant role
disjoint_from: OBI:1110120  ! assay antigen role

[Term]
id: OBI:0000092
name: role of certified IRB professional
def: "is a role of which inheres in a Homo sapiens and realized during administration and oversight of the daily activities of Institutional Review Boards (IRBs) in the USA" []
is_a: OBI:0000016  ! regulation-assigned role
disjoint_from: OBI:0000196  ! role of impartial witness
disjoint_from: OBI:0000215  ! role of legally acceptable representative

[Term]
id: OBI:0000093
name: patient role
def: "Patient is a role which inheres in a person and is realized by the process of being under the care of a physician or health care provider" []
is_a: snap:Role 
relationship: http://purl.org/obo/owl/OBO_REL#inheres_in NCBITaxon:9606 ! Homo sapiens
disjoint_from: OBI:0000017  ! regulatory role
disjoint_from: OBI:0000025  ! reference substance role
disjoint_from: OBI:0000029  ! centrifuge pellet role
disjoint_from: OBI:0000034  ! supernatant role
disjoint_from: OBI:0000040  ! drug role
disjoint_from: OBI:0000067  ! evaluant role
disjoint_from: OBI:0000086  ! reagent role
disjoint_from: OBI:0000091  ! detector reagent role
disjoint_from: OBI:0000097  ! study subject role
disjoint_from: OBI:0000112  ! specimen role
disjoint_from: OBI:0000140  ! label role
disjoint_from: OBI:0000174  ! study group role
disjoint_from: OBI:0000204  ! nutrient role
disjoint_from: OBI:0000237  ! antigen role
disjoint_from: OBI:0000275  ! analyte role
disjoint_from: OBI:0000319  ! material to be added role
disjoint_from: OBI:0000405  ! primer role
disjoint_from: OBI:0000416  ! cloning insert role
disjoint_from: OBI:0000444  ! target of material addition role
disjoint_from: OBI:0000571  ! manufacturer role
disjoint_from: OBI:0000718  ! pathogen role
disjoint_from: OBI:0000720  ! adjuvent role
disjoint_from: OBI:0000725  ! host role
disjoint_from: OBI:0000847  ! test substance role
disjoint_from: OBI:0302731  ! buffer role
disjoint_from: OBI:0302732  ! solvent role
disjoint_from: OBI:0302733  ! solute role
disjoint_from: OBI:1110082  ! immunogen role
disjoint_from: OBI:1110083  ! host of immune response role
disjoint_from: OBI:1110086  ! restricting MHC role
disjoint_from: OBI:1110087  ! donor
disjoint_from: OBI:1110091  ! carrier role
disjoint_from: OBI:1110092  ! adjuvant role
disjoint_from: OBI:1110120  ! assay antigen role

[Term]
id: OBI:0000094
name: material processing
def: "A planned process which results in physical changes in a specified input material" []
synonym: "material transformation" EXACT []
is_a: OBI:0000011  ! planned process
relationship: OBI:0000293 snap:MaterialEntity
relationship: OBI:0000299 OBI:0000047 ! processed material

[Term]
id: OBI:0000096
name: protocol testing objective
def: "Protocol_testing_objective is a methodology_testing_objective role describing a study designed to examine the effects of using different protocols." []
is_a: OBI:0000208  ! methodology testing objective
disjoint_from: OBI:0000134  ! hardware testing objective
disjoint_from: OBI:0000242  ! software testing objective

[Term]
id: OBI:0000097
name: study subject role
def: "study subject role inheres in an entity and realized through the execution of a study design in which the entity participates by being that which the results are about." []
is_a: snap:Role 
relationship: OBI:0000300 OBI:0000471 ! study design execution
disjoint_from: OBI:0000017  ! regulatory role
disjoint_from: OBI:0000025  ! reference substance role
disjoint_from: OBI:0000029  ! centrifuge pellet role
disjoint_from: OBI:0000034  ! supernatant role
disjoint_from: OBI:0000040  ! drug role
disjoint_from: OBI:0000067  ! evaluant role
disjoint_from: OBI:0000086  ! reagent role
disjoint_from: OBI:0000091  ! detector reagent role
disjoint_from: OBI:0000093  ! patient role
disjoint_from: OBI:0000112  ! specimen role
disjoint_from: OBI:0000140  ! label role
disjoint_from: OBI:0000174  ! study group role
disjoint_from: OBI:0000204  ! nutrient role
disjoint_from: OBI:0000237  ! antigen role
disjoint_from: OBI:0000275  ! analyte role
disjoint_from: OBI:0000319  ! material to be added role
disjoint_from: OBI:0000405  ! primer role
disjoint_from: OBI:0000416  ! cloning insert role
disjoint_from: OBI:0000444  ! target of material addition role
disjoint_from: OBI:0000571  ! manufacturer role
disjoint_from: OBI:0000718  ! pathogen role
disjoint_from: OBI:0000720  ! adjuvent role
disjoint_from: OBI:0000725  ! host role
disjoint_from: OBI:0000847  ! test substance role
disjoint_from: OBI:0302731  ! buffer role
disjoint_from: OBI:0302732  ! solvent role
disjoint_from: OBI:0302733  ! solute role
disjoint_from: OBI:1110082  ! immunogen role
disjoint_from: OBI:1110083  ! host of immune response role
disjoint_from: OBI:1110086  ! restricting MHC role
disjoint_from: OBI:1110087  ! donor
disjoint_from: OBI:1110091  ! carrier role
disjoint_from: OBI:1110092  ! adjuvant role
disjoint_from: OBI:1110120  ! assay antigen role

[Term]
id: OBI:0000100
name: role of being first subject treated
def: "First subject treated role is a study subject role borne by the subject realized in the application of the process specified in intervention study design with no previous study subject realizing the role prior in the study" []
is_a: OBI:0000097  ! study subject role
disjoint_from: OBI:0000205  ! dropout role
disjoint_from: OBI:0000220  ! reference subject role
disjoint_from: OBI:0000813  ! to be treated with active ingredient role
disjoint_from: OBI:0000825  ! to be treated with placebo role

[Term]
id: OBI:0000101
name: measured expression level
def: "A measured expression level is a datum that is the outcome of the quantification of an assay for the activity of a gene, or the number of RNA transcripts." []
is_a: IAO:0000109 
disjoint_from: OBI:0000010  ! fluorescent reporter intensity
disjoint_from: OBI:0000054  ! ratio of collected to emitted light
disjoint_from: OBI:0000119  ! number of particles in subset
disjoint_from: OBI:0000125  ! number of lost events electronic
disjoint_from: OBI:0000172  ! parameter threshold
disjoint_from: OBI:0000269  ! number of lost events computer
disjoint_from: OBI:0000789  ! survival rate
disjoint_from: OBI:0000801  ! spike train datum

[Term]
id: OBI:0000102
name: responsible party role
def: "A responsible party role is a study personnel role played by a party who is accountable for the execution of a study component and can make decisions about the conduct of the study" []
is_a: OBI:0000202  ! investigation agent role

[Term]
id: OBI:0000103
name: principal investigator role
def: "Principal investigator is a responsible party role played by a person responsible for the overall conduct of a study" []
is_a: OBI:0000102  ! responsible party role

[Term]
id: OBI:0000105
name: transplantation
def: "a protocol application to replace an organ or tissue of an organism" []
is_a: OBI:0000094  ! material processing
relationship: OBI:0000417 OBI:0000456 ! material transformation objective

[Term]
id: OBI:0000109
name: biological vector role
def: "a biological vector role is a material to be added role that is realized by the process of transmitting material to the organism that is the target of the transmission." []
is_a: OBI:0000319  ! material to be added role

[Term]
id: OBI:0000110
name: pH indicator dye role
def: "the role of a dye that is realized when the dye is used in an experiment to measure the pH in a material entity" []
is_a: OBI:0000250  ! dye role
disjoint_from: OBI:0000026  ! cytological stain role
disjoint_from: OBI:0000221  ! vital dye role

[Term]
id: OBI:0000112
name: specimen role
def: "a role borne by a material entity that is gained during a specimen creation process and that is realized by use of the specimen in an investigation" []
is_a: snap:Role 
disjoint_from: OBI:0000017  ! regulatory role
disjoint_from: OBI:0000025  ! reference substance role
disjoint_from: OBI:0000029  ! centrifuge pellet role
disjoint_from: OBI:0000034  ! supernatant role
disjoint_from: OBI:0000040  ! drug role
disjoint_from: OBI:0000067  ! evaluant role
disjoint_from: OBI:0000086  ! reagent role
disjoint_from: OBI:0000091  ! detector reagent role
disjoint_from: OBI:0000093  ! patient role
disjoint_from: OBI:0000097  ! study subject role
disjoint_from: OBI:0000140  ! label role
disjoint_from: OBI:0000174  ! study group role
disjoint_from: OBI:0000204  ! nutrient role
disjoint_from: OBI:0000237  ! antigen role
disjoint_from: OBI:0000275  ! analyte role
disjoint_from: OBI:0000319  ! material to be added role
disjoint_from: OBI:0000405  ! primer role
disjoint_from: OBI:0000416  ! cloning insert role
disjoint_from: OBI:0000444  ! target of material addition role
disjoint_from: OBI:0000571  ! manufacturer role
disjoint_from: OBI:0000718  ! pathogen role
disjoint_from: OBI:0000720  ! adjuvent role
disjoint_from: OBI:0000725  ! host role
disjoint_from: OBI:0000847  ! test substance role
disjoint_from: OBI:0302731  ! buffer role
disjoint_from: OBI:0302732  ! solvent role
disjoint_from: OBI:0302733  ! solute role
disjoint_from: OBI:1110082  ! immunogen role
disjoint_from: OBI:1110083  ! host of immune response role
disjoint_from: OBI:1110086  ! restricting MHC role
disjoint_from: OBI:1110087  ! donor
disjoint_from: OBI:1110091  ! carrier role
disjoint_from: OBI:1110092  ! adjuvant role
disjoint_from: OBI:1110120  ! assay antigen role

[Term]
id: OBI:0000113
name: sequence feature identification objective
def: "Sequence_feature_identification_objective is a biological_feature_identification_objective role describing a study designed to examine or characterize molecular features exhibited at the level of a macromolecular sequence, e.g. nucleic acid, protein, polysaccharide." []
is_a: OBI:0000015  ! biological feature identification objective
disjoint_from: OBI:0000131  ! molecular feature identification objective
disjoint_from: OBI:0000219  ! cellular feature identification objective
disjoint_from: OBI:0000268  ! organism feature identification objective

[Term]
id: OBI:0000115
name: intervention design
def: "an intervention design is a study design in which treatments (perturbations or intervention) defined as a combination of values taken by independent variable manipulated by the experimentalists are applied to the recruited subjects assigned (possibly by applying specific methods) to treatment groups. The specificity of intervention design is the fact that independent variables are being manipulated and a response of the biological system is evaluated via response variables as monitored by possibly a series of assays." []
is_a: OBI:0500000  ! study design
disjoint_from: OBI:0300311  ! observation design
disjoint_from: OBI:0500005  ! matched pairs design
disjoint_from: OBI:0500009  ! loop design
disjoint_from: OBI:0500010  ! reference design
disjoint_from: OBI:0500017  ! dye swap design
disjoint_from: OBI:0500018  ! replicate design
disjoint_from: OBI:0500019  ! self vs self design
disjoint_from: OBI:0500020  ! time series design

[Term]
id: OBI:0000116
name: worker role
def: "Worker is a personnel role played by a party who executes a component of the study plan; this can occur before, during, after or outside the study timeline" []
is_a: OBI:0000202  ! investigation agent role

[Term]
id: OBI:0000117
name: Bernoulli trial
def: "is an assay where the output data is a datum with one of two values denoted success and failure." []
is_a: OBI:0000070  ! assay
relationship: OBI:0000417 OBI:0000441 ! assay objective

[Term]
id: OBI:0000118
name: gene list
def: "A gene list is a report of the names or identifiers of genes that are the outcome of an analysis or have been put together for the purpose of an analysis." []
is_a: IAO:0000100 
disjoint_from: OBI:0000251  ! cluster

[Term]
id: OBI:0000119
name: number of particles in subset
def: "A number of particles in subset is a datum measuring the number of subjects in a defined subset in a flow cytometer instrument. The datum has a qualitative role" []
is_a: IAO:0000109 
disjoint_from: OBI:0000010  ! fluorescent reporter intensity
disjoint_from: OBI:0000054  ! ratio of collected to emitted light
disjoint_from: OBI:0000101  ! measured expression level
disjoint_from: OBI:0000125  ! number of lost events electronic
disjoint_from: OBI:0000172  ! parameter threshold
disjoint_from: OBI:0000269  ! number of lost events computer
disjoint_from: OBI:0000789  ! survival rate
disjoint_from: OBI:0000801  ! spike train datum

[Term]
id: OBI:0000125
name: number of lost events electronic
def: "A number of lost events electronic is a datum measuring the number of analysis events lost due to errors in data acquisition electronic coincidence in a flow cytometer instrument. The datum has a qualitative role." []
is_a: IAO:0000109 
disjoint_from: OBI:0000010  ! fluorescent reporter intensity
disjoint_from: OBI:0000054  ! ratio of collected to emitted light
disjoint_from: OBI:0000101  ! measured expression level
disjoint_from: OBI:0000119  ! number of particles in subset
disjoint_from: OBI:0000172  ! parameter threshold
disjoint_from: OBI:0000269  ! number of lost events computer
disjoint_from: OBI:0000789  ! survival rate
disjoint_from: OBI:0000801  ! spike train datum

[Term]
id: OBI:0000129
name: calibration substance role
def: "A reference substance role that is realized when characteristics or responses elicited by the bearer are used to ensure an instrument is within protocol specification of accuracy or performance" []
is_a: OBI:0000025  ! reference substance role
disjoint_from: OBI:0000064  ! positive reference substance role
disjoint_from: OBI:0000214  ! negative reference substance role
disjoint_from: OBI:0000409  ! nucleic acid template role

[Term]
id: OBI:0000131
name: molecular feature identification objective
def: "Molecular_feature_identification_objective is a biological_feature_identification_objective role describing a study designed to examine or characterize molecular features of a biological system, e.g. expression profiling, copy number of molecular components, epigenetic modifications." []
is_a: OBI:0000015  ! biological feature identification objective
disjoint_from: OBI:0000113  ! sequence feature identification objective
disjoint_from: OBI:0000219  ! cellular feature identification objective
disjoint_from: OBI:0000268  ! organism feature identification objective

[Term]
id: OBI:0000134
name: hardware testing objective
def: "Hardware_testing_objective is a methodology_testing_objective role describing a study designed to examine the effects of using different hardware, e.g. scanner." []
is_a: OBI:0000208  ! methodology testing objective
disjoint_from: OBI:0000096  ! protocol testing objective
disjoint_from: OBI:0000242  ! software testing objective

[Term]
id: OBI:0000136
name: incubator
def: "An incubator is an instrument in which environmental conditions (light, photoperiod, temperature, humidity, etc.) can be controlled" []
is_a: OBI:0000047  ! processed material
relationship: OBI:0000306 OBI:0000401 ! environment control function

[Term]
id: OBI:0000140
name: label role
def: "Label role is a reagent role where the bearer is a material entity and which is realized in a detection of label assay" []
is_a: snap:Role 
disjoint_from: OBI:0000017  ! regulatory role
disjoint_from: OBI:0000025  ! reference substance role
disjoint_from: OBI:0000029  ! centrifuge pellet role
disjoint_from: OBI:0000034  ! supernatant role
disjoint_from: OBI:0000040  ! drug role
disjoint_from: OBI:0000067  ! evaluant role
disjoint_from: OBI:0000086  ! reagent role
disjoint_from: OBI:0000091  ! detector reagent role
disjoint_from: OBI:0000093  ! patient role
disjoint_from: OBI:0000097  ! study subject role
disjoint_from: OBI:0000112  ! specimen role
disjoint_from: OBI:0000174  ! study group role
disjoint_from: OBI:0000204  ! nutrient role
disjoint_from: OBI:0000237  ! antigen role
disjoint_from: OBI:0000275  ! analyte role
disjoint_from: OBI:0000319  ! material to be added role
disjoint_from: OBI:0000405  ! primer role
disjoint_from: OBI:0000416  ! cloning insert role
disjoint_from: OBI:0000444  ! target of material addition role
disjoint_from: OBI:0000571  ! manufacturer role
disjoint_from: OBI:0000718  ! pathogen role
disjoint_from: OBI:0000720  ! adjuvent role
disjoint_from: OBI:0000725  ! host role
disjoint_from: OBI:0000847  ! test substance role
disjoint_from: OBI:0302731  ! buffer role
disjoint_from: OBI:0302732  ! solvent role
disjoint_from: OBI:0302733  ! solute role
disjoint_from: OBI:1110082  ! immunogen role
disjoint_from: OBI:1110083  ! host of immune response role
disjoint_from: OBI:1110086  ! restricting MHC role
disjoint_from: OBI:1110087  ! donor
disjoint_from: OBI:1110091  ! carrier role
disjoint_from: OBI:1110092  ! adjuvant role
disjoint_from: OBI:1110120  ! assay antigen role

[Term]
id: OBI:0000143
name: baseline participant role
def: "baseline participant role is a reference participant role which is realized by making the reference to qualities at the start of the study or intervention" []
is_a: OBI:0000220  ! reference subject role
disjoint_from: OBI:0000161  ! crossover population role
disjoint_from: OBI:0000198  ! biological replicate role
disjoint_from: OBI:0000249  ! technical replicate role

[Term]
id: OBI:0000144
name: role of independent data monitoring committee
def: "Independent data monitoring committee is a trial monitor role charged recommending whether to continue, modify, or end the trial" []
is_a: OBI:0000060  ! trial monitor role

[Term]
id: OBI:0000145
name: pathologist role
def: "Pathologist is a worker role of being responsible for making the histopathology diagnoses associated with data from a study; this activity occurs outside the study timeline" []
is_a: OBI:0000116  ! worker role

[Term]
id: OBI:0000146
name: supernatant collection system harvesting frame
def: "The Supernatant Collection system is designed for collecting 90% of the supernatant in a microplate well and separating the living cell with no stress, eliminating centrifugation and other similar techniques. It can be used in a variety of release assays with different radioactive isotopes, such as Cr51 or I125." []
is_a: snap:MaterialEntity 
relationship: OBI:0000306 OBI:0000370 ! contain function
disjoint_from: OBI:0000050  ! platform
disjoint_from: OBI:0000245  ! organization
disjoint_from: OBI:0000318  ! eluate
disjoint_from: OBI:0000390  ! thermostatic circulator
disjoint_from: OBI:0000420  ! trypsinized material
disjoint_from: OBI:0000432  ! polyacrylamide gel
disjoint_from: OBI:0000439  ! agarose gel
disjoint_from: OBI:0000576  ! scattered molecular aggregate
disjoint_from: OBI:0000651  ! urine specimen
disjoint_from: OBI:0000655  ! blood specimen
disjoint_from: OBI:0000680  ! whole organism preparation
disjoint_from: OBI:0000798  ! capsule shell
disjoint_from: OBI:0000814  ! guar gum
disjoint_from: OBI:0100014  ! chimera
disjoint_from: OBI:0100016  ! blood plasma
disjoint_from: OBI:0100017  ! blood serum specimen
disjoint_from: OBI:0100039  ! fragment derived from protein
disjoint_from: OBI:0100055  ! cell line cell
disjoint_from: OBI:0100056  ! immortalized cell line
disjoint_from: OBI:0100058  ! xenograft
disjoint_from: OBI:0100060  ! cell culture
disjoint_from: OBI:0100067  ! bronchial alveolar lavage
disjoint_from: OBI:0100069  ! polymer
disjoint_from: OBI:0100086  ! glucose in solution
disjoint_from: OBI:0302714  ! collection (of entities of organismal origin)
disjoint_from: OBI:0400102  ! waste tank
disjoint_from: OBI:1000023  ! cell culture supernatant
disjoint_from: OBI:1000024  ! cell pellet
disjoint_from: OBI:1000036  ! cell lysate
disjoint_from: OBI:1000042  ! peptide construct
disjoint_from: OBI:1000048  ! transgenic organism

[Term]
id: OBI:0000151
name: filter paper
def: "Fliter paper is a device manufacture with the intent to provide a porous unsized paper used for filtering." []
is_a: OBI:0000047  ! processed material
relationship: OBI:0000306 OBI:0000378 ! filter function

[Term]
id: OBI:0000153
name: cell co-culturing
def: "A material combination in which cell cultures of two or more different types are are combined and allowed to culture as one." []
is_a: OBI:0000094  ! material processing
relationship: OBI:0000299 OBI:0100060 ! cell culture
relationship: OBI:0000417 OBI:0000456 ! material transformation objective

[Term]
id: OBI:0000154
name: role of Institutional Review Board
def: "the role of a organization that is realized by members reviewing study designs for their agreement with regulations" []
is_a: OBI:0000014  ! regulator role
disjoint_from: OBI:0000089  ! role of regulator of chemical manufacturer
disjoint_from: OBI:0000273  ! role of regulator of consumables and medical devices

[Term]
id: OBI:0000158
name: eSource document
def: "an eSource document is a digital document consisting of a logical collection of Source data and other eSource documents that can be presented in an ordered way and capture the time of completion, change, and any signatures" []
is_a: IAO:0000030 
disjoint_from: OBI:0000021  ! list-mode data file
disjoint_from: OBI:0000078  ! eMedical record
disjoint_from: OBI:0000083  ! electronic case report tabulation
disjoint_from: OBI:0000167  ! electronic case report form
disjoint_from: OBI:0000210  ! analytical cytology data file
disjoint_from: OBI:0000213  ! fluorescence compensation matrix
disjoint_from: OBI:0000682  ! study result
disjoint_from: OBI:0302840  ! curated
disjoint_from: OBI:0302874  ! edited information

[Term]
id: OBI:0000161
name: crossover population role
def: "crossover population role is a role realized when a participant serves as reference to itself" []
is_a: OBI:0000220  ! reference subject role
disjoint_from: OBI:0000143  ! baseline participant role
disjoint_from: OBI:0000198  ! biological replicate role
disjoint_from: OBI:0000249  ! technical replicate role

[Term]
id: OBI:0000162
name: complete nutrient role
def: "A nutrient role is a role that inheres in a material entity and is realized in the use of that material entity by an organism to provide all needed nourishment." []
is_a: OBI:0000204  ! nutrient role

[Term]
id: OBI:0000163
name: radiolabel role
def: "Radiolabelrole is a label role which uses radiological decay as the signal" []
synonym: "Label_role" EXACT []
is_a: OBI:0000140  ! label role
disjoint_from: OBI:0000250  ! dye role

[Term]
id: OBI:0000164
name: cDNA library
def: "Mixed population of cDNAs (complementaryDNA) made from mRNA from a defined source, usually a specific cell type. This term should be associated only to nucleic acid interactors not to their proteins product. For instance in 2h screening use living cells (MI:0349) as sample process.\n\nALT DEF (PRS):: a cDNA library is a collection of host cells, typically E.Coli cells but not exclusively. modified by transfer of plasmid DNA molecule used as vector containing a fragment or totality of cDNA molecule (the insert) .  cDNA library may have an array of role and applications." []
is_a: OBI:0000731  ! recombinant vector
is_a: OBI:0302714  ! collection (of entities of organismal origin)
relationship: OBI:0000312 OBI:0600064 ! recombinant vector cloning
disjoint_from: OBI:0000181  ! population
disjoint_from: OBI:0000722  ! paired-end library
disjoint_from: OBI:0000736  ! single fragment library
disjoint_from: OBI:0100064  ! screening library
disjoint_from: OBI:1000029  ! phage display library

[Term]
id: OBI:0000167
name: electronic case report form
def: "An electronic case report form is a digital document used to record all of the protocol required information to be reported for each trial subject. An eCRF has the property that it can be audited and compliant with requirements of 21 CFR Part 11." []
is_a: IAO:0000030 
disjoint_from: OBI:0000021  ! list-mode data file
disjoint_from: OBI:0000078  ! eMedical record
disjoint_from: OBI:0000083  ! electronic case report tabulation
disjoint_from: OBI:0000158  ! eSource document
disjoint_from: OBI:0000210  ! analytical cytology data file
disjoint_from: OBI:0000213  ! fluorescence compensation matrix
disjoint_from: OBI:0000682  ! study result
disjoint_from: OBI:0302840  ! curated
disjoint_from: OBI:0302874  ! edited information

[Term]
id: OBI:0000169
name: placebo role
def: "Reference substance is a reference role in which the characteristics or responses elicited by the substance playing the reference substance role are used to establish a \"no effect\" response and which is physically similar in appearance to the test substance" []
is_a: OBI:0000214  ! negative reference substance role

[Term]
id: OBI:0000171
name: autotransplantation
def: "is the transplantation of tissue from one part of \nthe body to another in the same individual. )" []
is_a: OBI:0000105  ! transplantation
disjoint_from: OBI:0000043  ! xenotransplantation
disjoint_from: OBI:0000057  ! allotransplantation

[Term]
id: OBI:0000172
name: parameter threshold
def: "A parameter threshold is a datum measuring the minimal signal that must be detected to generate an electrical event, as compared to the maximal detected signal in a flow cytometer instrument. The datum has a qualitative role" []
is_a: IAO:0000109 
disjoint_from: OBI:0000010  ! fluorescent reporter intensity
disjoint_from: OBI:0000054  ! ratio of collected to emitted light
disjoint_from: OBI:0000101  ! measured expression level
disjoint_from: OBI:0000119  ! number of particles in subset
disjoint_from: OBI:0000125  ! number of lost events electronic
disjoint_from: OBI:0000269  ! number of lost events computer
disjoint_from: OBI:0000789  ! survival rate
disjoint_from: OBI:0000801  ! spike train datum

[Term]
id: OBI:0000174
name: study group role
def: "study group role is a study population role where the bearer is a population of material entities and the role is realized in the implementation of a study design wherein the entities bearing the study population role are observed or subjected to intervention according to the study design and are biological replicates, i.e. they receive the same treatment under the protocol" []
is_a: snap:Role 
disjoint_from: OBI:0000017  ! regulatory role
disjoint_from: OBI:0000025  ! reference substance role
disjoint_from: OBI:0000029  ! centrifuge pellet role
disjoint_from: OBI:0000034  ! supernatant role
disjoint_from: OBI:0000040  ! drug role
disjoint_from: OBI:0000067  ! evaluant role
disjoint_from: OBI:0000086  ! reagent role
disjoint_from: OBI:0000091  ! detector reagent role
disjoint_from: OBI:0000093  ! patient role
disjoint_from: OBI:0000097  ! study subject role
disjoint_from: OBI:0000112  ! specimen role
disjoint_from: OBI:0000140  ! label role
disjoint_from: OBI:0000204  ! nutrient role
disjoint_from: OBI:0000237  ! antigen role
disjoint_from: OBI:0000275  ! analyte role
disjoint_from: OBI:0000319  ! material to be added role
disjoint_from: OBI:0000405  ! primer role
disjoint_from: OBI:0000416  ! cloning insert role
disjoint_from: OBI:0000444  ! target of material addition role
disjoint_from: OBI:0000571  ! manufacturer role
disjoint_from: OBI:0000718  ! pathogen role
disjoint_from: OBI:0000720  ! adjuvent role
disjoint_from: OBI:0000725  ! host role
disjoint_from: OBI:0000847  ! test substance role
disjoint_from: OBI:0302731  ! buffer role
disjoint_from: OBI:0302732  ! solvent role
disjoint_from: OBI:0302733  ! solute role
disjoint_from: OBI:1110082  ! immunogen role
disjoint_from: OBI:1110083  ! host of immune response role
disjoint_from: OBI:1110086  ! restricting MHC role
disjoint_from: OBI:1110087  ! donor
disjoint_from: OBI:1110091  ! carrier role
disjoint_from: OBI:1110092  ! adjuvant role
disjoint_from: OBI:1110120  ! assay antigen role

[Term]
id: OBI:0000175
name: p-value
def: "A quantitative confidence value that represents the probability of obtaining a result at least as extreme as that actually obtained, assuming that the actual value was the result of chance alone." []
is_a: OBI:0000071  ! quantitative confidence value
disjoint_from: OBI:0000235  ! standard error

[Term]
id: OBI:0000181
name: population
def: "a population is a collection of individuals from the same taxonomic class living, counted or sampled at a particular site or in a particular area" []
is_a: OBI:0302714  ! collection (of entities of organismal origin)
disjoint_from: OBI:0000164  ! cDNA library
disjoint_from: OBI:0000722  ! paired-end library
disjoint_from: OBI:0000736  ! single fragment library
disjoint_from: OBI:0100064  ! screening library
disjoint_from: OBI:1000029  ! phage display library

[Term]
id: OBI:0000182
name: nuclear magnetic resonance assay
def: "A nuclear magnetic resonance assay is an assay used to identify the chemical structure of a compound or biological macromolecule. definition_source: www.nature.com/nrd/journal/v2/n5/glossary/nrd1086_glossary.html" []
is_a: OBI:0000070  ! assay
relationship: OBI:0000293 snap:MaterialEntity
relationship: OBI:0000299 IAO:0000109
relationship: OBI:0000417 OBI:0000441 ! assay objective

[Term]
id: OBI:0000185
name: imaging assay
def: "An imaging assay is an assay to produce a picture of an entity. definition_source: OBI." []
is_a: OBI:0000070  ! assay
relationship: OBI:0000417 OBI:0000441 ! assay objective

[Term]
id: OBI:0000186
name: protocol optimization
def: "Protocol_optimization is a protocol_testing_objective role describing a study designed to identify the best protocol.  This may be carried out by comparing different protocols or by modifying the parameters used within a single protocol." []
is_a: OBI:0000096  ! protocol testing objective

[Term]
id: OBI:0000188
name: role of pathology review board
def: "Pathology review board is a worker role comprised of providing a confirmed and consensus diagnosis for histopathology results obtained during the investigation" []
is_a: OBI:0000116  ! worker role

[Term]
id: OBI:0000192
name: microtiter plate
def: "A microtiter_plate is a flat plate with multiple wells used as small test tubes." []
synonym: "microplate" EXACT []
is_a: OBI:0000047  ! processed material
relationship: OBI:0000306 OBI:0000370 ! contain function

[Term]
id: OBI:0000196
name: role of impartial witness
def: "Is a role which inheres in a Homo sapiens and is realized during a clinical trial - the impartial witness is independent of the trial and cannot be unfairly influenced by people involved with the trial" []
is_a: OBI:0000016  ! regulation-assigned role
disjoint_from: OBI:0000092  ! role of certified IRB professional
disjoint_from: OBI:0000215  ! role of legally acceptable representative

[Term]
id: OBI:0000198
name: biological replicate role
def: "biological replicate role is a reference participant role realized by equivalent treatment of participants" []
is_a: OBI:0000220  ! reference subject role
disjoint_from: OBI:0000143  ! baseline participant role
disjoint_from: OBI:0000161  ! crossover population role
disjoint_from: OBI:0000249  ! technical replicate role

[Term]
id: OBI:0000201
name: radioactivity detection
def: "An assay in which a material's radioactivity is measured." []
is_a: OBI:0000070  ! assay
relationship: OBI:0000417 OBI:0000441 ! assay objective

[Term]
id: OBI:0000202
name: investigation agent role
def: "Investigation agent role is a role borne by a person or organization which is realized in a process that is part of an investigation in which an objective is achieved. These processes include: planning, overseeing, funding, reviewing." []
is_a: snap:Role 

[Term]
id: OBI:0000204
name: nutrient role
def: "A nutrient role is a role that inheres in a material entity and is realized in the use of that material entity by an organism when it is used in that organism's metabolism and provides nourishment." []
is_a: snap:Role 
relationship: http://purl.org/obo/owl/OBO_REL#inheres_in snap:MaterialEntity
disjoint_from: OBI:0000017  ! regulatory role
disjoint_from: OBI:0000025  ! reference substance role
disjoint_from: OBI:0000029  ! centrifuge pellet role
disjoint_from: OBI:0000034  ! supernatant role
disjoint_from: OBI:0000040  ! drug role
disjoint_from: OBI:0000067  ! evaluant role
disjoint_from: OBI:0000086  ! reagent role
disjoint_from: OBI:0000091  ! detector reagent role
disjoint_from: OBI:0000093  ! patient role
disjoint_from: OBI:0000097  ! study subject role
disjoint_from: OBI:0000112  ! specimen role
disjoint_from: OBI:0000140  ! label role
disjoint_from: OBI:0000174  ! study group role
disjoint_from: OBI:0000237  ! antigen role
disjoint_from: OBI:0000275  ! analyte role
disjoint_from: OBI:0000319  ! material to be added role
disjoint_from: OBI:0000405  ! primer role
disjoint_from: OBI:0000416  ! cloning insert role
disjoint_from: OBI:0000444  ! target of material addition role
disjoint_from: OBI:0000571  ! manufacturer role
disjoint_from: OBI:0000718  ! pathogen role
disjoint_from: OBI:0000720  ! adjuvent role
disjoint_from: OBI:0000725  ! host role
disjoint_from: OBI:0000847  ! test substance role
disjoint_from: OBI:0302731  ! buffer role
disjoint_from: OBI:0302732  ! solvent role
disjoint_from: OBI:0302733  ! solute role
disjoint_from: OBI:1110082  ! immunogen role
disjoint_from: OBI:1110083  ! host of immune response role
disjoint_from: OBI:1110086  ! restricting MHC role
disjoint_from: OBI:1110087  ! donor
disjoint_from: OBI:1110091  ! carrier role
disjoint_from: OBI:1110092  ! adjuvant role
disjoint_from: OBI:1110120  ! assay antigen role

[Term]
id: OBI:0000205
name: dropout role
def: "Dropout is a study subject role borne by an entity realized by a process of leaving the study earlier than the protocol specified and where the bearer of the dropout role had been borne study subject role prior to bearing dropout role." []
is_a: OBI:0000097  ! study subject role
disjoint_from: OBI:0000100  ! role of being first subject treated
disjoint_from: OBI:0000220  ! reference subject role
disjoint_from: OBI:0000813  ! to be treated with active ingredient role
disjoint_from: OBI:0000825  ! to be treated with placebo role

[Term]
id: OBI:0000207
name: health care provider role
def: "Healthcare provider is a worker role of providing medical care either within or outside the study timeline" []
is_a: OBI:0000116  ! worker role

[Term]
id: OBI:0000208
name: methodology testing objective
def: "Methodology_testing_objective is an objective role carried out by a proposition defining the aim of the study is to examine the effect of using different methodologies." []
is_a: IAO:0000005 
disjoint_from: OBI:0000015  ! biological feature identification objective
disjoint_from: OBI:0000441  ! assay objective
disjoint_from: OBI:0000456  ! material transformation objective
disjoint_from: OBI:0000684  ! specimen creation objective
disjoint_from: OBI:0000806  ! material maintenance objective
disjoint_from: OBI:0200166  ! data transformation objective

[Term]
id: OBI:0000210
name: analytical cytology data file
def: "A digital entity intended to capture data in analytical cytology domain." []
is_a: IAO:0000030 
disjoint_from: OBI:0000021  ! list-mode data file
disjoint_from: OBI:0000078  ! eMedical record
disjoint_from: OBI:0000083  ! electronic case report tabulation
disjoint_from: OBI:0000158  ! eSource document
disjoint_from: OBI:0000167  ! electronic case report form
disjoint_from: OBI:0000213  ! fluorescence compensation matrix
disjoint_from: OBI:0000682  ! study result
disjoint_from: OBI:0302840  ! curated
disjoint_from: OBI:0302874  ! edited information

[Term]
id: OBI:0000211
name: proxy respondent role
def: "Proxy respondent is a worker role of describing patient's symptoms or condition to medical personnel" []
is_a: OBI:0000116  ! worker role

[Term]
id: OBI:0000213
name: fluorescence compensation matrix
def: "A fluorescence compensation matrix is a square matrix which is used as the left multiplier of the vector of fluorescence values while performing digital fluorescence compensation. Also, fluorescence compensation matrix is the inverse of the fluorescence spillover matrix." []
is_a: IAO:0000030 
disjoint_from: OBI:0000021  ! list-mode data file
disjoint_from: OBI:0000078  ! eMedical record
disjoint_from: OBI:0000083  ! electronic case report tabulation
disjoint_from: OBI:0000158  ! eSource document
disjoint_from: OBI:0000167  ! electronic case report form
disjoint_from: OBI:0000210  ! analytical cytology data file
disjoint_from: OBI:0000682  ! study result
disjoint_from: OBI:0302840  ! curated
disjoint_from: OBI:0302874  ! edited information

[Term]
id: OBI:0000214
name: negative reference substance role
def: "Reference substance is a reference role in which the characteristics or responses elicited by the substance playing the reference substance role are used to establish a \"no effect\" response" []
is_a: OBI:0000025  ! reference substance role
disjoint_from: OBI:0000064  ! positive reference substance role
disjoint_from: OBI:0000129  ! calibration substance role
disjoint_from: OBI:0000409  ! nucleic acid template role

[Term]
id: OBI:0000215
name: role of legally acceptable representative
def: "is  a role which inheres in a human or organization who are able subject to applicable law to consent, on behalf of a prospective subject, to the subject`s participation in as clinical trial. " []
is_a: OBI:0000016  ! regulation-assigned role
disjoint_from: OBI:0000092  ! role of certified IRB professional
disjoint_from: OBI:0000196  ! role of impartial witness

[Term]
id: OBI:0000218
name: investigation results report
def: "An investigation report is a report on the results of an investigation." []
is_a: IAO:0000088 
disjoint_from: OBI:1110300  ! direct submission to IEDB

[Term]
id: OBI:0000219
name: cellular feature identification objective
def: "Cellular_feature_identification_objective is a biological_feature_identification_objective role describing a study designed to examine or characterize a biological feature monitored at the cellular level, e.g. stage of cell cycle, stage of differentiation." []
is_a: OBI:0000015  ! biological feature identification objective
disjoint_from: OBI:0000113  ! sequence feature identification objective
disjoint_from: OBI:0000131  ! molecular feature identification objective
disjoint_from: OBI:0000268  ! organism feature identification objective

[Term]
id: OBI:0000220
name: reference subject role
def: "a study subject role in which the characteristics or responses of the participant playing the reference participant role are used for comparison or reference." []
is_a: OBI:0000097  ! study subject role
disjoint_from: OBI:0000100  ! role of being first subject treated
disjoint_from: OBI:0000205  ! dropout role
disjoint_from: OBI:0000813  ! to be treated with active ingredient role
disjoint_from: OBI:0000825  ! to be treated with placebo role

[Term]
id: OBI:0000221
name: vital dye role
def: "The role of a dye that is realized when used in an experiment to stain live cells " []
is_a: OBI:0000250  ! dye role
disjoint_from: OBI:0000026  ! cytological stain role
disjoint_from: OBI:0000110  ! pH indicator dye role

[Term]
id: OBI:0000223
name: blinded medication role
def: "Is a role which inheres in a material entity which is manufactured to be similar in appearance to a test material entity in e.g. a clinical trial to prevent participants from detecting which is the active and inactive substance" []
is_a: OBI:0000169  ! placebo role

[Term]
id: OBI:0000224
name: sub-investigator role
def: "Sub-investigator is a worker role authorized to make study-related decisions and carry out tasks related to the study; this role occurs during the study timeline" []
is_a: OBI:0000116  ! worker role

[Term]
id: OBI:0000227
name: data encoding
def: "is a process to encode an information entity into a digital document" []
is_a: OBI:0000340  ! documenting
disjoint_from: OBI:0302908  ! document editing
disjoint_from: OBI:0302914  ! digital curation

[Term]
id: OBI:0000231
name: enzymatic cleavage
def: "enzymatic cleavage is a protocol application to digest the fraction of input material that is susceptible to that enzyme" []
is_a: OBI:0000094  ! material processing
relationship: OBI:0000293 OBI:0100051 ! specimen
relationship: OBI:0000417 OBI:0000456 ! material transformation objective

[Term]
id: OBI:0000232
name: hardware optimization
def: "Hardware_optimization is a hardware_testing_objective describing a study designed to identify the best hardware." []
is_a: OBI:0000134  ! hardware testing objective

[Term]
id: OBI:0000234
name: trial statistician role
def: "Trial statistician is a worker who analyzes data obtained during a trial or study; this role occurs after the trial or study is completed or terminated." []
is_a: OBI:0000116  ! worker role

[Term]
id: OBI:0000235
name: standard error
def: "Standard error is a quantitative confidence value which is the standard deviations of the sample in a frequency distribution, obtained by dividing the standard deviation by the total number of cases in the frequency distribution." []
is_a: OBI:0000071  ! quantitative confidence value
disjoint_from: OBI:0000175  ! p-value

[Term]
id: OBI:0000237
name: antigen role
def: "Antigen is a role played by material which when introduced into an immune-competent organism causes an immune response" []
is_a: snap:Role 
relationship: OBI:0000300 GO:0006955 ! immune response
disjoint_from: OBI:0000017  ! regulatory role
disjoint_from: OBI:0000025  ! reference substance role
disjoint_from: OBI:0000029  ! centrifuge pellet role
disjoint_from: OBI:0000034  ! supernatant role
disjoint_from: OBI:0000040  ! drug role
disjoint_from: OBI:0000067  ! evaluant role
disjoint_from: OBI:0000086  ! reagent role
disjoint_from: OBI:0000091  ! detector reagent role
disjoint_from: OBI:0000093  ! patient role
disjoint_from: OBI:0000097  ! study subject role
disjoint_from: OBI:0000112  ! specimen role
disjoint_from: OBI:0000140  ! label role
disjoint_from: OBI:0000174  ! study group role
disjoint_from: OBI:0000204  ! nutrient role
disjoint_from: OBI:0000275  ! analyte role
disjoint_from: OBI:0000319  ! material to be added role
disjoint_from: OBI:0000405  ! primer role
disjoint_from: OBI:0000416  ! cloning insert role
disjoint_from: OBI:0000444  ! target of material addition role
disjoint_from: OBI:0000571  ! manufacturer role
disjoint_from: OBI:0000718  ! pathogen role
disjoint_from: OBI:0000720  ! adjuvent role
disjoint_from: OBI:0000725  ! host role
disjoint_from: OBI:0000847  ! test substance role
disjoint_from: OBI:0302731  ! buffer role
disjoint_from: OBI:0302732  ! solvent role
disjoint_from: OBI:0302733  ! solute role
disjoint_from: OBI:1110082  ! immunogen role
disjoint_from: OBI:1110083  ! host of immune response role
disjoint_from: OBI:1110086  ! restricting MHC role
disjoint_from: OBI:1110087  ! donor
disjoint_from: OBI:1110091  ! carrier role
disjoint_from: OBI:1110092  ! adjuvant role
disjoint_from: OBI:1110120  ! assay antigen role

[Term]
id: OBI:0000242
name: software testing objective
def: "Software_testing_objective is a hardware_optimization role describing a study designed to examine the effects of using different software or software parameters, e.g. data processing software." []
is_a: OBI:0000208  ! methodology testing objective
disjoint_from: OBI:0000096  ! protocol testing objective
disjoint_from: OBI:0000134  ! hardware testing objective

[Term]
id: OBI:0000243
name: sponsor role
def: "Sponsor is a responsible party role involved with any of the following activities:  initiating, managing and funding a study" []
is_a: OBI:0000102  ! responsible party role

[Term]
id: OBI:0000245
name: organization
def: "An organization is a continuant entity which can play roles,  has members, and has a set of organization rules.  Members of organizations are either organizations themselves or individual people. Members can bear specific organization member roles that are determined in the organization rules. The organization rules also determine how decisions are made on behalf of the organization by the organization members." []
is_a: snap:MaterialEntity 
disjoint_from: OBI:0000050  ! platform
disjoint_from: OBI:0000146  ! supernatant collection system harvesting frame
disjoint_from: OBI:0000318  ! eluate
disjoint_from: OBI:0000390  ! thermostatic circulator
disjoint_from: OBI:0000420  ! trypsinized material
disjoint_from: OBI:0000432  ! polyacrylamide gel
disjoint_from: OBI:0000439  ! agarose gel
disjoint_from: OBI:0000576  ! scattered molecular aggregate
disjoint_from: OBI:0000651  ! urine specimen
disjoint_from: OBI:0000655  ! blood specimen
disjoint_from: OBI:0000680  ! whole organism preparation
disjoint_from: OBI:0000798  ! capsule shell
disjoint_from: OBI:0000814  ! guar gum
disjoint_from: OBI:0100014  ! chimera
disjoint_from: OBI:0100016  ! blood plasma
disjoint_from: OBI:0100017  ! blood serum specimen
disjoint_from: OBI:0100039  ! fragment derived from protein
disjoint_from: OBI:0100055  ! cell line cell
disjoint_from: OBI:0100056  ! immortalized cell line
disjoint_from: OBI:0100058  ! xenograft
disjoint_from: OBI:0100060  ! cell culture
disjoint_from: OBI:0100067  ! bronchial alveolar lavage
disjoint_from: OBI:0100069  ! polymer
disjoint_from: OBI:0100086  ! glucose in solution
disjoint_from: OBI:0302714  ! collection (of entities of organismal origin)
disjoint_from: OBI:0400102  ! waste tank
disjoint_from: OBI:1000023  ! cell culture supernatant
disjoint_from: OBI:1000024  ! cell pellet
disjoint_from: OBI:1000036  ! cell lysate
disjoint_from: OBI:1000042  ! peptide construct
disjoint_from: OBI:1000048  ! transgenic organism

[Instance]
id: OBI:0000245_11
name: U.S. Food and Drug Administration
instance_of: OBI:0000245  ! organization
instance_of: owl:Thing 
synonym: "FDA" EXACT []
relationship: OBI:0000316 OBI:0000014_1 ! the regulator role of the FDA

[Term]
id: OBI:0000248
name: feed role
def: "Feed role is a role that inheres in a material entity and is realized in the use of that material entity by lab animal to provide all needed nourishment." []
is_a: OBI:0000162  ! complete nutrient role
disjoint_from: OBI:0000079  ! culture medium role

[Term]
id: OBI:0000249
name: technical replicate role
def: "technical replicate role is realized when two portions from one evaluant are used in replicate runs of an assay" []
is_a: OBI:0000220  ! reference subject role
disjoint_from: OBI:0000143  ! baseline participant role
disjoint_from: OBI:0000161  ! crossover population role
disjoint_from: OBI:0000198  ! biological replicate role

[Term]
id: OBI:0000250
name: dye role
def: "Label role is a reagent role where the bearer is a material entity and which is realized in the process of dyeing or imparting color to a target material" []
is_a: OBI:0000140  ! label role
disjoint_from: OBI:0000163  ! radiolabel role

[Term]
id: OBI:0000251
name: cluster
def: "A data cluster is a data set which is a subset of data that are a similar to each other in some way." []
is_a: IAO:0000100 
disjoint_from: OBI:0000118  ! gene list

[Term]
id: OBI:0000252
name: cohort role
def: "a cohort role is a biological replicate role played by a group of study participants who share a common characteristic of interest to the study." []
is_a: OBI:0000198  ! biological replicate role

[Term]
id: OBI:0000253
name: artificially induced nucleic acid hybridization
def: "Is a material transformation in which strands of nucleic acids that are (somewhat) complementary form a double-stranded molecule. Has input at least two single stranded molecules of nucleic acid molecules." []
is_a: OBI:0000094  ! material processing
relationship: OBI:0000417 OBI:0000456 ! material transformation objective

[Term]
id: OBI:0000257
name: DNA extraction
def: "A DNA extraction is a nucleic acid extraction where the desired output material is DNA." []
is_a: OBI:0666667  ! nucleic acid extraction
disjoint_from: OBI:0666666  ! RNA extraction

[Term]
id: OBI:0000260
name: plan
def: "A plan is a realizable entity that is the inheres in a bearer who is committed to realizing it as a planned process." []
is_a: snap:RealizableEntity 

[Term]
id: OBI:0000264
name: sample population
def: "A sample population is an object aggregate that is selected from the population, e.g. the fish in the net that were sampled from the lake, the people that responded to the call for volunteers." []
synonym: "recruited population" EXACT []
is_a: OBI:0000181  ! population

[Term]
id: OBI:0000268
name: organism feature identification objective
def: "Organism_feature_identification_objective is a biological_feature_identification_objective role describing a study designed to examine or characterize a biological feature monitored at the level of the organism, e.g. height, weight, stage of development, stage of life cycle." []
is_a: OBI:0000015  ! biological feature identification objective
disjoint_from: OBI:0000113  ! sequence feature identification objective
disjoint_from: OBI:0000131  ! molecular feature identification objective
disjoint_from: OBI:0000219  ! cellular feature identification objective

[Term]
id: OBI:0000269
name: number of lost events computer
def: "A number of lost events is a datum recording the number of measurement events lost due to overloading of the analysis chip in a flow cytometer instrument. The datum has a qualitative role" []
is_a: IAO:0000109 
disjoint_from: OBI:0000010  ! fluorescent reporter intensity
disjoint_from: OBI:0000054  ! ratio of collected to emitted light
disjoint_from: OBI:0000101  ! measured expression level
disjoint_from: OBI:0000119  ! number of particles in subset
disjoint_from: OBI:0000125  ! number of lost events electronic
disjoint_from: OBI:0000172  ! parameter threshold
disjoint_from: OBI:0000789  ! survival rate
disjoint_from: OBI:0000801  ! spike train datum

[Term]
id: OBI:0000272
name: protocol
def: "a protocol is a plan specification which has sufficient level of detail and quantitative information to communicate it between domain experts, so that different domain experts will reliably be able to independently reproduce the process." []
is_a: IAO:0000104 
relationship: OBO_REL:has_part IAO:0000005
disjoint_from: OBI:0500000  ! study design

[Term]
id: OBI:0000273
name: role of regulator of consumables and medical devices
def: "A regulator of consumables and medical devices is a regulator involved with making and enforcing legislation and governmental orders relevant to the development, testing, manufacture and use of food, drugs and medical devices" []
is_a: OBI:0000014  ! regulator role
disjoint_from: OBI:0000089  ! role of regulator of chemical manufacturer
disjoint_from: OBI:0000154  ! role of Institutional Review Board

[Term]
id: OBI:0000274
name: adding a material entity into a target
def: "is a process with the objective to place a material entity bearing the 'material to be added role' into a material bearing the 'target of material addition role'." []
is_a: OBI:0000652  ! material combination
relationship: OBI:0000308 OBI:0000319 ! material to be added role
relationship: OBI:0000308 OBI:0000444 ! target of material addition role

[Term]
id: OBI:0000275
name: analyte role
def: "Analyte role is a role borne by a molecular entity and realized in an analyte assay which achieves the objective to measure the magnitude/concentration/amount of the analyte in the entity bearing evaluant role" []
is_a: snap:Role 
disjoint_from: OBI:0000017  ! regulatory role
disjoint_from: OBI:0000025  ! reference substance role
disjoint_from: OBI:0000029  ! centrifuge pellet role
disjoint_from: OBI:0000034  ! supernatant role
disjoint_from: OBI:0000040  ! drug role
disjoint_from: OBI:0000067  ! evaluant role
disjoint_from: OBI:0000086  ! reagent role
disjoint_from: OBI:0000091  ! detector reagent role
disjoint_from: OBI:0000093  ! patient role
disjoint_from: OBI:0000097  ! study subject role
disjoint_from: OBI:0000112  ! specimen role
disjoint_from: OBI:0000140  ! label role
disjoint_from: OBI:0000174  ! study group role
disjoint_from: OBI:0000204  ! nutrient role
disjoint_from: OBI:0000237  ! antigen role
disjoint_from: OBI:0000319  ! material to be added role
disjoint_from: OBI:0000405  ! primer role
disjoint_from: OBI:0000416  ! cloning insert role
disjoint_from: OBI:0000444  ! target of material addition role
disjoint_from: OBI:0000571  ! manufacturer role
disjoint_from: OBI:0000718  ! pathogen role
disjoint_from: OBI:0000720  ! adjuvent role
disjoint_from: OBI:0000725  ! host role
disjoint_from: OBI:0000847  ! test substance role
disjoint_from: OBI:0302731  ! buffer role
disjoint_from: OBI:0302732  ! solvent role
disjoint_from: OBI:0302733  ! solute role
disjoint_from: OBI:1110082  ! immunogen role
disjoint_from: OBI:1110083  ! host of immune response role
disjoint_from: OBI:1110086  ! restricting MHC role
disjoint_from: OBI:1110087  ! donor
disjoint_from: OBI:1110091  ! carrier role
disjoint_from: OBI:1110092  ! adjuvant role
disjoint_from: OBI:1110120  ! assay antigen role

[Term]
id: OBI:0000278
name: disease stage
def: "a part of an occurrence of a disease process which is associated with position in the normal progression of the disease" []
is_a: span:ProcessualEntity 
relationship: OBO_REL:part_of OBI:1110002 ! occurrence of disease

[Term]
id: OBI:0000281
name: intraperitoneal injection
def: "is the injection of a material entity (bearing the administered substance role) into the peritoneum (bearing the target role) of an organism using a syringe" []
is_a: OBI:0000426  ! injection
is_a: OBI:0000429  ! intraperitoneal administration
relationship: OBI:0000417 OBI:0000434 ! adding material objective

[Term]
id: OBI:0000286
name: precipitate
def: "a precipitate is a material entity which is output of a precipitation process" []
synonym: "precipited material" EXACT []
is_a: OBI:0000047  ! processed material
relationship: OBI:0000312 OBI:0600034 ! precipitation

[Term]
id: OBI:0000288
name: protein-protein interaction detection
def: "An assay with the objective to determine interactions between proteins, such as protein-protein binding." []
is_a: OBI:0000011  ! planned process

[Term]
id: OBI:0000291
name: transcription factor binding site  identification
def: "a planned process with objective to find DNA region specifically recognized by proteins that function as transcription factors" []
is_a: OBI:0000011  ! planned process

[Typedef]
id: OBI:0000293
name: has_specified_input
def: "A relation between a planned process and a continuant participating in that process that is not created during  the process. The presence of the continuant during the process is explicitly specified in the plan specification which the process realizes the concretization of." []
is_a: OBO_REL:has_participant 

[Typedef]
id: OBI:0000294
name: is_concretization_of
def: "Is a relationship between a generically dependent continuant and a specifically dependent continuant. A generically dependent continuant may inhere in more than one entity. It does so by virtue of the fact that there is, for each entity that it inheres, a specifically dependent *concretization* of the generically dependent continuant that is specifically dependent. For instance, consider a story, which is an information artifact that inheres in some number of books. Each book bears some quality that carries the story. The relation between this quality and the generically dependent continuant is that the former is the concretization of the latter." []

[Typedef]
id: OBI:0000295
name: is_specified_input_of
def: "A relation between a planned process and a continuant participating in that process that is not created during  the process. The presence of the continuant during the process is explicitly specified in the plan specification which the process realizes the concretization of." []
inverse_of_on_instance_level: OBI:0000293  ! has_specified_input
is_a: OBO_REL:participates_in 

[Term]
id: OBI:0000296
name: enrollment
def: "enrollment is a process of identifying a set of objects for further use in an investigation based on a set of criteria or rules" []
is_a: OBI:0000011  ! planned process
relationship: OBI:0000293 OBI:0100026 ! organism
relationship: OBI:0000299 OBI:0100026 ! organism

[Typedef]
id: OBI:0000297
name: is_concretized_as
def: "Is a relationship between a specifically dependent continuant and a generically dependent continuant. A generically dependent continuant may inhere in more than one entity. It does so by virtue of the fact that there is, for each entity that it inheres, a specifically dependent *concretization* of the generically dependent continuant that is specifically dependent. For instance, consider a story, which is an information artifact that inheres in some number of books. Each book bears some quality that carries the story. The relation between this quality and the generically dependent continuant is that the former is the concretization of the latter." []
inverse_of_on_instance_level: OBI:0000294  ! is_concretization_of

[Typedef]
id: OBI:0000298
name: has_quality
def: "A relation between an entity and a quality. For types: E has_quality Q iff: \nfor any eEt, exists qQt such that q inheres_in e at t. \nFor instances: e has_quality q at t iff q inheres_in e at t and q instance-of Quality [GOC:cjm]" []
inverse_of_on_instance_level: http://purl.org/obo/owl/OBO_REL#quality_of  ! quality_of
is_a: http://purl.org/obo/owl/OBO_REL#bearer_of  ! bearer_of

[Typedef]
id: OBI:0000299
name: has_specified_output
def: "A relation between a planned process and a continuant participating in that process. The presence of the continuant at the end of the process is explicitly specified in the objective specification which the process realizes the concretization of." []
inverse_of_on_instance_level: OBI:0000312  ! is_specified_output_of
is_a: OBO_REL:has_participant 

[Typedef]
id: OBI:0000300
name: is_realized_by
def: "Relation between a realizable and a process. Reciprocal relation of realizes [GOC:cjm]" []
synonym: "executed_during" EXACT []
synonym: "has_realization" EXACT []
synonym: "is_realized_as" EXACT []

[Typedef]
id: OBI:0000304
name: is_manufactured_by
def: "c is_manufactured_by o means that there was a process p in which c was built in which a person, or set of people or machines did the work(bore the \"Manufacturer Role\", and those people/and or machines were members or of directed by the organization to do this." []
synonym: "has_make" EXACT []
synonym: "has_manufacturer" EXACT []

[Typedef]
id: OBI:0000306
name: has_function
def: "Relation between an independent continuant and a function." []
inverse_of_on_instance_level: http://purl.org/obo/owl/OBO_REL#function_of  ! function_of
is_a: http://purl.org/obo/owl/OBO_REL#bearer_of  ! bearer_of

[Typedef]
id: OBI:0000308
name: realizes
def: "Relation between a process and a function, where the unfolding of the \nprocess requires the execution of the function. Class level: P realizes F iff: \ngiven any p that instantiates P, there exists some f, t such that f instantiates\n F at t and p *realizes* f. Here, *realizes* is the primitive \ninstance level relation [GOC:cjm]" []
inverse_of_on_instance_level: OBI:0000300  ! is_realized_by
synonym: "executes" EXACT []
synonym: "has_function_part" EXACT []
synonym: "involves_execution_of" EXACT []
synonym: "is_realization_of" EXACT []

[Term]
id: OBI:0000310
name: adverse event trigger
def: "revisit?" []
is_a: IAO:0000001 

[Typedef]
id: OBI:0000312
name: is_specified_output_of
def: "A relation between a planned process and a continuant participating in that process. The presence of the continuant at the end of the process is explicitly specified in the objective specification which the process realizes the concretization of." []
is_a: OBO_REL:participates_in 

[Typedef]
id: OBI:0000314
name: is_proxy_for
def: "A relation between continuant instances c1 and c2 where within an experiment/ protocol application,  measurement of c1 is used to determine what a measurement of c2 would be." []

[Typedef]
id: OBI:0000316
name: has_role
def: "A relation between a continuant C and a role R. The reciprocal relation of role_of." []
inverse_of_on_instance_level: http://purl.org/obo/owl/OBO_REL#role_of  ! role_of
is_a: http://purl.org/obo/owl/OBO_REL#bearer_of  ! bearer_of

[Instance]
id: OBI:0000317
name: Transformation-ML
instance_of: IAO:0000098 
instance_of: owl:Thing 

[Term]
id: OBI:0000318
name: eluate
def: "a eluate is a material entity which results from an elution, e.g. from a chromatography column. it has as part a material entity with role mobile phase" []
synonym: "eluted material" EXACT []
is_a: OBI:0000047  ! processed material
relationship: OBI:0000312 OBI:0302905 ! elution
disjoint_from: OBI:0000050  ! platform
disjoint_from: OBI:0000146  ! supernatant collection system harvesting frame
disjoint_from: OBI:0000245  ! organization
disjoint_from: OBI:0000390  ! thermostatic circulator
disjoint_from: OBI:0000420  ! trypsinized material
disjoint_from: OBI:0000432  ! polyacrylamide gel
disjoint_from: OBI:0000439  ! agarose gel
disjoint_from: OBI:0000576  ! scattered molecular aggregate
disjoint_from: OBI:0000651  ! urine specimen
disjoint_from: OBI:0000655  ! blood specimen
disjoint_from: OBI:0000680  ! whole organism preparation
disjoint_from: OBI:0000798  ! capsule shell
disjoint_from: OBI:0000814  ! guar gum
disjoint_from: OBI:0100014  ! chimera
disjoint_from: OBI:0100016  ! blood plasma
disjoint_from: OBI:0100017  ! blood serum specimen
disjoint_from: OBI:0100039  ! fragment derived from protein
disjoint_from: OBI:0100055  ! cell line cell
disjoint_from: OBI:0100056  ! immortalized cell line
disjoint_from: OBI:0100058  ! xenograft
disjoint_from: OBI:0100060  ! cell culture
disjoint_from: OBI:0100067  ! bronchial alveolar lavage
disjoint_from: OBI:0100069  ! polymer
disjoint_from: OBI:0100086  ! glucose in solution
disjoint_from: OBI:0302714  ! collection (of entities of organismal origin)
disjoint_from: OBI:0400102  ! waste tank
disjoint_from: OBI:1000023  ! cell culture supernatant
disjoint_from: OBI:1000024  ! cell pellet
disjoint_from: OBI:1000036  ! cell lysate
disjoint_from: OBI:1000042  ! peptide construct
disjoint_from: OBI:1000048  ! transgenic organism

[Term]
id: OBI:0000319
name: material to be added role
def: "material to be added role is a protocol participant role realized by a material which is added into a material bearing the target of material addition role in a material addition process" []
is_a: snap:Role 
disjoint_from: OBI:0000017  ! regulatory role
disjoint_from: OBI:0000025  ! reference substance role
disjoint_from: OBI:0000029  ! centrifuge pellet role
disjoint_from: OBI:0000034  ! supernatant role
disjoint_from: OBI:0000040  ! drug role
disjoint_from: OBI:0000067  ! evaluant role
disjoint_from: OBI:0000086  ! reagent role
disjoint_from: OBI:0000091  ! detector reagent role
disjoint_from: OBI:0000093  ! patient role
disjoint_from: OBI:0000097  ! study subject role
disjoint_from: OBI:0000112  ! specimen role
disjoint_from: OBI:0000140  ! label role
disjoint_from: OBI:0000174  ! study group role
disjoint_from: OBI:0000204  ! nutrient role
disjoint_from: OBI:0000237  ! antigen role
disjoint_from: OBI:0000275  ! analyte role
disjoint_from: OBI:0000405  ! primer role
disjoint_from: OBI:0000416  ! cloning insert role
disjoint_from: OBI:0000444  ! target of material addition role
disjoint_from: OBI:0000571  ! manufacturer role
disjoint_from: OBI:0000718  ! pathogen role
disjoint_from: OBI:0000720  ! adjuvent role
disjoint_from: OBI:0000725  ! host role
disjoint_from: OBI:0000847  ! test substance role
disjoint_from: OBI:0302731  ! buffer role
disjoint_from: OBI:0302732  ! solvent role
disjoint_from: OBI:0302733  ! solute role
disjoint_from: OBI:1110082  ! immunogen role
disjoint_from: OBI:1110083  ! host of immune response role
disjoint_from: OBI:1110086  ! restricting MHC role
disjoint_from: OBI:1110087  ! donor
disjoint_from: OBI:1110091  ! carrier role
disjoint_from: OBI:1110092  ! adjuvant role
disjoint_from: OBI:1110120  ! assay antigen role

[Instance]
id: OBI:0000321
name: ACS
instance_of: IAO:0000098 
instance_of: owl:Thing 

[Instance]
id: OBI:0000322
name: XML
instance_of: IAO:0000098 
instance_of: owl:Thing 

[Term]
id: OBI:0000323
name: peritoneum
def: "is the serous membrane that forms the lining of the abdominal cavity" []
is_a: CARO:0000055  ! multi-tissue structure
disjoint_from: OBI:0000442  ! heart
disjoint_from: OBI:0302743  ! liver
disjoint_from: OBI:0302745  ! adipose tissue

[Instance]
id: OBI:0000324
name: RDF
instance_of: IAO:0000098 
instance_of: owl:Thing 

[Instance]
id: OBI:0000325
name: zip
instance_of: IAO:0000098 
instance_of: owl:Thing 

[Instance]
id: OBI:0000326
name: tar
instance_of: IAO:0000098 
instance_of: owl:Thing 

[Instance]
id: OBI:0000327
name: FCS
instance_of: IAO:0000098 
instance_of: owl:Thing 

[Instance]
id: OBI:0000329
name: Compensation-ML
instance_of: IAO:0000098 
instance_of: owl:Thing 

[Instance]
id: OBI:0000330
name: Gating-ML
instance_of: IAO:0000098 
instance_of: owl:Thing 

[Instance]
id: OBI:0000332
name: OWL
instance_of: IAO:0000098 
instance_of: owl:Thing 

[Term]
id: OBI:0000338
name: interpreting data
def: "the process of evaluating the data gathered in an investigation in the context of literature knowledge with the objective to generate more general conclusions or to identify what additional data is necessary to draw conclusions" []
is_a: OBI:0000011  ! planned process

[Term]
id: OBI:0000339
name: planning
def: "a process of creating or modifying a plan." []
is_a: OBI:0000011  ! planned process
disjoint_from: OBI:0000070  ! assay

[Term]
id: OBI:0000340
name: documenting
def: "a planned process of capturing information in an enduring form with the intent to communicate this information" []
is_a: OBI:0000011  ! planned process
relationship: OBI:0000293 IAO:0000030
relationship: OBI:0000299 IAO:0000030

[Term]
id: OBI:0000341
name: histological sample preparation
def: "histological sample preparation is the preparation of an input tissue via slicing and labeling to make tissue microstructure of interest visible in a future histology assay" []
is_a: OBI:0000094  ! material processing
relationship: OBI:0000293 OBI:0100066 ! organ section
relationship: OBI:0000417 OBI:0000456 ! material transformation objective
relationship: OBI:0000417 OBI:0000684 ! specimen creation objective
relationship: OBO_REL:has_participant OBI:0400168 ! microtome

[Term]
id: OBI:0000343
name: inductive reasoning
def: "It is used to ascribe properties or relations to types based on an observation instance (i.e., on a number of observations or experiences); or to formulate laws based on limited observations of recurring phenomenal patterns." []
is_a: OBI:0000338  ! interpreting data

[Term]
id: OBI:0000345
name: mass analyzer
def: "A Mass analyzer is a device that separates ions according to their mass-to-charge ratio. All mass spectrometers are based on dynamics of charged particles in electric and magnetic fields in vacuum where the two laws of Lorentz force law and Newton's second law of motion apply." []
is_a: OBI:0000832  ! measurement device
relationship: OBI:0000306 OBI:0000372 ! separation function
relationship: OBI:0000306 OBI:0000453 ! measure function

[Term]
id: OBI:0000355
name: hypothesis driven investigation
def: "is an investigation with the goal to test one or more hypothesis" []
is_a: OBI:0000066  ! investigation
disjoint_from: OBI:0000356  ! hypothesis generating investigation

[Term]
id: OBI:0000356
name: hypothesis generating investigation
def: "is an investigation in which data is generated and analyzed with the purpose of generating new hypothesis" []
is_a: OBI:0000066  ! investigation
disjoint_from: OBI:0000355  ! hypothesis driven investigation

[Term]
id: OBI:0000361
name: ion source
def: "An ion source is a device that is part of a mass\nspectrometer that ionizes the material under analysis. The ions are\nthen transported by magnetic or electric fields to the mass analyzer.\nTechniques for ionization have been key to determining what types of\nsamples can be analyzed by mass spectrometry. Electron ionization and\nchemical ionization are used for gases and vapors. In chemical\nionization sources, the material is ionized by chemical ion-molecule\nreactions during collisions in the source. Two techniques often used\nwith liquid and solid biological samples include electrospray\nionization (due to John Fenn PMID 2675315.) and matrix-assisted laser\ndesorption/ionization (MALDI, due to M. Karas and F. Hillenkamp\n(Measuring Mass: From Positive Rays to Proteins by Michael A. Grayson\n(Editor) (ISBN 0-941901-31-9)))." []
is_a: OBI:0000047  ! processed material
relationship: OBI:0000306 OBI:0000385 ! ionization function

[Term]
id: OBI:0000364
name: ion detector
def: "An ion detector is a device that measures and records\nthe charge induced or current produced when an ion passes by or hits a\nsurface. In a scanning instrument the signal produced in the detector\nduring the course of the scan versus where the instrument is in the\nscan (at what m/Q) will produce a mass spectrum, a record of ions as a\nfunction of m/Q." []
is_a: OBI:0000832  ! measurement device
relationship: OBI:0000306 OBI:0000453 ! measure function

[Typedef]
id: OBI:0000365
name: results_from

[Term]
id: OBI:0000366
name: metabolite profiling
def: "metabolite profiling is a process which aims at detecting and identifying chemical entities resulting from biochemical and cellular metabolism" []
is_a: OBI:0000070  ! assay
relationship: OBI:0000293 OBI:0100051 ! specimen
relationship: OBI:0000299 IAO:0000109
relationship: OBI:0000417 OBI:0000441 ! assay objective

[Term]
id: OBI:0000367
name: light emission function
def: "A light emission function is an excitation function to excite a material to a specific excitation state that it emits light." []
is_a: OBI:0000374  ! excitation function

[Term]
id: OBI:0000368
name: record function
def: "A record function is a function that registers or collects information in a particular format on a particular recording medium. For example on paper or a digital representation" []
is_a: snap:Function 
disjoint_from: OBI:0000369  ! magnify function
disjoint_from: OBI:0000370  ! contain function
disjoint_from: OBI:0000371  ! heat function
disjoint_from: OBI:0000372  ! separation function
disjoint_from: OBI:0000374  ! excitation function
disjoint_from: OBI:0000375  ! freeze function
disjoint_from: OBI:0000376  ! synthesizing function
disjoint_from: OBI:0000377  ! perturbe function
disjoint_from: OBI:0000379  ! mechanical function
disjoint_from: OBI:0000383  ! transfer function
disjoint_from: OBI:0000385  ! ionization function
disjoint_from: OBI:0000387  ! cool function
disjoint_from: OBI:0000388  ! connection function
disjoint_from: OBI:0000391  ! energy supply function
disjoint_from: OBI:0000392  ! information processor function
disjoint_from: OBI:0000401  ! environment control function
disjoint_from: OBI:0000403  ! sort function
disjoint_from: OBI:0000453  ! measure function
disjoint_from: OBI:0000455  ! consume data function
disjoint_from: OBI:0005246  ! injection function
disjoint_from: OBI:1110016  ! adaptive immune effector function
disjoint_from: OBI:1110085  ! antigen presentation function

[Term]
id: OBI:0000369
name: magnify function
def: "A magnify function is a function to increase the size of a transmitted object image through the precise arrangement of energy diffraction elements along an imaging path." []
is_a: snap:Function 
disjoint_from: OBI:0000368  ! record function
disjoint_from: OBI:0000370  ! contain function
disjoint_from: OBI:0000371  ! heat function
disjoint_from: OBI:0000372  ! separation function
disjoint_from: OBI:0000374  ! excitation function
disjoint_from: OBI:0000375  ! freeze function
disjoint_from: OBI:0000376  ! synthesizing function
disjoint_from: OBI:0000377  ! perturbe function
disjoint_from: OBI:0000379  ! mechanical function
disjoint_from: OBI:0000383  ! transfer function
disjoint_from: OBI:0000385  ! ionization function
disjoint_from: OBI:0000387  ! cool function
disjoint_from: OBI:0000388  ! connection function
disjoint_from: OBI:0000391  ! energy supply function
disjoint_from: OBI:0000392  ! information processor function
disjoint_from: OBI:0000401  ! environment control function
disjoint_from: OBI:0000403  ! sort function
disjoint_from: OBI:0000453  ! measure function
disjoint_from: OBI:0000455  ! consume data function
disjoint_from: OBI:0005246  ! injection function
disjoint_from: OBI:1110016  ! adaptive immune effector function
disjoint_from: OBI:1110085  ! antigen presentation function

[Term]
id: OBI:0000370
name: contain function
def: "A contain function is a function to bound or constrain some quantity of material in some space" []
is_a: snap:Function 
disjoint_from: OBI:0000368  ! record function
disjoint_from: OBI:0000369  ! magnify function
disjoint_from: OBI:0000371  ! heat function
disjoint_from: OBI:0000372  ! separation function
disjoint_from: OBI:0000374  ! excitation function
disjoint_from: OBI:0000375  ! freeze function
disjoint_from: OBI:0000376  ! synthesizing function
disjoint_from: OBI:0000377  ! perturbe function
disjoint_from: OBI:0000379  ! mechanical function
disjoint_from: OBI:0000383  ! transfer function
disjoint_from: OBI:0000385  ! ionization function
disjoint_from: OBI:0000387  ! cool function
disjoint_from: OBI:0000388  ! connection function
disjoint_from: OBI:0000391  ! energy supply function
disjoint_from: OBI:0000392  ! information processor function
disjoint_from: OBI:0000401  ! environment control function
disjoint_from: OBI:0000403  ! sort function
disjoint_from: OBI:0000453  ! measure function
disjoint_from: OBI:0000455  ! consume data function
disjoint_from: OBI:0005246  ! injection function
disjoint_from: OBI:1110016  ! adaptive immune effector function
disjoint_from: OBI:1110085  ! antigen presentation function

[Term]
id: OBI:0000371
name: heat function
def: "A heat function is a function that increases the internal kinetic energy of a material" []
is_a: snap:Function 
disjoint_from: OBI:0000368  ! record function
disjoint_from: OBI:0000369  ! magnify function
disjoint_from: OBI:0000370  ! contain function
disjoint_from: OBI:0000372  ! separation function
disjoint_from: OBI:0000374  ! excitation function
disjoint_from: OBI:0000375  ! freeze function
disjoint_from: OBI:0000376  ! synthesizing function
disjoint_from: OBI:0000377  ! perturbe function
disjoint_from: OBI:0000379  ! mechanical function
disjoint_from: OBI:0000383  ! transfer function
disjoint_from: OBI:0000385  ! ionization function
disjoint_from: OBI:0000387  ! cool function
disjoint_from: OBI:0000388  ! connection function
disjoint_from: OBI:0000391  ! energy supply function
disjoint_from: OBI:0000392  ! information processor function
disjoint_from: OBI:0000401  ! environment control function
disjoint_from: OBI:0000403  ! sort function
disjoint_from: OBI:0000453  ! measure function
disjoint_from: OBI:0000455  ! consume data function
disjoint_from: OBI:0005246  ! injection function
disjoint_from: OBI:1110016  ! adaptive immune effector function
disjoint_from: OBI:1110085  ! antigen presentation function

[Term]
id: OBI:0000372
name: separation function
def: "A separation function is a function that increases the resolution between two or more material entities. The  to distinction between the entities is usually based on some associated physical quality." []
is_a: snap:Function 
disjoint_from: OBI:0000368  ! record function
disjoint_from: OBI:0000369  ! magnify function
disjoint_from: OBI:0000370  ! contain function
disjoint_from: OBI:0000371  ! heat function
disjoint_from: OBI:0000374  ! excitation function
disjoint_from: OBI:0000375  ! freeze function
disjoint_from: OBI:0000376  ! synthesizing function
disjoint_from: OBI:0000377  ! perturbe function
disjoint_from: OBI:0000379  ! mechanical function
disjoint_from: OBI:0000383  ! transfer function
disjoint_from: OBI:0000385  ! ionization function
disjoint_from: OBI:0000387  ! cool function
disjoint_from: OBI:0000388  ! connection function
disjoint_from: OBI:0000391  ! energy supply function
disjoint_from: OBI:0000392  ! information processor function
disjoint_from: OBI:0000401  ! environment control function
disjoint_from: OBI:0000403  ! sort function
disjoint_from: OBI:0000453  ! measure function
disjoint_from: OBI:0000455  ! consume data function
disjoint_from: OBI:0005246  ! injection function
disjoint_from: OBI:1110016  ! adaptive immune effector function
disjoint_from: OBI:1110085  ! antigen presentation function

[Term]
id: OBI:0000373
name: ionize process
def: "The physical process of converting an atom or molecule into an ion by adding or removing charged particles such as electrons or other ions. This excludes chemical processes of dissociation." []
is_a: OBI:0000094  ! material processing
relationship: OBI:0000308 OBI:0000385 ! ionization function
relationship: OBI:0000417 OBI:0000456 ! material transformation objective
relationship: OBO_REL:has_participant snap:Continuant

[Term]
id: OBI:0000374
name: excitation function
def: "A excitation function is a function  to inject energy by bombarding a material with energetic particles (e.g., photons) thereby imbuing internal material components such as electrons with additional energy.  These internal, 'excited' particles may lead to the rupturing of covalent chemical bonds or may quickly relax back to there unexcited state with an exponential time course thereby locally emitting energy in the form of photons." []
is_a: snap:Function 
disjoint_from: OBI:0000368  ! record function
disjoint_from: OBI:0000369  ! magnify function
disjoint_from: OBI:0000370  ! contain function
disjoint_from: OBI:0000371  ! heat function
disjoint_from: OBI:0000372  ! separation function
disjoint_from: OBI:0000375  ! freeze function
disjoint_from: OBI:0000376  ! synthesizing function
disjoint_from: OBI:0000377  ! perturbe function
disjoint_from: OBI:0000379  ! mechanical function
disjoint_from: OBI:0000383  ! transfer function
disjoint_from: OBI:0000385  ! ionization function
disjoint_from: OBI:0000387  ! cool function
disjoint_from: OBI:0000388  ! connection function
disjoint_from: OBI:0000391  ! energy supply function
disjoint_from: OBI:0000392  ! information processor function
disjoint_from: OBI:0000401  ! environment control function
disjoint_from: OBI:0000403  ! sort function
disjoint_from: OBI:0000453  ! measure function
disjoint_from: OBI:0000455  ! consume data function
disjoint_from: OBI:0005246  ! injection function
disjoint_from: OBI:1110016  ! adaptive immune effector function
disjoint_from: OBI:1110085  ! antigen presentation function

[Term]
id: OBI:0000375
name: freeze function
def: "A freeze function is a function to decrease the internal kinetic energy of a material below the freezing point of that type of material." []
is_a: snap:Function 
disjoint_from: OBI:0000368  ! record function
disjoint_from: OBI:0000369  ! magnify function
disjoint_from: OBI:0000370  ! contain function
disjoint_from: OBI:0000371  ! heat function
disjoint_from: OBI:0000372  ! separation function
disjoint_from: OBI:0000374  ! excitation function
disjoint_from: OBI:0000376  ! synthesizing function
disjoint_from: OBI:0000377  ! perturbe function
disjoint_from: OBI:0000379  ! mechanical function
disjoint_from: OBI:0000383  ! transfer function
disjoint_from: OBI:0000385  ! ionization function
disjoint_from: OBI:0000387  ! cool function
disjoint_from: OBI:0000388  ! connection function
disjoint_from: OBI:0000391  ! energy supply function
disjoint_from: OBI:0000392  ! information processor function
disjoint_from: OBI:0000401  ! environment control function
disjoint_from: OBI:0000403  ! sort function
disjoint_from: OBI:0000453  ! measure function
disjoint_from: OBI:0000455  ! consume data function
disjoint_from: OBI:0005246  ! injection function
disjoint_from: OBI:1110016  ! adaptive immune effector function
disjoint_from: OBI:1110085  ! antigen presentation function

[Term]
id: OBI:0000376
name: synthesizing function
def: "A synthesizing function is a function to assemble new output materials from distinct input materials.  The output materials typically consist of chemically distinct monomeric objects or object aggregate polymers." []
is_a: snap:Function 
disjoint_from: OBI:0000368  ! record function
disjoint_from: OBI:0000369  ! magnify function
disjoint_from: OBI:0000370  ! contain function
disjoint_from: OBI:0000371  ! heat function
disjoint_from: OBI:0000372  ! separation function
disjoint_from: OBI:0000374  ! excitation function
disjoint_from: OBI:0000375  ! freeze function
disjoint_from: OBI:0000377  ! perturbe function
disjoint_from: OBI:0000379  ! mechanical function
disjoint_from: OBI:0000383  ! transfer function
disjoint_from: OBI:0000385  ! ionization function
disjoint_from: OBI:0000387  ! cool function
disjoint_from: OBI:0000388  ! connection function
disjoint_from: OBI:0000391  ! energy supply function
disjoint_from: OBI:0000392  ! information processor function
disjoint_from: OBI:0000401  ! environment control function
disjoint_from: OBI:0000403  ! sort function
disjoint_from: OBI:0000453  ! measure function
disjoint_from: OBI:0000455  ! consume data function
disjoint_from: OBI:0005246  ! injection function
disjoint_from: OBI:1110016  ! adaptive immune effector function
disjoint_from: OBI:1110085  ! antigen presentation function

[Term]
id: OBI:0000377
name: perturbe function
def: "A perturbe function is a function that disrupts the normal function of a system induced through either internal or external means.  External means of perturbation include: (1) displacement fields in the physical sense - e.g., temperature change, osmotic shock, pressure change; (2) application of small molecules such as drugs or toxins to perturb the function of specific pathways or application of surfactants to perturb the normal function of plasma membrane.  Internal means of perturbation include: (1) manipulation of gene function via gene knockout or transcript knockdown via RNAi; (2) directed genetic mutation leading to minimal aa alterations that interfere with peptide function." []
is_a: snap:Function 
disjoint_from: OBI:0000368  ! record function
disjoint_from: OBI:0000369  ! magnify function
disjoint_from: OBI:0000370  ! contain function
disjoint_from: OBI:0000371  ! heat function
disjoint_from: OBI:0000372  ! separation function
disjoint_from: OBI:0000374  ! excitation function
disjoint_from: OBI:0000375  ! freeze function
disjoint_from: OBI:0000376  ! synthesizing function
disjoint_from: OBI:0000379  ! mechanical function
disjoint_from: OBI:0000383  ! transfer function
disjoint_from: OBI:0000385  ! ionization function
disjoint_from: OBI:0000387  ! cool function
disjoint_from: OBI:0000388  ! connection function
disjoint_from: OBI:0000391  ! energy supply function
disjoint_from: OBI:0000392  ! information processor function
disjoint_from: OBI:0000401  ! environment control function
disjoint_from: OBI:0000403  ! sort function
disjoint_from: OBI:0000453  ! measure function
disjoint_from: OBI:0000455  ! consume data function
disjoint_from: OBI:0005246  ! injection function
disjoint_from: OBI:1110016  ! adaptive immune effector function
disjoint_from: OBI:1110085  ! antigen presentation function

[Term]
id: OBI:0000378
name: filter function
def: "A filter function is a function to prevent the flow of certain entities based on a quality or qualities of the entity while allowing entities which have different qualities to pass through" []
is_a: OBI:0000372  ! separation function

[Term]
id: OBI:0000379
name: mechanical function
def: "A mechanical function is a function that is realised via mechanical work (through an certain amount of energy transferred by some force." []
is_a: snap:Function 
disjoint_from: OBI:0000368  ! record function
disjoint_from: OBI:0000369  ! magnify function
disjoint_from: OBI:0000370  ! contain function
disjoint_from: OBI:0000371  ! heat function
disjoint_from: OBI:0000372  ! separation function
disjoint_from: OBI:0000374  ! excitation function
disjoint_from: OBI:0000375  ! freeze function
disjoint_from: OBI:0000376  ! synthesizing function
disjoint_from: OBI:0000377  ! perturbe function
disjoint_from: OBI:0000383  ! transfer function
disjoint_from: OBI:0000385  ! ionization function
disjoint_from: OBI:0000387  ! cool function
disjoint_from: OBI:0000388  ! connection function
disjoint_from: OBI:0000391  ! energy supply function
disjoint_from: OBI:0000392  ! information processor function
disjoint_from: OBI:0000401  ! environment control function
disjoint_from: OBI:0000403  ! sort function
disjoint_from: OBI:0000453  ! measure function
disjoint_from: OBI:0000455  ! consume data function
disjoint_from: OBI:0005246  ! injection function
disjoint_from: OBI:1110016  ! adaptive immune effector function
disjoint_from: OBI:1110085  ! antigen presentation function

[Term]
id: OBI:0000380
name: gas filter function
def: "A gas filter function is a filter function which prevents the flow of solid objects, defined by specific qualities, in a gas-solid mixture" []
is_a: OBI:0000378  ! filter function
disjoint_from: OBI:0000381  ! liquid filter function

[Term]
id: OBI:0000381
name: liquid filter function
def: "A liquid filter function is a filter function which prevents the flow of solid objects, defined by specific qualities, in a liquid-solid mixture" []
is_a: OBI:0000378  ! filter function
disjoint_from: OBI:0000380  ! gas filter function

[Term]
id: OBI:0000383
name: transfer function
def: "A transfer function is a function to displace a material from one location to another." []
is_a: snap:Function 
disjoint_from: OBI:0000368  ! record function
disjoint_from: OBI:0000369  ! magnify function
disjoint_from: OBI:0000370  ! contain function
disjoint_from: OBI:0000371  ! heat function
disjoint_from: OBI:0000372  ! separation function
disjoint_from: OBI:0000374  ! excitation function
disjoint_from: OBI:0000375  ! freeze function
disjoint_from: OBI:0000376  ! synthesizing function
disjoint_from: OBI:0000377  ! perturbe function
disjoint_from: OBI:0000379  ! mechanical function
disjoint_from: OBI:0000385  ! ionization function
disjoint_from: OBI:0000387  ! cool function
disjoint_from: OBI:0000388  ! connection function
disjoint_from: OBI:0000391  ! energy supply function
disjoint_from: OBI:0000392  ! information processor function
disjoint_from: OBI:0000401  ! environment control function
disjoint_from: OBI:0000403  ! sort function
disjoint_from: OBI:0000453  ! measure function
disjoint_from: OBI:0000455  ! consume data function
disjoint_from: OBI:0005246  ! injection function
disjoint_from: OBI:1110016  ! adaptive immune effector function
disjoint_from: OBI:1110085  ! antigen presentation function

[Term]
id: OBI:0000384
name: electricity supply function
def: "An electricity supply function is an energy supply function to transfer electricity from one source to another, typically a consumer of the electricity." []
synonym: "power supply" EXACT []
is_a: OBI:0000391  ! energy supply function

[Term]
id: OBI:0000385
name: ionization function
def: "An ionization function is a function to physically convert an atom or molecule into an ion by adding or removing charged particles such as electrons or other ions." []
is_a: snap:Function 
disjoint_from: OBI:0000368  ! record function
disjoint_from: OBI:0000369  ! magnify function
disjoint_from: OBI:0000370  ! contain function
disjoint_from: OBI:0000371  ! heat function
disjoint_from: OBI:0000372  ! separation function
disjoint_from: OBI:0000374  ! excitation function
disjoint_from: OBI:0000375  ! freeze function
disjoint_from: OBI:0000376  ! synthesizing function
disjoint_from: OBI:0000377  ! perturbe function
disjoint_from: OBI:0000379  ! mechanical function
disjoint_from: OBI:0000383  ! transfer function
disjoint_from: OBI:0000387  ! cool function
disjoint_from: OBI:0000388  ! connection function
disjoint_from: OBI:0000391  ! energy supply function
disjoint_from: OBI:0000392  ! information processor function
disjoint_from: OBI:0000401  ! environment control function
disjoint_from: OBI:0000403  ! sort function
disjoint_from: OBI:0000453  ! measure function
disjoint_from: OBI:0000455  ! consume data function
disjoint_from: OBI:0005246  ! injection function
disjoint_from: OBI:1110016  ! adaptive immune effector function
disjoint_from: OBI:1110085  ! antigen presentation function

[Term]
id: OBI:0000387
name: cool function
def: "A cool function is a function to decrease the internal kinetic energy of a material below the initial kinetic energy of that type of material." []
is_a: snap:Function 
disjoint_from: OBI:0000368  ! record function
disjoint_from: OBI:0000369  ! magnify function
disjoint_from: OBI:0000370  ! contain function
disjoint_from: OBI:0000371  ! heat function
disjoint_from: OBI:0000372  ! separation function
disjoint_from: OBI:0000374  ! excitation function
disjoint_from: OBI:0000375  ! freeze function
disjoint_from: OBI:0000376  ! synthesizing function
disjoint_from: OBI:0000377  ! perturbe function
disjoint_from: OBI:0000379  ! mechanical function
disjoint_from: OBI:0000383  ! transfer function
disjoint_from: OBI:0000385  ! ionization function
disjoint_from: OBI:0000388  ! connection function
disjoint_from: OBI:0000391  ! energy supply function
disjoint_from: OBI:0000392  ! information processor function
disjoint_from: OBI:0000401  ! environment control function
disjoint_from: OBI:0000403  ! sort function
disjoint_from: OBI:0000453  ! measure function
disjoint_from: OBI:0000455  ! consume data function
disjoint_from: OBI:0005246  ! injection function
disjoint_from: OBI:1110016  ! adaptive immune effector function
disjoint_from: OBI:1110085  ! antigen presentation function

[Term]
id: OBI:0000388
name: connection function
def: "A connection function is a function to couple two or more flow channels so that material or signals can be transported from one set of channels to another." []
is_a: snap:Function 
disjoint_from: OBI:0000368  ! record function
disjoint_from: OBI:0000369  ! magnify function
disjoint_from: OBI:0000370  ! contain function
disjoint_from: OBI:0000371  ! heat function
disjoint_from: OBI:0000372  ! separation function
disjoint_from: OBI:0000374  ! excitation function
disjoint_from: OBI:0000375  ! freeze function
disjoint_from: OBI:0000376  ! synthesizing function
disjoint_from: OBI:0000377  ! perturbe function
disjoint_from: OBI:0000379  ! mechanical function
disjoint_from: OBI:0000383  ! transfer function
disjoint_from: OBI:0000385  ! ionization function
disjoint_from: OBI:0000387  ! cool function
disjoint_from: OBI:0000391  ! energy supply function
disjoint_from: OBI:0000392  ! information processor function
disjoint_from: OBI:0000401  ! environment control function
disjoint_from: OBI:0000403  ! sort function
disjoint_from: OBI:0000453  ! measure function
disjoint_from: OBI:0000455  ! consume data function
disjoint_from: OBI:0005246  ! injection function
disjoint_from: OBI:1110016  ! adaptive immune effector function
disjoint_from: OBI:1110085  ! antigen presentation function

[Term]
id: OBI:0000389
name: isoelectric focusing device
def: "An isoelectric focusing device is a device in which isoelectric focusing can be performed. An isoelectric focussing device had the function to contain and control the contained environment and transfer electrical energy from a power supply to a separation medium and the charged material to be separated." []
synonym: "isoelectric focusing unit" EXACT []
is_a: OBI:0000047  ! processed material
relationship: OBI:0000306 OBI:0000370 ! contain function
relationship: OBI:0000306 OBI:0000383 ! transfer function
relationship: OBI:0000306 OBI:0000401 ! environment control function
relationship: http://purl.org/obo/owl/OBO_REL#bearer_of OBI:0000654 ! device setting

[Term]
id: OBI:0000390
name: thermostatic circulator
def: "A thermostatic circulator is a device which cools or heats a circulating liquid. It has the function to contain control the contained environment and transfer energy from or to the circulating liquid" []
is_a: snap:MaterialEntity 
relationship: OBI:0000306 OBI:0000370 ! contain function
relationship: OBI:0000306 OBI:0000401 ! environment control function
disjoint_from: OBI:0000050  ! platform
disjoint_from: OBI:0000146  ! supernatant collection system harvesting frame
disjoint_from: OBI:0000245  ! organization
disjoint_from: OBI:0000318  ! eluate
disjoint_from: OBI:0000420  ! trypsinized material
disjoint_from: OBI:0000432  ! polyacrylamide gel
disjoint_from: OBI:0000439  ! agarose gel
disjoint_from: OBI:0000576  ! scattered molecular aggregate
disjoint_from: OBI:0000651  ! urine specimen
disjoint_from: OBI:0000655  ! blood specimen
disjoint_from: OBI:0000680  ! whole organism preparation
disjoint_from: OBI:0000798  ! capsule shell
disjoint_from: OBI:0000814  ! guar gum
disjoint_from: OBI:0100014  ! chimera
disjoint_from: OBI:0100016  ! blood plasma
disjoint_from: OBI:0100017  ! blood serum specimen
disjoint_from: OBI:0100039  ! fragment derived from protein
disjoint_from: OBI:0100055  ! cell line cell
disjoint_from: OBI:0100056  ! immortalized cell line
disjoint_from: OBI:0100058  ! xenograft
disjoint_from: OBI:0100060  ! cell culture
disjoint_from: OBI:0100067  ! bronchial alveolar lavage
disjoint_from: OBI:0100069  ! polymer
disjoint_from: OBI:0100086  ! glucose in solution
disjoint_from: OBI:0302714  ! collection (of entities of organismal origin)
disjoint_from: OBI:0400102  ! waste tank
disjoint_from: OBI:1000023  ! cell culture supernatant
disjoint_from: OBI:1000024  ! cell pellet
disjoint_from: OBI:1000036  ! cell lysate
disjoint_from: OBI:1000042  ! peptide construct
disjoint_from: OBI:1000048  ! transgenic organism

[Term]
id: OBI:0000391
name: energy supply function
def: "An energy supply function is a function to supply or transfer energy from an energy source to a consumer of the energy" []
is_a: snap:Function 
disjoint_from: OBI:0000368  ! record function
disjoint_from: OBI:0000369  ! magnify function
disjoint_from: OBI:0000370  ! contain function
disjoint_from: OBI:0000371  ! heat function
disjoint_from: OBI:0000372  ! separation function
disjoint_from: OBI:0000374  ! excitation function
disjoint_from: OBI:0000375  ! freeze function
disjoint_from: OBI:0000376  ! synthesizing function
disjoint_from: OBI:0000377  ! perturbe function
disjoint_from: OBI:0000379  ! mechanical function
disjoint_from: OBI:0000383  ! transfer function
disjoint_from: OBI:0000385  ! ionization function
disjoint_from: OBI:0000387  ! cool function
disjoint_from: OBI:0000388  ! connection function
disjoint_from: OBI:0000392  ! information processor function
disjoint_from: OBI:0000401  ! environment control function
disjoint_from: OBI:0000403  ! sort function
disjoint_from: OBI:0000453  ! measure function
disjoint_from: OBI:0000455  ! consume data function
disjoint_from: OBI:0005246  ! injection function
disjoint_from: OBI:1110016  ! adaptive immune effector function
disjoint_from: OBI:1110085  ! antigen presentation function

[Term]
id: OBI:0000392
name: information processor function
def: "An information processor function is a function that converts information from one form to another, by a lossless process or an extraction process." []
synonym: "data processor function" EXACT []
is_a: snap:Function 
relationship: OBO_REL:has_part OBI:0000453 ! measure function
relationship: OBO_REL:has_part OBI:0000455 ! consume data function
disjoint_from: OBI:0000368  ! record function
disjoint_from: OBI:0000369  ! magnify function
disjoint_from: OBI:0000370  ! contain function
disjoint_from: OBI:0000371  ! heat function
disjoint_from: OBI:0000372  ! separation function
disjoint_from: OBI:0000374  ! excitation function
disjoint_from: OBI:0000375  ! freeze function
disjoint_from: OBI:0000376  ! synthesizing function
disjoint_from: OBI:0000377  ! perturbe function
disjoint_from: OBI:0000379  ! mechanical function
disjoint_from: OBI:0000383  ! transfer function
disjoint_from: OBI:0000385  ! ionization function
disjoint_from: OBI:0000387  ! cool function
disjoint_from: OBI:0000388  ! connection function
disjoint_from: OBI:0000391  ! energy supply function
disjoint_from: OBI:0000401  ! environment control function
disjoint_from: OBI:0000403  ! sort function
disjoint_from: OBI:0000453  ! measure function
disjoint_from: OBI:0000455  ! consume data function
disjoint_from: OBI:0005246  ! injection function
disjoint_from: OBI:1110016  ! adaptive immune effector function
disjoint_from: OBI:1110085  ! antigen presentation function

[Term]
id: OBI:0000393
name: signal conversion function
def: "A signal conversion function is an information processor function which transforms a signal into another type of signal. For example an analog-to-digital_converter, Ac/Ac converter, a synapse converts electrical action potentials into an intermediate chemical signal. The post synapse converts it back into an electric one passed on to the axon." []
is_a: OBI:0000392  ! information processor function
disjoint_from: OBI:0000400  ! display function

[Term]
id: OBI:0000394
name: blot module
def: "A blot module is a device which has the function to conatin and facilitate the material transfer process blotting to be realised" []
is_a: OBI:0000047  ! processed material
relationship: OBI:0000306 OBI:0000370 ! contain function
relationship: OBI:0000306 OBI:0000383 ! transfer function
relationship: OBI:0000306 OBI:0000401 ! environment control function

[Term]
id: OBI:0000395
name: signal amplification function
def: "A signal amplification function is a signal conversion function to inject energy into an input signal so as to produce an output signal with increased differential magnitude while also seeking to minimize increases in the signal to noise ratio. For example, to produce a 0.1 KW output signal from a 1 mW RMS input signal." []
is_a: OBI:0000393  ! signal conversion function

[Term]
id: OBI:0000397
name: image acquisition function
def: "An image acquisition function is a function to acquire an image of a material" []
is_a: OBI:0000453  ! measure function

[Term]
id: OBI:0000398
name: image acquisition device
def: "An image acquisition device is a device which captures a digitized image of an object" []
is_a: OBI:0000832  ! measurement device
relationship: OBI:0000306 OBI:0000397 ! image acquisition function

[Term]
id: OBI:0000399
name: immobilize function
def: "An immobilize function is a contain function to fix an entity in a defined position and prevent its movement" []
is_a: OBI:0000370  ! contain function

[Term]
id: OBI:0000400
name: display function
def: "A display function is a function to present information by translating that information through some lookup process into visual form." []
is_a: OBI:0000392  ! information processor function
disjoint_from: OBI:0000393  ! signal conversion function

[Term]
id: OBI:0000401
name: environment control function
def: "An environmental control function is a function that regulates a contained environment within specified parameter ranges. For example the control of light exposure, humidity and temperature." []
is_a: snap:Function 
disjoint_from: OBI:0000368  ! record function
disjoint_from: OBI:0000369  ! magnify function
disjoint_from: OBI:0000370  ! contain function
disjoint_from: OBI:0000371  ! heat function
disjoint_from: OBI:0000372  ! separation function
disjoint_from: OBI:0000374  ! excitation function
disjoint_from: OBI:0000375  ! freeze function
disjoint_from: OBI:0000376  ! synthesizing function
disjoint_from: OBI:0000377  ! perturbe function
disjoint_from: OBI:0000379  ! mechanical function
disjoint_from: OBI:0000383  ! transfer function
disjoint_from: OBI:0000385  ! ionization function
disjoint_from: OBI:0000387  ! cool function
disjoint_from: OBI:0000388  ! connection function
disjoint_from: OBI:0000391  ! energy supply function
disjoint_from: OBI:0000392  ! information processor function
disjoint_from: OBI:0000403  ! sort function
disjoint_from: OBI:0000453  ! measure function
disjoint_from: OBI:0000455  ! consume data function
disjoint_from: OBI:0005246  ! injection function
disjoint_from: OBI:1110016  ! adaptive immune effector function
disjoint_from: OBI:1110085  ! antigen presentation function

[Term]
id: OBI:0000403
name: sort function
def: "A sort function is a function to distinguish material components based on some associated physical quality or entity and to partition the separate components into distinct fractions according to a defined order." []
is_a: snap:Function 
relationship: OBO_REL:has_part OBI:0000372 ! separation function
relationship: OBO_REL:has_part OBI:0000453 ! measure function
disjoint_from: OBI:0000368  ! record function
disjoint_from: OBI:0000369  ! magnify function
disjoint_from: OBI:0000370  ! contain function
disjoint_from: OBI:0000371  ! heat function
disjoint_from: OBI:0000372  ! separation function
disjoint_from: OBI:0000374  ! excitation function
disjoint_from: OBI:0000375  ! freeze function
disjoint_from: OBI:0000376  ! synthesizing function
disjoint_from: OBI:0000377  ! perturbe function
disjoint_from: OBI:0000379  ! mechanical function
disjoint_from: OBI:0000383  ! transfer function
disjoint_from: OBI:0000385  ! ionization function
disjoint_from: OBI:0000387  ! cool function
disjoint_from: OBI:0000388  ! connection function
disjoint_from: OBI:0000391  ! energy supply function
disjoint_from: OBI:0000392  ! information processor function
disjoint_from: OBI:0000401  ! environment control function
disjoint_from: OBI:0000453  ! measure function
disjoint_from: OBI:0000455  ! consume data function
disjoint_from: OBI:0005246  ! injection function
disjoint_from: OBI:1110016  ! adaptive immune effector function
disjoint_from: OBI:1110085  ! antigen presentation function

[Term]
id: OBI:0000404
name: gel dryer
def: "A gel dryer is a device which has the function to contain and to control the contained environment to facilitate the drying of gels" []
is_a: OBI:0000047  ! processed material
relationship: OBI:0000306 OBI:0000370 ! contain function
relationship: OBI:0000306 OBI:0000401 ! environment control function

[Term]
id: OBI:0000405
name: primer role
def: "primer role is a reagent role which inheres in nucleic acid molecular entity and is realized by the use of the entity bearing the role to initiate chain elongation." []
is_a: snap:Role 
disjoint_from: OBI:0000017  ! regulatory role
disjoint_from: OBI:0000025  ! reference substance role
disjoint_from: OBI:0000029  ! centrifuge pellet role
disjoint_from: OBI:0000034  ! supernatant role
disjoint_from: OBI:0000040  ! drug role
disjoint_from: OBI:0000067  ! evaluant role
disjoint_from: OBI:0000086  ! reagent role
disjoint_from: OBI:0000091  ! detector reagent role
disjoint_from: OBI:0000093  ! patient role
disjoint_from: OBI:0000097  ! study subject role
disjoint_from: OBI:0000112  ! specimen role
disjoint_from: OBI:0000140  ! label role
disjoint_from: OBI:0000174  ! study group role
disjoint_from: OBI:0000204  ! nutrient role
disjoint_from: OBI:0000237  ! antigen role
disjoint_from: OBI:0000275  ! analyte role
disjoint_from: OBI:0000319  ! material to be added role
disjoint_from: OBI:0000416  ! cloning insert role
disjoint_from: OBI:0000444  ! target of material addition role
disjoint_from: OBI:0000571  ! manufacturer role
disjoint_from: OBI:0000718  ! pathogen role
disjoint_from: OBI:0000720  ! adjuvent role
disjoint_from: OBI:0000725  ! host role
disjoint_from: OBI:0000847  ! test substance role
disjoint_from: OBI:0302731  ! buffer role
disjoint_from: OBI:0302732  ! solvent role
disjoint_from: OBI:0302733  ! solute role
disjoint_from: OBI:1110082  ! immunogen role
disjoint_from: OBI:1110083  ! host of immune response role
disjoint_from: OBI:1110086  ! restricting MHC role
disjoint_from: OBI:1110087  ! donor
disjoint_from: OBI:1110091  ! carrier role
disjoint_from: OBI:1110092  ! adjuvant role
disjoint_from: OBI:1110120  ! assay antigen role

[Term]
id: OBI:0000406
name: PCR product
def: "is double stranded DNA that is the specified output of a polymerase chain reaction" []
is_a: CHEBI:4705  ! double-stranded DNA
is_a: OBI:0000809  ! amplified DNA
intersection_of: CHEBI:4705  ! double-stranded DNA
intersection_of: OBI:0000312 OBI:0000415 ! polymerase chain reaction

[Term]
id: OBI:0000407
name: viral RNA extraction
def: "The extraction of RNA from an input material that specifically isolates viral RNA" []
is_a: OBI:0666666  ! RNA extraction
relationship: OBI:0000293 NCBITaxon:10239 ! Viruses

[Term]
id: OBI:0000409
name: nucleic acid template role
def: "nucleic acid template role is a reference role which inheres in nucleic acid material entity and is realized in the process of using the nucleic acid bearing the template role as a reference during synthesis of a reverse copy." []
is_a: OBI:0000025  ! reference substance role
disjoint_from: OBI:0000064  ! positive reference substance role
disjoint_from: OBI:0000129  ! calibration substance role
disjoint_from: OBI:0000214  ! negative reference substance role

[Term]
id: OBI:0000410
name: recombinant plasmid
def: "A recombinant plasmid is a plasmid in which extraneous DNA has been inserted." []
is_a: OBI:0000430  ! plasmid
is_a: OBI:0000731  ! recombinant vector
intersection_of: OBI:0000430  ! plasmid
intersection_of: OBI:0000312 OBI:0600064 ! recombinant vector cloning

[Term]
id: OBI:0000411
name: cloning vector role
def: "A cloning vector role is a vector role played by a small, self-replicating DNA or RNA molecule - usually a plasmid or chromosome - and realized in a process whereby foreign DNA or RNA is inserted into the vector during the process of cloning." []
is_a: OBI:0000109  ! biological vector role

[Term]
id: OBI:0000413
name: cell cycle synchronization
def: "cell cycle synchronization is a process with the objective to obtain a cell culture in which all cells are in the same stage of the cell cycle" []
is_a: OBI:0000094  ! material processing
relationship: OBI:0000293 OBI:0100060 ! cell culture
relationship: OBI:0000299 OBI:0100060 ! cell culture
relationship: OBI:0000417 OBI:0000456 ! material transformation objective

[Term]
id: OBI:0000415
name: polymerase chain reaction
def: "PCR is the process in which a DNA polymerase is used to amplify a piece of DNA by in vitro enzymatic replication. As PCR progresses, the DNA thus generated is itself used as a template for replication. This sets in motion a chain reaction in which the DNA template is exponentially amplified." []
synonym: "PCR" EXACT []
is_a: OBI:0600058  ! enzymatic amplification
relationship: OBI:0000293 CHEBI:16991 ! deoxyribonucleic acids
relationship: OBI:0000299 OBI:0000406 ! PCR product
relationship: OBI:0000417 OBI:0000456 ! material transformation objective
disjoint_from: OBI:0000552  ! reverse transcribed polymerase chain reaction
disjoint_from: OBI:0600049  ! DNA polymerase amplification
disjoint_from: OBI:0600057  ! enzymatic DNA replication

[Term]
id: OBI:0000416
name: cloning insert role
def: "cloning insert role is a role which inheres in DNA or RNA and is realized by the process of being inserted into a cloning vector in a cloning process." []
is_a: snap:Role 
disjoint_from: OBI:0000017  ! regulatory role
disjoint_from: OBI:0000025  ! reference substance role
disjoint_from: OBI:0000029  ! centrifuge pellet role
disjoint_from: OBI:0000034  ! supernatant role
disjoint_from: OBI:0000040  ! drug role
disjoint_from: OBI:0000067  ! evaluant role
disjoint_from: OBI:0000086  ! reagent role
disjoint_from: OBI:0000091  ! detector reagent role
disjoint_from: OBI:0000093  ! patient role
disjoint_from: OBI:0000097  ! study subject role
disjoint_from: OBI:0000112  ! specimen role
disjoint_from: OBI:0000140  ! label role
disjoint_from: OBI:0000174  ! study group role
disjoint_from: OBI:0000204  ! nutrient role
disjoint_from: OBI:0000237  ! antigen role
disjoint_from: OBI:0000275  ! analyte role
disjoint_from: OBI:0000319  ! material to be added role
disjoint_from: OBI:0000405  ! primer role
disjoint_from: OBI:0000444  ! target of material addition role
disjoint_from: OBI:0000571  ! manufacturer role
disjoint_from: OBI:0000718  ! pathogen role
disjoint_from: OBI:0000720  ! adjuvent role
disjoint_from: OBI:0000725  ! host role
disjoint_from: OBI:0000847  ! test substance role
disjoint_from: OBI:0302731  ! buffer role
disjoint_from: OBI:0302732  ! solvent role
disjoint_from: OBI:0302733  ! solute role
disjoint_from: OBI:1110082  ! immunogen role
disjoint_from: OBI:1110083  ! host of immune response role
disjoint_from: OBI:1110086  ! restricting MHC role
disjoint_from: OBI:1110087  ! donor
disjoint_from: OBI:1110091  ! carrier role
disjoint_from: OBI:1110092  ! adjuvant role
disjoint_from: OBI:1110120  ! assay antigen role

[Typedef]
id: OBI:0000417
name: achieves_planned_objective
def: "This relation obtains between a planned process and a objective specification when the criteria specified in the objective specification are met at the end of the planned process." []
inverse_of_on_instance_level: OBI:0000833  ! objective_achieved_by

[Term]
id: OBI:0000418
name: measuring glucose concentration in blood serum
def: "An assay that determines the concentration of glucose molecules in a blood serum sample" []
is_a: OBI:0000443  ! analyte assay

[Term]
id: OBI:0000419
name: reverse transcriptase
def: "enzyme and has_function some GO:0003964 (RNA-directed DNA polymerase\nactivity)" []
is_a: OBI:0000427  ! enzyme
intersection_of: OBI:0000427  ! enzyme
intersection_of: OBI:0000306 GO:0003964 ! RNA-directed DNA polymerase activity

[Term]
id: OBI:0000420
name: trypsinized material
def: "A material entity that has undergone a process of digestion with trypsin" []
is_a: snap:MaterialEntity 
disjoint_from: OBI:0000050  ! platform
disjoint_from: OBI:0000146  ! supernatant collection system harvesting frame
disjoint_from: OBI:0000245  ! organization
disjoint_from: OBI:0000318  ! eluate
disjoint_from: OBI:0000390  ! thermostatic circulator
disjoint_from: OBI:0000432  ! polyacrylamide gel
disjoint_from: OBI:0000439  ! agarose gel
disjoint_from: OBI:0000576  ! scattered molecular aggregate
disjoint_from: OBI:0000651  ! urine specimen
disjoint_from: OBI:0000655  ! blood specimen
disjoint_from: OBI:0000680  ! whole organism preparation
disjoint_from: OBI:0000798  ! capsule shell
disjoint_from: OBI:0000814  ! guar gum
disjoint_from: OBI:0100014  ! chimera
disjoint_from: OBI:0100016  ! blood plasma
disjoint_from: OBI:0100017  ! blood serum specimen
disjoint_from: OBI:0100039  ! fragment derived from protein
disjoint_from: OBI:0100055  ! cell line cell
disjoint_from: OBI:0100056  ! immortalized cell line
disjoint_from: OBI:0100058  ! xenograft
disjoint_from: OBI:0100060  ! cell culture
disjoint_from: OBI:0100067  ! bronchial alveolar lavage
disjoint_from: OBI:0100069  ! polymer
disjoint_from: OBI:0100086  ! glucose in solution
disjoint_from: OBI:0302714  ! collection (of entities of organismal origin)
disjoint_from: OBI:0400102  ! waste tank
disjoint_from: OBI:1000023  ! cell culture supernatant
disjoint_from: OBI:1000024  ! cell pellet
disjoint_from: OBI:1000036  ! cell lysate
disjoint_from: OBI:1000042  ! peptide construct
disjoint_from: OBI:1000048  ! transgenic organism

[Term]
id: OBI:0000422
name: syringe
def: "a processed material which is used to introduce or draw fluids from a material entity. A syringe is made of a piston and body. the movement of the piston in the body determines the amount/volume of fluid to inject or draw" []
is_a: OBI:0000047  ! processed material
relationship: OBI:0000306 OBI:0000383 ! transfer function

[Term]
id: OBI:0000423
name: extract
def: "an extract is a material entity which results from an extraction process" []
synonym: "extracted material" EXACT []
is_a: OBI:0000047  ! processed material
relationship: OBI:0000312 OBI:0302884 ! extraction

[Term]
id: OBI:0000424
name: transcription profiling
def: "trancription profiling is a process which aims to provide information about gene expression and transcription activity using ribonucleic acids collected from a material entity using a range of techniques and instrument such as DNA sequencers, DNA microarrays, Northern Blot" []
synonym: "gene expression profiling" EXACT []
is_a: OBI:0000070  ! assay
relationship: OBI:0000293 CHEBI:33697 ! ribonucleic acids
relationship: OBI:0000299 IAO:0000109
relationship: OBI:0000417 OBI:0000015 ! biological feature identification objective
relationship: OBI:0000417 OBI:0000441 ! assay objective

[Term]
id: OBI:0000425
name: averaging objective
def: "An averaging objective is a data transformation objective where the aim is to perform mean calculations on the input of the data transformation." []
is_a: OBI:0200166  ! data transformation objective
disjoint_from: OBI:0000653  ! fuzzy clustering objective
disjoint_from: OBI:0000675  ! statistical hypothesis test objective
disjoint_from: OBI:0000704  ! decision tree induction objective
disjoint_from: OBI:0200005  ! feature extraction objective
disjoint_from: OBI:0200031  ! differential expression analysis objective
disjoint_from: OBI:0200078  ! descriptive statistical calculation objective
disjoint_from: OBI:0200081  ! sequence analysis objective
disjoint_from: OBI:0200083  ! survival analysis objective
disjoint_from: OBI:0200157  ! data vector reduction objective
disjoint_from: OBI:0200167  ! data normalization objective
disjoint_from: OBI:0200168  ! correction objective
disjoint_from: OBI:0200172  ! partitioning objective
disjoint_from: OBI:0200174  ! curve fitting objective
disjoint_from: OBI:0200177  ! center calculation objective
disjoint_from: OBI:0200178  ! class discovery objective
disjoint_from: OBI:0200179  ! class prediction objective
disjoint_from: OBI:0200180  ! spread calculation objective
disjoint_from: OBI:0200183  ! scaling objective
disjoint_from: OBI:0200189  ! merging objective
disjoint_from: OBI:0200196  ! correlation study objective
disjoint_from: OBI:0200197  ! spectrum analysis objective

[Term]
id: OBI:0000426
name: injection
def: "injection is process which aims at introducing a compound or a mixture into a material entity (either biological entity or instrument) by relying on devices such as syringe or injector connection, attached or forced into a vascular system (veins of an organism or tubes of a machine) or in a tissue." []
is_a: OBI:0000274  ! adding a material entity into a target
relationship: OBI:0000417 OBI:0000434 ! adding material objective

[Term]
id: OBI:0000427
name: enzyme
def: "(protein or rna) or has_part (protein or rna) and\nhas_function some GO:0003824 (catalytic activity)" []
is_a: snap:MaterialEntity 

[Term]
id: OBI:0000429
name: intraperitoneal administration
def: "The administration of a substance into the peritoneum of an organism" []
is_a: OBI:0600007  ! administering substance in vivo
relationship: OBI:0000417 OBI:0000434 ! adding material objective

[Term]
id: OBI:0000430
name: plasmid
def: "plasmid = DNA and has_quality circular and has_function\n(is_realized_as some gene expression) GO:0010467" []
is_a: CHEBI:4705  ! double-stranded DNA

[Term]
id: OBI:0000431
name: injection into organ section
def: "A process in which an input substance is injected into a organ section. " []
is_a: OBI:0000426  ! injection
relationship: OBI:0000417 OBI:0000434 ! adding material objective

[Term]
id: OBI:0000432
name: polyacrylamide gel
def: "agarose gel is a material entity resulting from the polymerization of agarose after heating agarose suspended in some buffer solution" []
is_a: snap:MaterialEntity 
relationship: OBO_REL:has_part CHEBI:28619 ! acrylamide
disjoint_from: OBI:0000050  ! platform
disjoint_from: OBI:0000146  ! supernatant collection system harvesting frame
disjoint_from: OBI:0000245  ! organization
disjoint_from: OBI:0000318  ! eluate
disjoint_from: OBI:0000390  ! thermostatic circulator
disjoint_from: OBI:0000420  ! trypsinized material
disjoint_from: OBI:0000439  ! agarose gel
disjoint_from: OBI:0000576  ! scattered molecular aggregate
disjoint_from: OBI:0000651  ! urine specimen
disjoint_from: OBI:0000655  ! blood specimen
disjoint_from: OBI:0000680  ! whole organism preparation
disjoint_from: OBI:0000798  ! capsule shell
disjoint_from: OBI:0000814  ! guar gum
disjoint_from: OBI:0100014  ! chimera
disjoint_from: OBI:0100016  ! blood plasma
disjoint_from: OBI:0100017  ! blood serum specimen
disjoint_from: OBI:0100039  ! fragment derived from protein
disjoint_from: OBI:0100055  ! cell line cell
disjoint_from: OBI:0100056  ! immortalized cell line
disjoint_from: OBI:0100058  ! xenograft
disjoint_from: OBI:0100060  ! cell culture
disjoint_from: OBI:0100067  ! bronchial alveolar lavage
disjoint_from: OBI:0100069  ! polymer
disjoint_from: OBI:0100086  ! glucose in solution
disjoint_from: OBI:0302714  ! collection (of entities of organismal origin)
disjoint_from: OBI:0400102  ! waste tank
disjoint_from: OBI:1000023  ! cell culture supernatant
disjoint_from: OBI:1000024  ! cell pellet
disjoint_from: OBI:1000036  ! cell lysate
disjoint_from: OBI:1000042  ! peptide construct
disjoint_from: OBI:1000048  ! transgenic organism

[Term]
id: OBI:0000433
name: DNA sequence feature detection
def: "An assay with the objective to determine a sequence feature of DNA" []
is_a: OBI:0000070  ! assay
relationship: OBI:0000293 CHEBI:16991 ! deoxyribonucleic acids
relationship: OBI:0000299 IAO:0000109
relationship: OBI:0000417 OBI:0000113 ! sequence feature identification objective
relationship: OBI:0000417 OBI:0000441 ! assay objective

[Term]
id: OBI:0000434
name: adding material objective
def: "is the specification of an objective to add a material into a target material. The adding is asymmetric in the sense that the target material largely retains its identity" []
is_a: OBI:0000686  ! material combination objective

[Term]
id: OBI:0000435
name: genotyping
def: "a process which generates data about a genotype from a specimen of genomic DNA. A variety of\ntechniques and instruments can be used to produce information about sequence variation at particular genomic positions." []
synonym: "genotype profiling, SNP genotyping" EXACT []
is_a: OBI:0000011  ! planned process
relationship: OBI:0000299 IAO:0000109
relationship: OBI:0000417 OBI:0000113 ! sequence feature identification objective

[Term]
id: OBI:0000436
name: needle
def: "a needle is a sharp, hollow device used to penetrate tissue or soft material. When attached to a syringe. it allows delivery of a specific volume of liquid or gaseous mixture." []
is_a: OBI:0000047  ! processed material

[Term]
id: OBI:0000437
name: analyte measurement objective
def: "is an assay objective to determine the presence or concentration of an analyte in the evaluant" []
is_a: OBI:0000441  ! assay objective

[Term]
id: OBI:0000438
name: DNA sequence variation detection
def: "DNA sequence variation detection is a process which aims at finding changes (expansion, amplification, deletion, mutation) in sequence of DNA molecule." []
is_a: OBI:0000070  ! assay
relationship: OBI:0000293 CHEBI:16991 ! deoxyribonucleic acids
relationship: OBI:0000299 IAO:0000109
relationship: OBI:0000417 OBI:0000113 ! sequence feature identification objective
relationship: OBI:0000417 OBI:0000441 ! assay objective

[Term]
id: OBI:0000439
name: agarose gel
def: "agarose gel is a material entity resulting from the polymerization of agarose after heating agarose suspended in some buffer solution" []
is_a: OBI:0000047  ! processed material
relationship: OBI:0000312 OBI:0302890 ! polymerization
disjoint_from: OBI:0000050  ! platform
disjoint_from: OBI:0000146  ! supernatant collection system harvesting frame
disjoint_from: OBI:0000245  ! organization
disjoint_from: OBI:0000318  ! eluate
disjoint_from: OBI:0000390  ! thermostatic circulator
disjoint_from: OBI:0000420  ! trypsinized material
disjoint_from: OBI:0000432  ! polyacrylamide gel
disjoint_from: OBI:0000576  ! scattered molecular aggregate
disjoint_from: OBI:0000651  ! urine specimen
disjoint_from: OBI:0000655  ! blood specimen
disjoint_from: OBI:0000680  ! whole organism preparation
disjoint_from: OBI:0000798  ! capsule shell
disjoint_from: OBI:0000814  ! guar gum
disjoint_from: OBI:0100014  ! chimera
disjoint_from: OBI:0100016  ! blood plasma
disjoint_from: OBI:0100017  ! blood serum specimen
disjoint_from: OBI:0100039  ! fragment derived from protein
disjoint_from: OBI:0100055  ! cell line cell
disjoint_from: OBI:0100056  ! immortalized cell line
disjoint_from: OBI:0100058  ! xenograft
disjoint_from: OBI:0100060  ! cell culture
disjoint_from: OBI:0100067  ! bronchial alveolar lavage
disjoint_from: OBI:0100069  ! polymer
disjoint_from: OBI:0100086  ! glucose in solution
disjoint_from: OBI:0302714  ! collection (of entities of organismal origin)
disjoint_from: OBI:0400102  ! waste tank
disjoint_from: OBI:1000023  ! cell culture supernatant
disjoint_from: OBI:1000024  ! cell pellet
disjoint_from: OBI:1000036  ! cell lysate
disjoint_from: OBI:1000042  ! peptide construct
disjoint_from: OBI:1000048  ! transgenic organism

[Term]
id: OBI:0000441
name: assay objective
def: "is the specification of an objective to determine a specified type of information about an evaluated entity (independent continuant bearing evaluant role)" []
is_a: IAO:0000005 
disjoint_from: OBI:0000015  ! biological feature identification objective
disjoint_from: OBI:0000208  ! methodology testing objective
disjoint_from: OBI:0000456  ! material transformation objective
disjoint_from: OBI:0000684  ! specimen creation objective
disjoint_from: OBI:0000806  ! material maintenance objective
disjoint_from: OBI:0200166  ! data transformation objective

[Term]
id: OBI:0000442
name: heart
def: "The heart is a muscular organ found in all vertebrates that is responsible for pumping blood throughout the blood vessels by repeated, rhythmic contractions" []
is_a: CARO:0000055  ! multi-tissue structure
disjoint_from: OBI:0000323  ! peritoneum
disjoint_from: OBI:0302743  ! liver
disjoint_from: OBI:0302745  ! adipose tissue

[Term]
id: OBI:0000443
name: analyte assay
def: "An assay with the objective to capture information about the presence, concentration, or amount of an analyte in an evaluant." []
is_a: OBI:0000070  ! assay
relationship: OBI:0000299 IAO:0000109

[Term]
id: OBI:0000444
name: target of material addition role
def: "target of material addition role is a role realized by an entity into which a material is added in a material addition process" []
is_a: snap:Role 
relationship: OBI:0000300 OBI:0000274 ! adding a material entity into a target
relationship: http://purl.org/obo/owl/OBO_REL#inheres_in snap:MaterialEntity
disjoint_from: OBI:0000017  ! regulatory role
disjoint_from: OBI:0000025  ! reference substance role
disjoint_from: OBI:0000029  ! centrifuge pellet role
disjoint_from: OBI:0000034  ! supernatant role
disjoint_from: OBI:0000040  ! drug role
disjoint_from: OBI:0000067  ! evaluant role
disjoint_from: OBI:0000086  ! reagent role
disjoint_from: OBI:0000091  ! detector reagent role
disjoint_from: OBI:0000093  ! patient role
disjoint_from: OBI:0000097  ! study subject role
disjoint_from: OBI:0000112  ! specimen role
disjoint_from: OBI:0000140  ! label role
disjoint_from: OBI:0000174  ! study group role
disjoint_from: OBI:0000204  ! nutrient role
disjoint_from: OBI:0000237  ! antigen role
disjoint_from: OBI:0000275  ! analyte role
disjoint_from: OBI:0000319  ! material to be added role
disjoint_from: OBI:0000405  ! primer role
disjoint_from: OBI:0000416  ! cloning insert role
disjoint_from: OBI:0000571  ! manufacturer role
disjoint_from: OBI:0000718  ! pathogen role
disjoint_from: OBI:0000720  ! adjuvent role
disjoint_from: OBI:0000725  ! host role
disjoint_from: OBI:0000847  ! test substance role
disjoint_from: OBI:0302731  ! buffer role
disjoint_from: OBI:0302732  ! solvent role
disjoint_from: OBI:0302733  ! solute role
disjoint_from: OBI:1110082  ! immunogen role
disjoint_from: OBI:1110083  ! host of immune response role
disjoint_from: OBI:1110086  ! restricting MHC role
disjoint_from: OBI:1110087  ! donor
disjoint_from: OBI:1110091  ! carrier role
disjoint_from: OBI:1110092  ! adjuvant role
disjoint_from: OBI:1110120  ! assay antigen role

[Term]
id: OBI:0000445
name: mass measurement assay
def: "a process to determine the mass of an evaluant" []
is_a: OBI:0000070  ! assay
relationship: OBI:0000299 IAO:0000109
relationship: OBI:0000417 OBI:0000441 ! assay objective

[Term]
id: OBI:0000446
name: identification
def: "a process by which the identity (what a thing is) of a material entity is established within a certain confidence interval" []
is_a: span:ProcessualEntity 

[Term]
id: OBI:0000447
name: intra cellular electrophysiology recording
def: "An intracellular electrophysiology recording is a process where the recording location of the electrode is intracellular" []
is_a: OBI:0000070  ! assay
relationship: OBI:0000299 IAO:0000109
relationship: OBI:0000417 OBI:0000441 ! assay objective

[Term]
id: OBI:0000448
name: packed column
def: "A packed column is a chromatography column where the particles of the solid stationary phase or the support coated with a liquid stationary phase may fill the whole inside volume of the tube." []
is_a: OBI:0000047  ! processed material

[Term]
id: OBI:0000450
name: regulatory agency
def: "A regulatory agency is a organization that has responsibility over or for  the legislation (acts and regulations) for a given sector of the government." []
is_a: OBI:0000245  ! organization
intersection_of: OBI:0000245  ! organization
intersection_of: OBI:0000316 OBI:0000014 ! regulator role

[Term]
id: OBI:0000451
name: normalized data set
def: "A normalized data set is a data set that is produced as the output of a normalization data transformation." []
is_a: IAO:0000100 

[Term]
id: OBI:0000453
name: measure function
def: "Measure function is a function that is borne by a processed material  and realized in a process in which information about some entity is expressed relative to some reference." []
is_a: snap:Function 
relationship: http://purl.org/obo/owl/OBO_REL#function_of OBI:0000047 ! processed material
disjoint_from: OBI:0000368  ! record function
disjoint_from: OBI:0000369  ! magnify function
disjoint_from: OBI:0000370  ! contain function
disjoint_from: OBI:0000371  ! heat function
disjoint_from: OBI:0000372  ! separation function
disjoint_from: OBI:0000374  ! excitation function
disjoint_from: OBI:0000375  ! freeze function
disjoint_from: OBI:0000376  ! synthesizing function
disjoint_from: OBI:0000377  ! perturbe function
disjoint_from: OBI:0000379  ! mechanical function
disjoint_from: OBI:0000383  ! transfer function
disjoint_from: OBI:0000385  ! ionization function
disjoint_from: OBI:0000387  ! cool function
disjoint_from: OBI:0000388  ! connection function
disjoint_from: OBI:0000391  ! energy supply function
disjoint_from: OBI:0000392  ! information processor function
disjoint_from: OBI:0000401  ! environment control function
disjoint_from: OBI:0000403  ! sort function
disjoint_from: OBI:0000455  ! consume data function
disjoint_from: OBI:0005246  ! injection function
disjoint_from: OBI:1110016  ! adaptive immune effector function
disjoint_from: OBI:1110085  ! antigen presentation function

[Term]
id: OBI:0000454
name: extracellular electrophysiology recording
def: "An extracellular electrophysiology recording is process where the recording location of the electrode is extracellular and data" []
is_a: OBI:0000070  ! assay
relationship: OBI:0000299 IAO:0000109
relationship: OBI:0000417 OBI:0000441 ! assay objective

[Term]
id: OBI:0000455
name: consume data function
def: "Process data function is a function that is borne by in a material entity by virtue of its structure. When realized the material entity consumes data." []
is_a: snap:Function 
relationship: http://purl.org/obo/owl/OBO_REL#function_of snap:MaterialEntity
disjoint_from: OBI:0000368  ! record function
disjoint_from: OBI:0000369  ! magnify function
disjoint_from: OBI:0000370  ! contain function
disjoint_from: OBI:0000371  ! heat function
disjoint_from: OBI:0000372  ! separation function
disjoint_from: OBI:0000374  ! excitation function
disjoint_from: OBI:0000375  ! freeze function
disjoint_from: OBI:0000376  ! synthesizing function
disjoint_from: OBI:0000377  ! perturbe function
disjoint_from: OBI:0000379  ! mechanical function
disjoint_from: OBI:0000383  ! transfer function
disjoint_from: OBI:0000385  ! ionization function
disjoint_from: OBI:0000387  ! cool function
disjoint_from: OBI:0000388  ! connection function
disjoint_from: OBI:0000391  ! energy supply function
disjoint_from: OBI:0000392  ! information processor function
disjoint_from: OBI:0000401  ! environment control function
disjoint_from: OBI:0000403  ! sort function
disjoint_from: OBI:0000453  ! measure function
disjoint_from: OBI:0005246  ! injection function
disjoint_from: OBI:1110016  ! adaptive immune effector function
disjoint_from: OBI:1110085  ! antigen presentation function

[Term]
id: OBI:0000456
name: material transformation objective
def: "is the objective to create an specific output object from input materials." []
synonym: "artifact  creation objective" EXACT []
is_a: IAO:0000005 
disjoint_from: OBI:0000015  ! biological feature identification objective
disjoint_from: OBI:0000208  ! methodology testing objective
disjoint_from: OBI:0000441  ! assay objective
disjoint_from: OBI:0000684  ! specimen creation objective
disjoint_from: OBI:0000806  ! material maintenance objective
disjoint_from: OBI:0200166  ! data transformation objective

[Term]
id: OBI:0000457
name: manufacturing
def: "Manufacturing is a process with the intent to produce a processed material which will have a function for future use. A person or organization (having manufacturer role) is a participant in this process" []
is_a: OBI:0000094  ! material processing
relationship: OBI:0000293 snap:MaterialEntity
relationship: OBI:0000299 OBI:0000047 ! processed material

[Term]
id: OBI:0000458
name: manufacturing objective
def: "is the objective to manufacture a material of a certain function (device)" []
is_a: OBI:0000456  ! material transformation objective
disjoint_from: OBI:0000686  ! material combination objective

[Instance]
id: OBI:0000461
name: the supplier role of Affymetrix
instance_of: OBI:0000018  ! supplier role
instance_of: owl:Thing 
relationship: http://purl.org/obo/owl/OBO_REL#role_of OBI:0000462 ! Affymetrix

[Instance]
id: OBI:0000462
name: Affymetrix
instance_of: OBI:0000245  ! organization
instance_of: owl:Thing 
relationship: OBI:0000316 OBI:0000461 ! the supplier role of Affymetrix

[Term]
id: OBI:0000463
name: column chromatography detector
def: "There is a wide range of detectors available for both GC and LC each having their own particular areas of application. In general the more catholic the response, the less sensitive the detector and the most sensitive detectors are those that have a specific response. The performance of all detectors should be properly specified so that the user can determine which is most suitable for a specific application. Such specifications are also essential to compare the performance of different detectors supplied by alternative instrument manufactures. Detector specifications should be presented in a standard form and in standard units, so that detectors can be compared that function on widely different principles." []
is_a: OBI:0000481  ! chromatography detector

[Term]
id: OBI:0000464
name: Bruker autosampler
def: "A Bruker autosampler is an autosampler made by Bruker." []
is_a: OBI:0000555  ! autosampler

[Term]
id: OBI:0000465
name: organic acid column
def: "An organic acid column is a chromatography column which enables (reversed-phase) separation of hydrophilic aliphatic and aromatic organic acids with UV detection. Organic acid columns allow retention of polar and apolar organic acids and are hydrolysis resistant." []
is_a: OBI:0000047  ! processed material

[Term]
id: OBI:0000466
name: thermal conductivity detector
def: "The most commonly used detector in preparative GC is the thermal conductivity detector (hot wire detector). Even this detector, however, is often too sensitive and has too high a flow impedance. Under such circumstances, the procedure mentioned above must be employed. The eluent from the preparative column is split and a small portion diverted through the detector (sometimes with further dilution with carrier gas to reduce sensitivity)." []
synonym: "TCD, hot wire detector" EXACT []
is_a: OBI:0000637  ! gas chromatography detector

[Term]
id: OBI:0000467
name: Bruker US 2 NMR magnet
def: "An actively-shielded superconducting magnet from Bruker that combines Bruker BioSpin's advanced, proprietary UltraShield active shielding and UltraStabilized sub-cooling technologies. This shielded and stabilized (US2) magnet system delivers high sensitivity and spectral dispersion." []
is_a: OBI:0000597  ! Bruker NMR magnet

[Term]
id: OBI:0000468
name: protein column
def: "A protein column is a chromatography column used for the separation of complex protein mixtures. Protein columns enable sample desalting, followed by chromatographic separation or fractionation of complex protein samples, e.g. immunodepleted serum or plasma proteins." []
is_a: OBI:0000047  ! processed material

[Term]
id: OBI:0000469
name: solvent mixer
def: "A liquid chromatography device that mixes different solvents, e.g. under high pressure and in differrent volumes ranging from 5 ml to 5 L capacity. Powerful magnetic mixers provide vigorous agitation required for high pressure reaction chemistry." []
is_a: OBI:0000485  ! chromatography instrument

[Term]
id: OBI:0000470
name: mass spectrometry assay
def: "This is a measuring method consisting of turning elements in a sample into ions, isolating them according to the ratio between the mass and charge numbers and detecting it electrically." []
synonym: "mass spectrometry" EXACT []
is_a: OBI:0000070  ! assay
relationship: OBI:0000293 OBI:0000049 ! mass spectrometer
relationship: OBI:0000417 OBI:0000441 ! assay objective

[Term]
id: OBI:0000471
name: study design execution
def: "a planned process that realizes the concretization of a study design" []

[Term]
id: OBI:0000473
name: Bruker NMR Case sample changer
def: "The NMR Case is an economical NMR sample changer for laboratories with modest automation needs. It expands the maximum number of samples your spectrometer can process during unattended operation to 24. The NMR Case consists of multiple components. The NMR Case exchange module installed atop your cryostat. The two front legs are adjustable, making the NMR Case compatible with many different cryostats." []
is_a: OBI:0000464  ! Bruker autosampler

[Term]
id: OBI:0000474
name: nano pump system
def: "A pump system optimized for nano flow chromatography." []
is_a: OBI:0000589  ! chromatography pump system

[Term]
id: OBI:0000475
name: Bruker AutoClean system
def: "NMR tubes are often used once and discarded, creating needless waste. With the Bruker BioSpin Autoclean system you can now recycle 5mm, 3mm, or 5mm/3mm step-down (Wilmad 520-1B) NMR tubes. AutoClean NMR Tube Washing System is a simple way to recoup the substantial investment your organization makes in quality NMR tubes, and cut back on needless waste material." []
is_a: OBI:0000498  ! NMR tube washing system

[Term]
id: OBI:0000476
name: manual injection system
def: "The traditional hardware system that allows a human to inject a sample into an inlet by hand, using a syringe." []
is_a: OBI:0000504  ! sample injection system

[Term]
id: OBI:0000477
name: Varian GEMINI spectrometer
def: "An older Varian Broadband NMR spectrometer." []
is_a: OBI:0000611  ! Varian NMR instrument

[Term]
id: OBI:0000478
name: column connector
def: "A device that connects two or more columns together in a functional way with leak-tight connection, low dead volume, low thermal mass and high inertness." []
is_a: OBI:0000048  ! chromatography device

[Term]
id: OBI:0000479
name: solid NMR probe
def: "An NMR probe that is designed to hold a solid sample." []
is_a: OBI:0000516  ! NMR probe

[Term]
id: OBI:0000480
name: Bruker high resolution probe
def: "BRUKER BIOSPIN's experienced Research & Development group not only delivers top-performance probes for the more common experiments, but also a wealth of special probes for almost any application. For high resolution (HR) NMR we offer probes with a variety of important characteristics and features.\n   defprov: Bruker website" []
synonym: "HR Probe" EXACT []
is_a: OBI:0000561  ! Bruker NMR probe

[Term]
id: OBI:0000481
name: chromatography detector
def: "A chromatography detector is a device that locates in the dimensions of space and time, the positions of the components of a mixture that has been subjected to a chromatographic process and thus permits the senses to appreciate the nature of the separation.  Defining characteristics are Dynamic Range, Response Index or Linearity, Linear Dynamic range, Detector Response,  Detector Noise Level, Detector Sensitivity or Minimum Detectable Concentration, Total System Dispersion, Sensor Dimensions, Detector Time Constant, Pressure Sensitivity, Flow Sensitivity, Operating Temperature Range." []
is_a: OBI:0000485  ! chromatography instrument

[Term]
id: OBI:0000482
name: normal phase column
def: "A normal phase column is a chromatography column in which the stationary phase is more polar than the mobile phase. Its counterpart is the reversed phase column." []
is_a: OBI:0000047  ! processed material

[Term]
id: OBI:0000483
name: APOLLO console
def: "The APOLLO is a compact, modular, multiple-DSP, Windows XP Professional-based console that can be equipped with up to 8 DDS-based RF transmitter channels configurable from 2 kHz to 3.5 GHz. Each transmitter channel produces a nominal 1V output and has the most agile frequency, phase and amplitude control of any system on the market. An array of additional options are available including multiple RF transmitters, linear high-power RF amplifiers, digital receiver arrays, low noise figure preamplifiers, a gradient control system, shim unit, MAS spin-speed controller, variable temperature unit, digital lock system and probe/coil interface. With its numerous options, the Apollo can be configured for any NMR, NQR or MRI application." []
is_a: OBI:0000599  ! tecmag NMR console

[Term]
id: OBI:0000484
name: NMR sample holder
def: "An NMR sample holder is the part of an NMR instrument, which carries the NMR probe,sample tube and the nmr sample." []
is_a: OBI:0000047  ! processed material

[Term]
id: OBI:0000485
name: chromatography instrument
def: "Any instrument that is used to carry out a chromatography experiment." []
is_a: OBI:0000047  ! processed material

[Term]
id: OBI:0000486
name: continuous wave NMR instrument
def: "Continuous wave NMR spectrometers are similar to optical spectrometers, but the sample is held in a strong magnetic field, where the frequency of the source is slowly scanned (in some instruments, the source frequency is held constant, and the field is scanned)." []
is_a: OBI:0000566  ! NMR instrument

[Term]
id: OBI:0000487
name: fourier transformation NMR instrument
def: "In fourier transformation NMR, all frequencies in a spectrum are irradiated simultaneously with a radio frequency pulse. Following the pulse, the nuclei return to thermal equilibrium. A time domain emission signal is recorded by the instrument as the nuclei relax. A frequency domain spectrum is obtained by Fourier transformation." []
is_a: OBI:0000566  ! NMR instrument

[Term]
id: OBI:0000489
name: nitrogen phosphorous detector
def: "The nitrogen phosphorus detector (NPD) (sometimes called the thermionic detector) is a very sensitive, specific detector the design of which, is based on the FID. Physically the sensor appears to be very similar to the FID but, in fact, operates on an entirely different principle. The nitrogen phosphorous detector (sometimes called the thermionic detector) is a very sensitive but specific detector that responds almost exclusively to nitrogen and phosphorous compounds. It is based on the flame ionization detector but differs in that it contains a rubidium or cesium silicate (glass) bead situated in a heater coil, a little distance from the hydrogen flame. If the detector is to respond to both nitrogen and phosphorous then the hydrogen flow should be minimal so that the gas does not ignite at the jet. If the detector is to respond to phosphorous only, a large flow of hydrogen is used which is burnt at the jet. The heated bead emits electrons by thermionic emission. These electrons are collected under a potential of a few volts by an appropriately placed anode, and provides a background current. When a solute containing nitrogen or phosphorous is eluted from the column, the partially combusted nitrogen and phosphorous materials are adsorbed on the surface of the bead. The adsorbed material reduces the work function of the surface and, as consequence, the emission of electrons is increased which raises the current collected at the electrode. The sensitivity of the detector to phosphorous is about 10-12 gram per ml and for nitrogen about 10-11 gram per ml at a signal to nose ratio of 2. The alkali bead as a finite life and needs regular replacement." []
is_a: OBI:0000637  ! gas chromatography detector

[Term]
id: OBI:0000490
name: cation exchange column
def: "A cation exchange column is a chromatography column that is used in cation exchange chromatography." []
is_a: OBI:0000560  ! ion exchange column

[Term]
id: OBI:0000491
name: direct detection NMR probe
def: "An NMR probe designed to allow the direct detection of acquisition nuclei." []
is_a: OBI:0000516  ! NMR probe

[Term]
id: OBI:0000492
name: Bruker B-ACS system
def: "The Bruker Automatic Sample Changer (B-ACS 60/120), used in conjunction with Bruker DISNMR, UXNMR or XWIN-NMR software, provides dialog-guided facilities which allow the user to easily and effectively perform automatic (continuous) experiments. Features include a 60 or 120 sample capacity, random accessing of samples, positive sample identification with the optional bar code reader, and temperature control of individual samples with the optional sample heater unit." []
is_a: OBI:0000464  ! Bruker autosampler

[Term]
id: OBI:0000493
name: rapid resolution column
def: "A rapid resolution column is a chromatography column as marketed by Agilent, which is used with a rapid resolution cartridge to ensure a fast chromatography process with good separation resolution." []
is_a: OBI:0000047  ! processed material

[Term]
id: OBI:0000494
name: liquid chromatography autosampler
def: "Designed to perform capillary LC with injection of sample volumes ranging from nL to L." []
is_a: OBI:0000485  ! chromatography instrument

[Term]
id: OBI:0000495
name: vacuum degasser
def: "A degassing system used for degassing solvents in liquid chromatography. Dissolved gasses, usually nitrogen and oxygen from the air, tend to be evolved in the mobile phase as the pressure is reduced when the mobile phase leaves the liquid chromatography column and enters the detector. Gasses in the mobile phase in the detector can produce completely unacceptable noise and, thus, must be removed. The dissolved gasses were originally removed under vacuum but, unfortunately, are soon replaced if the solvent is left in contact with air at atmospheric pressure. For this reason degassing is now usually carried out by bubbling helium through the mobile phase reservoirs. Secondly, vacuum is used in the thermionic detector. This consists of a device, very similar in design to the thermionic valve which is attached to a vacuum and a small quantity of the eluent from a gas chromatography column allowed to bleed through it. Helium is used as the carrier gas. The presence of solute vapor causes the thermionic current to fall. This type of detector tends to become contaminated rather readily." []
is_a: OBI:0000589  ! chromatography pump system

[Term]
id: OBI:0000496
name: capillary column
def: "A capillary column is a thin tube with a small inner diameter, usually around 0.5 mm." []
is_a: OBI:0000047  ! processed material

[Term]
id: OBI:0000497
name: sample inlet
def: "The column inlet (or injector) provides the means to introduce a sample into a continuous flow of carrier gas. The inlet is a piece of hardware attached to the column head." []
is_a: OBI:0000048  ! chromatography device

[Term]
id: OBI:0000498
name: NMR tube washing system
def: "An automatic cleaning system for NMR tubes that removes previous probe and sample residues in order to allow for tube recycling." []
is_a: OBI:0000047  ! processed material

[Term]
id: OBI:0000499
name: NMR console
def: "A component of an NMR instrument that controls the activities of the other components." []
is_a: OBI:0000047  ! processed material

[Term]
id: OBI:0000500
name: dual loop autosampler
def: "A dual loop autosampler is an autosampler that is designed for handling both analytical (10 mL/min flow rate) to preparative scale sample purification (100 mL/min flow rate)." []
is_a: OBI:0000494  ! liquid chromatography autosampler

[Term]
id: OBI:0000501
name: variable wavelength detector
def: "A chromatography detector, that can detect signals within a certain range at user-defined wavelengths." []
is_a: OBI:0000463  ! column chromatography detector

[Term]
id: OBI:0000503
name: Bruker LC-NMR platform
def: "The LC-NMR/MS setup was first introduced by Bruker BioSpin in 1999. An LC-NMR system including a Bruker Peak Sampling Unit (BPSU-36) was coupled with a Bruker Daltonics esquire series ion trap mass spectrometer via a Bruker NMR-MS interface (BNMI). Since October 2004 the Bruker Daltonics microTOF-LC time-of-flight mass spectrometer can also be integrated in an LC-NMR setup." []
is_a: OBI:0000596  ! Bruker NMR instrument

[Term]
id: OBI:0000504
name: sample injection system
def: "An automated chromatography system that injects the sample into the chromatography columns in order to increase speed and minimize human involvement in the purification process for  better reproducibility." []
is_a: OBI:0000048  ! chromatography device

[Term]
id: OBI:0000505
name: multiple wavelength detector
def: "A chromatography detector, that can detect many discrete wavelengths in parallel and produces a multiple wavelength chromatographic profile." []
is_a: OBI:0000463  ! column chromatography detector

[Term]
id: OBI:0000506
name: photoionization detector
def: "The selective determination of aromatic hydrocarbons or organo-heteroatom species is the job of the photoionization detector (PID). This device uses ultraviolet light as a means of ionizing an analyte exiting from a GC column. The ions produced by this process are collected by electrodes. The current generated is therefore a measure of the analyte concentration. f the amount of ionization is reproducible for a given compound, pressure, and light source then the current collected at the PID's reaction cell electrodes is reproducibly proportional to the amount of that compound entering the cell. The reason why the compounds that are routinely analyzed are either aromatic hydrocarbons or heteroatom containing compounds (like organosulfur or organophosphorus species) is because these species have ionization potentials (IP) that are within reach of commercially available UV lamps. The available lamp energies range from 8.3 to 11.7 ev, that is, lambda max ranging from 150 nm to 106 nm. Although most PIDs have only one lamp, lamps in the PID are exchanged depending on the compound selectivity required in the analysis." []
synonym: "PID" EXACT []
is_a: OBI:0000637  ! gas chromatography detector

[Term]
id: OBI:0000507
name: gas generator
def: "An instrument that generates gases for use with the gas chromatograph. Previously gas was obtained from gas tanks or gas cylinders. However, over the past decade the use of gas generators have become more popular as it avoids having gases at high pressure in the laboratory which is perceived by some as potentially dangerous. In addition, the use of a hydrogen generator avoids the use of a cylinder of hydrogen at high pressure which is also perceived by some as a serious fire hazard despite the fact that they have been used in laboratories, quite safely for nearly a century." []
is_a: OBI:0000542  ! gas chromatography equipment

[Term]
id: OBI:0000508
name: column jacket
def: "A column jacket is a piece of column chromatography equipment that covers a column in order to ensure thermoisolation and create a controllable thermostatic microenvironment." []
is_a: OBI:0000048  ! chromatography device

[Term]
id: OBI:0000509
name: electron capture detector
def: "The electron capture detector is a GC detector that uses a radioactive Beta emitter (electrons) to ionize some of the carrier gas and produce a current between a biased pair of electrodes. When organic molecules that contain electronegative functional groups, such as halogens, phosphorous, and nitro groups pass by the detector, they capture some of the electrons and reduce the current measured between the electrodes." []
synonym: "ECD" EXACT []
is_a: OBI:0000637  ! gas chromatography detector

[Term]
id: OBI:0000510
name: reversed phase column
def: "A reversed phase column is a chromatography column in which the mobile phase is more polar than the stationary phase. Its counterpart is the normal phase column." []
is_a: OBI:0000047  ! processed material

[Term]
id: OBI:0000511
name: injector lubricant
def: "A lubricant used in liquid chromatography that eases sample injector penetration." []
is_a: OBI:0000601  ! chromatography consumable

[Term]
id: OBI:0000512
name: isolation of cell population
def: "is a process in which a population of cells with certain characteristics is isolated from a larger population" []
is_a: OBI:0600014  ! material component separation
relationship: OBI:0000293 OBI:0100060 ! cell culture
relationship: OBI:0000299 OBI:0100060 ! cell culture
relationship: OBI:0000417 OBI:0000681 ! separation into different composition objective

[Term]
id: OBI:0000513
name: DISCOVERY console
def: "The Discovery console is a Windows XP Professional-based, integrated console designed especially for Solid-State NMR. The console includes everything needed to interface to any magnet and solids probe - from computer to cables to duplexing network\n   defprov: tecmag website" []
is_a: OBI:0000599  ! tecmag NMR console

[Term]
id: OBI:0000514
name: Bruker AMX series NMR instrument
def: "A series of older Bruker NMR magnets, now out of production. The Bruker AMX500 has proven an extremely reliable workhorse, with excellent lineshape yielding superior water suppression even without gradients. The Oxford 11.7 Tesla 5.2 cm bore magnet rests on a TMC vibration damping table. Homogeneity is controlled by a BSN-18 and BSN-2 with 19 shim controls. In addition to the 5 mm triple resonance probe, the AMX is equipped with a 10mm broadband observe probe." []
is_a: OBI:0000596  ! Bruker NMR instrument

[Term]
id: OBI:0000515
name: chromatofocusing column
def: "A chromatofocusing column is a chromatography column in which a resin is equilibrated at one pH and eluted at a second pH. The use of a weak ion-exchange resin causes a pH gradient to be formed at the solvent front owing to the buffering action of the resin. This pH gradient in turn leads to an ordering of proteins by isoelectric point. Molecules of charge sign opposite the resin bind; those of charge sign like the resin do not bind." []
is_a: OBI:0000047  ! processed material

[Term]
id: OBI:0000516
name: NMR probe
def: "Part of an NMR instrument that detects the signals emitted from a sample. No single probe can perform the full range of experiments, and probes that are designed to perform more than one type of measurement usually suffer from performance compromises. The probe represents a rather fragile single point of failure that can render an NMR system completely unusable if the probe is dropped or otherwise damaged. Probes are usually characterised by Sample diameter and Frequency.\n  alt The instrument that transmits and receives radiofrequency to and from the NMR sample." []
is_a: OBI:0000047  ! processed material

[Term]
id: OBI:0000517
name: NMR magnet
def: "A magnet which induces a certain frequency (MHz) and which has a certain bore diameter.\n  alt The NMR signal is a natural physical property of the certain atomic nuclei but it can only be detected with an external magnetic field. A magnet is a fundamental part of an NMR instrument which induces an electromagnetic force field (RF pulse) and by this excites and aligns the spins of the electrons of the NMR acquisition nucleus. It is usually a big (superconducting) electromagnet which is cooled by liquid helium and can be adjusted to a frequency between 200 and 950 MHz. The magnetic field strength is measured in Tesla or Gauss." []
is_a: OBI:0000047  ! processed material

[Term]
id: OBI:0000518
name: trap column
def: "A trap column is a chromatography column which is used prior to a, e.g. mass spectrometry, separation to clean up or concentrate controlled amounts of samples prior to elution to a detector." []
is_a: OBI:0000047  ! processed material

[Term]
id: OBI:0000519
name: flow probe
def: "An NMR probe that allows the automatized flow-through of a sample. The sample is aspirated via a syringe pump into the Flow probe, the NMR spectrum is acquired and when the experiment is complete, the sample is returned to back to an external source (well plate) or flushed to waste. Sometimes pulsed field gradients (PFG) can be established in flow probes." []
is_a: OBI:0000516  ! NMR probe

[Term]
id: OBI:0000520
name: clinical chemistry assay
def: "clinical chemistry assay is a process which uses analytical methods to produce measurements and data on the concentration of a chemical parameters (analytes) present in a bodily fluid collected from an organism." []
synonym: "chemical pathology" EXACT []
is_a: OBI:0000443  ! analyte assay
relationship: OBI:0000417 OBI:0000437 ! analyte measurement objective

[Term]
id: OBI:0000521
name: flame ionization detector
def: "A flame ionization detector is a GC detector that consist of a hydrogen/air flame and a collector plate which are normally heated independently of the chromatographic oven. Heating is necessary in order to prevent condensation of water generated by the flame and also to prevent any hold-up of solutes as they pass from the column to the flame. There is an electrode above the flame to collect the ions formed at a hydrogen/air flame. The number of ions hitting the collector is measured and a signal is generated. Flame ionization detectors are most widely used and generally applicable for gas chromatography and hence is used for routine and general purpose analysis. It is easy to use but destructive of the sample." []
synonym: "FID" EXACT []
is_a: OBI:0000637  ! gas chromatography detector

[Term]
id: OBI:0000522
name: vial
def: "A vial is a cylindrical container often made from glass tubing." []
is_a: OBI:0000601  ! chromatography consumable

[Term]
id: OBI:0000523
name: magic angle spinning rotor
def: "A rotor device that holds the NMR sample and enables the adjustment of the orientation of the rotation axis for a sample in a NMR instrument in the magic angle." []
synonym: "MAS rotor" EXACT []
is_a: OBI:0000047  ! processed material

[Term]
id: OBI:0000524
name: Varian VXR spectrometer
def: "A Varian NMR spectrometer." []
is_a: OBI:0000611  ! Varian NMR instrument

[Term]
id: OBI:0000525
name: splitless GC injector
def: "Injected sample enters column immediately (while split valve to split vent is closed). Here a sample is introduced into a heated small chamber via a syringe through a septum - the heat facilitates volatilization of the sample and sample matrix. The carrier gas then either sweeps the entirety (splitless mode) or a portion (split mode) of the sample into the column. In split mode, a part of the sample/carrier gas mixture in the injection chamber is exhausted through the split vent." []
is_a: OBI:0000504  ! sample injection system

[Term]
id: OBI:0000526
name: preparative autosampler
def: "For preparative LC with injection of sample volumes ranging from L to mL ranges." []
is_a: OBI:0000494  ! liquid chromatography autosampler

[Term]
id: OBI:0000527
name: flow high resolution probe
def: "Hyphenated analytical techniques combining mass spectrometry and chromatography are well-established laboratory tools. The combination of chromatography and NMR has also made its way into the analytical laboratory. Further developments even combine all three techniques into an LC-NMR/NMR-MS system. The use of solid phase extraction provides an efficient interface between chromatography and NMR with demands for special type of flow probes." []
synonym: "flow HR-probe" EXACT []
is_a: OBI:0000480  ! Bruker high resolution probe

[Term]
id: OBI:0000528
name: Liquid chromatography valve
def: "A sample valve that must be able to sustain pressures up to 10,000 p.s.i., although it is most likely to operate on a continuous basis, at pressures of 3,000 p.s.i. or less. The higher the operating pressure the tighter the valve seating surfaces must be forced together to eliminate any leak. It follows that any abrasive material, however fine, that passes into the valve can cause the valve seating to become scored each time it is rotated which will ultimately lead to leaks. This will cause the sample size to vary between samples and eventually affect the accuracy of the analysis. It follows that any solid material must be carefully removed from any sample before filling the valve. The sample volume of an internal loop valve is situated in the connecting slot of the valve rotor and can be used only for relatively small sample volumes. Internal sample loop valves provide samples with volumes ranging from 0.1 ml to about 0.5 ml. Valve operation is shown in figure 6. The left-hand side diagram shows the load position. The sample occupies the rotor slot and has been filled by passing the sample from an appropriate syringe through the rotor slot to waste. While loading the sample, the mobile phase supply is passed through the valve directly to the column. To place the sample onto the column, the valve is then rotated and the valve slot containing the sample is now placed between the solvent supply and the column. As a result, the sample is passed into the column by the flow of solvent." []
is_a: OBI:0000048  ! chromatography device

[Term]
id: OBI:0000529
name: JEOL NMR probe
def: "An NMR probe that is manufactured by JEOL." []
is_a: OBI:0000516  ! NMR probe

[Term]
id: OBI:0000530
name: Bruker UltraShield Plus NMR magnet
def: "An NMR magnet of which Brukers claims it is the latest and most advanced self-shielding NMR magnet technology ever developed. These magnets are the ultimate advancement in high performance, actively-shielded NMR solutions. They offer unprecedented shielding performance whilst ensuring no compromise in system homogeneity, stability or cryogenic specifications." []
is_a: OBI:0000597  ! Bruker NMR magnet

[Term]
id: OBI:0000531
name: Bruker CryoProbe
def: "The Bruker BioSpin CryoProbe is a high-performance cryogenically cooled probe developed for high-resolution applications. It has improved signal/noise (S/N) ratios obtained by reducing the operating temperature of the coil and the pre-amplifier. As a result, the efficiency of the coil is improved and the noise of the coil and the pre-amplifier are reduced.The dramatic increase in the S/N ratio by a factor of 3-4, as compared to conventional probes, leads to a possible reduction in experiment time of up to 16 or a reduction in required sample concentration by a factor of up to 4. The CryoProbes possess key characteristics for NMR analysis:\n   Significant S/N gains (with moderately salty samples also)\n   Short pulse widths\n   Short ring down times\n   Linear behavior in power response\n   Gradient capability\n   CryoProbes are available as Triple Resonance, Dual, Selective X Detection, MicroImaging, and Quad Nucleus Probes configurations at 400 MHz and higher\n   All high resolution probes have a lock circuit\n   All high resolution probes have Z-gradient." []
is_a: OBI:0000561  ! Bruker NMR probe

[Term]
id: OBI:0000532
name: column cartridge
def: "A device that binds the chromatography column and additional connector elements and / or valves or syringes into one physical unity for further processing." []
is_a: OBI:0000048  ! chromatography device

[Term]
id: OBI:0000533
name: affinity column
def: "An affinity column is a chromatography column that is used in affinity chromatography. Differences in the affinity of molecules to be separated to a stationary phase are used for discriminate retention." []
is_a: OBI:0000047  ! processed material

[Term]
id: OBI:0000534
name: tecmag NMR instrument
def: "An NMR instrument that is manufactured by tecmag." []
is_a: OBI:0000566  ! NMR instrument

[Term]
id: OBI:0000535
name: gel filtration column
def: "A Gel filtration column is a chromatography column for size-exclusion chromatography, in which the stationary phase is a gel. The main application of gel filtration chromatography is the fractionation of proteins and other water-soluble polymers." []
is_a: OBI:0000618  ! size exclusion column

[Term]
id: OBI:0000536
name: fraction collector
def: "A fraction detector is a device that allows regular or specified samples to be taken from a column eluate and stored in a retrievable form. The storage vessels are usually small sample tubes or vials that are oriented in a rotating disk or in a moving belt, there movement usually being controlled by a microprocessor. On receiving a signal from the microprocessor, the next vial is placed under the column outlet and the eluate collected until receiving another signal from the computer. Once the properties of the chromatogram that describes the separation has been ascertained, then the collection program can be defined. The fractions can be collected on a basis of time either at regular intervals or a specific times to collect specific peaks. Alternatively the fractions can be collected by monitoring the detector output and when a peak starts to elute the fraction collector is activated and the peak collected in a specific vial. When the peak returns to base line the column eluate is then directed to waste until the next peak starts eluting. Fraction collectors are in common use with most liquid chromatographs. They are used to collect samples for further purification, subsequent examination by spectroscopic techniques or for biological or organoleptic testing." []
is_a: OBI:0000485  ! chromatography instrument

[Term]
id: OBI:0000537
name: copy number variation profiling
def: "copy number variation profiling is a process which aims to provide information about lost or amplified genomic regions of DNA by comparing genomic DNA originated from tissues from same or different individuals using specific techniques such as CGH, array CGH, SNP genotyping." []
synonym: "CNV analysis" EXACT []
is_a: OBI:0000070  ! assay
relationship: OBI:0000417 OBI:0000441 ! assay objective

[Term]
id: OBI:0000538
name: in-line filter
def: "A solvent filter that sits between the pump and the injection valve that prevents dust particles, general debris and, to some extent, bacteria from entering the chromatography system. Contaminants can interfere with the low-pressure gradient former or the pump and particles entering valves may interfere with the proper function. The result could cause an increased baseline noise, non-repeatable gradient forming, unreliable flow rate or other interferences. Solvent in-line filters are low-pressure filters and will allow a high flow rate due to a large surface area and large porosity." []
is_a: OBI:0000592  ! chromatography detector filter

[Term]
id: OBI:0000539
name: imaging NMR probe
def: "An NMR probe that is designed for generating pictures from sample states via NMR imaging." []
is_a: OBI:0000516  ! NMR probe

[Term]
id: OBI:0000540
name: isolation of adherent cells
def: "is a material separation process in which cells that stick to the container in which they are grown as a cell culture are separated from those in the liquid component of the culture. The output of this process are adherent cells." []
is_a: OBI:0000512  ! isolation of cell population
relationship: OBI:0000293 OBI:0100060 ! cell culture
relationship: OBI:0000299 OBI:0100060 ! cell culture
disjoint_from: OBI:0000548  ! isolation of PBMCs

[Term]
id: OBI:0000541
name: Bruker AC series NMR instrument
def: "A series of older Bruker NMR magnets, now out of production." []
is_a: OBI:0000596  ! Bruker NMR instrument

[Term]
id: OBI:0000542
name: gas chromatography equipment
def: "Any device used in a gas chromatography experiment." []
is_a: OBI:0000048  ! chromatography device

[Term]
id: OBI:0000543
name: syringe filter
def: "A small membrane filter of defined pore size, that filters samples from a syringe." []
is_a: OBI:0000592  ! chromatography detector filter

[Term]
id: OBI:0000544
name: Bruker SampleRail system
def: "This Instrument system automatically prepares an NMR sample, inserts it into an NMR magnet, performs NMR experiments on the sample, and transports it back to the preparation system.\n   The SampleRail fulfills the transporting tasks from the preparation system into the NMR magnet and back." []
is_a: OBI:0000047  ! processed material

[Term]
id: OBI:0000545
name: column compartment
def: "For chromatography analyses, the ability to maintain a stable column environment regardless of ambient temperature fluctuations is critical for maintaining retention time precision. In order to ensure such stable conditions at different chromatography steps a column compartment can be installed that ensures e.g. stable temperature of the column in a given step." []
is_a: OBI:0000048  ! chromatography device

[Term]
id: OBI:0000546
name: capillary pump system
def: "A pump system optimized for capillary chromatography." []
is_a: OBI:0000589  ! chromatography pump system

[Term]
id: OBI:0000547
name: evaporative light scattering detector
def: "The evaporative light scattering detector, as its name implies, utilizes a spray that continuously atomizes the column eluent into small droplets. These droplets are allowed to evaporate, leaving the solutes as fine particulate matter suspended in the atomizing gas." []
is_a: OBI:0000463  ! column chromatography detector

[Term]
id: OBI:0000548
name: isolation of PBMCs
def: "is a process in which cells with a single nucleus are isolated from a blood sample" []
is_a: OBI:0000512  ! isolation of cell population
relationship: OBI:0000293 FMA:9670 ! Blood
relationship: OBI:0000299 OBI:0100060 ! cell culture
relationship: OBI:0000417 OBI:0000681 ! separation into different composition objective
disjoint_from: OBI:0000540  ! isolation of adherent cells

[Term]
id: OBI:0000549
name: column cartridger
def: "A chromatography device where the column cartridge is inserted into and stabilised." []
is_a: OBI:0000485  ! chromatography instrument

[Term]
id: OBI:0000550
name: nitrogen generator
def: "A gas generator that generates nitrogen gas." []
is_a: OBI:0000507  ! gas generator

[Term]
id: OBI:0000551
name: needle assembly
def: "The needle assembly attached to the autosampler, comprises the injector needle that feeds a sample or carrier gas into the inlet" []
is_a: OBI:0000048  ! chromatography device

[Term]
id: OBI:0000552
name: reverse transcribed polymerase chain reaction
def: "reverse transcribe pcr is a process which allow amplification of cDNA during a pcr reaction while the cDNA results from a retrotranscription of messenger RNA isolated from a material entity. rt-pcr is applied to test the presence and possibly the abundance of a transcript in the entity of organismal origin" []
synonym: "RT-PCR" EXACT []
is_a: OBI:0600058  ! enzymatic amplification
relationship: OBI:0000293 CHEBI:33697 ! ribonucleic acids
relationship: OBI:0000299 OBI:0000406 ! PCR product
relationship: OBI:0000417 OBI:0000456 ! material transformation objective
relationship: OBO_REL:has_participant OBI:0400116 ! thermal cycler
disjoint_from: OBI:0000415  ! polymerase chain reaction
disjoint_from: OBI:0600049  ! DNA polymerase amplification
disjoint_from: OBI:0600057  ! enzymatic DNA replication

[Term]
id: OBI:0000553
name: Bruker Capillary LC-NMR platform
def: "Capillary LC-NMR is a hyphenated technique coupling capillary liquid chromatography and NMR, which increases sensitivity dramatically through the use of miniaturization of the chromatographic techniques and NMR detection volume. LC-NMR hyphenated systems separate a mixture into its pure components and couple the output to NMR for automatic sample analysis. The ever increasing need to measure lower sample amounts and lower level impurities demands the highest NMR sensitivity. Traditional LC-NMR systems with relatively large peak volumes are not optimized for such low levels of detection. Bruker BioSpin, together with Waters and Protasis has developed a Capillary LC-NMR system. The latest capillary LC attributes and highest capillary flow probe sensitivity combine with state of the art NMR systems technology. Greater mass sensitivity and faster spectral analysis with smaller sample volumes is possible. This system is ideal for analysis of metabolites and impurities associated with the drug development process." []
is_a: OBI:0000596  ! Bruker NMR instrument

[Term]
id: OBI:0000554
name: gas chromatography oven
def: "A gas chromatography oven is an oven with a heated connection between the GC and the MS instrument in a GCMS-analysis, that keeps compounds in the gas phase as they leave the GC oven." []
is_a: OBI:0000542  ! gas chromatography equipment

[Term]
id: OBI:0000555
name: autosampler
def: "An optional part of an NMR instrument used to hold samples prior to NMR analysis and that sequentially loads these samples into the analytical part of the NMR instrument. \n   alt The autosampler is an automatic sample changer device." []
is_a: OBI:0000047  ! processed material

[Term]
id: OBI:0000556
name: isocratic pump system
def: "A pump system optimized for isocratic chromatography." []
is_a: OBI:0000589  ! chromatography pump system

[Term]
id: OBI:0000557
name: flash pump system
def: "Any pump system used in flash column chromatography to push the solvent through the column. Better flow rates can be achieved by using a pump or by using compressed gas (e.g. air, nitrogen, or argon) to push the solvent through the column (flash column chromatography)." []
is_a: OBI:0000589  ! chromatography pump system

[Term]
id: OBI:0000558
name: Varian UNITY INOVA spectrometer
def: "The UNITY INOVA is also the easiest spectrometer to use and is also the choice of those interested in using advanced NMR techniques in their own research, but without becoming, or hiring, an NMR expert. A complete set of turnkey operating environments is available for the UNITY INOVA covering the structure and dynamics of biological macromolecules, small molecules, solids, and imaging. These packages put the combined NMR expertise of the entire Varian NMR community at your fingertips." []
is_a: OBI:0000611  ! Varian NMR instrument

[Term]
id: OBI:0000559
name: liquid NMR probe
def: "An NMR probe that is designed to hold a liquid sample." []
is_a: OBI:0000516  ! NMR probe

[Term]
id: OBI:0000560
name: ion exchange column
def: "An ion exchange column is a chromatography column that is used in ion exchange chromatography and anion or cation exchange resins to enable separation." []
is_a: OBI:0000047  ! processed material

[Term]
id: OBI:0000561
name: Bruker NMR probe
def: "An NMR probe that is manufactured by Bruker." []
is_a: OBI:0000516  ! NMR probe

[Term]
id: OBI:0000562
name: anion trap column
def: "An anion trap column is a trap column and ion-exchange column which contains cationic anion-exchange resins." []
is_a: OBI:0000518  ! trap column

[Term]
id: OBI:0000563
name: fluorescene detector
def: "A single wavelength detector, where the excitation light wavelength is normally a mercury lamp generated high intensity UV light at 253.7 nm. Many substances that fluoresce will be excited by light of this wavelength and hence be detected." []
is_a: OBI:0000463  ! column chromatography detector

[Term]
id: OBI:0000564
name: tecmag EAGLE probe
def: "The Eagle is a 4 mm 1H/X solid-state MAS probe with a top spinning speed of 18 kHz. Its simple design is robust, reliable and easy to spin. Configurations are available for 200 to 600 MHz wide bore magnets on Tecmag, Bruker, Chemagnetics, JEOL and Varian spectrometers." []
is_a: OBI:0000479  ! solid NMR probe

[Term]
id: OBI:0000565
name: electrical conductivity detector
def: "The electrical conductivity detector measures the conductivity of the mobile phase. There is usually background conductivity which must be backed-off by suitable electronic adjustments. If the mobile phase contains buffers, the detector gives a base signal that completely overwhelms that from any solute usually making detection impossible. Thus, the electrical conductivity detector a bulk property detector. and senses all ions whether they are from a solute or from the mobile phase. In order to prevent polarization of the sensing electrodes, AC voltages must be used and so it is the impedance not the resistance of the electrode system that is actually measured. From a physical chemistry stand point the conductivity of a solution is more important than its resistance. However, it is the resistance (impedance) of the electrode system that determines the current across it. The resistance of any conductor varies directly as its length and inversely as its cross sectional area." []
is_a: OBI:0000463  ! column chromatography detector

[Term]
id: OBI:0000566
name: NMR instrument
def: "An Instrument which is used to carry out a NMR analysis of some sample." []
is_a: OBI:0000047  ! processed material

[Term]
id: OBI:0000567
name: Bruker UltraShield NMR magnet
def: "An NMR magnet manufactured by Bruker that ensures field homogeneity without amplified effects from vibrations or thermal changes. This magnet technology uses active shielding and optimizes coil design." []
is_a: OBI:0000597  ! Bruker NMR magnet

[Term]
id: OBI:0000568
name: piston-seal
def: "The seal made by a piston in a diaphragm pump. The unique property of the reciprocating diaphragm pump is that the actuating piston does not come into direct contact with the mobile phase and thus, the demands on the piston-cylinder seal are not so great. The diaphragm has a relatively high surface area and thus, the movement of the diaphragm is relatively small and consequently the pump can be operated at a fairly high frequency. High frequency pumping results in a very significant reduction in pulse amplitude and, in addition, high frequency pulses are more readily damped by the column system. Nevertheless, it must be emphasized that diaphragm pumps are not pulseless." []
is_a: OBI:0000601  ! chromatography consumable

[Term]
id: OBI:0000569
name: mass selective detector
def: "A mass selective detector is a GC detector that uses mass spectrometry. It is based upon the ionization of solute molecules in the ion source and the separation of the ions generated on the basis of their mass/charge ratio by an analyzer unit. This may be a magnetic sector analyzer, a quadruple mass filter, or an ion trap. Ions are detected by a dynode electron multiplier." []
synonym: "mass spectrometry detector" EXACT []
is_a: OBI:0000637  ! gas chromatography detector

[Term]
id: OBI:0000570
name: spin column
def: "A spin column is a chromatography column which is suitable for putting it into a centrifuge. A spin column enforces separation through increased G-forces while spinning the column in a centrifuge. It is often used in DNA gel extraction kits." []
is_a: OBI:0000047  ! processed material

[Term]
id: OBI:0000571
name: manufacturer role
def: "Manufacturer role is a role which inheres in a person or organization and which is realized by a manufacturing process." []
is_a: snap:Role 
relationship: OBI:0000300 OBI:0000457 ! manufacturing
disjoint_from: OBI:0000017  ! regulatory role
disjoint_from: OBI:0000025  ! reference substance role
disjoint_from: OBI:0000029  ! centrifuge pellet role
disjoint_from: OBI:0000034  ! supernatant role
disjoint_from: OBI:0000040  ! drug role
disjoint_from: OBI:0000067  ! evaluant role
disjoint_from: OBI:0000086  ! reagent role
disjoint_from: OBI:0000091  ! detector reagent role
disjoint_from: OBI:0000093  ! patient role
disjoint_from: OBI:0000097  ! study subject role
disjoint_from: OBI:0000112  ! specimen role
disjoint_from: OBI:0000140  ! label role
disjoint_from: OBI:0000174  ! study group role
disjoint_from: OBI:0000204  ! nutrient role
disjoint_from: OBI:0000237  ! antigen role
disjoint_from: OBI:0000275  ! analyte role
disjoint_from: OBI:0000319  ! material to be added role
disjoint_from: OBI:0000405  ! primer role
disjoint_from: OBI:0000416  ! cloning insert role
disjoint_from: OBI:0000444  ! target of material addition role
disjoint_from: OBI:0000718  ! pathogen role
disjoint_from: OBI:0000720  ! adjuvent role
disjoint_from: OBI:0000725  ! host role
disjoint_from: OBI:0000847  ! test substance role
disjoint_from: OBI:0302731  ! buffer role
disjoint_from: OBI:0302732  ! solvent role
disjoint_from: OBI:0302733  ! solute role
disjoint_from: OBI:1110082  ! immunogen role
disjoint_from: OBI:1110083  ! host of immune response role
disjoint_from: OBI:1110086  ! restricting MHC role
disjoint_from: OBI:1110087  ! donor
disjoint_from: OBI:1110091  ! carrier role
disjoint_from: OBI:1110092  ! adjuvant role
disjoint_from: OBI:1110120  ! assay antigen role

[Instance]
id: OBI:0000571_1
name: the manufacturer role of Ambion
instance_of: OBI:0000571  ! manufacturer role
instance_of: owl:Thing 
relationship: http://purl.org/obo/owl/OBO_REL#role_of OBI:0000756 ! Ambion

[Instance]
id: OBI:0000571_10
name: the manufacturer role of Thermo
instance_of: OBI:0000571  ! manufacturer role
instance_of: owl:Thing 
relationship: http://purl.org/obo/owl/OBO_REL#role_of OBI:0000752 ! Thermo

[Instance]
id: OBI:0000571_11
name: the manufacturer role of Waters
instance_of: OBI:0000571  ! manufacturer role
instance_of: owl:Thing 
relationship: http://purl.org/obo/owl/OBO_REL#role_of OBI:0000753 ! Waters

[Instance]
id: OBI:0000571_13
name: the manufacturer role of Agilent
instance_of: OBI:0000571  ! manufacturer role
instance_of: owl:Thing 
relationship: http://purl.org/obo/owl/OBO_REL#role_of OBI:0000765 ! Agilent

[Instance]
id: OBI:0000571_2
name: the manufacturer role of BIO-RAD
instance_of: OBI:0000571  ! manufacturer role
instance_of: owl:Thing 
relationship: http://purl.org/obo/owl/OBO_REL#role_of OBI:0000754 ! BIO-RAD

[Instance]
id: OBI:0000571_3
name: the manufacturer role of Helicos
instance_of: OBI:0000571  ! manufacturer role
instance_of: owl:Thing 
relationship: http://purl.org/obo/owl/OBO_REL#role_of OBI:0000757 ! Helicos

[Instance]
id: OBI:0000571_4
name: the manufacturer role of Illumina
instance_of: OBI:0000571  ! manufacturer role
instance_of: owl:Thing 
relationship: http://purl.org/obo/owl/OBO_REL#role_of OBI:0000759 ! Illumina

[Instance]
id: OBI:0000571_5
name: the manufacturer role of Li-Cor
instance_of: OBI:0000571  ! manufacturer role
instance_of: owl:Thing 
relationship: http://purl.org/obo/owl/OBO_REL#role_of OBI:0000769 ! Li-Cor

[Instance]
id: OBI:0000571_6
name: the manufacturer role of Roche
instance_of: OBI:0000571  ! manufacturer role
instance_of: owl:Thing 
relationship: http://purl.org/obo/owl/OBO_REL#role_of OBI:0000758 ! Roche

[Instance]
id: OBI:0000571_7
name: manufacturer role of applied biosystems
instance_of: OBI:0000571  ! manufacturer role
instance_of: owl:Thing 
relationship: http://purl.org/obo/owl/OBO_REL#role_of OBI:0000776 ! Applied Biosystems

[Instance]
id: OBI:0000571_8
name: manufacturer role of Bruker Corporation
instance_of: OBI:0000571  ! manufacturer role
instance_of: owl:Thing 
relationship: http://purl.org/obo/owl/OBO_REL#role_of OBI:0000770 ! Bruker Corporation

[Instance]
id: OBI:0000571_9
name: manufacturer role of Bruker Daltonics
instance_of: OBI:0000571  ! manufacturer role
instance_of: owl:Thing 
relationship: http://purl.org/obo/owl/OBO_REL#role_of OBI:0000779 ! Bruker Daltonics

[Term]
id: OBI:0000572
name: transfer line
def: "A combination of devices that are used in connection with a sampling head for transferring components of an applied sample to the analyzing part of a chromatography system." []
is_a: OBI:0000048  ! chromatography device

[Term]
id: OBI:0000573
name: gradient pump system
def: "A pump system optimized for gradient chromatography." []
is_a: OBI:0000589  ! chromatography pump system

[Term]
id: OBI:0000574
name: high temperature column
def: "A high temperature column is a chromatography column which is suitable for and withstands very high temperatures in chromatography ovens." []
is_a: OBI:0000047  ! processed material

[Term]
id: OBI:0000575
name: Bruker Ultrastabilized NMR magnet
def: "An NMR magnet manufactured by Bruker for Ultra-High Field NMR, available from 750 MHz to 900 MHz, which provides reliable operation at reduced temperature and ambient pressure via being rigidly mounted and stabilized." []
is_a: OBI:0000597  ! Bruker NMR magnet

[Term]
id: OBI:0000576
name: scattered molecular aggregate
def: "A scattered molecular aggregate is a material entity that consists of all the molecules of a specific type that are located in some bounded region and which is part of a more massive material entity that has parts that are other such aggregates" []
synonym: "Collective" EXACT []
is_a: snap:MaterialEntity 
relationship: OBI:0000643 CHEBI:23367 ! molecular entity
disjoint_from: OBI:0000050  ! platform
disjoint_from: OBI:0000146  ! supernatant collection system harvesting frame
disjoint_from: OBI:0000245  ! organization
disjoint_from: OBI:0000318  ! eluate
disjoint_from: OBI:0000390  ! thermostatic circulator
disjoint_from: OBI:0000420  ! trypsinized material
disjoint_from: OBI:0000432  ! polyacrylamide gel
disjoint_from: OBI:0000439  ! agarose gel
disjoint_from: OBI:0000651  ! urine specimen
disjoint_from: OBI:0000655  ! blood specimen
disjoint_from: OBI:0000680  ! whole organism preparation
disjoint_from: OBI:0000798  ! capsule shell
disjoint_from: OBI:0000814  ! guar gum
disjoint_from: OBI:0100014  ! chimera
disjoint_from: OBI:0100016  ! blood plasma
disjoint_from: OBI:0100017  ! blood serum specimen
disjoint_from: OBI:0100039  ! fragment derived from protein
disjoint_from: OBI:0100055  ! cell line cell
disjoint_from: OBI:0100056  ! immortalized cell line
disjoint_from: OBI:0100058  ! xenograft
disjoint_from: OBI:0100060  ! cell culture
disjoint_from: OBI:0100067  ! bronchial alveolar lavage
disjoint_from: OBI:0100069  ! polymer
disjoint_from: OBI:0100086  ! glucose in solution
disjoint_from: OBI:0302714  ! collection (of entities of organismal origin)
disjoint_from: OBI:0400102  ! waste tank
disjoint_from: OBI:1000023  ! cell culture supernatant
disjoint_from: OBI:1000024  ! cell pellet
disjoint_from: OBI:1000036  ! cell lysate
disjoint_from: OBI:1000042  ! peptide construct
disjoint_from: OBI:1000048  ! transgenic organism

[Term]
id: OBI:0000577
name: molecular concentration
def: "A concentration is a relational quality that inheres in a material entity towards molecular scattered aggregate that is part of it by virtue of some ratio of masses of the two or the counts of the grains of the two or volume occupied by the larger material entity." []
is_a: PATO:0001238  ! quality of related physical entities

[Term]
id: OBI:0000578
name: NMR sample tube
def: "The sample-tube holds the NMR sample and sits in the nmr probe. It is usually a glass tube of 5-20mm diameter." []
is_a: OBI:0000836  ! test tube

[Term]
id: OBI:0000579
name: Varian UNITY spectrometer
def: "The predecessor series of the Varian UNITY INOVA spectrometer." []
is_a: OBI:0000611  ! Varian NMR instrument

[Term]
id: OBI:0000580
name: AVANCE II spectrometer
def: "A spectrometer suitable for metabolomics and in vivo NMR studies but structural analysis of small molecules and low molecular weight proteins can also be performed. To accomplish these studies there are six probe-heads available. A successor, the AVANCE III came out recently." []
is_a: OBI:0000596  ! Bruker NMR instrument

[Term]
id: OBI:0000581
name: y-column connector
def: "A column connector that connects one column on one side with two columns at the other side, hence building a Y shaped structure." []
is_a: OBI:0000478  ! column connector

[Term]
id: OBI:0000582
name: Bruker LC-NMR/MS platform
def: "Includes the connection to a high-resolution TOF-LC-MS system." []
is_a: OBI:0000596  ! Bruker NMR instrument

[Term]
id: OBI:0000583
name: refractive index detector
def: "For analyzing non-UV absorbing substances, such as carbohydrates, lipids and polymers. This is also the detector of choice for gel permeation chromatography. The refractive index detector is one of the least sensitive LC detectors. It is very sensitive to changes in ambient temperature, pressure changes, flow-rate changes and can not be used for gradient elution. Despite these many disadvantages, this detector is extremely useful for detecting those compounds that are nonionic, do not adsorb in the UV, and do not fluoresce. There are many optical systems used in refractive index detectors but one of the most common is the differential refractive index detector." []
is_a: OBI:0000463  ! column chromatography detector

[Term]
id: OBI:0000584
name: anion exchange column
def: "An anion exchange column is a chromatography column that is used in anion exchange chromatography and which enables the separation of anion mixtures." []
is_a: OBI:0000560  ! ion exchange column

[Term]
id: OBI:0000586
name: plunger column
def: "A plunger column is a chromatography column with adjustable heigth control. By means of an adjustable endpiece (plunger) the user can adjust the column length without disturbing the packed bed. Plunger columns can equalize volume changes and thus avoids dead volumes within the column." []
is_a: OBI:0000047  ! processed material

[Term]
id: OBI:0000588
name: flame photometric detector
def: "The determination of sulfur or phosphorus containing compounds is the job of the flame photometric detector (FPD). This device uses the chemiluminescent reactions of these compounds in a hydrogen/air flame as a source of analytical information that is relatively specific for substances containing these two kinds of atoms. The emitting species for sulfur compounds is excited S2. The lambda max for emission of excited S2 is approximately 394 nm. The emitter for phosphorus compounds in the flame is excited HPO (lambda max = doublet 510-526 nm). In order to selectively detect one or the other family of compounds as it elutes from the GC column, an interference filter is used between the flame and the photomultiplier tube (PMT) to isolate the appropriate emission band. The drawback here being that the filter must be exchanged between chromatographic runs if the other family of compounds is to be detected." []
synonym: "FPD" EXACT []
is_a: OBI:0000637  ! gas chromatography detector

[Term]
id: OBI:0000589
name: chromatography pump system
def: "Better flow rates can be achieved by using a pump or by using compressed gas (e.g. air, nitrogen, or argon) to push the solvent through the column (flash column chromatography)." []
is_a: OBI:0000485  ! chromatography instrument

[Term]
id: OBI:0000590
name: Bruker 1mm MicroProbe
def: "Over the past few years there has been a significantly growing demand for miniaturization in all areas ofmodern research and development. Evoked by many exciting applications, there is a need for analytical methods which require less amounts of sample. Bruker BioSpin meets this challenge with a revolutionary NMR probe design: The 1mm MicroProbe. It operates with disposable 1mm capillary sample tubes and the sample volume of 5 microliters enables the use of lowest amounts of sample to run all high resolution NMR experiments with outstanding sensitivity and up to 16 times faster measurements. Due to the TXI-type probe design, the z-gradient coil and the automatic matching and tuning accessory, the 1mm MicroProbe can be used for a wide variety of NMR experiments. The key advantages of this probe include:\n   up to 4 times higher mass sensitivity than 5mm conventional probes (with respect to the same sample amount)\n   excellent solvent suppression properties\n   virtually no salt effect\n   discrete samples in tubes that can be sealed and stored\n   automation accessory for sample preparation and handling available\n   defprov: Bruker website" []
is_a: OBI:0000561  ! Bruker NMR probe

[Term]
id: OBI:0000591
name: Bruker BEST NMR system
def: "The introduction of biological screening and combinatorial chemistry for chemical synthesis has also introduced new requirements for NMR automation, e.g., the use of well plates for sample input, increased demands on throughput, and the need for quick and simple interpretation of the acquired NMR data." []
synonym: "Bruker Efficient Sample Transfer NMR" EXACT []
is_a: OBI:0000464  ! Bruker autosampler

[Term]
id: OBI:0000592
name: chromatography detector filter
def: "An optical filter that is used to obtain monochromatic light of a defined wavelength from detector lamps." []
is_a: OBI:0000601  ! chromatography consumable

[Term]
id: OBI:0000593
name: cation trap column
def: "A cation trap column is a trap column and ion-exchange column which contains anionic cation-exchange resins." []
is_a: OBI:0000518  ! trap column

[Term]
id: OBI:0000594
name: column adapter
def: "An Adapter that enabled the connection of a column to additional devices." []
is_a: OBI:0000048  ! chromatography device

[Term]
id: OBI:0000595
name: pulsed amperometric detector
def: "A chromatography detector as used by high-performance anion exchange chromatography that provides sensitive and specific detection of carbohydrates. Pulsed Electrochemical Detection (PED) allows simple, sensitive, and direct detection of numerous polar aliphatic compounds, especially carbohydrates. This technique exploits the electrocatalytic activity of noble metal electrode surfaces to oxidize various polar functional groups. In PED, multi-step potential-time waveforms at Au and Pt electrodes realize amperometric/coulometric detection while maintaining uniform and reproducible electrode activity. The response mechanisms in PED are dominated by the surface properties of the electrode, and, as a consequence, members of each chemical class of compounds produce virtually identical voltammetric responses. Thus, the full potential is realized when combined with high performance liquid chromatography (HPLC)." []
synonym: "PAD" EXACT []
is_a: OBI:0000463  ! column chromatography detector

[Term]
id: OBI:0000596
name: Bruker NMR instrument
def: "An NMR instrument that is manufactured by Bruker." []
is_a: OBI:0000566  ! NMR instrument

[Term]
id: OBI:0000597
name: Bruker NMR magnet
def: "An NMR magnet that is manufactured by Bruker." []
is_a: OBI:0000517  ! NMR magnet

[Term]
id: OBI:0000598
name: ozone-induced chemiluminescence detector
def: "Although there are many direct ozone chemiluminescent reactions with various gaseous molecules, the incorporation of a conversion step to convert various non-chemiluminescent analytes to a species capable of reacting with ozone to produce chemiluminescence broadens the horizon of this technique tremendously. The conversion of nearly all nitrogen- and sulfur-containing compounds to their respective chemiluminescent species for universal nitrogen and sulfur detection has made nitrogen/sulfur chemiluminescence detection the most widely used analytical methods based upon ozone-induced chemiluminescence. In addition to non-chromatographic applications, nitrogen/sulfur chemiluminescence detection has been adapted to various chromatographic techniques from gas chromatography to liquid and supercritical fluid chromatography as specialized element-specific detectors. The characteristics of these detectors are evaluated and compared to other element-selective detection techniques. The unique features of the chemiluminescence detectors have made them powerful tools in many diverse fields of analytical chemistry." []
is_a: OBI:0000637  ! gas chromatography detector

[Term]
id: OBI:0000599
name: tecmag NMR console
def: "An NMR console manufactured by tecmac." []
is_a: OBI:0000499  ! NMR console

[Term]
id: OBI:0000600
name: JEOL NMR instrument
def: "An NMR instrument that is manufactured by JEOL." []
is_a: OBI:0000566  ! NMR instrument

[Term]
id: OBI:0000601
name: chromatography consumable
def: "A chromatography consumable is a consumable that is used in a chromatography experiment." []
is_a: OBI:0000048  ! chromatography device

[Term]
id: OBI:0000602
name: column frit
def: "A part of the column content that separates column packing compartments. In radial columns the packing is supported between two cylindrical frits and the gap between represents the bed height or column length. The outer frit is the column inlet and consequently the sample initially has a large area of stationary phase with which to interact. Frits are porous metal products to prevent unwanted particles from entering the chromatography system. These particles may come from the sample, the solvent or debris generated by the chromatography system itself. Such particles entering the system may lead to clogging of capillaries, interference with the chromatography by changing chromatographic parameters or disturbance of the detector function. Characteristics of a frit, besides the diameter and the thickness, is the porosity (pore distribution, density)." []
is_a: OBI:0000048  ! chromatography device

[Term]
id: OBI:0000603
name: liquid chromatography column
def: "A liquid chromatography column is a chromatography column that is used in liquid chromatography, i.e. a column that is provided with a liquid sample mix." []
is_a: OBI:0000047  ! processed material

[Term]
id: OBI:0000604
name: detector lamp
def: "A lamp used in a chromatography detector that excites sample molecules at certain frequencies / emission wavelengths, e.g. Mercury Vapor Lamp (253.7 nm), Zinc Vapor Lamp (2123.9 nm and 307.6 nm), Cadmium Vapor Lamp (228.8, 326.1,340.3, and 346.6 nm). To obtain monochromatic light an appropriate light filter would be needed." []
is_a: OBI:0000601  ! chromatography consumable

[Term]
id: OBI:0000605
name: chart recorder
def: "The chart recorder is a device that transduces signal-intensities into a graphical peak output: As the separated components of the gas sample emerge into the detector, the change in voltage in the detecting bridge circuit causes a representative peak to be drawn on a chart recorder. The position of the peak along the time axis of the chart measures the component's retention time, which identifies the component. This is directly related to carrier gas flow rate, temperature and column packing and dimensions. The area under each peak is proportional to the concentration of the component of the sample. The area of the peaks inscribed on the chart recorder can be determined by multiplying the height of the peak in mm, by the width of the peak in mm at 1/2 the peak height. The calibration curves for use with the chart recorder are therefore peak area plotted against concentration." []
is_a: OBI:0000048  ! chromatography device

[Term]
id: OBI:0000606
name: open tubular column
def: "An open tubular column is a chromatography column in which the particles of the solid stationary phase or the support coated with a liquid stationary phase are concentrated on or along the inside tube wall leaving an open, unrestricted path for the mobile phase in the middle part of the tube." []
is_a: OBI:0000047  ! processed material

[Term]
id: OBI:0000607
name: high resolution magic angle spin probe
def: "Samples that are neither solid nor liquid, being of biological, chemical, or pharmaceutical interest, reveal highly resolved spectra when magic angle spinning is applied. The correct solution is a gradient, such that the field varies along the spinner axis. This so-called Magic Angle Gradient is employed in Brukers high resolution Magic Angle Spinning (hr-MAS) probes, and is implemented in such a way that it is compatible with the stator and does not interfere with the sample eject or insert. Bruker BioSpin has developed a series of dedicated probes for standard bore magnets to accommodate the rapidly expanding field of hr-MAS. These probes are available in double (e.g. 1H and 13C) and triple resonance (e.g. 1H, 13C, 15N) modes and come equipped with a deuterium lock channel. The probes have automatic sample ejection and insertion capability, with the availability of an optional sample changer, enabling fully automated sample runs. Probes can be equipped with an optional B0 gradient, directed along the magic angle, so that gradient spectroscopy can be done used.\n   defprov: Bruker website\n   alt High resolution MAS (hr-MAS) provides an easy means of obtaining high resolution spectra for a variety of samples that would otherwise result in poorly resolved spectra. The addition of an hr-MAS probe and a MAS pneumatic unit to a standard high resolution spectrometer is all that is needed to open the gate to the world of hr-MAS spectroscopy and gain access to a vast amount of highly interesting samples." []
synonym: "high resolution MAS, hr-MAS" EXACT []
is_a: OBI:0000480  ! Bruker high resolution probe

[Term]
id: OBI:0000608
name: hydrogen generator
def: "A gas generator that generates hydrogen gas." []
is_a: OBI:0000507  ! gas generator

[Term]
id: OBI:0000609
name: glass column
def: "A glass column is a chromatography column made out of glass that is usually used for larger scale and preparative liquid chromatography separations." []
is_a: OBI:0000047  ! processed material

[Term]
id: OBI:0000610
name: auto injector
def: "A gas chromatography device that can auto-inject a small number of samples an inlet." []
is_a: OBI:0000504  ! sample injection system

[Term]
id: OBI:0000611
name: Varian NMR instrument
def: "An NMR instrument that is manufactured by Varian." []
is_a: OBI:0000566  ! NMR instrument

[Term]
id: OBI:0000612
name: Bruker MATCH tube holder system
def: "The Bruker Multiple Adjustable Tube Clamp Holder MATCH system is a holder for 100 mm long NMR sample tubes with diameters ranging from micro tubes up to 5 mm NMR tubes. The MATCH insert fits into a standard 10 mm Bruker spinner and is suitable for all non-spinning applications.\n   The MATCH system provides an easy and cost efficient means of optimizing the signal-to-noise ratio of each sample. By matching the NMR tube diameter to the size of the sample, most of the sample can be placed in the active column of the NMR coil. This leads to an enhanced signal detection compared to diluting the same sample quantity in a larger tube." []
synonym: "Bruker Multiple Adjustable Tube Clamp Holder" EXACT []
is_a: OBI:0000484  ! NMR sample holder

[Term]
id: OBI:0000613
name: Bruker SPE-NMR platform
def: "A Solid Phase Extraction (SPE) system provides an interface between liquid chromatography (LC) and NMR. For the process of LC-SPE  NMR a chromatographic separation is done and the peaks of interest are trapped on an individual SPE cartridge after the column. The peak selection is done either by UV detection or by evaluation of the on-line registered MS or MSn spectra." []
is_a: OBI:0000596  ! Bruker NMR instrument

[Term]
id: OBI:0000614
name: guard column
def: "Guard columns are installed between the injection valve and the analytical or preparative column and here will remove contaminants and prolong the lifetime of the columns." []
is_a: OBI:0000048  ! chromatography device

[Term]
id: OBI:0000615
name: protein expression profiling
def: "a planned process which aims to provide information about protein expression and translation activity using protein extracts collected from a material entity using a range of techniques and instrument such as Mass spectrometers, Gel electrophoresis, Western Blots, Protein microarrays" []
synonym: "proteomic analysis" EXACT []
is_a: OBI:0000011  ! planned process

[Term]
id: OBI:0000616
name: high resolution probe with automatic tuning and matching
def: "The Automatic Tuning and Matching (ATM) option for AVANCE spectrometers is available for double resonance probes in fixed-frequency and broadband tunable configurations with either direct or indirect detection. Thus, for multinuclear operation, as often required for applications in inorganic chemistry, ATM facilitates the accurate setting of 90 degree pulse widths on both observe and decoupling channels for each chosen nucleus and each individual sample - even with full automation. Triple resonance probes in fixed-frequency configurations, as typically used for inverse detection with high-field systems." []
synonym: "High Resolution Probes with Automatic Tuning and Matching, HR_probe_with_ATM" EXACT []
is_a: OBI:0000480  ! Bruker high resolution probe

[Term]
id: OBI:0000617
name: fluorine-induced chemiluminescence detector
def: "A gas chromatographic detection system based on the low pressure, gas phase chemiluminescence of the reaction mixture of molecular fluorine with organo-sulfur, -selenium, and -tellurium compounds separated from (gas phase) headspace samples. This detector was originally developed in the research group of John Birks at the University of Colorado, USA and was manufactured and sold by Sievers Instruments (Boulder Colorado, USA). This system can be divided up into three parts: the chromatograph, transfer line, and reaction cell; PMT and photon counting electronics; and the molecular fluorine generator." []
is_a: OBI:0000637  ! gas chromatography detector

[Term]
id: OBI:0000618
name: size exclusion column
def: "A size exclusion column is a chromatography column as used in size exclusion chromatography and which enables the separation of mixtures according to differrences in molecular size." []
is_a: OBI:0000047  ! processed material

[Term]
id: OBI:0000619
name: chromatography splitter
def: "An adjustable restriction that is placed in the waste outlet to allow the necessary pressure to develop at the column inlet to force a flow (q ml/min) through the column. If the flow of mobile phase is Q ml/min then the waste flow will be (Q-q) ml/min. by adjusting the waste flow, the proportion of the sample entering the capillary column can be varied over a wide range of values and the necessary minimum permissible volume for the particular column in use can be selected for analysis. Unfortunately, the fraction taken in this way may not be representative of the original sample. This is due to the individual solutes in the mixture having different diffusivities and, thus, they distribute themselves across the sampling tube in an irregular manner. In general, the components with higher diffusivities (e.g., those solutes of lower molecular weight) will diffuse away from the bulk sample more quickly than those having lower diffusivities." []
is_a: OBI:0000048  ! chromatography device

[Term]
id: OBI:0000620
name: Bruker micro imaging probe
def: "For medical, biological and material sciences research, avance imaging systems provide optimal object handling and performance with a variety of samples types. Two classes of imaging probes are available: in vivo probes for handling and sustaining live objects such as animals and plants, and conventional imaging probes for materials samples." []
is_a: OBI:0000561  ! Bruker NMR probe

[Term]
id: OBI:0000621
name: custom made column
def: "A custom made column ia a chromatography column which is specifically tailored according to the needs of the separation as requested by a scientist or working group." []
is_a: OBI:0000047  ! processed material

[Term]
id: OBI:0000622
name: gel permeation column
def: "A gel permeation column is a chromatography column which is used in gel permeation chromatography and which employs as the stationary phase a swollen gel made by polymerizing and cross-linking styrene in the presence of a diluent which is a nonsolvent for the styrene polymer. The polymer to be analyzed is introduced at the top of the column and then is elutriated with a solvent. The polymer molecules diffuse through the gel at rates depending on their molecular size." []
is_a: OBI:0000047  ! processed material

[Term]
id: OBI:0000623
name: NMR spectroscopy
def: "NMR spectroscopy is a process which exploits the magnetic properties of certain nuclei (those with a spin) to resonate when placed in particular magnetic field conditions. Instruments recording NMR spectrum and sets of analysis can be used to deduce  identity of chemical as well as composition of complex chemical mixtures." []
synonym: "Nuclear magnetic resonance spectroscopy" EXACT []
is_a: OBI:0000070  ! assay
relationship: OBI:0000417 OBI:0000441 ! assay objective

[Term]
id: OBI:0000624
name: Bruker SampleJet system
def: "Bruker BioSpin introduces the SampleJet, a robot for NMR tube automation. The SampleJet has been consciously designed to meet the growing customer demand for simplicity, versatility and higher throughput in NMR sample tube automation.\n  The SampleJet utilizes the modern-day industry standard for sample arrangements-the 96 well plate array. Therefore, the samples may be handled by standard lab automation devices before or after the NMR measurement." []
is_a: OBI:0000464  ! Bruker autosampler

[Term]
id: OBI:0000625
name: JEOL ECX NMR spectrometer
def: "The ECX series of NMR spectrometers is designed for any laboratory needing an easy-to-use, reliable, routine NMR system. The ECX NMR series is available from 300 to 500 MHz. The console is designed around a modular, digital NMR electronics chassis controlled by an intelligent acquisition computer. For unprecedented flexibility, the JEOL NMR system offers a Windows XP, Mac OSX or LINUX. Both the workstation and spectrometer may be connected to a standard network, allowing seamless remote operation anywhere in the world." []
is_a: OBI:0000600  ! JEOL NMR instrument

[Term]
id: OBI:0000626
name: DNA sequencing
def: "DNA sequencing is a sequencing process which uses deoxyribonucleic acid as input and results in a the creation of DNA sequence information artifact using a DNA sequencer instrument." []
is_a: OBI:0600047  ! sequencing assay
relationship: OBI:0000417 OBI:0000441 ! assay objective
disjoint_from: OBI:0000705  ! Edman degradation

[Term]
id: OBI:0000627
name: quaternary pump system
def: "A pump system that pump and mix up to four different solvents in parallel." []
is_a: OBI:0000589  ! chromatography pump system

[Term]
id: OBI:0000628
name: carbon nanotube column
def: "Carbon nanotubes (CNTs) are known to have high thermal and mechanical stability and have the potential to be high-performance separation media that utilize the nanoscale interactions. CNT can be applied in long capillary tubes for the development of gas chromatography columns. A film of CNTs can be deposited by chemical vapor deposition (CVD) to form the stationary phase in the open tubular format. Altering the CVD conditions can vary the thickness and the morphology of the CNT film, which opens the possibility of selectivity tuning. The ability to fabricate long tubes coated with CNTs can be readily employed in other gas- and liquid-phase separations as well." []
is_a: OBI:0000047  ! processed material

[Term]
id: OBI:0000629
name: Bruker solid magic angle spinning probe
def: "Magic angle spinning, nowadays a routine technique for solids NMR, still offers the capability of innovation. The high mechanical performance of MAS probes in conjunction with efficient rf pulse techniques open new exciting fields in solids NMR of biological samples and in the field of quadrupolar nuclei." []
synonym: "solid MAS probe" EXACT []
is_a: OBI:0000561  ! Bruker NMR probe

[Term]
id: OBI:0000630
name: hematology
def: "hematology is a process studying blood and blood producing organs relying on a variety of techniques and instruments" []
synonym: "blood analysis, haematology" EXACT []
is_a: OBI:0000070  ! assay
relationship: OBI:0000417 OBI:0000441 ! assay objective

[Term]
id: OBI:0000631
name: Varian MERCURY spectrometer
def: "MERCURYplus spectrometers provide superior control, stability, and performance for high-productivity environments. Surface-mount electronics enable a small footprint without compromising data quality. Modular design allows flexible configuration. Direct digital synthesis, linear amplifiers, and other innovative RF and digital technologies enable push-button operation." []
is_a: OBI:0000611  ! Varian NMR instrument

[Term]
id: OBI:0000632
name: Bruker Metabolic Profiler
def: "An NMR platform for conducting metabonomics studies, traditional metabolism studies, and analysis of complex mixtures, featuring an Avance NMR spectrometer and a microTOF from Bruker Daltonics. By combining the structural resolving power of NMR with mass accuracy of the microTOF Bruker offers a complete system for metabolic research. The Metabolic Profiler provides a simple, easy to use and inexpensive base-system to acquire the spectroscopic data, needed to do basic metabolic profiling including metabonomic statistical analysis." []
is_a: OBI:0000596  ! Bruker NMR instrument

[Term]
id: OBI:0000633
name: column heater
def: "The glass liner can be fitted with a separate heater and the volatilization temperature can, thus, be controlled. This flash heater system is available in most chromatographs. By using a syringe with a long needle, the tip can be made to penetrate past the liner and discharge its contents directly into the column packing. This procedure is called 'on-column injection' and, as it reduces peak dispersion on injection and thus, provides higher column efficiencies, is often the preferred procedure." []
is_a: OBI:0000485  ! chromatography instrument

[Term]
id: OBI:0000634
name: DNA methylation profiling
def: "DNA methylation profiling is a process which aims to provide information about state of methylation of DNA molecules using genomic DNA collected from a material entity using a range of techniques and instrument such as DNA sequencers and often relying on treatment with bisulfites to ensure cytosine conversion." []
is_a: OBI:0000070  ! assay
relationship: OBI:0000417 OBI:0000441 ! assay objective

[Term]
id: OBI:0000635
name: JEOL CapNMR probe
def: "The JEOL ECA and ECX NMR spectrometers now support the MRM/Protasis CapNMR Probe for well plate-based and microvial-based NMR analysis. The CapNMR probe is available at proton frequencies ranging from 300 MHz to 800 MHz in both indirect configurations (e.g. 1H\{13C\} and 1H \{31P\}) and also in triple resonance configurations (e.g. 1H\{13C, 15N\}, 1H\{31P, 15N\}). Both employ a high-strength z-directed field gradient. The flowprobes come with the choice of two flowcell volumes: a 5 µl flowcell with an NMR active volume of 2.5 µl, and a 10 µl flowcell with an NMR active volume of 5 µl. The fluidic connections are 75 µm i.d. and 1/32 o.d. FEP Teflon with hastelloy unions for exceptional solvent compatibility." []
is_a: OBI:0000529  ! JEOL NMR probe

[Term]
id: OBI:0000636
name: acquisition computer
def: "A Computer used for NMR, can be divided into central processing unit (CPU), consisting of instruction, interpretation and arithmetic unit plus fast access memory, and peripheral devices such as bulk data storage and input and output devices (including, via the interface, the spectrometer). Under software control, the computer controls the RF pulses and gradients necessary to acquire data, and process the data to produce spectra or images. Note that devices such as the spectrometer may themselves incorporate small computers." []
is_a: OBI:0000047  ! processed material
relationship: OBI:0000306 OBI:0000392 ! information processor function

[Term]
id: OBI:0000637
name: gas chromatography detector
def: "A gas chromatography detector is a chromatography detector that locates in the dimensions of space and time, the positions of the components of a mixture that has been subjected to a gas chromatographic process and thus permits the senses to appreciate the nature of the separation. There is no LC detector that has an equivalent performance to the flame ionization detector (FID) used in GC. In general, LC detectors have sensitivities of two to three orders of magnitude less than their GC counterparts and linear dynamic ranges one to two orders of magnitude lower. Only highly specific LC detectors have sensitivities that can approach those of GC detectors." []
synonym: "FID" EXACT []
is_a: OBI:0000481  ! chromatography detector

[Term]
id: OBI:0000638
name: gas purifier
def: "Gas purifiers are instruments used for the removal of gas impurities like hydrocarbons, oxygen, and moisture from carrier gas and fuel gases for GC or GC-MS systems." []
is_a: OBI:0000542  ! gas chromatography equipment

[Term]
id: OBI:0000639
name: material separation objective
def: "is an objective to transform a material entity into spatially separated components." []
is_a: OBI:0000456  ! material transformation objective
union_of: OBI:0000678  ! portioning objective
union_of: OBI:0000681  ! separation into different composition objective

[Term]
id: OBI:0000640
name: indirect detection probe
def: "An NMR probe designed to allow the indirect detection of acquisition nuclei." []
is_a: OBI:0000516  ! NMR probe

[Term]
id: OBI:0000641
name: JEOL ECA NMR spectrometer
def: "The ECA series of NMR spectrometers is a high performance, research grade NMR system configurable to a wide range off applications. The ECA NMR is available from 300 to 930 MHz field strengths and is 1GHz ready. The system is designed around a modular, digital NMR electronics chassis controlled from a UNIX or Windows workstation and acquisition system. Both the workstation and spectrometer may be connected to a standard network, allowing seamless remote operation anywhere in the world." []
is_a: OBI:0000600  ! JEOL NMR instrument

[Term]
id: OBI:0000642
name: atomic emission detector
def: "Instead of measuring simple gas phase (carbon containing) ions created in a flame as with the flame ionization detector, or the change in background current because of electronegative element capture of thermal electrons as with the electron capture detector, the AED has a much wider applicability because it is based on the detection of atomic emissions. The strength of the AED lies in the detector's ability to simultaneously determine the atomic emissions of many of the elements in analytes that elute from a GC capillary column (called eluants or solutes in some books). As eluants come off the capillary column they are fed into a microwave powered plasma (or discharge) cavity where the compounds are destroyed and their atoms are excited by the energy of the plasma. The light that is emitted by the excited particles is separated into individual lines via a photodiode array. The associated computer then sorts out the individual emission lines and can produce chromatograms made up of peaks from eluants that contain only a specific element." []
synonym: "AED" EXACT []
is_a: OBI:0000637  ! gas chromatography detector

[Typedef]
id: OBI:0000643
name: has grain
def: "the relation of the cells in the finger of the skin to the finger, in which an indeterminate number of grains are parts of the whole by virtue of being grains in a collective that is part of the whole, and in which removing one granular part does not necessarily damage or diminish the whole. Ontological Whether there is a fixed, or nearly fixed number of parts - e.g. fingers of the hand, chambers of the heart, or wheels of a car - such that there can be a notion of a single one being missing, or whether, by contrast, the number of parts is indeterminate - e.g., cells in the skin of the hand, red cells in blood, or rubber molecules in the tread of the tire of the wheel of the car." []
is_a: OBO_REL:has_part 

[Typedef]
id: OBI:0000645
name: is grain of
is_a: OBO_REL:part_of 

[Typedef]
id: OBI:0000646
name: supplies
def: "A relation between an organisation or person and a material entity who owned or has license to the material entity and there was a legal transfer of ownership or licensing of the material entity to the current owner." []

[Typedef]
id: OBI:0000647
name: has_supplier
def: "A relation between a material entity and an organisation or person who owned or has license to the material entity and there was a legal transfer of ownership or licensing of the material entity to the current owner." []
inverse_of_on_instance_level: OBI:0000646  ! supplies

[Term]
id: OBI:0000648
name: clustered data set
def: "A clustered data set is a data set that is produced as the output of a class discovery data transformation and consists of a data set with assigned discovered class labels." []
synonym: "data set with assigned discovered class labels" EXACT []
is_a: IAO:0000100 

[Term]
id: OBI:0000649
name: data set of features
def: "A data set of features is a data set that is produced as the output of a descriptive statistical calculation data transformation and consists of producing a data set that represents one or more features of interest about the input data set." []
is_a: IAO:0000100 

[Term]
id: OBI:0000650
name: differential expression analysis data transformation
def: "A differential expression analysis data transformation is a data transformation that has objective differential expression analysis and that consists of" []
is_a: OBI:0200000  ! data transformation

[Term]
id: OBI:0000651
name: urine specimen
def: "is a portion of urine collected from an organism" []
is_a: OBI:0100051  ! specimen
relationship: OBI:0000312 OBI:0600005 ! collecting specimen from organism
relationship: OBI:0000316 OBI:0000112 ! specimen role
disjoint_from: OBI:0000050  ! platform
disjoint_from: OBI:0000146  ! supernatant collection system harvesting frame
disjoint_from: OBI:0000245  ! organization
disjoint_from: OBI:0000318  ! eluate
disjoint_from: OBI:0000390  ! thermostatic circulator
disjoint_from: OBI:0000420  ! trypsinized material
disjoint_from: OBI:0000432  ! polyacrylamide gel
disjoint_from: OBI:0000439  ! agarose gel
disjoint_from: OBI:0000576  ! scattered molecular aggregate
disjoint_from: OBI:0000655  ! blood specimen
disjoint_from: OBI:0000680  ! whole organism preparation
disjoint_from: OBI:0000798  ! capsule shell
disjoint_from: OBI:0000814  ! guar gum
disjoint_from: OBI:0100014  ! chimera
disjoint_from: OBI:0100016  ! blood plasma
disjoint_from: OBI:0100017  ! blood serum specimen
disjoint_from: OBI:0100039  ! fragment derived from protein
disjoint_from: OBI:0100055  ! cell line cell
disjoint_from: OBI:0100056  ! immortalized cell line
disjoint_from: OBI:0100058  ! xenograft
disjoint_from: OBI:0100060  ! cell culture
disjoint_from: OBI:0100067  ! bronchial alveolar lavage
disjoint_from: OBI:0100069  ! polymer
disjoint_from: OBI:0100086  ! glucose in solution
disjoint_from: OBI:0302714  ! collection (of entities of organismal origin)
disjoint_from: OBI:0400102  ! waste tank
disjoint_from: OBI:1000023  ! cell culture supernatant
disjoint_from: OBI:1000024  ! cell pellet
disjoint_from: OBI:1000036  ! cell lysate
disjoint_from: OBI:1000042  ! peptide construct
disjoint_from: OBI:1000048  ! transgenic organism

[Term]
id: OBI:0000652
name: material combination
def: "is a material processing with the objective to combine two or more material entities as input into a single material entity as output." []
is_a: OBI:0000094  ! material processing
relationship: OBI:0000293 snap:MaterialEntity
relationship: OBI:0000299 snap:MaterialEntity

[Term]
id: OBI:0000653
name: fuzzy clustering objective
def: "A fuzzy clustering objective is a data transformation objective where the aim is to assign input objects (typically vectors of attributes) a probability that a point belongs to a class, where the number of class and their specifications are not known a priori." []
is_a: OBI:0200166  ! data transformation objective
disjoint_from: OBI:0000425  ! averaging objective
disjoint_from: OBI:0000675  ! statistical hypothesis test objective
disjoint_from: OBI:0000704  ! decision tree induction objective
disjoint_from: OBI:0200005  ! feature extraction objective
disjoint_from: OBI:0200031  ! differential expression analysis objective
disjoint_from: OBI:0200078  ! descriptive statistical calculation objective
disjoint_from: OBI:0200081  ! sequence analysis objective
disjoint_from: OBI:0200083  ! survival analysis objective
disjoint_from: OBI:0200157  ! data vector reduction objective
disjoint_from: OBI:0200167  ! data normalization objective
disjoint_from: OBI:0200168  ! correction objective
disjoint_from: OBI:0200172  ! partitioning objective
disjoint_from: OBI:0200174  ! curve fitting objective
disjoint_from: OBI:0200177  ! center calculation objective
disjoint_from: OBI:0200178  ! class discovery objective
disjoint_from: OBI:0200179  ! class prediction objective
disjoint_from: OBI:0200180  ! spread calculation objective
disjoint_from: OBI:0200183  ! scaling objective
disjoint_from: OBI:0200189  ! merging objective
disjoint_from: OBI:0200196  ! correlation study objective
disjoint_from: OBI:0200197  ! spectrum analysis objective

[Term]
id: OBI:0000654
name: device setting
def: "Device_setting inheres_in some device and is concretization of some (device_setting_specification and is_about a quality of the device" []
is_a: snap:Quality 
relationship: http://purl.org/obo/owl/OBO_REL#inheres_in OBI:0000047 ! processed material

[Term]
id: OBI:0000655
name: blood specimen
def: "a material entity derived from a portion of blood collected from an organism" []
is_a: OBI:0100051  ! specimen
relationship: OBI:0000312 OBI:0600005 ! collecting specimen from organism
relationship: OBI:0000316 OBI:0000112 ! specimen role
relationship: OBO_REL:derives_from FMA:9670 ! Blood
disjoint_from: OBI:0000050  ! platform
disjoint_from: OBI:0000146  ! supernatant collection system harvesting frame
disjoint_from: OBI:0000245  ! organization
disjoint_from: OBI:0000318  ! eluate
disjoint_from: OBI:0000390  ! thermostatic circulator
disjoint_from: OBI:0000420  ! trypsinized material
disjoint_from: OBI:0000432  ! polyacrylamide gel
disjoint_from: OBI:0000439  ! agarose gel
disjoint_from: OBI:0000576  ! scattered molecular aggregate
disjoint_from: OBI:0000651  ! urine specimen
disjoint_from: OBI:0000680  ! whole organism preparation
disjoint_from: OBI:0000798  ! capsule shell
disjoint_from: OBI:0000814  ! guar gum
disjoint_from: OBI:0100014  ! chimera
disjoint_from: OBI:0100016  ! blood plasma
disjoint_from: OBI:0100017  ! blood serum specimen
disjoint_from: OBI:0100039  ! fragment derived from protein
disjoint_from: OBI:0100055  ! cell line cell
disjoint_from: OBI:0100056  ! immortalized cell line
disjoint_from: OBI:0100058  ! xenograft
disjoint_from: OBI:0100060  ! cell culture
disjoint_from: OBI:0100067  ! bronchial alveolar lavage
disjoint_from: OBI:0100069  ! polymer
disjoint_from: OBI:0100086  ! glucose in solution
disjoint_from: OBI:0302714  ! collection (of entities of organismal origin)
disjoint_from: OBI:0400102  ! waste tank
disjoint_from: OBI:1000023  ! cell culture supernatant
disjoint_from: OBI:1000024  ! cell pellet
disjoint_from: OBI:1000036  ! cell lysate
disjoint_from: OBI:1000042  ! peptide construct
disjoint_from: OBI:1000048  ! transgenic organism

[Term]
id: OBI:0000656
name: data set of predicted values according to fitted curve
def: "A data set of predicted values according to fitted curvet is a data set which is the output of a curve fitting data transformation in which the aim is to find a curve which matches a series of data points and possibly other constraints." []
is_a: IAO:0000100 

[Term]
id: OBI:0000658
name: data representational model
def: "Data representational model is an information content entity of the  relationships between data items. A data representational model is encoded in a data format specification such as for cytoscape or biopax." []
synonym: "data structure" EXACT []
synonym: "data structure specification" EXACT []
is_a: IAO:0000033 
disjoint_from: OBI:0000750  ! independent variable specification
disjoint_from: OBI:0000751  ! dependent variable specification
disjoint_from: OBI:0000785  ! controlled variable specification

[Term]
id: OBI:0000659
name: specimen creation
def: "a planned process with the objective of obtaining specimen." []
is_a: OBI:0000011  ! planned process
intersection_of: OBI:0000011  ! planned process
intersection_of: OBI:0000299 OBI:0100051 ! specimen
intersection_of: OBI:0000417 OBI:0000684 ! specimen creation objective

[Term]
id: OBI:0000660
name: background corrected data set
def: "A background corrected data set is a data set that is produced as the output of a background correction data transformation." []
is_a: IAO:0000100 

[Term]
id: OBI:0000661
name: ELISA
def: "ELISA is an assay where an enzyme linked antibody is used to detect a plate bound material in a liquid (the evaluant) utilizing a chemiluminescent reaction. The detected signal is proxy for the concentration of an analyte in the evaluant." []
synonym: "Enzyme-Linked ImmunoSorbent Assay" EXACT []
is_a: OBI:0000443  ! analyte assay
relationship: OBI:0000308 OBI:0000275 ! analyte role
relationship: OBI:0000417 OBI:0000437 ! analyte measurement objective

[Term]
id: OBI:0000662
name: error corrected data set
def: "An error corrected data set is a data set that is produced as the output of an error correction data transformation and consists of producing a data set which has had erroneous contributions from the input to the data transformation removed (corrected for)." []
is_a: IAO:0000100 

[Term]
id: OBI:0000663
name: class prediction data transformation
def: "A class prediction data transformation (sometimes called supervised classification) is a data transformation that has objective class prediction." []
synonym: "supervised classification data transformation" EXACT []
is_a: OBI:0200000  ! data transformation
union_of: http://purl.obolibrary.org/obo/OBI_0000299(http://purl.obolibrary.org/obo/OBI_0000023) 
union_of: http://purl.obolibrary.org/obo/OBI_0000417(http://purl.obolibrary.org/obo/OBI_0200179) 

[Term]
id: OBI:0000664
name: BrdU incorporation assay
def: "A BrdU incorporation assay is an assay to detect actively replicating cells.  BrdU is incorporated into the newly synthesized DNA of replicating cells (during the S phase of the cell cycle), substituting for thymidine during DNA replication. Antibodies specific for BrdU can then be used to detect the incorporated chemical, thus indicating cells that were actively replicating their DNA." []
is_a: OBI:0000070  ! assay
relationship: OBI:0000293 CL:0000000 ! cell
relationship: OBI:0000417 OBI:0000441 ! assay objective

[Term]
id: OBI:0000665
name: intracellular cytokine staining assay
def: "The measurement of cytokines within the cytoplasm of a cell by permeabilizing the cell membrane to allow entry of specific antibodies, and counting the stained cells using a flow cytometer." []
synonym: "ICCS" EXACT []
synonym: "ICS" EXACT []
is_a: OBI:0000070  ! assay
relationship: OBI:0000293 OBI:0100060 ! cell culture
relationship: OBI:0000417 OBI:0000441 ! assay objective
relationship: OBO_REL:has_part OBI:0600033 ! cell permeabilization

[Term]
id: OBI:0000666
name: background correction data transformation
def: "A background correction data transformation (sometimes called supervised classification) is a data transformation that has the objective background correction." []
is_a: OBI:0200000  ! data transformation
union_of: http://purl.obolibrary.org/obo/OBI_0000299(http://purl.obolibrary.org/obo/OBI_0000660) 
union_of: http://purl.obolibrary.org/obo/OBI_0000417(http://purl.obolibrary.org/obo/OBI_0200173) 

[Term]
id: OBI:0000667
name: MHC multimer assay
def: "An MHC multimer assay is an assay that detects T cells capable of binding the MHC:ligand complexes present in the multimer. The multimer is fluorescently labelled. The T cells bound to multimers are counted in a flow cytometer" []
synonym: "MHC tetramer assay" EXACT []
is_a: OBI:0000070  ! assay
relationship: OBI:0000293 OBI:0100060 ! cell culture
relationship: OBI:0000417 OBI:0000441 ! assay objective

[Term]
id: OBI:0000668
name: error correction data transformation
def: "An error correction data transformation is a data transformation that has the objective of error correction, where the aim is to remove (correct for) erroneous contributions from the input to the data transformation." []
is_a: OBI:0200000  ! data transformation

[Term]
id: OBI:0000669
name: tritiated thymidine incorporation assay
def: "A tritiated thymidine incorporation assay is an assay to detect actively replicating cells. Tritiated thymidine is incorporated into the newly synthesized DNA of replicating cells (during the S phase of the cell cycle). The radioactivity of tritiated thymidine can then be detected thus indicating cells that were actively replicating their DNA." []
is_a: OBI:0000070  ! assay
relationship: OBI:0000293 CL:0000000 ! cell
relationship: OBI:0000417 OBI:0000441 ! assay objective

[Term]
id: OBI:0000671
name: sample from organism
def: "a sample from organism is a material obtained from an organism in order to be a representative of the whole" []
is_a: OBI:0000747  ! material sample
relationship: OBO_REL:derives_from OBI:0100015 ! anatomical entity

[Term]
id: OBI:0000673
name: statistical hypothesis test
def: "A statistical hypothesis test data transformation is a data transformation that has objective statistical hypothesis test." []
is_a: OBI:0200000  ! data transformation

[Term]
id: OBI:0000674
name: center value
def: "A centre value is a data item that is produced as the output of a center calculation data transformation and represents the center value of the input data." []
synonym: "centre value" EXACT []
is_a: IAO:0000027 

[Term]
id: OBI:0000675
name: statistical hypothesis test objective
def: "is a data transformation objective where the aim is to estimate statistical significance with the aim of proving or disproving a hypothesis by means of some data transformation " []
synonym: "hypothesis test objective" EXACT []
is_a: OBI:0200166  ! data transformation objective
disjoint_from: OBI:0000425  ! averaging objective
disjoint_from: OBI:0000653  ! fuzzy clustering objective
disjoint_from: OBI:0000704  ! decision tree induction objective
disjoint_from: OBI:0200005  ! feature extraction objective
disjoint_from: OBI:0200031  ! differential expression analysis objective
disjoint_from: OBI:0200078  ! descriptive statistical calculation objective
disjoint_from: OBI:0200081  ! sequence analysis objective
disjoint_from: OBI:0200083  ! survival analysis objective
disjoint_from: OBI:0200157  ! data vector reduction objective
disjoint_from: OBI:0200167  ! data normalization objective
disjoint_from: OBI:0200168  ! correction objective
disjoint_from: OBI:0200172  ! partitioning objective
disjoint_from: OBI:0200174  ! curve fitting objective
disjoint_from: OBI:0200177  ! center calculation objective
disjoint_from: OBI:0200178  ! class discovery objective
disjoint_from: OBI:0200179  ! class prediction objective
disjoint_from: OBI:0200180  ! spread calculation objective
disjoint_from: OBI:0200183  ! scaling objective
disjoint_from: OBI:0200189  ! merging objective
disjoint_from: OBI:0200196  ! correlation study objective
disjoint_from: OBI:0200197  ! spectrum analysis objective

[Term]
id: OBI:0000676
name: reduced dimension data set
def: "A reduced dimension data set is a data set that is produced as the output of a data vector reduction data transformation and consists of producing a data set which has fewer vectors than the input data set." []
is_a: IAO:0000100 

[Term]
id: OBI:0000678
name: portioning objective
def: "is the objective to separate material into multiple portions, each of which contains a similar composition of the input material." []
is_a: OBI:0000639  ! material separation objective
disjoint_from: OBI:0000681  ! separation into different composition objective

[Term]
id: OBI:0000679
name: average value
def: "An average value is a data item that is produced as the output of an averaging data transformation and represents the average value of the input data." []
is_a: IAO:0000027 

[Term]
id: OBI:0000680
name: whole organism preparation
def: "A material entity which is the output of a process in which one or more whole organisms are prepared in a way to make it easier to study them, and in which the great majority of organismal parts are maintained" []
is_a: snap:MaterialEntity 
relationship: OBI:0000312 OBI:0000659 ! specimen creation
relationship: OBO_REL:derives_from OBI:0100026 ! organism
disjoint_from: OBI:0000050  ! platform
disjoint_from: OBI:0000146  ! supernatant collection system harvesting frame
disjoint_from: OBI:0000245  ! organization
disjoint_from: OBI:0000318  ! eluate
disjoint_from: OBI:0000390  ! thermostatic circulator
disjoint_from: OBI:0000420  ! trypsinized material
disjoint_from: OBI:0000432  ! polyacrylamide gel
disjoint_from: OBI:0000439  ! agarose gel
disjoint_from: OBI:0000576  ! scattered molecular aggregate
disjoint_from: OBI:0000651  ! urine specimen
disjoint_from: OBI:0000655  ! blood specimen
disjoint_from: OBI:0000798  ! capsule shell
disjoint_from: OBI:0000814  ! guar gum
disjoint_from: OBI:0100014  ! chimera
disjoint_from: OBI:0100016  ! blood plasma
disjoint_from: OBI:0100017  ! blood serum specimen
disjoint_from: OBI:0100039  ! fragment derived from protein
disjoint_from: OBI:0100055  ! cell line cell
disjoint_from: OBI:0100056  ! immortalized cell line
disjoint_from: OBI:0100058  ! xenograft
disjoint_from: OBI:0100060  ! cell culture
disjoint_from: OBI:0100067  ! bronchial alveolar lavage
disjoint_from: OBI:0100069  ! polymer
disjoint_from: OBI:0100086  ! glucose in solution
disjoint_from: OBI:0302714  ! collection (of entities of organismal origin)
disjoint_from: OBI:0400102  ! waste tank
disjoint_from: OBI:1000023  ! cell culture supernatant
disjoint_from: OBI:1000024  ! cell pellet
disjoint_from: OBI:1000036  ! cell lysate
disjoint_from: OBI:1000042  ! peptide construct
disjoint_from: OBI:1000048  ! transgenic organism

[Term]
id: OBI:0000681
name: separation into different composition objective
def: "is the objective to separate a material entity that has parts of different types, and end with at least one output that is a material with parts of fewer types (modulo impurities)" []
is_a: OBI:0000639  ! material separation objective
disjoint_from: OBI:0000678  ! portioning objective

[Term]
id: OBI:0000682
name: study result
def: "Study result is an information content entity  that is a specified data output of a study." []
is_a: IAO:0000030 
disjoint_from: OBI:0000021  ! list-mode data file
disjoint_from: OBI:0000078  ! eMedical record
disjoint_from: OBI:0000083  ! electronic case report tabulation
disjoint_from: OBI:0000158  ! eSource document
disjoint_from: OBI:0000167  ! electronic case report form
disjoint_from: OBI:0000210  ! analytical cytology data file
disjoint_from: OBI:0000213  ! fluorescence compensation matrix
disjoint_from: OBI:0302840  ! curated
disjoint_from: OBI:0302874  ! edited information

[Term]
id: OBI:0000684
name: specimen creation objective
def: "A specimen creation objective is to obtain and store a material entity for potential use as an input during an investigation" []
is_a: IAO:0000005 
disjoint_from: OBI:0000015  ! biological feature identification objective
disjoint_from: OBI:0000208  ! methodology testing objective
disjoint_from: OBI:0000441  ! assay objective
disjoint_from: OBI:0000456  ! material transformation objective
disjoint_from: OBI:0000806  ! material maintenance objective
disjoint_from: OBI:0200166  ! data transformation objective

[Term]
id: OBI:0000685
name: creating a mixture of molecules in solution
def: "is a process with the objective to prepare a liquid solution of one or more chemicals at desired concentrations." []
is_a: OBI:0000652  ! material combination
relationship: OBI:0000293 snap:MaterialEntity
relationship: OBI:0000299 OBI:0302729 ! chemical solution
relationship: OBI:0000417 OBI:0000456 ! material transformation objective
relationship: OBI:0000417 OBI:0000686 ! material combination objective

[Term]
id: OBI:0000686
name: material combination objective
def: "is an objective to obtain an output material that contains several input materials." []
is_a: OBI:0000456  ! material transformation objective
disjoint_from: OBI:0000458  ! manufacturing objective

[Term]
id: OBI:0000687
name: nucleotide overhang cloning
def: "Nucleotide overhang cloning is the process of inserting nucleic acid into a vector using nucleotide overhangs used to prevent self ligation" []
is_a: OBI:0600064  ! recombinant vector cloning
disjoint_from: OBI:0000692  ! recombination enzyme based cloning
disjoint_from: OBI:0000738  ! restriction enzyme based cloning
disjoint_from: OBI:0000790  ! recombinant BAC cloning
disjoint_from: OBI:0000799  ! recombinant phage cloning
disjoint_from: OBI:0000824  ! recombinant YAC cloning
disjoint_from: OBI:0600048  ! vector mediated amplification
disjoint_from: OBI:0600063  ! vector mediated expression

[Term]
id: OBI:0000688
name: rodent care protocol
def: "A rodent care protocol is an animal protocol in which the animals being taken care of are rodents." []
is_a: OBI:0000715  ! animal care protocol

[Term]
id: OBI:0000689
name: 454 Genome Sequence 20
def: "is a DNA sequencer which is manufactured by 454 Life Science Corporation and enables pyrosequencing to be performed. It comprises both optics and fluidics subsystems, which are\ncontrolled by a computer subsystem. The fluidics subsystem ensures accurate reagent dispensing. It consists of a reagents cassette (which holds the reagent containers), a sipper manifold, pumps, valves, and debubblers. The fluidics subsystem flows the sequencing reagents across the wells of the PicoTiterPlate device, and moves the spent reagents from the PicoTiterPlate device to the waste receptacle. The optics subsystem consists of a CCD camera and a camera controller. The camera captures the light emitted in the wells of the PicoTiterPlate device during each step of the sequencing cycle, and sends the digital images to the computer subsystem for processing. The computer controls the other Sequencer subsystems, and processes the digital images sent by the camera to extract the DNA sequence information." []
synonym: "GS 20" EXACT []
is_a: OBI:0400103  ! DNA sequencer

[Term]
id: OBI:0000690
name: immunoprecipitation
def: "is a process which realizes a material separation objective by relying on antibodies to specifically binding to material entity" []
is_a: OBI:0600014  ! material component separation
relationship: OBI:0000293 GO:0042571 ! immunoglobulin complex, circulating
relationship: OBI:0000417 OBI:0000639 ! material separation objective

[Term]
id: OBI:0000691
name: ABI 377 automated sequencer
def: "is a DNA sequencer which is manufactured by Applied Biosystems corporation (formerly Perkin-Elmer). It allows automated chain termination DNA sequencing. It has part polyacrylamide gel electrophoresis system and a laser -based detection system to detect fluorescence intensity emitted by the dyes attached to the dideoxyterminator nucleotides or to the primers." []
is_a: OBI:0400103  ! DNA sequencer

[Term]
id: OBI:0000692
name: recombination enzyme based cloning
def: "a recombination enzyme based cloning is a recombinant vector cloning process that uses complementary nucleotide sequences in both the insert genetic material and the cloning vector with a recombination enzyme to directly create a recombinant vector" []
is_a: OBI:0600064  ! recombinant vector cloning
disjoint_from: OBI:0000687  ! nucleotide overhang cloning
disjoint_from: OBI:0000738  ! restriction enzyme based cloning
disjoint_from: OBI:0000790  ! recombinant BAC cloning
disjoint_from: OBI:0000799  ! recombinant phage cloning
disjoint_from: OBI:0000824  ! recombinant YAC cloning
disjoint_from: OBI:0600048  ! vector mediated amplification
disjoint_from: OBI:0600063  ! vector mediated expression

[Term]
id: OBI:0000693
name: MeDIP-SEQ assay
def: "is an assay which aims at identifying methylated sites in genomic DNA and determining methylation pattern that affect  gene transcription by relying on immunoprecipitation of methylated genomic DNA, creation of a library of corresponding DNA fragments (either single or paired-end fragments) and subsequent sequencing using parallelized sequencing methods." []
synonym: "Methylated DNA immunoprecipitation sequencing assay" EXACT []
is_a: OBI:0000070  ! assay
relationship: OBI:0000417 OBI:0000441 ! assay objective
relationship: OBO_REL:has_part OBI:0000690 ! immunoprecipitation

[Term]
id: OBI:0000694
name: animal feeding
def: "animal feeding is a process in which animals are provided with food" []
is_a: OBI:0000011  ! planned process
relationship: OBI:0000293 OBI:0100026 ! organism
relationship: OBI:0000299 OBI:0100026 ! organism
relationship: OBI:0000308 OBI:0000248 ! feed role

[Term]
id: OBI:0000695
name: chain termination sequencing
def: "is a DNA sequencing which rely on the use of dideoxynucleotides used in 4 distinct sequencing reaction on the same DNA sample. The dideoxynucleotides, once incorporated in the complementary DNA strand being synthesized by the DNA polymerase prevent any further chain elongation. The newly generated sequences are resolved on a polyacrylamide gel using electrophoresis and labels (either fluorochrome or radioactivity) are used to determine the nucleotide present at a given position" []
synonym: "Sanger sequencing" EXACT []
synonym: "dye terminator sequencing" EXACT []
is_a: OBI:0000734  ! DNA sequencing by synthesis
relationship: OBI:0000293 OBI:0000406 ! PCR product
disjoint_from: OBI:0000697  ! Helicos sequencing
disjoint_from: OBI:0000724  ! Solexa sequencing
disjoint_from: OBI:0000730  ! pyrosequencing

[Term]
id: OBI:0000696
name: AB SOLiD System
def: "is a DNA sequencer which is manufactured by Applied Biosystems and which enable DNA sequencing by ligation" []
is_a: OBI:0400103  ! DNA sequencer

[Term]
id: OBI:0000697
name: Helicos sequencing
def: "is a DNA sequencing which allows sequence identification of billions of DNA molecules immobilized to a surface by using DNA polymerase and fluorescently labeled nucleotides added one at a time. The sequencing process does not requires amplification step and is typically able to produce reads of 25 base pair length." []
synonym: "true single molecule sequencing" EXACT []
is_a: OBI:0000734  ! DNA sequencing by synthesis
relationship: OBO_REL:has_participant OBI:0000717 ! HeliScope Single Molecule Sequencer
relationship: OBO_REL:preceded_by OBI:0302902 ! immobilization
disjoint_from: OBI:0000695  ! chain termination sequencing
disjoint_from: OBI:0000724  ! Solexa sequencing
disjoint_from: OBI:0000730  ! pyrosequencing

[Term]
id: OBI:0000698
name: DNA ligase
def: "A DNA ligase is an enzyme that covalently joins two compatible pieces of DNA through the cleavage of an ATP molecule" []
synonym: "ligase" EXACT []
is_a: OBI:0000427  ! enzyme
is_a: PRO:000000001  ! protein
relationship: OBI:0000306 GO:0003824 ! catalytic activity
disjoint_from: OBI:0000732  ! restriction enzyme
disjoint_from: OBI:1110132  ! CD8 receptor

[Term]
id: OBI:0000699
name: survival assessment
def: "Survival assessment is an assay that measures the occurrence of death events in one or more organisms that are monitored over time" []
is_a: OBI:0000070  ! assay
relationship: OBI:0000293 OBI:0100026 ! organism
relationship: OBI:0000417 OBI:0000441 ! assay objective

[Term]
id: OBI:0000700
name: support vector machine
def: "A support vector machine is a data transformation with a class prediction objective based on the construction of a separating hyperplane that maximizes the margin between two data sets of vectors in n-dimensional space." []
synonym: "SVM" EXACT []
is_a: OBI:0000663  ! class prediction data transformation
relationship: OBI:0000417 OBI:0200179 ! class prediction objective
disjoint_from: OBI:0000701  ! self-organizing map
disjoint_from: OBI:0000726  ! peak matching
disjoint_from: OBI:0000727  ! k-nearest neighbors
disjoint_from: OBI:0000739  ! Student's t-test
disjoint_from: OBI:0000749  ! CART
disjoint_from: OBI:0200002  ! logistic-log curve fitting
disjoint_from: OBI:0200003  ! logit-log curve fitting
disjoint_from: OBI:0200004  ! log-log curve fitting
disjoint_from: OBI:0200006  ! biexponential transformation
disjoint_from: OBI:0200007  ! box-cox transformation
disjoint_from: OBI:0200008  ! hyperlog transformation
disjoint_from: OBI:0200011  ! logical transformation
disjoint_from: OBI:0200014  ! split-scale transformation
disjoint_from: OBI:0200016  ! sine transformation
disjoint_from: OBI:0200017  ! cosine transformation
disjoint_from: OBI:0200021  ! linlog transformation
disjoint_from: OBI:0200022  ! variance stabilizing transformation
disjoint_from: OBI:0200025  ! loess scale group transformation
disjoint_from: OBI:0200026  ! total intensity transformation single
disjoint_from: OBI:0200027  ! total intensity transformation paired
disjoint_from: OBI:0200028  ! quantile transformation
disjoint_from: OBI:0200029  ! mean centering
disjoint_from: OBI:0200030  ! median centering
disjoint_from: OBI:0200033  ! leave one out cross validation method
disjoint_from: OBI:0200034  ! jackknifing method
disjoint_from: OBI:0200035  ! boostrapping
disjoint_from: OBI:0200036  ! Benjamini and Hochberg false discovery rate correction method
disjoint_from: OBI:0200037  ! pareto scaling
disjoint_from: OBI:0200041  ! k-means clustering
disjoint_from: OBI:0200042  ! hierarchical clustering
disjoint_from: OBI:0200049  ! Benjamini and Yekutieli false discovery rate correction method
disjoint_from: OBI:0200050  ! dimensionality reduction
disjoint_from: OBI:0200052  ! probabilistic algorithm
disjoint_from: OBI:0200056  ! moving average
disjoint_from: OBI:0200057  ! replicate analysis
disjoint_from: OBI:0200058  ! b cell epitope prediction
disjoint_from: OBI:0200059  ! mhc binding prediction
disjoint_from: OBI:0200060  ! t cell epitope prediction
disjoint_from: OBI:0200061  ! data imputation
disjoint_from: OBI:0200062  ! continuum mass spectrum
disjoint_from: OBI:0200063  ! characteristic path length calculation
disjoint_from: OBI:0200064  ! centroid mass spectrum
disjoint_from: OBI:0200066  ! Holm false discovery rate correction method
disjoint_from: OBI:0200071  ! loess transformation
disjoint_from: OBI:0200073  ! family wise error rate correction method
disjoint_from: OBI:0200077  ! gating
disjoint_from: OBI:0200079  ! mean calculation
disjoint_from: OBI:0200080  ! network analysis
disjoint_from: OBI:0200082  ! longitudinal data analysis
disjoint_from: OBI:0200088  ! Kaplan Meier
disjoint_from: OBI:0200092  ! Westfall and Young family wise error rate correction
disjoint_from: OBI:0200093  ! polynomial transformation
disjoint_from: OBI:0200094  ! logarithmic transformation
disjoint_from: OBI:0200095  ! exponential transformation
disjoint_from: OBI:0200097  ! non-negative matrix factorization
disjoint_from: OBI:0200098  ! soft independent modeling of class analogy analysis
disjoint_from: OBI:0200102  ! regression analysis method
disjoint_from: OBI:0200106  ! discriminant analysis
disjoint_from: OBI:0200108  ! eh transformation
disjoint_from: OBI:0200109  ! b transformation
disjoint_from: OBI:0200110  ! s transformation
disjoint_from: OBI:0200113  ! similarity calculation
disjoint_from: OBI:0200116  ! loess fitting
disjoint_from: OBI:0200117  ! mode calculation
disjoint_from: OBI:0200118  ! quantile calculation
disjoint_from: OBI:0200119  ! median calculation
disjoint_from: OBI:0200120  ! variance calculation
disjoint_from: OBI:0200121  ! standard deviation calculation
disjoint_from: OBI:0200122  ! interquartile-range calculation
disjoint_from: OBI:0200123  ! skewness calculation
disjoint_from: OBI:0200124  ! kurtosis calculation
disjoint_from: OBI:0200125  ! data combination
disjoint_from: OBI:0200140  ! mathematical feature
disjoint_from: OBI:0200149  ! unit-variance scaling
disjoint_from: OBI:0200150  ! MA transformation
disjoint_from: OBI:0200156  ! data partitioning
disjoint_from: OBI:0200160  ! generalized family wise error rate correction method
disjoint_from: OBI:0200161  ! quantile number of false positives correction method
disjoint_from: OBI:0200162  ! tail probability for the proportion of false positives correction method
disjoint_from: OBI:0200163  ! false discovery rate correction method
disjoint_from: OBI:0200164  ! proportion of expected false positives correction method
disjoint_from: OBI:0200165  ! quantile proportion of false positives correction method
disjoint_from: OBI:0200176  ! Fisher's exact test
disjoint_from: OBI:0200195  ! proportional hazards model estimation
disjoint_from: OBI:0200198  ! tandem mass spectrometry
disjoint_from: OBI:0200199  ! gas chromatography mass spectrometry
disjoint_from: OBI:0200200  ! chi square test

[Term]
id: OBI:0000701
name: self-organizing map
def: "A self-organizing map (SOM) is an artificial neural network with objective class discovery that uses a neighborhood function to preserve the topological properties of a dataset to produce low-dimensional (typically 2) discretized representation of the training data set. A set of artificial neurons learn to map points in an input space to coordinates in an output space. The input space can have different dimensions and topology from the output space, and the SOM will attempt to preserve these." []
synonym: "SOM" EXACT []
is_a: OBI:0200175  ! class discovery data transformation
disjoint_from: OBI:0000700  ! support vector machine
disjoint_from: OBI:0000726  ! peak matching
disjoint_from: OBI:0000727  ! k-nearest neighbors
disjoint_from: OBI:0000739  ! Student's t-test
disjoint_from: OBI:0000749  ! CART
disjoint_from: OBI:0200002  ! logistic-log curve fitting
disjoint_from: OBI:0200003  ! logit-log curve fitting
disjoint_from: OBI:0200004  ! log-log curve fitting
disjoint_from: OBI:0200006  ! biexponential transformation
disjoint_from: OBI:0200007  ! box-cox transformation
disjoint_from: OBI:0200008  ! hyperlog transformation
disjoint_from: OBI:0200011  ! logical transformation
disjoint_from: OBI:0200014  ! split-scale transformation
disjoint_from: OBI:0200016  ! sine transformation
disjoint_from: OBI:0200017  ! cosine transformation
disjoint_from: OBI:0200021  ! linlog transformation
disjoint_from: OBI:0200022  ! variance stabilizing transformation
disjoint_from: OBI:0200025  ! loess scale group transformation
disjoint_from: OBI:0200026  ! total intensity transformation single
disjoint_from: OBI:0200027  ! total intensity transformation paired
disjoint_from: OBI:0200028  ! quantile transformation
disjoint_from: OBI:0200029  ! mean centering
disjoint_from: OBI:0200030  ! median centering
disjoint_from: OBI:0200033  ! leave one out cross validation method
disjoint_from: OBI:0200034  ! jackknifing method
disjoint_from: OBI:0200035  ! boostrapping
disjoint_from: OBI:0200036  ! Benjamini and Hochberg false discovery rate correction method
disjoint_from: OBI:0200037  ! pareto scaling
disjoint_from: OBI:0200041  ! k-means clustering
disjoint_from: OBI:0200042  ! hierarchical clustering
disjoint_from: OBI:0200049  ! Benjamini and Yekutieli false discovery rate correction method
disjoint_from: OBI:0200050  ! dimensionality reduction
disjoint_from: OBI:0200052  ! probabilistic algorithm
disjoint_from: OBI:0200056  ! moving average
disjoint_from: OBI:0200057  ! replicate analysis
disjoint_from: OBI:0200058  ! b cell epitope prediction
disjoint_from: OBI:0200059  ! mhc binding prediction
disjoint_from: OBI:0200060  ! t cell epitope prediction
disjoint_from: OBI:0200061  ! data imputation
disjoint_from: OBI:0200062  ! continuum mass spectrum
disjoint_from: OBI:0200063  ! characteristic path length calculation
disjoint_from: OBI:0200064  ! centroid mass spectrum
disjoint_from: OBI:0200066  ! Holm false discovery rate correction method
disjoint_from: OBI:0200071  ! loess transformation
disjoint_from: OBI:0200073  ! family wise error rate correction method
disjoint_from: OBI:0200077  ! gating
disjoint_from: OBI:0200079  ! mean calculation
disjoint_from: OBI:0200080  ! network analysis
disjoint_from: OBI:0200082  ! longitudinal data analysis
disjoint_from: OBI:0200088  ! Kaplan Meier
disjoint_from: OBI:0200092  ! Westfall and Young family wise error rate correction
disjoint_from: OBI:0200093  ! polynomial transformation
disjoint_from: OBI:0200094  ! logarithmic transformation
disjoint_from: OBI:0200095  ! exponential transformation
disjoint_from: OBI:0200097  ! non-negative matrix factorization
disjoint_from: OBI:0200098  ! soft independent modeling of class analogy analysis
disjoint_from: OBI:0200102  ! regression analysis method
disjoint_from: OBI:0200106  ! discriminant analysis
disjoint_from: OBI:0200108  ! eh transformation
disjoint_from: OBI:0200109  ! b transformation
disjoint_from: OBI:0200110  ! s transformation
disjoint_from: OBI:0200113  ! similarity calculation
disjoint_from: OBI:0200116  ! loess fitting
disjoint_from: OBI:0200117  ! mode calculation
disjoint_from: OBI:0200118  ! quantile calculation
disjoint_from: OBI:0200119  ! median calculation
disjoint_from: OBI:0200120  ! variance calculation
disjoint_from: OBI:0200121  ! standard deviation calculation
disjoint_from: OBI:0200122  ! interquartile-range calculation
disjoint_from: OBI:0200123  ! skewness calculation
disjoint_from: OBI:0200124  ! kurtosis calculation
disjoint_from: OBI:0200125  ! data combination
disjoint_from: OBI:0200140  ! mathematical feature
disjoint_from: OBI:0200149  ! unit-variance scaling
disjoint_from: OBI:0200150  ! MA transformation
disjoint_from: OBI:0200156  ! data partitioning
disjoint_from: OBI:0200160  ! generalized family wise error rate correction method
disjoint_from: OBI:0200161  ! quantile number of false positives correction method
disjoint_from: OBI:0200162  ! tail probability for the proportion of false positives correction method
disjoint_from: OBI:0200163  ! false discovery rate correction method
disjoint_from: OBI:0200164  ! proportion of expected false positives correction method
disjoint_from: OBI:0200165  ! quantile proportion of false positives correction method
disjoint_from: OBI:0200176  ! Fisher's exact test
disjoint_from: OBI:0200195  ! proportional hazards model estimation
disjoint_from: OBI:0200198  ! tandem mass spectrometry
disjoint_from: OBI:0200199  ! gas chromatography mass spectrometry
disjoint_from: OBI:0200200  ! chi square test

[Term]
id: OBI:0000702
name: 454 Genome Sequencer FLX
def: "is a DNA sequencer which is manufactured by 454 Life Science Corporation and enables pyrosequencing to be performed. It comprises both optics and fluidics subsystems, which are\ncontrolled by a computer subsystem. The fluidics subsystem ensures accurate reagent dispensing. It consists of a reagents cassette (which holds the reagent containers), a sipper manifold, pumps, valves, and debubblers. The fluidics subsystem flows the sequencing reagents across the wells of the PicoTiterPlate device, and moves the spent reagents from the PicoTiterPlate device to the waste receptacle. The optics subsystem consists of a CCD camera and a camera controller. The camera captures the light emitted in the wells of the PicoTiterPlate device during each step of the sequencing cycle, and sends the digital images to the computer subsystem for processing. The computer controls the other Sequencer subsystems, and processes the digital images sent by the camera to extract the DNA sequence information." []
synonym: "454 GS FLX" EXACT []
synonym: "GS-FLX" EXACT []
is_a: OBI:0400103  ! DNA sequencer

[Term]
id: OBI:0000703
name: Illumina Genome Analyzer II
def: "is a DNA sequence which is manufactured by Illumina (Solexa) corporation. it support sequencing of single or paired end clone libraries relying on sequencing by synthesis technology" []
is_a: OBI:0400103  ! DNA sequencer

[Term]
id: OBI:0000704
name: decision tree induction objective
def: "A decision tree induction objective is a data transformation objective in which a tree-like graph of edges and nodes is created and from which the selection of each branch requires that some type of logical decision is made." []
is_a: OBI:0200166  ! data transformation objective
disjoint_from: OBI:0000425  ! averaging objective
disjoint_from: OBI:0000653  ! fuzzy clustering objective
disjoint_from: OBI:0000675  ! statistical hypothesis test objective
disjoint_from: OBI:0200005  ! feature extraction objective
disjoint_from: OBI:0200031  ! differential expression analysis objective
disjoint_from: OBI:0200078  ! descriptive statistical calculation objective
disjoint_from: OBI:0200081  ! sequence analysis objective
disjoint_from: OBI:0200083  ! survival analysis objective
disjoint_from: OBI:0200157  ! data vector reduction objective
disjoint_from: OBI:0200167  ! data normalization objective
disjoint_from: OBI:0200168  ! correction objective
disjoint_from: OBI:0200172  ! partitioning objective
disjoint_from: OBI:0200174  ! curve fitting objective
disjoint_from: OBI:0200177  ! center calculation objective
disjoint_from: OBI:0200178  ! class discovery objective
disjoint_from: OBI:0200179  ! class prediction objective
disjoint_from: OBI:0200180  ! spread calculation objective
disjoint_from: OBI:0200183  ! scaling objective
disjoint_from: OBI:0200189  ! merging objective
disjoint_from: OBI:0200196  ! correlation study objective
disjoint_from: OBI:0200197  ! spectrum analysis objective

[Term]
id: OBI:0000705
name: Edman degradation
def: "is a process which produces a sequence from an input peptide or protein. In this process, the amino-terminal (N-terminal) residue is labeled and cleaved from the peptide without disrupting the peptide bonds between other amino acid residues." []
is_a: OBI:0600047  ! sequencing assay
relationship: OBI:0000293 CHEBI:23367 ! molecular entity
disjoint_from: OBI:0000626  ! DNA sequencing

[Term]
id: OBI:0000706
name: SOLiD sequencing
def: "is a DNA sequencing which allows sequence identification by relying on the following steps:\n1. Primers hybridize to the P1 adapter sequence within the library template.\n2. A set of four fluorescently labeled di-base probes compete for ligation to the sequencing primer. Specificity of the di-base probe is achieved by interrogating every 1st and 2nd base in each ligation reaction.\n3. Multiple cycles of ligation, detection and cleavage are performed with the number of cycles determining the eventual read length.\n4. Following a series of ligation cycles, the extension product is removed and the template is reset with a primer complementary to the n-1 position for a second round of ligation cycles" []
is_a: OBI:0000723  ! DNA sequencing by ligation
relationship: OBI:0000293 OBI:0000698 ! DNA ligase
relationship: OBO_REL:has_participant OBI:0000696 ! AB SOLiD System

[Term]
id: OBI:0000707
name: decision tree building data transformation
def: "A decision tree building data transformation is a data transformation that has objective decision tree induction." []
is_a: OBI:0200000  ! data transformation

[Term]
id: OBI:0000708
name: laboratory animal care
def: "laboratory animal care is a process that realizes an animal care protocol that specifies how animals are kept and maintained" []
is_a: OBI:0000011  ! planned process

[Term]
id: OBI:0000709
name: yeast artificial chromosome vector
def: "A yeast artificial chromosome vector is a DNA molecule that was engineered to contain a yeast origin of replication, encodes for a selectable gene product, contains a cloning site, and has yeast telomerase sequences" []
synonym: "YAC" EXACT []
is_a: CHEBI:4705  ! double-stranded DNA
is_a: OBI:0000737  ! cloning vector
relationship: OBI:0000316 OBI:0000411 ! cloning vector role

[Term]
id: OBI:0000710
name: Li-Cor 4300 DNA Analysis System
def: "is a DNA sequencer which is manufactured by Li-Cor corporation and enable automated chain termination based DNA sequencing" []
is_a: OBI:0400103  ! DNA sequencer

[Term]
id: OBI:0000711
name: library preparation
def: "is a process which results in the creation of a library from fragments of DNA using cloning vectors or oligonucleotides with the role of adaptors." []
synonym: "library construction" EXACT []
is_a: OBI:0000094  ! material processing
relationship: OBI:0000417 OBI:0000456 ! material transformation objective

[Term]
id: OBI:0000712
name: pathogen challenge
def: "A pathogen challenge is the administration of a live pathogenic organism to a host" []
is_a: OBI:0600007  ! administering substance in vivo
relationship: OBI:0000308 OBI:0000718 ! pathogen role
relationship: OBI:0000308 OBI:0000725 ! host role

[Term]
id: OBI:0000713
name: GenePattern software
def: "Is software that provides access to more than 100 tools for gene expression analysis, proteomics, SNP analysis and common data processing tasks. " []
is_a: IAO:0000010 

[Term]
id: OBI:0000714
name: graph of vertices
def: "A construct that consists of many nodes connected with edges. The edges represent a relationship between the objects represented by the nodes.  A graph can be equivalently represented as a matrix." []
is_a: IAO:0000038 

[Term]
id: OBI:0000715
name: animal care protocol
def: "An animal care protocol is a protocol which specifies the environment in which animals are being kept in captivity for research purposes" []
is_a: OBI:0000272  ! protocol

[Term]
id: OBI:0000716
name: ChIP-SEQ assay
def: "is an assay which aims at identifying protein binding sites in genomic DNA and determining how protein may regulate gene transcription by relying on immunoprecipitation of DNA bound protein, creation of a library of corresponding DNA fragments  (either single or paired-end fragments) and subsequent sequencing using parallelized sequencing methods." []
synonym: "chromatin immunoprecipitation sequencing assay" EXACT []
is_a: OBI:0000070  ! assay
relationship: OBI:0000293 GO:0043234 ! protein complex
relationship: OBI:0000417 OBI:0000441 ! assay objective
relationship: OBO_REL:has_part OBI:0000690 ! immunoprecipitation
relationship: OBO_REL:has_part OBI:0000711 ! library preparation

[Term]
id: OBI:0000717
name: HeliScope Single Molecule Sequencer
def: "is a DNA sequencer manufacturer by Helicos Corporation to carry out Single Molecule sequencing using reversible termination chemistry" []
is_a: OBI:0400103  ! DNA sequencer

[Term]
id: OBI:0000718
name: pathogen role
def: "pathogen role is a role which inheres in an organism and realized in the process of disease course in the organism bearing host role caused by the organism bearing pathogen role" []
is_a: snap:Role 
relationship: OBI:0000300 OBI:1110002 ! occurrence of disease
relationship: http://purl.org/obo/owl/OBO_REL#inheres_in OBI:0100026 ! organism
disjoint_from: OBI:0000017  ! regulatory role
disjoint_from: OBI:0000025  ! reference substance role
disjoint_from: OBI:0000029  ! centrifuge pellet role
disjoint_from: OBI:0000034  ! supernatant role
disjoint_from: OBI:0000040  ! drug role
disjoint_from: OBI:0000067  ! evaluant role
disjoint_from: OBI:0000086  ! reagent role
disjoint_from: OBI:0000091  ! detector reagent role
disjoint_from: OBI:0000093  ! patient role
disjoint_from: OBI:0000097  ! study subject role
disjoint_from: OBI:0000112  ! specimen role
disjoint_from: OBI:0000140  ! label role
disjoint_from: OBI:0000174  ! study group role
disjoint_from: OBI:0000204  ! nutrient role
disjoint_from: OBI:0000237  ! antigen role
disjoint_from: OBI:0000275  ! analyte role
disjoint_from: OBI:0000319  ! material to be added role
disjoint_from: OBI:0000405  ! primer role
disjoint_from: OBI:0000416  ! cloning insert role
disjoint_from: OBI:0000444  ! target of material addition role
disjoint_from: OBI:0000571  ! manufacturer role
disjoint_from: OBI:0000720  ! adjuvent role
disjoint_from: OBI:0000725  ! host role
disjoint_from: OBI:0000847  ! test substance role
disjoint_from: OBI:0302731  ! buffer role
disjoint_from: OBI:0302732  ! solvent role
disjoint_from: OBI:0302733  ! solute role
disjoint_from: OBI:1110082  ! immunogen role
disjoint_from: OBI:1110083  ! host of immune response role
disjoint_from: OBI:1110086  ! restricting MHC role
disjoint_from: OBI:1110087  ! donor
disjoint_from: OBI:1110091  ! carrier role
disjoint_from: OBI:1110092  ! adjuvant role
disjoint_from: OBI:1110120  ! assay antigen role

[Term]
id: OBI:0000719
name: vaccine preparation
def: "vaccine preparation is a manufacturing process to produce a vaccine" []
is_a: OBI:0000011  ! planned process

[Term]
id: OBI:0000720
name: adjuvent role
def: "Adjuvant role is a role that inheres in a material entity and which is realized through a process of modifying a biological response." []
is_a: snap:Role 
disjoint_from: OBI:0000017  ! regulatory role
disjoint_from: OBI:0000025  ! reference substance role
disjoint_from: OBI:0000029  ! centrifuge pellet role
disjoint_from: OBI:0000034  ! supernatant role
disjoint_from: OBI:0000040  ! drug role
disjoint_from: OBI:0000067  ! evaluant role
disjoint_from: OBI:0000086  ! reagent role
disjoint_from: OBI:0000091  ! detector reagent role
disjoint_from: OBI:0000093  ! patient role
disjoint_from: OBI:0000097  ! study subject role
disjoint_from: OBI:0000112  ! specimen role
disjoint_from: OBI:0000140  ! label role
disjoint_from: OBI:0000174  ! study group role
disjoint_from: OBI:0000204  ! nutrient role
disjoint_from: OBI:0000237  ! antigen role
disjoint_from: OBI:0000275  ! analyte role
disjoint_from: OBI:0000319  ! material to be added role
disjoint_from: OBI:0000405  ! primer role
disjoint_from: OBI:0000416  ! cloning insert role
disjoint_from: OBI:0000444  ! target of material addition role
disjoint_from: OBI:0000571  ! manufacturer role
disjoint_from: OBI:0000718  ! pathogen role
disjoint_from: OBI:0000725  ! host role
disjoint_from: OBI:0000847  ! test substance role
disjoint_from: OBI:0302731  ! buffer role
disjoint_from: OBI:0302732  ! solvent role
disjoint_from: OBI:0302733  ! solute role
disjoint_from: OBI:1110082  ! immunogen role
disjoint_from: OBI:1110083  ! host of immune response role
disjoint_from: OBI:1110086  ! restricting MHC role
disjoint_from: OBI:1110087  ! donor
disjoint_from: OBI:1110091  ! carrier role
disjoint_from: OBI:1110092  ! adjuvant role
disjoint_from: OBI:1110120  ! assay antigen role

[Term]
id: OBI:0000721
name: glucose tolerance test
def: "is a process in  which following administration of a bolus a glucose in-vivo, glucose clearance from blood plasma is monitored over time by repeated glucose measurement in blood serum. the output of a process is a measure which can be used to evaluate the severity of insulin resistance or the efficiency of glucose clearance." []
is_a: OBI:0000070  ! assay
relationship: OBI:0000417 OBI:0000015 ! biological feature identification objective
relationship: OBI:0000417 OBI:0000441 ! assay objective

[Term]
id: OBI:0000722
name: paired-end library
def: "is a collection of short paired tags from the two ends of DNA fragments are extracted and covalently linked as ditag constructs" []
synonym: "mate-paired library" EXACT []
synonym: "paired-end tag (PET) library" EXACT []
is_a: OBI:0302714  ! collection (of entities of organismal origin)
disjoint_from: OBI:0000164  ! cDNA library
disjoint_from: OBI:0000181  ! population
disjoint_from: OBI:0000736  ! single fragment library
disjoint_from: OBI:0100064  ! screening library
disjoint_from: OBI:1000029  ! phage display library

[Term]
id: OBI:0000723
name: DNA sequencing by ligation
def: "is a DNA sequencing which relies on DNA ligase activity to perform chain extension during the sequencing reaction step." []
is_a: OBI:0000626  ! DNA sequencing
relationship: OBI:0000293 OBI:0000698 ! DNA ligase
disjoint_from: OBI:0000734  ! DNA sequencing by synthesis

[Term]
id: OBI:0000724
name: Solexa sequencing
def: "is a DNA sequencing which allows sequence identification by relying on use of DNA polymerase and reversible terminator. The methods requires immobilization of genomic DNA fragment onto a surface and a specific clonal amplification step known as bridge PCR. Reliance on reversible terminator allow cycles of DNA chain extension by DNA polymerase and imaging without the need of electrophoretic separation of newly synthesized DNA fragment as with Sanger sequencing." []
synonym: "reversible terminator sequencing" EXACT []
is_a: OBI:0000734  ! DNA sequencing by synthesis
relationship: OBO_REL:has_participant OBI:0000703 ! Illumina Genome Analyzer II
disjoint_from: OBI:0000695  ! chain termination sequencing
disjoint_from: OBI:0000697  ! Helicos sequencing
disjoint_from: OBI:0000730  ! pyrosequencing

[Term]
id: OBI:0000725
name: host role
def: "host role is a role played by an organism and realized by providing nourishment, shelter or a means of reproduction to another organism within the organism playing the host role" []
is_a: snap:Role 
relationship: http://purl.org/obo/owl/OBO_REL#inheres_in OBI:0100026 ! organism
disjoint_from: OBI:0000017  ! regulatory role
disjoint_from: OBI:0000025  ! reference substance role
disjoint_from: OBI:0000029  ! centrifuge pellet role
disjoint_from: OBI:0000034  ! supernatant role
disjoint_from: OBI:0000040  ! drug role
disjoint_from: OBI:0000067  ! evaluant role
disjoint_from: OBI:0000086  ! reagent role
disjoint_from: OBI:0000091  ! detector reagent role
disjoint_from: OBI:0000093  ! patient role
disjoint_from: OBI:0000097  ! study subject role
disjoint_from: OBI:0000112  ! specimen role
disjoint_from: OBI:0000140  ! label role
disjoint_from: OBI:0000174  ! study group role
disjoint_from: OBI:0000204  ! nutrient role
disjoint_from: OBI:0000237  ! antigen role
disjoint_from: OBI:0000275  ! analyte role
disjoint_from: OBI:0000319  ! material to be added role
disjoint_from: OBI:0000405  ! primer role
disjoint_from: OBI:0000416  ! cloning insert role
disjoint_from: OBI:0000444  ! target of material addition role
disjoint_from: OBI:0000571  ! manufacturer role
disjoint_from: OBI:0000718  ! pathogen role
disjoint_from: OBI:0000720  ! adjuvent role
disjoint_from: OBI:0000847  ! test substance role
disjoint_from: OBI:0302731  ! buffer role
disjoint_from: OBI:0302732  ! solvent role
disjoint_from: OBI:0302733  ! solute role
disjoint_from: OBI:1110082  ! immunogen role
disjoint_from: OBI:1110083  ! host of immune response role
disjoint_from: OBI:1110086  ! restricting MHC role
disjoint_from: OBI:1110087  ! donor
disjoint_from: OBI:1110091  ! carrier role
disjoint_from: OBI:1110092  ! adjuvant role
disjoint_from: OBI:1110120  ! assay antigen role

[Term]
id: OBI:0000726
name: peak matching
def: "Peak matching is a data transformation performed on a dataset of a graph of ordered data points (e.g. a spectrum) with the objective of pattern matching local maxima above a noise threshold" []
is_a: OBI:0200000  ! data transformation
disjoint_from: OBI:0000700  ! support vector machine
disjoint_from: OBI:0000701  ! self-organizing map
disjoint_from: OBI:0000727  ! k-nearest neighbors
disjoint_from: OBI:0000739  ! Student's t-test
disjoint_from: OBI:0000749  ! CART
disjoint_from: OBI:0200002  ! logistic-log curve fitting
disjoint_from: OBI:0200003  ! logit-log curve fitting
disjoint_from: OBI:0200004  ! log-log curve fitting
disjoint_from: OBI:0200006  ! biexponential transformation
disjoint_from: OBI:0200007  ! box-cox transformation
disjoint_from: OBI:0200008  ! hyperlog transformation
disjoint_from: OBI:0200011  ! logical transformation
disjoint_from: OBI:0200014  ! split-scale transformation
disjoint_from: OBI:0200016  ! sine transformation
disjoint_from: OBI:0200017  ! cosine transformation
disjoint_from: OBI:0200021  ! linlog transformation
disjoint_from: OBI:0200022  ! variance stabilizing transformation
disjoint_from: OBI:0200025  ! loess scale group transformation
disjoint_from: OBI:0200026  ! total intensity transformation single
disjoint_from: OBI:0200027  ! total intensity transformation paired
disjoint_from: OBI:0200028  ! quantile transformation
disjoint_from: OBI:0200029  ! mean centering
disjoint_from: OBI:0200030  ! median centering
disjoint_from: OBI:0200033  ! leave one out cross validation method
disjoint_from: OBI:0200034  ! jackknifing method
disjoint_from: OBI:0200035  ! boostrapping
disjoint_from: OBI:0200036  ! Benjamini and Hochberg false discovery rate correction method
disjoint_from: OBI:0200037  ! pareto scaling
disjoint_from: OBI:0200041  ! k-means clustering
disjoint_from: OBI:0200042  ! hierarchical clustering
disjoint_from: OBI:0200049  ! Benjamini and Yekutieli false discovery rate correction method
disjoint_from: OBI:0200050  ! dimensionality reduction
disjoint_from: OBI:0200052  ! probabilistic algorithm
disjoint_from: OBI:0200056  ! moving average
disjoint_from: OBI:0200057  ! replicate analysis
disjoint_from: OBI:0200058  ! b cell epitope prediction
disjoint_from: OBI:0200059  ! mhc binding prediction
disjoint_from: OBI:0200060  ! t cell epitope prediction
disjoint_from: OBI:0200061  ! data imputation
disjoint_from: OBI:0200062  ! continuum mass spectrum
disjoint_from: OBI:0200063  ! characteristic path length calculation
disjoint_from: OBI:0200064  ! centroid mass spectrum
disjoint_from: OBI:0200066  ! Holm false discovery rate correction method
disjoint_from: OBI:0200071  ! loess transformation
disjoint_from: OBI:0200073  ! family wise error rate correction method
disjoint_from: OBI:0200077  ! gating
disjoint_from: OBI:0200079  ! mean calculation
disjoint_from: OBI:0200080  ! network analysis
disjoint_from: OBI:0200082  ! longitudinal data analysis
disjoint_from: OBI:0200088  ! Kaplan Meier
disjoint_from: OBI:0200092  ! Westfall and Young family wise error rate correction
disjoint_from: OBI:0200093  ! polynomial transformation
disjoint_from: OBI:0200094  ! logarithmic transformation
disjoint_from: OBI:0200095  ! exponential transformation
disjoint_from: OBI:0200097  ! non-negative matrix factorization
disjoint_from: OBI:0200098  ! soft independent modeling of class analogy analysis
disjoint_from: OBI:0200102  ! regression analysis method
disjoint_from: OBI:0200106  ! discriminant analysis
disjoint_from: OBI:0200108  ! eh transformation
disjoint_from: OBI:0200109  ! b transformation
disjoint_from: OBI:0200110  ! s transformation
disjoint_from: OBI:0200113  ! similarity calculation
disjoint_from: OBI:0200116  ! loess fitting
disjoint_from: OBI:0200117  ! mode calculation
disjoint_from: OBI:0200118  ! quantile calculation
disjoint_from: OBI:0200119  ! median calculation
disjoint_from: OBI:0200120  ! variance calculation
disjoint_from: OBI:0200121  ! standard deviation calculation
disjoint_from: OBI:0200122  ! interquartile-range calculation
disjoint_from: OBI:0200123  ! skewness calculation
disjoint_from: OBI:0200124  ! kurtosis calculation
disjoint_from: OBI:0200125  ! data combination
disjoint_from: OBI:0200140  ! mathematical feature
disjoint_from: OBI:0200149  ! unit-variance scaling
disjoint_from: OBI:0200150  ! MA transformation
disjoint_from: OBI:0200156  ! data partitioning
disjoint_from: OBI:0200160  ! generalized family wise error rate correction method
disjoint_from: OBI:0200161  ! quantile number of false positives correction method
disjoint_from: OBI:0200162  ! tail probability for the proportion of false positives correction method
disjoint_from: OBI:0200163  ! false discovery rate correction method
disjoint_from: OBI:0200164  ! proportion of expected false positives correction method
disjoint_from: OBI:0200165  ! quantile proportion of false positives correction method
disjoint_from: OBI:0200176  ! Fisher's exact test
disjoint_from: OBI:0200195  ! proportional hazards model estimation
disjoint_from: OBI:0200198  ! tandem mass spectrometry
disjoint_from: OBI:0200199  ! gas chromatography mass spectrometry
disjoint_from: OBI:0200200  ! chi square test

[Term]
id: OBI:0000727
name: k-nearest neighbors
def: "A k-nearest neighbors is a data transformation which achieves a class discovery or partitioning objective, in which an input data object with vector y is assigned to a class label based upon the k closest training data set points to y; where k is the largest value that class label is assigned." []
synonym: "k-NN" EXACT []
is_a: OBI:0200171  ! partitioning data transformation
is_a: OBI:0200175  ! class discovery data transformation
relationship: OBI:0000417 OBI:0200172 ! partitioning objective
disjoint_from: OBI:0000700  ! support vector machine
disjoint_from: OBI:0000701  ! self-organizing map
disjoint_from: OBI:0000726  ! peak matching
disjoint_from: OBI:0000739  ! Student's t-test
disjoint_from: OBI:0000749  ! CART
disjoint_from: OBI:0200002  ! logistic-log curve fitting
disjoint_from: OBI:0200003  ! logit-log curve fitting
disjoint_from: OBI:0200004  ! log-log curve fitting
disjoint_from: OBI:0200006  ! biexponential transformation
disjoint_from: OBI:0200007  ! box-cox transformation
disjoint_from: OBI:0200008  ! hyperlog transformation
disjoint_from: OBI:0200011  ! logical transformation
disjoint_from: OBI:0200014  ! split-scale transformation
disjoint_from: OBI:0200016  ! sine transformation
disjoint_from: OBI:0200017  ! cosine transformation
disjoint_from: OBI:0200021  ! linlog transformation
disjoint_from: OBI:0200022  ! variance stabilizing transformation
disjoint_from: OBI:0200025  ! loess scale group transformation
disjoint_from: OBI:0200026  ! total intensity transformation single
disjoint_from: OBI:0200027  ! total intensity transformation paired
disjoint_from: OBI:0200028  ! quantile transformation
disjoint_from: OBI:0200029  ! mean centering
disjoint_from: OBI:0200030  ! median centering
disjoint_from: OBI:0200033  ! leave one out cross validation method
disjoint_from: OBI:0200034  ! jackknifing method
disjoint_from: OBI:0200035  ! boostrapping
disjoint_from: OBI:0200036  ! Benjamini and Hochberg false discovery rate correction method
disjoint_from: OBI:0200037  ! pareto scaling
disjoint_from: OBI:0200041  ! k-means clustering
disjoint_from: OBI:0200042  ! hierarchical clustering
disjoint_from: OBI:0200049  ! Benjamini and Yekutieli false discovery rate correction method
disjoint_from: OBI:0200050  ! dimensionality reduction
disjoint_from: OBI:0200052  ! probabilistic algorithm
disjoint_from: OBI:0200056  ! moving average
disjoint_from: OBI:0200057  ! replicate analysis
disjoint_from: OBI:0200058  ! b cell epitope prediction
disjoint_from: OBI:0200059  ! mhc binding prediction
disjoint_from: OBI:0200060  ! t cell epitope prediction
disjoint_from: OBI:0200061  ! data imputation
disjoint_from: OBI:0200062  ! continuum mass spectrum
disjoint_from: OBI:0200063  ! characteristic path length calculation
disjoint_from: OBI:0200064  ! centroid mass spectrum
disjoint_from: OBI:0200066  ! Holm false discovery rate correction method
disjoint_from: OBI:0200071  ! loess transformation
disjoint_from: OBI:0200073  ! family wise error rate correction method
disjoint_from: OBI:0200077  ! gating
disjoint_from: OBI:0200079  ! mean calculation
disjoint_from: OBI:0200080  ! network analysis
disjoint_from: OBI:0200082  ! longitudinal data analysis
disjoint_from: OBI:0200088  ! Kaplan Meier
disjoint_from: OBI:0200092  ! Westfall and Young family wise error rate correction
disjoint_from: OBI:0200093  ! polynomial transformation
disjoint_from: OBI:0200094  ! logarithmic transformation
disjoint_from: OBI:0200095  ! exponential transformation
disjoint_from: OBI:0200097  ! non-negative matrix factorization
disjoint_from: OBI:0200098  ! soft independent modeling of class analogy analysis
disjoint_from: OBI:0200102  ! regression analysis method
disjoint_from: OBI:0200106  ! discriminant analysis
disjoint_from: OBI:0200108  ! eh transformation
disjoint_from: OBI:0200109  ! b transformation
disjoint_from: OBI:0200110  ! s transformation
disjoint_from: OBI:0200113  ! similarity calculation
disjoint_from: OBI:0200116  ! loess fitting
disjoint_from: OBI:0200117  ! mode calculation
disjoint_from: OBI:0200118  ! quantile calculation
disjoint_from: OBI:0200119  ! median calculation
disjoint_from: OBI:0200120  ! variance calculation
disjoint_from: OBI:0200121  ! standard deviation calculation
disjoint_from: OBI:0200122  ! interquartile-range calculation
disjoint_from: OBI:0200123  ! skewness calculation
disjoint_from: OBI:0200124  ! kurtosis calculation
disjoint_from: OBI:0200125  ! data combination
disjoint_from: OBI:0200140  ! mathematical feature
disjoint_from: OBI:0200149  ! unit-variance scaling
disjoint_from: OBI:0200150  ! MA transformation
disjoint_from: OBI:0200156  ! data partitioning
disjoint_from: OBI:0200160  ! generalized family wise error rate correction method
disjoint_from: OBI:0200161  ! quantile number of false positives correction method
disjoint_from: OBI:0200162  ! tail probability for the proportion of false positives correction method
disjoint_from: OBI:0200163  ! false discovery rate correction method
disjoint_from: OBI:0200164  ! proportion of expected false positives correction method
disjoint_from: OBI:0200165  ! quantile proportion of false positives correction method
disjoint_from: OBI:0200176  ! Fisher's exact test
disjoint_from: OBI:0200195  ! proportional hazards model estimation
disjoint_from: OBI:0200198  ! tandem mass spectrometry
disjoint_from: OBI:0200199  ! gas chromatography mass spectrometry
disjoint_from: OBI:0200200  ! chi square test

[Term]
id: OBI:0000728
name: rodent care
def: "rodent care  is the process by which rodents are being provided with a controlled living environment while kept in captivity for the purpose of research." []
is_a: OBI:0000011  ! planned process
relationship: OBI:0000293 NCBITaxon:9989 ! Rodentia
relationship: OBI:0000299 NCBITaxon:9989 ! Rodentia
relationship: OBO_REL:has_part OBI:0000694 ! animal feeding

[Term]
id: OBI:0000729
name: cloning plasmid
def: "A cloning plasmid is a plasmid that was engineered to contain a bacterial origin of replication, encodes for a selectable gene product and contains a cloning site." []
is_a: OBI:0000430  ! plasmid
is_a: OBI:0000737  ! cloning vector
intersection_of: OBI:0000430  ! plasmid
intersection_of: OBI:0000316 OBI:0000411 ! cloning vector role

[Term]
id: OBI:0000730
name: pyrosequencing
def: "is a DNA sequencing which allows sequencing of a single strand of DNA by synthesizing the complementary strand along it, one base pair at a time, and detecting which base was actually added at each step. The template DNA is immobilized, and solutions of A, C, G, and T nucleotides are added and removed after the reaction, sequentially. Light is produced only when the nucleotide solution complements the first unpaired base of the template. The sequence of solutions which produce chemiluminescent signals allows the determination of the sequence of the template.\n\nssDNA template is hybridized to a sequencing primer and incubated with the enzymes DNA polymerase, ATP sulfurylase, luciferase and apyrase, and with the substrates adenosine 5-prime phosphosulfate (APS) and luciferin." []
is_a: OBI:0000734  ! DNA sequencing by synthesis
disjoint_from: OBI:0000695  ! chain termination sequencing
disjoint_from: OBI:0000697  ! Helicos sequencing
disjoint_from: OBI:0000724  ! Solexa sequencing

[Term]
id: OBI:0000731
name: recombinant vector
def: "A recombinant vector is created by a recombinant vector cloning process, and contains nucleic acids that can be amplified. It retains functions of the original cloning vector." []
is_a: OBI:0000047  ! processed material
intersection_of: snap:MaterialEntity 
intersection_of: OBI:0000312 OBI:0600064 ! recombinant vector cloning

[Term]
id: OBI:0000732
name: restriction enzyme
def: "A restriction enzyme is an enzyme that has a specific target cleavage sites within nucleic acids" []
is_a: OBI:0000427  ! enzyme
is_a: PRO:000000001  ! protein
relationship: OBI:0000306 GO:0003824 ! catalytic activity
disjoint_from: OBI:0000698  ! DNA ligase
disjoint_from: OBI:1110132  ! CD8 receptor

[Term]
id: OBI:0000734
name: DNA sequencing by synthesis
def: "is a DNA sequencing which relies on DNA polymerase activity to perform chain extension during the sequencing reaction step." []
is_a: OBI:0000626  ! DNA sequencing
relationship: OBI:0000293 GO:0042575 ! DNA polymerase complex
disjoint_from: OBI:0000723  ! DNA sequencing by ligation

[Term]
id: OBI:0000735
name: NTP-2000
def: "NTP-2000 is a material consisting of 14.5% protein, 8.5% fat and 9.5% fiber produced to feed rodents" []
is_a: OBI:0000047  ! processed material
relationship: OBI:0000312 OBI:0000457 ! manufacturing
relationship: OBI:0000316 OBI:0000248 ! feed role

[Term]
id: OBI:0000736
name: single fragment library
def: "is a collection of short tags from DNA fragments, are extracted and covalently linked as single tag constructs" []
synonym: "fragment library" EXACT []
is_a: OBI:0302714  ! collection (of entities of organismal origin)
disjoint_from: OBI:0000164  ! cDNA library
disjoint_from: OBI:0000181  ! population
disjoint_from: OBI:0000722  ! paired-end library
disjoint_from: OBI:0100064  ! screening library
disjoint_from: OBI:1000029  ! phage display library

[Term]
id: OBI:0000737
name: cloning vector
def: "A cloning vector is an engineered material that is used as an input material for a recombinant vector cloning process to carry inserted nucleic acids. It contains an origin of replication for a specific destination host organism, encodes for a selectable gene product and contains a cloning site." []
is_a: OBI:0000047  ! processed material
is_a: OBI:1110108  ! material to be added
relationship: OBI:0000312 OBI:0000094 ! material processing
intersection_of: snap:MaterialEntity 
intersection_of: OBI:0000316 OBI:0000411 ! cloning vector role

[Term]
id: OBI:0000738
name: restriction enzyme based cloning
def: "restriction enzyme based cloning is a recombinant vector cloning process that has as an input genetic material that was cleaved with restriction enzymes, and a cloning vector that was cleaved with complementary restriction enzymes. It uses ligase to chemically join the input genetic material and the cloning vector to create a recombinant vector." []
is_a: OBI:0600064  ! recombinant vector cloning
relationship: OBO_REL:has_part OBI:0302892 ! enzymatic ligation
disjoint_from: OBI:0000687  ! nucleotide overhang cloning
disjoint_from: OBI:0000692  ! recombination enzyme based cloning
disjoint_from: OBI:0000790  ! recombinant BAC cloning
disjoint_from: OBI:0000799  ! recombinant phage cloning
disjoint_from: OBI:0000824  ! recombinant YAC cloning
disjoint_from: OBI:0600048  ! vector mediated amplification
disjoint_from: OBI:0600063  ! vector mediated expression

[Term]
id: OBI:0000739
name: Student's t-test
def: "Studen't t-test is a data transformation with the objective of a statistical hypothesis test in which the test statistic has a Student's t distribution if the null hypothesis is true. It is applied when the population is assumed to be normally distributed but the sample sizes are small enough that the statistic on which inference is based is not normally distributed because it relies on an uncertain estimate of standard deviation rather than on a precisely known value." []
is_a: OBI:0000673  ! statistical hypothesis test
relationship: OBI:0000417 OBI:0000675 ! statistical hypothesis test objective
disjoint_from: OBI:0000700  ! support vector machine
disjoint_from: OBI:0000701  ! self-organizing map
disjoint_from: OBI:0000726  ! peak matching
disjoint_from: OBI:0000727  ! k-nearest neighbors
disjoint_from: OBI:0000749  ! CART
disjoint_from: OBI:0200002  ! logistic-log curve fitting
disjoint_from: OBI:0200003  ! logit-log curve fitting
disjoint_from: OBI:0200004  ! log-log curve fitting
disjoint_from: OBI:0200006  ! biexponential transformation
disjoint_from: OBI:0200007  ! box-cox transformation
disjoint_from: OBI:0200008  ! hyperlog transformation
disjoint_from: OBI:0200011  ! logical transformation
disjoint_from: OBI:0200014  ! split-scale transformation
disjoint_from: OBI:0200016  ! sine transformation
disjoint_from: OBI:0200017  ! cosine transformation
disjoint_from: OBI:0200021  ! linlog transformation
disjoint_from: OBI:0200022  ! variance stabilizing transformation
disjoint_from: OBI:0200025  ! loess scale group transformation
disjoint_from: OBI:0200026  ! total intensity transformation single
disjoint_from: OBI:0200027  ! total intensity transformation paired
disjoint_from: OBI:0200028  ! quantile transformation
disjoint_from: OBI:0200029  ! mean centering
disjoint_from: OBI:0200030  ! median centering
disjoint_from: OBI:0200033  ! leave one out cross validation method
disjoint_from: OBI:0200034  ! jackknifing method
disjoint_from: OBI:0200035  ! boostrapping
disjoint_from: OBI:0200036  ! Benjamini and Hochberg false discovery rate correction method
disjoint_from: OBI:0200037  ! pareto scaling
disjoint_from: OBI:0200041  ! k-means clustering
disjoint_from: OBI:0200042  ! hierarchical clustering
disjoint_from: OBI:0200049  ! Benjamini and Yekutieli false discovery rate correction method
disjoint_from: OBI:0200050  ! dimensionality reduction
disjoint_from: OBI:0200052  ! probabilistic algorithm
disjoint_from: OBI:0200056  ! moving average
disjoint_from: OBI:0200057  ! replicate analysis
disjoint_from: OBI:0200058  ! b cell epitope prediction
disjoint_from: OBI:0200059  ! mhc binding prediction
disjoint_from: OBI:0200060  ! t cell epitope prediction
disjoint_from: OBI:0200061  ! data imputation
disjoint_from: OBI:0200062  ! continuum mass spectrum
disjoint_from: OBI:0200063  ! characteristic path length calculation
disjoint_from: OBI:0200064  ! centroid mass spectrum
disjoint_from: OBI:0200066  ! Holm false discovery rate correction method
disjoint_from: OBI:0200071  ! loess transformation
disjoint_from: OBI:0200073  ! family wise error rate correction method
disjoint_from: OBI:0200077  ! gating
disjoint_from: OBI:0200079  ! mean calculation
disjoint_from: OBI:0200080  ! network analysis
disjoint_from: OBI:0200082  ! longitudinal data analysis
disjoint_from: OBI:0200088  ! Kaplan Meier
disjoint_from: OBI:0200092  ! Westfall and Young family wise error rate correction
disjoint_from: OBI:0200093  ! polynomial transformation
disjoint_from: OBI:0200094  ! logarithmic transformation
disjoint_from: OBI:0200095  ! exponential transformation
disjoint_from: OBI:0200097  ! non-negative matrix factorization
disjoint_from: OBI:0200098  ! soft independent modeling of class analogy analysis
disjoint_from: OBI:0200102  ! regression analysis method
disjoint_from: OBI:0200106  ! discriminant analysis
disjoint_from: OBI:0200108  ! eh transformation
disjoint_from: OBI:0200109  ! b transformation
disjoint_from: OBI:0200110  ! s transformation
disjoint_from: OBI:0200113  ! similarity calculation
disjoint_from: OBI:0200116  ! loess fitting
disjoint_from: OBI:0200117  ! mode calculation
disjoint_from: OBI:0200118  ! quantile calculation
disjoint_from: OBI:0200119  ! median calculation
disjoint_from: OBI:0200120  ! variance calculation
disjoint_from: OBI:0200121  ! standard deviation calculation
disjoint_from: OBI:0200122  ! interquartile-range calculation
disjoint_from: OBI:0200123  ! skewness calculation
disjoint_from: OBI:0200124  ! kurtosis calculation
disjoint_from: OBI:0200125  ! data combination
disjoint_from: OBI:0200140  ! mathematical feature
disjoint_from: OBI:0200149  ! unit-variance scaling
disjoint_from: OBI:0200150  ! MA transformation
disjoint_from: OBI:0200156  ! data partitioning
disjoint_from: OBI:0200160  ! generalized family wise error rate correction method
disjoint_from: OBI:0200161  ! quantile number of false positives correction method
disjoint_from: OBI:0200162  ! tail probability for the proportion of false positives correction method
disjoint_from: OBI:0200163  ! false discovery rate correction method
disjoint_from: OBI:0200164  ! proportion of expected false positives correction method
disjoint_from: OBI:0200165  ! quantile proportion of false positives correction method
disjoint_from: OBI:0200176  ! Fisher's exact test
disjoint_from: OBI:0200195  ! proportional hazards model estimation
disjoint_from: OBI:0200198  ! tandem mass spectrometry
disjoint_from: OBI:0200199  ! gas chromatography mass spectrometry
disjoint_from: OBI:0200200  ! chi square test

[Term]
id: OBI:0000740
name: material sample role
def: "A material sample role is a specimen role borne by a material entity that is the output of a material sampling process." []
is_a: OBI:0000112  ! specimen role

[Term]
id: OBI:0000741
name: topologically preserved clustered data set
def: "A clustered data set in which the topology, i.e. the spatial properties between data points, is preserved from the original input data from which it was derived." []
is_a: OBI:0000648  ! clustered data set

[Term]
id: OBI:0000742
name: nucleic acid restriction enzyme digest
def: "A nucleic acid digest is a material that is the output of a process in which nucleic acids are combined with a restriction enzyme resulting in digested fragments with defined ends based on the enzymes cleavage site" []
is_a: CHEBI:33696  ! nucleic acid
is_a: OBI:0000047  ! processed material

[Term]
id: OBI:0000743
name: immune response assay
def: "Is an assay with the objective to determine information about an immune response" []
is_a: OBI:0000070  ! assay

[Term]
id: OBI:0000744
name: material sampling process
def: "A specimen gathering process with the objective to obtain a specimen that is representative of the input material entity" []
is_a: OBI:0000659  ! specimen creation
relationship: OBI:0000293 snap:MaterialEntity
relationship: OBI:0000299 OBI:0000747 ! material sample
relationship: OBI:0000417 OBI:0000684 ! specimen creation objective

[Term]
id: OBI:0000747
name: material sample
def: "A material entity that has the material sample role" []
is_a: OBI:0100051  ! specimen

[Term]
id: OBI:0000748
name: bisulfite sequencing
def: "is a DNA sequencing which allows to determine the methylation status of genomic DNA using DNA sequencing techniques preceded by a bisulfite based chemical modification of genomic DNA at CpG island location." []
is_a: OBI:0000070  ! assay
relationship: OBI:0000293 CHEBI:17137 ! hydrogensulfite
relationship: OBI:0000417 OBI:0000441 ! assay objective
relationship: OBO_REL:has_part OBI:0000626 ! DNA sequencing

[Term]
id: OBI:0000749
name: CART
def: "A CART (classification and regression trees) is a data transformation method for producing a classification or regression model with a tree-based structure." []
synonym: "classification and regression trees" EXACT []
is_a: OBI:0000707  ! decision tree building data transformation
relationship: OBI:0000417 OBI:0000704 ! decision tree induction objective
disjoint_from: OBI:0000700  ! support vector machine
disjoint_from: OBI:0000701  ! self-organizing map
disjoint_from: OBI:0000726  ! peak matching
disjoint_from: OBI:0000727  ! k-nearest neighbors
disjoint_from: OBI:0000739  ! Student's t-test
disjoint_from: OBI:0200002  ! logistic-log curve fitting
disjoint_from: OBI:0200003  ! logit-log curve fitting
disjoint_from: OBI:0200004  ! log-log curve fitting
disjoint_from: OBI:0200006  ! biexponential transformation
disjoint_from: OBI:0200007  ! box-cox transformation
disjoint_from: OBI:0200008  ! hyperlog transformation
disjoint_from: OBI:0200011  ! logical transformation
disjoint_from: OBI:0200014  ! split-scale transformation
disjoint_from: OBI:0200016  ! sine transformation
disjoint_from: OBI:0200017  ! cosine transformation
disjoint_from: OBI:0200021  ! linlog transformation
disjoint_from: OBI:0200022  ! variance stabilizing transformation
disjoint_from: OBI:0200025  ! loess scale group transformation
disjoint_from: OBI:0200026  ! total intensity transformation single
disjoint_from: OBI:0200027  ! total intensity transformation paired
disjoint_from: OBI:0200028  ! quantile transformation
disjoint_from: OBI:0200029  ! mean centering
disjoint_from: OBI:0200030  ! median centering
disjoint_from: OBI:0200033  ! leave one out cross validation method
disjoint_from: OBI:0200034  ! jackknifing method
disjoint_from: OBI:0200035  ! boostrapping
disjoint_from: OBI:0200036  ! Benjamini and Hochberg false discovery rate correction method
disjoint_from: OBI:0200037  ! pareto scaling
disjoint_from: OBI:0200041  ! k-means clustering
disjoint_from: OBI:0200042  ! hierarchical clustering
disjoint_from: OBI:0200049  ! Benjamini and Yekutieli false discovery rate correction method
disjoint_from: OBI:0200050  ! dimensionality reduction
disjoint_from: OBI:0200052  ! probabilistic algorithm
disjoint_from: OBI:0200056  ! moving average
disjoint_from: OBI:0200057  ! replicate analysis
disjoint_from: OBI:0200058  ! b cell epitope prediction
disjoint_from: OBI:0200059  ! mhc binding prediction
disjoint_from: OBI:0200060  ! t cell epitope prediction
disjoint_from: OBI:0200061  ! data imputation
disjoint_from: OBI:0200062  ! continuum mass spectrum
disjoint_from: OBI:0200063  ! characteristic path length calculation
disjoint_from: OBI:0200064  ! centroid mass spectrum
disjoint_from: OBI:0200066  ! Holm false discovery rate correction method
disjoint_from: OBI:0200071  ! loess transformation
disjoint_from: OBI:0200073  ! family wise error rate correction method
disjoint_from: OBI:0200077  ! gating
disjoint_from: OBI:0200079  ! mean calculation
disjoint_from: OBI:0200080  ! network analysis
disjoint_from: OBI:0200082  ! longitudinal data analysis
disjoint_from: OBI:0200088  ! Kaplan Meier
disjoint_from: OBI:0200092  ! Westfall and Young family wise error rate correction
disjoint_from: OBI:0200093  ! polynomial transformation
disjoint_from: OBI:0200094  ! logarithmic transformation
disjoint_from: OBI:0200095  ! exponential transformation
disjoint_from: OBI:0200097  ! non-negative matrix factorization
disjoint_from: OBI:0200098  ! soft independent modeling of class analogy analysis
disjoint_from: OBI:0200102  ! regression analysis method
disjoint_from: OBI:0200106  ! discriminant analysis
disjoint_from: OBI:0200108  ! eh transformation
disjoint_from: OBI:0200109  ! b transformation
disjoint_from: OBI:0200110  ! s transformation
disjoint_from: OBI:0200113  ! similarity calculation
disjoint_from: OBI:0200116  ! loess fitting
disjoint_from: OBI:0200117  ! mode calculation
disjoint_from: OBI:0200118  ! quantile calculation
disjoint_from: OBI:0200119  ! median calculation
disjoint_from: OBI:0200120  ! variance calculation
disjoint_from: OBI:0200121  ! standard deviation calculation
disjoint_from: OBI:0200122  ! interquartile-range calculation
disjoint_from: OBI:0200123  ! skewness calculation
disjoint_from: OBI:0200124  ! kurtosis calculation
disjoint_from: OBI:0200125  ! data combination
disjoint_from: OBI:0200140  ! mathematical feature
disjoint_from: OBI:0200149  ! unit-variance scaling
disjoint_from: OBI:0200150  ! MA transformation
disjoint_from: OBI:0200156  ! data partitioning
disjoint_from: OBI:0200160  ! generalized family wise error rate correction method
disjoint_from: OBI:0200161  ! quantile number of false positives correction method
disjoint_from: OBI:0200162  ! tail probability for the proportion of false positives correction method
disjoint_from: OBI:0200163  ! false discovery rate correction method
disjoint_from: OBI:0200164  ! proportion of expected false positives correction method
disjoint_from: OBI:0200165  ! quantile proportion of false positives correction method
disjoint_from: OBI:0200176  ! Fisher's exact test
disjoint_from: OBI:0200195  ! proportional hazards model estimation
disjoint_from: OBI:0200198  ! tandem mass spectrometry
disjoint_from: OBI:0200199  ! gas chromatography mass spectrometry
disjoint_from: OBI:0200200  ! chi square test

[Term]
id: OBI:0000750
name: independent variable specification
def: "a directive information entity that is part of a study design. Independent variables are entities whose values are selected to determine its relationship to an observed phenomenon (the dependent variable). In such an experiment, an attempt is made to find evidence that the values of the independent variable determine the values of the dependent variable (that which is being measured). The independent variable can be changed as required, and its values do not represent a problem requiring explanation in an analysis, but are taken simply as given. The dependent variable on the other hand, usually cannot be directly controlled" []
is_a: IAO:0000033 
relationship: OBO_REL:part_of IAO:0000104
disjoint_from: OBI:0000658  ! data representational model
disjoint_from: OBI:0000751  ! dependent variable specification
disjoint_from: OBI:0000785  ! controlled variable specification

[Term]
id: OBI:0000751
name: dependent variable specification
def: "dependent variable specification is part of a study design. The dependent variable is the event studied and expected to change when the independent variable varies." []
is_a: IAO:0000033 
relationship: OBO_REL:part_of IAO:0000104
disjoint_from: OBI:0000658  ! data representational model
disjoint_from: OBI:0000750  ! independent variable specification
disjoint_from: OBI:0000785  ! controlled variable specification

[Instance]
id: OBI:0000752
name: Thermo
instance_of: OBI:0000245  ! organization
instance_of: owl:Thing 
relationship: OBI:0000316 OBI:0000571_10 ! the manufacturer role of Thermo

[Instance]
id: OBI:0000753
name: Waters
instance_of: OBI:0000245  ! organization
instance_of: owl:Thing 
relationship: OBI:0000316 OBI:0000571_11 ! the manufacturer role of Waters

[Instance]
id: OBI:0000754
name: BIO-RAD
instance_of: OBI:0000245  ! organization
instance_of: owl:Thing 
relationship: OBI:0000316 OBI:0000571_2 ! the manufacturer role of BIO-RAD

[Instance]
id: OBI:0000755
name: GenePattern hierarchical clustering
instance_of: OBI:0200042  ! hierarchical clustering
instance_of: owl:Thing 

[Instance]
id: OBI:0000756
name: Ambion
instance_of: OBI:0000245  ! organization
instance_of: owl:Thing 
relationship: OBI:0000316 OBI:0000571_1 ! the manufacturer role of Ambion

[Instance]
id: OBI:0000757
name: Helicos
instance_of: OBI:0000245  ! organization
instance_of: owl:Thing 
relationship: OBI:0000316 OBI:0000571_3 ! the manufacturer role of Helicos

[Instance]
id: OBI:0000758
name: Roche
instance_of: OBI:0000245  ! organization
instance_of: owl:Thing 
relationship: OBI:0000316 OBI:0000571_6 ! the manufacturer role of Roche

[Instance]
id: OBI:0000759
name: Illumina
instance_of: OBI:0000245  ! organization
instance_of: owl:Thing 
relationship: OBI:0000316 OBI:0000571_4 ! the manufacturer role of Illumina

[Instance]
id: OBI:0000760
name: GenePattern PCA
instance_of: OBI:0200051  ! principal components analysis dimensionality reduction
instance_of: owl:Thing 

[Instance]
id: OBI:0000761
name: GenePattern module SVM
instance_of: OBI:0000713  ! GenePattern software
instance_of: owl:Thing 
relationship: IAO:0000136 OBI:0000775 ! GenePattern SVM

[Instance]
id: OBI:0000762
name: GenePattern k-nearest neighbors
instance_of: OBI:0000727  ! k-nearest neighbors
instance_of: owl:Thing 

[Instance]
id: OBI:0000763
name: GenePattern LOOCV
instance_of: OBI:0200033  ! leave one out cross validation method
instance_of: owl:Thing 

[Instance]
id: OBI:0000764
name: GenePattern k-means clustering
instance_of: OBI:0200041  ! k-means clustering
instance_of: owl:Thing 

[Instance]
id: OBI:0000765
name: Agilent
instance_of: OBI:0000245  ! organization
instance_of: owl:Thing 
relationship: OBI:0000316 OBI:0000571_13 ! the manufacturer role of Agilent

[Instance]
id: OBI:0000766
name: GenePattern module KMeansClustering
instance_of: OBI:0000713  ! GenePattern software
instance_of: owl:Thing 
relationship: IAO:0000136 OBI:0000764 ! GenePattern k-means clustering

[Instance]
id: OBI:0000767
name: GenePattern CART
instance_of: OBI:0000749  ! CART
instance_of: owl:Thing 

[Instance]
id: OBI:0000768
name: GenePattern module CARTXValidation
instance_of: OBI:0000713  ! GenePattern software
instance_of: owl:Thing 
relationship: IAO:0000136 OBI:0000763 ! GenePattern LOOCV
relationship: IAO:0000136 OBI:0000767 ! GenePattern CART

[Instance]
id: OBI:0000769
name: Li-Cor
instance_of: OBI:0000245  ! organization
instance_of: owl:Thing 
relationship: OBI:0000316 OBI:0000571_5 ! the manufacturer role of Li-Cor

[Instance]
id: OBI:0000770
name: Bruker Corporation
instance_of: OBI:0000245  ! organization
instance_of: owl:Thing 
relationship: OBI:0000316 OBI:0000571_8 ! manufacturer role of Bruker Corporation

[Instance]
id: OBI:0000771
name: GenePattern module KNNXValidation
instance_of: OBI:0000713  ! GenePattern software
instance_of: owl:Thing 

[Instance]
id: OBI:0000772
name: GenePattern module PeakMatch
instance_of: OBI:0000713  ! GenePattern software
instance_of: owl:Thing 
relationship: IAO:0000136 OBI:0000778 ! GenePattern peak matching

[Instance]
id: OBI:0000773
name: GenePattern module KNN
instance_of: OBI:0000713  ! GenePattern software
instance_of: owl:Thing 
relationship: IAO:0000136 OBI:0000762 ! GenePattern k-nearest neighbors

[Instance]
id: OBI:0000774
name: GenePattern module HierarchicalClustering
instance_of: OBI:0000713  ! GenePattern software
instance_of: owl:Thing 
relationship: IAO:0000136 OBI:0000755 ! GenePattern hierarchical clustering

[Instance]
id: OBI:0000775
name: GenePattern SVM
instance_of: OBI:0000700  ! support vector machine
instance_of: owl:Thing 

[Instance]
id: OBI:0000776
name: Applied Biosystems
instance_of: OBI:0000245  ! organization
instance_of: owl:Thing 
relationship: OBI:0000316 OBI:0000571_7 ! manufacturer role of applied biosystems

[Instance]
id: OBI:0000777
name: GenePattern module PCA
instance_of: OBI:0000713  ! GenePattern software
instance_of: owl:Thing 
relationship: IAO:0000136 OBI:0000760 ! GenePattern PCA

[Instance]
id: OBI:0000778
name: GenePattern peak matching
instance_of: OBI:0000726  ! peak matching
instance_of: owl:Thing 

[Instance]
id: OBI:0000779
name: Bruker Daltonics
instance_of: OBI:0000245  ! organization
instance_of: owl:Thing 
relationship: OBI:0000316 OBI:0000571_9 ! manufacturer role of Bruker Daltonics

[Instance]
id: OBI:0000780
name: GenePattern HeatMapViewer data visualization
instance_of: OBI:0200190  ! clustered data visualization

[Instance]
id: OBI:0000781
name: GenePattern HierarchicalClusteringViewer data visualization
instance_of: OBI:0200190  ! clustered data visualization

[Instance]
id: OBI:0000782
name: GenePattern module HeatMapViewer
instance_of: OBI:0000713  ! GenePattern software
relationship: IAO:0000136 OBI:0000780 ! GenePattern HeatMapViewer data visualization

[Instance]
id: OBI:0000783
name: GenePattern module HierarchicalClusteringViewer
instance_of: OBI:0000713  ! GenePattern software
relationship: IAO:0000136 OBI:0000781 ! GenePattern HierarchicalClusteringViewer data visualization

[Term]
id: OBI:0000784
name: anticoagulant-containing test tube
def: "A 'blue top' test tube that contains anticoagulant for storing blood specimens'" []
is_a: OBI:0000836  ! test tube

[Term]
id: OBI:0000785
name: controlled variable specification
def: "Controlled variable specification  is a part of a study design. They are the entities that could vary, but are kept constant to prevent their influence on the effect of the independent variable on the dependent." []
is_a: IAO:0000033 
relationship: OBO_REL:part_of IAO:0000104
disjoint_from: OBI:0000658  ! data representational model
disjoint_from: OBI:0000750  ! independent variable specification
disjoint_from: OBI:0000751  ! dependent variable specification

[Term]
id: OBI:0000787
name: human antithrombin-III (AT-III) in blood assay
def: "An assay to measure the amount of antithrombin III in blood." []
is_a: OBI:0000443  ! analyte assay

[Term]
id: OBI:0000788
name: fluorescently labeled MHC multimer
def: "A complex of two or more linked MHC molecules including a fluorescent label that can be loaded with a ligand, and is used in flow cytometry assay to bind to T cell receptors of T cells specific for the ligand" []
is_a: OBI:0000047  ! processed material
relationship: http://purl.org/obo/owl/OBO_REL#bearer_of PATO:0000018 ! fluorescence

[Term]
id: OBI:0000789
name: survival rate
def: "Survival rate is a measurement data that represents the percentage of people or\nanimals in a study or treatment group who are alive for a given period\nof time after diagnosis or initiation of monitoring." []
is_a: IAO:0000109 
disjoint_from: OBI:0000010  ! fluorescent reporter intensity
disjoint_from: OBI:0000054  ! ratio of collected to emitted light
disjoint_from: OBI:0000101  ! measured expression level
disjoint_from: OBI:0000119  ! number of particles in subset
disjoint_from: OBI:0000125  ! number of lost events electronic
disjoint_from: OBI:0000172  ! parameter threshold
disjoint_from: OBI:0000269  ! number of lost events computer
disjoint_from: OBI:0000801  ! spike train datum

[Term]
id: OBI:0000790
name: recombinant BAC cloning
def: "Recombinant BAC cloning is a  process with the objective to insert genetic material into an F plasmid based bacterial artificial chromosome for future replication of the inserted material" []
is_a: OBI:0600064  ! recombinant vector cloning
disjoint_from: OBI:0000687  ! nucleotide overhang cloning
disjoint_from: OBI:0000692  ! recombination enzyme based cloning
disjoint_from: OBI:0000738  ! restriction enzyme based cloning
disjoint_from: OBI:0000799  ! recombinant phage cloning
disjoint_from: OBI:0000824  ! recombinant YAC cloning
disjoint_from: OBI:0600048  ! vector mediated amplification
disjoint_from: OBI:0600063  ! vector mediated expression

[Term]
id: OBI:0000791
name: multiple testing correction objective
def: "A multiple testing correction objectives is a data transformation objective where the aim is to correct for a set of statistical inferences considered simultaneously" []
synonym: "multiple comparison correction objective" EXACT []
is_a: OBI:0200186  ! error correction objective

[Term]
id: OBI:0000792
name: statistical model validation
def: "A data transformation which assesses how the results of a statistical analysis will generalize to an independent data set." []
is_a: OBI:0200171  ! partitioning data transformation

[Term]
id: OBI:0000793
name: double blind study execution
def: "A double blind study execution is defined as any study execution in which neither the subjects nor the investigators are informed of which study arm the subjects are part of during the portion of the trial when the subjects are being treated" []
is_a: OBI:0000822  ! single blind study execution

[Term]
id: OBI:0000795
name: glucometer
def: "A measurement device with the function to measure and record the level/amount of glucose in a blood sample" []
synonym: "glucose meter" EXACT []
is_a: OBI:0000832  ! measurement device
relationship: OBI:0000306 OBI:0000453 ! measure function

[Term]
id: OBI:0000796
name: purification objective
def: "The objective to separate a material entity into different compositions of which one or more have are purified fractions that contain higher concentration of a desired component, while others contain impurities and are not of interest" []
synonym: "isolation objective" EXACT []
is_a: OBI:0000681  ! separation into different composition objective

[Term]
id: OBI:0000797
name: primary structure of protein
def: "The primary structure of a protein that is completely defined by the set of its amino acid residue parts and the linear order induced by the peptide bonds that hold them together" []
is_a: OBI:0000830  ! primary structure of sequence macromolecule
disjoint_from: OBI:0000811  ! primary structure of DNA macromolecule
disjoint_from: OBI:0000845  ! primary structure of RNA molecule

[Term]
id: OBI:0000798
name: capsule shell
def: "a small rounded gelatinous container" []
is_a: snap:MaterialEntity 
disjoint_from: OBI:0000050  ! platform
disjoint_from: OBI:0000146  ! supernatant collection system harvesting frame
disjoint_from: OBI:0000245  ! organization
disjoint_from: OBI:0000318  ! eluate
disjoint_from: OBI:0000390  ! thermostatic circulator
disjoint_from: OBI:0000420  ! trypsinized material
disjoint_from: OBI:0000432  ! polyacrylamide gel
disjoint_from: OBI:0000439  ! agarose gel
disjoint_from: OBI:0000576  ! scattered molecular aggregate
disjoint_from: OBI:0000651  ! urine specimen
disjoint_from: OBI:0000655  ! blood specimen
disjoint_from: OBI:0000680  ! whole organism preparation
disjoint_from: OBI:0000814  ! guar gum
disjoint_from: OBI:0100014  ! chimera
disjoint_from: OBI:0100016  ! blood plasma
disjoint_from: OBI:0100017  ! blood serum specimen
disjoint_from: OBI:0100039  ! fragment derived from protein
disjoint_from: OBI:0100055  ! cell line cell
disjoint_from: OBI:0100056  ! immortalized cell line
disjoint_from: OBI:0100058  ! xenograft
disjoint_from: OBI:0100060  ! cell culture
disjoint_from: OBI:0100067  ! bronchial alveolar lavage
disjoint_from: OBI:0100069  ! polymer
disjoint_from: OBI:0100086  ! glucose in solution
disjoint_from: OBI:0302714  ! collection (of entities of organismal origin)
disjoint_from: OBI:0400102  ! waste tank
disjoint_from: OBI:1000023  ! cell culture supernatant
disjoint_from: OBI:1000024  ! cell pellet
disjoint_from: OBI:1000036  ! cell lysate
disjoint_from: OBI:1000042  ! peptide construct
disjoint_from: OBI:1000048  ! transgenic organism

[Term]
id: OBI:0000799
name: recombinant phage cloning
def: "Recombinant phage cloning is the process of using a phage plus some insert nucleic acid for the purposes of amplification of the insert material achieved by phage assembly in vitro." []
is_a: OBI:0600064  ! recombinant vector cloning
disjoint_from: OBI:0000687  ! nucleotide overhang cloning
disjoint_from: OBI:0000692  ! recombination enzyme based cloning
disjoint_from: OBI:0000738  ! restriction enzyme based cloning
disjoint_from: OBI:0000790  ! recombinant BAC cloning
disjoint_from: OBI:0000824  ! recombinant YAC cloning
disjoint_from: OBI:0600048  ! vector mediated amplification
disjoint_from: OBI:0600063  ! vector mediated expression

[Term]
id: OBI:0000800
name: cross linking
def: "A process in which bonds are created that link one polymer to another" []
is_a: OBI:0000011  ! planned process
relationship: OBI:0000299 CHEBI:23367 ! molecular entity

[Term]
id: OBI:0000801
name: spike train datum
def: "A spike train datum is a measurement datum which represents information about an ordered series of action potentials in an organism's CNS measured over time." []
synonym: "spike train measurement" EXACT []
is_a: IAO:0000109 
disjoint_from: OBI:0000010  ! fluorescent reporter intensity
disjoint_from: OBI:0000054  ! ratio of collected to emitted light
disjoint_from: OBI:0000101  ! measured expression level
disjoint_from: OBI:0000119  ! number of particles in subset
disjoint_from: OBI:0000125  ! number of lost events electronic
disjoint_from: OBI:0000172  ! parameter threshold
disjoint_from: OBI:0000269  ! number of lost events computer
disjoint_from: OBI:0000789  ! survival rate

[Term]
id: OBI:0000802
name: prothrombin time assay
def: "The prothrombin time is an assay most commonly measured using blood plasma. Blood is drawn into a test tube containing liquid citrate, which acts as an anticoagulant by binding the calcium in a sample. The blood is mixed, then centrifuged to separate blood cells from plasma. In newborns, whole blood is used. The plasma is analyzed by a biomedical scientist on an automated instrument at 37 degrees C, which takes a sample of the plasma. An excess of calcium is added (thereby reversing the effects of citrate), which enables the blood to clot again. For an accurate measurement the proportion of blood to citrate needs to be fixed; many laboratories will not perform the assay if the tube is underfilled and contains a relatively high concentration of citrate. If the tube is underfilled or overfilled with blood, the standardized dilution of 1 part anticoagulant to 9 parts whole blood is no longer valid. For the prothrombin time test the appropriate sample is the blue top tube, or sodium citrate tube, which is a liquid anticoagulant. Tissue factor (also known as factor III or thromboplastin) is added, and the time the sample takes to clot is measured optically. Some laboratories use a mechanical measurement, which eliminates interferences from lipemic and icteric samples. The prothrombin ratio is the prothrombin time for a patient, divided by the result for control plasma." []
is_a: OBI:0000070  ! assay

[Term]
id: OBI:0000803
name: denaturing
def: "Is a process in which the tertiary or secondary structure of a polymer is disrupted" []
is_a: OBI:0000094  ! material processing
relationship: OBI:0000417 OBI:0000456 ! material transformation objective

[Term]
id: OBI:0000804
name: informing investigator of subject study arm
def: "A process in which an investigator is made aware of which study arm that a patient is participating in, for example whether they are receiving a placebo or a treatment with an investigational compound." []
is_a: OBI:0000011  ! planned process

[Term]
id: OBI:0000805
name: antithrombin-III (AT-III) berichrome assay
def: "An antithrombin-III (AT-III) assay in which exogenous bovine thrombin and heparin are added to test plasma to form a thrombin-heparin-AT complex. The residual thrombin not bound then hydrolyzes the p-nitroalanine substrate to produce a yellow color, which is read at 405 nm. The intensity of color produced is inversely proportional to the AT present. A calibration is done with standard human plasma reagent and results for a given specimen are reported as a percentage relative to the standard" []
is_a: OBI:0000787  ! human antithrombin-III (AT-III) in blood assay

[Term]
id: OBI:0000806
name: material maintenance objective
def: "is the objective to maintain some or all of the qualities of a material over time." []
is_a: IAO:0000005 
disjoint_from: OBI:0000015  ! biological feature identification objective
disjoint_from: OBI:0000208  ! methodology testing objective
disjoint_from: OBI:0000441  ! assay objective
disjoint_from: OBI:0000456  ! material transformation objective
disjoint_from: OBI:0000684  ! specimen creation objective
disjoint_from: OBI:0200166  ! data transformation objective

[Term]
id: OBI:0000807
name: presentation of stimulus
def: "a planned process in which an organism is exposed to some stimulus with the intent to invoke an action" []
synonym: "stimulation of organism" EXACT []
is_a: OBI:0000011  ! planned process

[Term]
id: OBI:0000808
name: spectrolyse heparin antifactor-Xa assay
def: "A Spectrolyse Heparin (Xa) assay is intended for the quantitative determination of therapeutic Heparin in human plasma.\n\nThe principle inhibitor of Thrombin, Factor Xa and other coagulation serine proteases in plasma is Antithrombin III. The rate of inhibition, under normal conditions, is slow, but can be increased several thousand-fold by Heparin. This mechanism accounts for the anticoagulant effect of Heparin. Low Molecular Weight Therapeutic Heparin (LMWH) preparations appear to catalyze the reaction between Factor Xa and Antithrombin III more readily than the reaction between Thrombin and Antithrombin III while standard Heparin catalyzes both reactions equally. The Factor Xa inhibition test is the most useful test for assaying the widest variety of therapeutic Heparin preparations. In this method, when both Factor Xa and Antithrombin III are present in excess, the rate of Factor Xa inhibition is directly proportional to the Heparin concentration. The residual Factor Xa activity, measured with a Factor Xa-specific chromogenic substrate, is inversely proportional to the Heparin concentration." []
is_a: OBI:0000070  ! assay

[Term]
id: OBI:0000809
name: amplified DNA
def: "DNA that has been produced in an enzymatic amplification process" []
is_a: CHEBI:16991  ! deoxyribonucleic acids
is_a: OBI:0000047  ! processed material
intersection_of: CHEBI:16991  ! deoxyribonucleic acids
intersection_of: OBI:0000312 OBI:0600058 ! enzymatic amplification

[Term]
id: OBI:0000810
name: informed consent process
def: "a planned process in which subject is taught key facts about a clinical trial both before deciding whether or not to participate, and throughout the study. Agents of the investigation, such as doctors and nurses involved in the trial, explain the details of the study." []
is_a: OBI:0000011  ! planned process

[Term]
id: OBI:0000811
name: primary structure of DNA macromolecule
def: "a quality of a DNA molecule that inheres in its bearer due to the order of its DNA nucleotide residues." []
is_a: OBI:0000830  ! primary structure of sequence macromolecule
disjoint_from: OBI:0000797  ! primary structure of protein
disjoint_from: OBI:0000845  ! primary structure of RNA molecule

[Term]
id: OBI:0000812
name: measuring neural activity in the caudate nucleus
def: "The process of measuring neural activity  in the caudate nucleus" []
is_a: OBI:0000454  ! extracellular electrophysiology recording
relationship: http://purl.org/obo/owl/OBO_REL#unfolds_in http://ontology.neuinfo.org/NIF/BiomaterialEntities/NIF-GrossAnatomy.owl#birnlex_1373 ! Caudate nucleus

[Term]
id: OBI:0000813
name: to be treated with active ingredient role
def: "A study subject role which begins to exist when a subject is assigned to be one of those who will receive active ingredient, and is realized in a study execution in which they receive the active ingredient" []
is_a: OBI:0000097  ! study subject role
disjoint_from: OBI:0000100  ! role of being first subject treated
disjoint_from: OBI:0000205  ! dropout role
disjoint_from: OBI:0000220  ! reference subject role
disjoint_from: OBI:0000825  ! to be treated with placebo role

[Term]
id: OBI:0000814
name: guar gum
def: "Guar gum, also called guaran, is a galactomannan. It is primarily the ground endosperm of guar beans. The guar seeds are dehusked, milled and screened to obtain the guar gum.[1] It is typically produced as a free flowing, pale, off-white colored, coarse to fine ground powder." []
is_a: snap:MaterialEntity 
disjoint_from: OBI:0000050  ! platform
disjoint_from: OBI:0000146  ! supernatant collection system harvesting frame
disjoint_from: OBI:0000245  ! organization
disjoint_from: OBI:0000318  ! eluate
disjoint_from: OBI:0000390  ! thermostatic circulator
disjoint_from: OBI:0000420  ! trypsinized material
disjoint_from: OBI:0000432  ! polyacrylamide gel
disjoint_from: OBI:0000439  ! agarose gel
disjoint_from: OBI:0000576  ! scattered molecular aggregate
disjoint_from: OBI:0000651  ! urine specimen
disjoint_from: OBI:0000655  ! blood specimen
disjoint_from: OBI:0000680  ! whole organism preparation
disjoint_from: OBI:0000798  ! capsule shell
disjoint_from: OBI:0100014  ! chimera
disjoint_from: OBI:0100016  ! blood plasma
disjoint_from: OBI:0100017  ! blood serum specimen
disjoint_from: OBI:0100039  ! fragment derived from protein
disjoint_from: OBI:0100055  ! cell line cell
disjoint_from: OBI:0100056  ! immortalized cell line
disjoint_from: OBI:0100058  ! xenograft
disjoint_from: OBI:0100060  ! cell culture
disjoint_from: OBI:0100067  ! bronchial alveolar lavage
disjoint_from: OBI:0100069  ! polymer
disjoint_from: OBI:0100086  ! glucose in solution
disjoint_from: OBI:0302714  ! collection (of entities of organismal origin)
disjoint_from: OBI:0400102  ! waste tank
disjoint_from: OBI:1000023  ! cell culture supernatant
disjoint_from: OBI:1000024  ! cell pellet
disjoint_from: OBI:1000036  ! cell lysate
disjoint_from: OBI:1000042  ! peptide construct
disjoint_from: OBI:1000048  ! transgenic organism

[Term]
id: OBI:0000815
name: Berichrom(r) Antithrombin III (A) Kit
def: "For the chromogenic determination of antithrombin III. Autoanalyzer method for undiluted samples. For the quantitative chromogenic determination of the functional activity of antithrombin III in plasma on autoanalyzers for the diagnosis of diminished AT III synthesis, increased consumption, and for monitoring substitution therapy. Berichrom(r) Antithrombin III (A) is used for the rapid determination of the physiologically active antithrombin III and permits the diagnosis of congenital and acquired antithrombin III deficiency, a condition frequently associated with an increased risk of thrombosis. Acquired antithrombin III deficiencies frequently occur due to consumption following major operations or due to disseminated intravascular coagulation (DIC) in cases of septicaemia, nephroses, liver parenchymal damage (hepatitis, drug intoxication, alcoholism) and estrogen-containing contraceptives. The test permits early detection of patients at increased risk for thrombosis. Kit contains: 6 x for 5.0 mL Thrombin (bovine), 3 x for 3.0 mL Substrate Reagent, 1 x 30.0 mL Buffer Solution" []
is_a: OBI:0000047  ! processed material

[Term]
id: OBI:0000816
name: micro electrode
def: "An electrode of very fine caliber consisting usually of a fine wire or a glass tube of capillary diameter drawn to a fine point and filled with saline or a metal used in physiological experiments to stimulate or record action currents of extracellular or intracellular origin in the nervous system." []
synonym: "micro electrode measuring device" EXACT []
is_a: OBI:0000832  ! measurement device
relationship: OBI:0000304 OBI:0000245 ! organization
relationship: OBI:0000306 OBI:0000453 ! measure function

[Term]
id: OBI:0000817
name: fucoidan
def: "Fucoidan is a sulfated polysaccharide (MW: average 20,000) found mainly in various species of brown seaweed such as kombu, limu moui,bladderwrack, wakame, mozuku, and hijiki (variant forms of fucoidan have also been found in animal species, including the sea cucumber)." []
is_a: CHEBI:23367  ! molecular entity
disjoint_from: OBI:0000065  ! polyethylene glycol p-(1,1,3,3-tetramethylbutyl)-phenyl ether

[Term]
id: OBI:0000818
name: calibration
def: "A planned process with the objective to establish the relationship between data produced by a measurement device and physical qualities. This is done by using the measurement device under defined conditions, and either tuning it to adjust the measured output, or record the output and use it as a reference in future measurements." []
is_a: OBI:0000011  ! planned process
relationship: OBI:0000299 OBI:0000832 ! measurement device
relationship: OBO_REL:has_part OBI:0000070 ! assay

[Term]
id: OBI:0000819
name: anticoagulant tube storage of blood specimen
def: "Storage of a blood specimen in a tube with anticoagulant" []
is_a: OBI:0302893  ! storage

[Term]
id: OBI:0000820
name: activated partial thromboplastin time (aPTT) assay
def: "An activated partial thromboplastin time (aPTT) assay is a an assay measuring the efficacy of both the 'intrinsic' (now referred to as the contact activation pathway) and the common coagulation pathways. In order to activate the intrinsic pathway, phospholipid, an activator (such as silica, celite, kaolin, ellagic acid), and calcium (to reverse the anticoagulant effect of the oxalate) are mixed into the plasma sample . The time is measured until a thrombus (clot) forms." []
is_a: OBI:0000070  ! assay

[Term]
id: OBI:0000821
name: filled capsule
def: "A pill in the form of a small rounded gelatinous container with medicine inside." []
is_a: OBI:0000827  ! pill
relationship: OBO_REL:has_part OBI:0000798 ! capsule shell

[Term]
id: OBI:0000822
name: single blind study execution
def: "A single blind study execution is defined as any study execution in which the subjects are not informed of which study arm they are part of during the portion of the trial when the subjects are being treated" []
is_a: OBI:0000826  ! treatment portion of study execution

[Term]
id: OBI:0000823
name: thrombin time assay
def: "A  thrombin time assay is on in which after liberating the plasma from whole blood by centrifugation, bovine Thrombin is added to the sample of plasma. The clot is formed and is detected optically or mechanically by a coagulation instrument. The time between the addition of the thrombin and the clot formation is recorded as the thrombin clotting time" []
is_a: OBI:0000070  ! assay

[Term]
id: OBI:0000824
name: recombinant YAC cloning
def: "Recombinant YAC cloning is a  process with the objective to insert genetic material into a yeast artificial chromosome vector for future replication of the inserted material" []
is_a: OBI:0600064  ! recombinant vector cloning
disjoint_from: OBI:0000687  ! nucleotide overhang cloning
disjoint_from: OBI:0000692  ! recombination enzyme based cloning
disjoint_from: OBI:0000738  ! restriction enzyme based cloning
disjoint_from: OBI:0000790  ! recombinant BAC cloning
disjoint_from: OBI:0000799  ! recombinant phage cloning
disjoint_from: OBI:0600048  ! vector mediated amplification
disjoint_from: OBI:0600063  ! vector mediated expression

[Term]
id: OBI:0000825
name: to be treated with placebo role
def: "A study subject role which begins to exist when a subject is assigned to be one of those who will receive a placebo, and realized in a study execution in which they receive the placebo" []
is_a: OBI:0000097  ! study subject role
disjoint_from: OBI:0000100  ! role of being first subject treated
disjoint_from: OBI:0000205  ! dropout role
disjoint_from: OBI:0000220  ! reference subject role
disjoint_from: OBI:0000813  ! to be treated with active ingredient role

[Term]
id: OBI:0000826
name: treatment portion of study execution
def: "A planned process, part of a study design execution, during which the treatment of subjects is ongoing" []
is_a: OBI:0000011  ! planned process
relationship: OBO_REL:part_of OBI:0000471 ! study design execution

[Term]
id: OBI:0000827
name: pill
def: "A dose of medicine or placebo in the form of a small pellet." []
is_a: OBI:0000047  ! processed material

[Term]
id: OBI:0000828
name: research organization
def: "An organization formed with a goal to have its members conduct investigations" []
is_a: OBI:0000245  ! organization
disjoint_from: OBI:0000844  ! hospital

[Instance]
id: OBI:0000829
name: Sysmex Corporation, Kobe, Japan
instance_of: OBI:0000245  ! organization
instance_of: owl:Thing 

[Term]
id: OBI:0000830
name: primary structure of sequence macromolecule
def: "A quality inhering in a molecule that is completely defined by the linear sequence of a set of residues which are connected by directional, linear bonds" []
is_a: PATO:0001237  ! quality of a single physical entity
disjoint_from: OBI:0000831  ! DNA residue methylation

[Term]
id: OBI:0000831
name: DNA residue methylation
def: "=def a quality of a DNA residue that has a methyl group attached to it" []
is_a: PATO:0001237  ! quality of a single physical entity
disjoint_from: OBI:0000830  ! primary structure of sequence macromolecule

[Term]
id: OBI:0000832
name: measurement device
def: "a processed material created to have the function to measure" []
is_a: OBI:0000047  ! processed material
intersection_of: OBI:0000047  ! processed material
intersection_of: OBI:0000306 OBI:0000453 ! measure function

[Typedef]
id: OBI:0000833
name: objective_achieved_by
def: "This relation obtains between a a objective specification and a planned process when the criteria specified in the objective specification are met at the end of the planned process." []
inverse_of_on_instance_level: OBI:0000417  ! achieves_planned_objective

[Term]
id: OBI:0000835
name: manufacturer
def: "A person or organization that has a manufacturer role" []
is_a: snap:MaterialEntity 

[Term]
id: OBI:0000836
name: test tube
def: "A test tube is a device consisting of a glass or plastic tubing, open at the top, usually with a rounded U-shaped bottom which has the function to contain material" []
synonym: "collection tube" EXACT []
synonym: "sample tube" EXACT []
is_a: OBI:0000047  ! processed material
relationship: OBI:0000306 OBI:0000370 ! contain function

[Term]
id: OBI:0000837
name: oral ingestion of pill
def: "An adding a material entity to target with the entity is a pill and the target is the mouth" []
is_a: OBI:0600007  ! administering substance in vivo

[Term]
id: OBI:0000838
name: material maintenance
def: "a process with that achieves the objective to maintain some or all of the characteristics of an input material over time" []
is_a: OBI:0000011  ! planned process

[Term]
id: OBI:0000840
name: unblinding process
def: "The part of the study execution in which the subjects are told what study arm they are in and in which the investigators are told which subjects are in which trials" []
is_a: OBI:0000011  ! planned process

[Term]
id: OBI:0000841
name: subject agrees they understand informed consent document
def: "A process in which a subject receives an informed consent document and agrees that they have understood it" []
is_a: OBI:0000011  ! planned process
relationship: OBO_REL:part_of OBI:0000810 ! informed consent process

[Term]
id: OBI:0000842
name: informing subject of study arm
def: "A process in which the subject is made aware of which study arm they are participating in, for example whether they are receiving a placebo or a treatment with an investigational compound." []
is_a: OBI:0000011  ! planned process

[Term]
id: OBI:0000843
name: Sysmex CA-6000 Coagulation Analyzer
def: "The Sysmex CA-6000 automated coagulation analyzer is a random access instrument that is capable of performing 20 clot-based and chromogenic assays" []
is_a: OBI:0000047  ! processed material

[Term]
id: OBI:0000844
name: hospital
def: "A medical organization at which sick or injured people are given clinical care" []
is_a: OBI:0000245  ! organization
disjoint_from: OBI:0000828  ! research organization

[Term]
id: OBI:0000845
name: primary structure of RNA molecule
def: "The primary structure of an RNA molecule that is completely defined by the set of its nucleic residue parts and the linear order induced by the peptide bonds that hold them together" []
is_a: OBI:0000830  ! primary structure of sequence macromolecule
disjoint_from: OBI:0000797  ! primary structure of protein
disjoint_from: OBI:0000811  ! primary structure of DNA macromolecule

[Typedef]
id: OBI:0000846
name: is member of
def: "Relating a legal person to an organization in the case where the legal person has a role as member of the organization" []

[Term]
id: OBI:0000847
name: test substance role
def: "A role born by a material entity and realized in a process where the substance is used as specified as the independent variable for an investigation" []
is_a: snap:Role 
disjoint_from: OBI:0000017  ! regulatory role
disjoint_from: OBI:0000025  ! reference substance role
disjoint_from: OBI:0000029  ! centrifuge pellet role
disjoint_from: OBI:0000034  ! supernatant role
disjoint_from: OBI:0000040  ! drug role
disjoint_from: OBI:0000067  ! evaluant role
disjoint_from: OBI:0000086  ! reagent role
disjoint_from: OBI:0000091  ! detector reagent role
disjoint_from: OBI:0000093  ! patient role
disjoint_from: OBI:0000097  ! study subject role
disjoint_from: OBI:0000112  ! specimen role
disjoint_from: OBI:0000140  ! label role
disjoint_from: OBI:0000174  ! study group role
disjoint_from: OBI:0000204  ! nutrient role
disjoint_from: OBI:0000237  ! antigen role
disjoint_from: OBI:0000275  ! analyte role
disjoint_from: OBI:0000319  ! material to be added role
disjoint_from: OBI:0000405  ! primer role
disjoint_from: OBI:0000416  ! cloning insert role
disjoint_from: OBI:0000444  ! target of material addition role
disjoint_from: OBI:0000571  ! manufacturer role
disjoint_from: OBI:0000718  ! pathogen role
disjoint_from: OBI:0000720  ! adjuvent role
disjoint_from: OBI:0000725  ! host role
disjoint_from: OBI:0302731  ! buffer role
disjoint_from: OBI:0302732  ! solvent role
disjoint_from: OBI:0302733  ! solute role
disjoint_from: OBI:1110082  ! immunogen role
disjoint_from: OBI:1110083  ! host of immune response role
disjoint_from: OBI:1110086  ! restricting MHC role
disjoint_from: OBI:1110087  ! donor
disjoint_from: OBI:1110091  ! carrier role
disjoint_from: OBI:1110092  ! adjuvant role
disjoint_from: OBI:1110120  ! assay antigen role

[Term]
id: OBI:0005246
name: injection function
def: "The function of a device realized when administering a substance in vivo, applied particularly to the forcible insertion of a liquid or gas by means of a syringe, pump, etc." []
is_a: snap:Function 
disjoint_from: OBI:0000368  ! record function
disjoint_from: OBI:0000369  ! magnify function
disjoint_from: OBI:0000370  ! contain function
disjoint_from: OBI:0000371  ! heat function
disjoint_from: OBI:0000372  ! separation function
disjoint_from: OBI:0000374  ! excitation function
disjoint_from: OBI:0000375  ! freeze function
disjoint_from: OBI:0000376  ! synthesizing function
disjoint_from: OBI:0000377  ! perturbe function
disjoint_from: OBI:0000379  ! mechanical function
disjoint_from: OBI:0000383  ! transfer function
disjoint_from: OBI:0000385  ! ionization function
disjoint_from: OBI:0000387  ! cool function
disjoint_from: OBI:0000388  ! connection function
disjoint_from: OBI:0000391  ! energy supply function
disjoint_from: OBI:0000392  ! information processor function
disjoint_from: OBI:0000401  ! environment control function
disjoint_from: OBI:0000403  ! sort function
disjoint_from: OBI:0000453  ! measure function
disjoint_from: OBI:0000455  ! consume data function
disjoint_from: OBI:1110016  ! adaptive immune effector function
disjoint_from: OBI:1110085  ! antigen presentation function

[Term]
id: OBI:0100010
name: Epstein Barr virus transformed B cell
def: "A material entity which results from viral transformation process using EBV as transformation agent when applied to B-cell entity" []
is_a: OBI:0000047  ! processed material

[Term]
id: OBI:0100014
name: chimera
def: "An organism which contains cells or tissues with a different genotype" []
is_a: snap:MaterialEntity 
disjoint_from: OBI:0000050  ! platform
disjoint_from: OBI:0000146  ! supernatant collection system harvesting frame
disjoint_from: OBI:0000245  ! organization
disjoint_from: OBI:0000318  ! eluate
disjoint_from: OBI:0000390  ! thermostatic circulator
disjoint_from: OBI:0000420  ! trypsinized material
disjoint_from: OBI:0000432  ! polyacrylamide gel
disjoint_from: OBI:0000439  ! agarose gel
disjoint_from: OBI:0000576  ! scattered molecular aggregate
disjoint_from: OBI:0000651  ! urine specimen
disjoint_from: OBI:0000655  ! blood specimen
disjoint_from: OBI:0000680  ! whole organism preparation
disjoint_from: OBI:0000798  ! capsule shell
disjoint_from: OBI:0000814  ! guar gum
disjoint_from: OBI:0100016  ! blood plasma
disjoint_from: OBI:0100017  ! blood serum specimen
disjoint_from: OBI:0100039  ! fragment derived from protein
disjoint_from: OBI:0100055  ! cell line cell
disjoint_from: OBI:0100056  ! immortalized cell line
disjoint_from: OBI:0100058  ! xenograft
disjoint_from: OBI:0100060  ! cell culture
disjoint_from: OBI:0100067  ! bronchial alveolar lavage
disjoint_from: OBI:0100069  ! polymer
disjoint_from: OBI:0100086  ! glucose in solution
disjoint_from: OBI:0302714  ! collection (of entities of organismal origin)
disjoint_from: OBI:0400102  ! waste tank
disjoint_from: OBI:1000023  ! cell culture supernatant
disjoint_from: OBI:1000024  ! cell pellet
disjoint_from: OBI:1000036  ! cell lysate
disjoint_from: OBI:1000042  ! peptide construct
disjoint_from: OBI:1000048  ! transgenic organism

[Term]
id: OBI:0100015
name: anatomical entity
def: "An anatomical entity is a material entity that is part of a multicellular organism, and which is large enough so that it forms an identifiable structure in the organism. Specifically, it excludes granular parts of the organism, such as atoms, molecules, cells, which can be removed from the organism without affecting it. It is defined as the union of 'multi-tissue structure', 'body substance' and 'portion of tissue'" []
is_a: snap:MaterialEntity 
relationship: OBO_REL:part_of OBI:0100026 ! organism
union_of: CARO:0000043  ! portion of tissue
union_of: CARO:0000055  ! multi-tissue structure
union_of: FMA:9669  ! Body substance

[Term]
id: OBI:0100016
name: blood plasma
def: "blood plasma is a material entity which corresponds to the liquid component of blood, in which the blood cells are suspended." []
synonym: "plasma" EXACT []
is_a: OBI:0000047  ! processed material
disjoint_from: OBI:0000050  ! platform
disjoint_from: OBI:0000146  ! supernatant collection system harvesting frame
disjoint_from: OBI:0000245  ! organization
disjoint_from: OBI:0000318  ! eluate
disjoint_from: OBI:0000390  ! thermostatic circulator
disjoint_from: OBI:0000420  ! trypsinized material
disjoint_from: OBI:0000432  ! polyacrylamide gel
disjoint_from: OBI:0000439  ! agarose gel
disjoint_from: OBI:0000576  ! scattered molecular aggregate
disjoint_from: OBI:0000651  ! urine specimen
disjoint_from: OBI:0000655  ! blood specimen
disjoint_from: OBI:0000680  ! whole organism preparation
disjoint_from: OBI:0000798  ! capsule shell
disjoint_from: OBI:0000814  ! guar gum
disjoint_from: OBI:0100014  ! chimera
disjoint_from: OBI:0100017  ! blood serum specimen
disjoint_from: OBI:0100039  ! fragment derived from protein
disjoint_from: OBI:0100055  ! cell line cell
disjoint_from: OBI:0100056  ! immortalized cell line
disjoint_from: OBI:0100058  ! xenograft
disjoint_from: OBI:0100060  ! cell culture
disjoint_from: OBI:0100067  ! bronchial alveolar lavage
disjoint_from: OBI:0100069  ! polymer
disjoint_from: OBI:0100086  ! glucose in solution
disjoint_from: OBI:0302714  ! collection (of entities of organismal origin)
disjoint_from: OBI:0400102  ! waste tank
disjoint_from: OBI:1000023  ! cell culture supernatant
disjoint_from: OBI:1000024  ! cell pellet
disjoint_from: OBI:1000036  ! cell lysate
disjoint_from: OBI:1000042  ! peptide construct
disjoint_from: OBI:1000048  ! transgenic organism

[Term]
id: OBI:0100017
name: blood serum specimen
def: "A material entity which derives from blood and corresponds to blood plasma without fibrinogen or the other clotting factors." []
is_a: OBI:0000047  ! processed material
is_a: OBI:0100051  ! specimen
relationship: OBI:0000316 OBI:0000112 ! specimen role
disjoint_from: OBI:0000050  ! platform
disjoint_from: OBI:0000146  ! supernatant collection system harvesting frame
disjoint_from: OBI:0000245  ! organization
disjoint_from: OBI:0000318  ! eluate
disjoint_from: OBI:0000390  ! thermostatic circulator
disjoint_from: OBI:0000420  ! trypsinized material
disjoint_from: OBI:0000432  ! polyacrylamide gel
disjoint_from: OBI:0000439  ! agarose gel
disjoint_from: OBI:0000576  ! scattered molecular aggregate
disjoint_from: OBI:0000651  ! urine specimen
disjoint_from: OBI:0000655  ! blood specimen
disjoint_from: OBI:0000680  ! whole organism preparation
disjoint_from: OBI:0000798  ! capsule shell
disjoint_from: OBI:0000814  ! guar gum
disjoint_from: OBI:0100014  ! chimera
disjoint_from: OBI:0100016  ! blood plasma
disjoint_from: OBI:0100039  ! fragment derived from protein
disjoint_from: OBI:0100055  ! cell line cell
disjoint_from: OBI:0100056  ! immortalized cell line
disjoint_from: OBI:0100058  ! xenograft
disjoint_from: OBI:0100060  ! cell culture
disjoint_from: OBI:0100067  ! bronchial alveolar lavage
disjoint_from: OBI:0100069  ! polymer
disjoint_from: OBI:0100086  ! glucose in solution
disjoint_from: OBI:0302714  ! collection (of entities of organismal origin)
disjoint_from: OBI:0400102  ! waste tank
disjoint_from: OBI:1000023  ! cell culture supernatant
disjoint_from: OBI:1000024  ! cell pellet
disjoint_from: OBI:1000036  ! cell lysate
disjoint_from: OBI:1000042  ! peptide construct
disjoint_from: OBI:1000048  ! transgenic organism

[Term]
id: OBI:0100026
name: organism
def: "A material entity that is an individual living system, such as animal, plant, bacteria or virus, that is capable of replicating or reproducing, growth and maintenance in the right environment. An organism may be unicellular or made up, like humans, of many billions of cells divided into specialized tissues and organs." []
is_a: snap:MaterialEntity 
union_of: NCBITaxon:10239  ! Viruses
union_of: NCBITaxon:2  ! Bacteria
union_of: NCBITaxon:2157  ! Archaea
union_of: NCBITaxon:2759  ! Eukaryota

[Term]
id: OBI:0100035
name: immortal cell
def: "a cell derived from a multicellular organism that has the potential to replicate indefinitely" []
is_a: CL:0000000  ! cell
disjoint_from: OBI:1110041  ! lymph node cell

[Term]
id: OBI:0100039
name: fragment derived from protein
def: "A material entity which is derived from a  protein" []
is_a: snap:MaterialEntity 
disjoint_from: OBI:0000050  ! platform
disjoint_from: OBI:0000146  ! supernatant collection system harvesting frame
disjoint_from: OBI:0000245  ! organization
disjoint_from: OBI:0000318  ! eluate
disjoint_from: OBI:0000390  ! thermostatic circulator
disjoint_from: OBI:0000420  ! trypsinized material
disjoint_from: OBI:0000432  ! polyacrylamide gel
disjoint_from: OBI:0000439  ! agarose gel
disjoint_from: OBI:0000576  ! scattered molecular aggregate
disjoint_from: OBI:0000651  ! urine specimen
disjoint_from: OBI:0000655  ! blood specimen
disjoint_from: OBI:0000680  ! whole organism preparation
disjoint_from: OBI:0000798  ! capsule shell
disjoint_from: OBI:0000814  ! guar gum
disjoint_from: OBI:0100014  ! chimera
disjoint_from: OBI:0100016  ! blood plasma
disjoint_from: OBI:0100017  ! blood serum specimen
disjoint_from: OBI:0100055  ! cell line cell
disjoint_from: OBI:0100056  ! immortalized cell line
disjoint_from: OBI:0100058  ! xenograft
disjoint_from: OBI:0100060  ! cell culture
disjoint_from: OBI:0100067  ! bronchial alveolar lavage
disjoint_from: OBI:0100069  ! polymer
disjoint_from: OBI:0100086  ! glucose in solution
disjoint_from: OBI:0302714  ! collection (of entities of organismal origin)
disjoint_from: OBI:0400102  ! waste tank
disjoint_from: OBI:1000023  ! cell culture supernatant
disjoint_from: OBI:1000024  ! cell pellet
disjoint_from: OBI:1000036  ! cell lysate
disjoint_from: OBI:1000042  ! peptide construct
disjoint_from: OBI:1000048  ! transgenic organism

[Term]
id: OBI:0100046
name: phosphate buffered saline solution
def: "Phosphate buffered saline (abbreviated PBS) is a buffer solution commonly used in biochemistry. It is a salty solution containing sodium chloride, sodium phosphate and in some preparations potassium chloride and potassium phosphate. The buffer helps to maintain a constant pH. The concentration usually matches the human body (isotonic)." []
synonym: "PBS buffer" EXACT []
is_a: OBI:0302729  ! chemical solution
relationship: OBI:0000316 OBI:0302731 ! buffer role

[Term]
id: OBI:0100051
name: specimen
def: "A material entity that has the specimen role." []
is_a: snap:MaterialEntity 
intersection_of: snap:MaterialEntity 
intersection_of: OBI:0000316 OBI:0000112 ! specimen role

[Term]
id: OBI:0100055
name: cell line cell
def: "A material entity that represents generations of a primary culture." []
is_a: OBI:0000047  ! processed material
relationship: OBI:0000312 OBI:0600036 ! establishing cell culture
disjoint_from: OBI:0000050  ! platform
disjoint_from: OBI:0000146  ! supernatant collection system harvesting frame
disjoint_from: OBI:0000245  ! organization
disjoint_from: OBI:0000318  ! eluate
disjoint_from: OBI:0000390  ! thermostatic circulator
disjoint_from: OBI:0000420  ! trypsinized material
disjoint_from: OBI:0000432  ! polyacrylamide gel
disjoint_from: OBI:0000439  ! agarose gel
disjoint_from: OBI:0000576  ! scattered molecular aggregate
disjoint_from: OBI:0000651  ! urine specimen
disjoint_from: OBI:0000655  ! blood specimen
disjoint_from: OBI:0000680  ! whole organism preparation
disjoint_from: OBI:0000798  ! capsule shell
disjoint_from: OBI:0000814  ! guar gum
disjoint_from: OBI:0100014  ! chimera
disjoint_from: OBI:0100016  ! blood plasma
disjoint_from: OBI:0100017  ! blood serum specimen
disjoint_from: OBI:0100039  ! fragment derived from protein
disjoint_from: OBI:0100056  ! immortalized cell line
disjoint_from: OBI:0100058  ! xenograft
disjoint_from: OBI:0100060  ! cell culture
disjoint_from: OBI:0100067  ! bronchial alveolar lavage
disjoint_from: OBI:0100069  ! polymer
disjoint_from: OBI:0100086  ! glucose in solution
disjoint_from: OBI:0302714  ! collection (of entities of organismal origin)
disjoint_from: OBI:0400102  ! waste tank
disjoint_from: OBI:1000023  ! cell culture supernatant
disjoint_from: OBI:1000024  ! cell pellet
disjoint_from: OBI:1000036  ! cell lysate
disjoint_from: OBI:1000042  ! peptide construct
disjoint_from: OBI:1000048  ! transgenic organism

[Term]
id: OBI:0100056
name: immortalized cell line
def: "An immortalized cell line is a cell line that is able to replicate indefinitely as a result of an immortalization process" []
is_a: OBI:0000047  ! processed material
relationship: OBI:0000312 OBI:0600036 ! establishing cell culture
disjoint_from: OBI:0000050  ! platform
disjoint_from: OBI:0000146  ! supernatant collection system harvesting frame
disjoint_from: OBI:0000245  ! organization
disjoint_from: OBI:0000318  ! eluate
disjoint_from: OBI:0000390  ! thermostatic circulator
disjoint_from: OBI:0000420  ! trypsinized material
disjoint_from: OBI:0000432  ! polyacrylamide gel
disjoint_from: OBI:0000439  ! agarose gel
disjoint_from: OBI:0000576  ! scattered molecular aggregate
disjoint_from: OBI:0000651  ! urine specimen
disjoint_from: OBI:0000655  ! blood specimen
disjoint_from: OBI:0000680  ! whole organism preparation
disjoint_from: OBI:0000798  ! capsule shell
disjoint_from: OBI:0000814  ! guar gum
disjoint_from: OBI:0100014  ! chimera
disjoint_from: OBI:0100016  ! blood plasma
disjoint_from: OBI:0100017  ! blood serum specimen
disjoint_from: OBI:0100039  ! fragment derived from protein
disjoint_from: OBI:0100055  ! cell line cell
disjoint_from: OBI:0100058  ! xenograft
disjoint_from: OBI:0100060  ! cell culture
disjoint_from: OBI:0100067  ! bronchial alveolar lavage
disjoint_from: OBI:0100069  ! polymer
disjoint_from: OBI:0100086  ! glucose in solution
disjoint_from: OBI:0302714  ! collection (of entities of organismal origin)
disjoint_from: OBI:0400102  ! waste tank
disjoint_from: OBI:1000023  ! cell culture supernatant
disjoint_from: OBI:1000024  ! cell pellet
disjoint_from: OBI:1000036  ! cell lysate
disjoint_from: OBI:1000042  ! peptide construct
disjoint_from: OBI:1000048  ! transgenic organism

[Term]
id: OBI:0100058
name: xenograft
def: "A material entity which results from the transplantation of living cells, tissues or organs  from on organism of one species to an organism of another species." []
synonym: "xenotransplant" EXACT []
is_a: OBI:0000047  ! processed material
relationship: OBI:0000312 OBI:0000105 ! transplantation
relationship: OBO_REL:derives_from OBI:0100026 ! organism
disjoint_from: OBI:0000050  ! platform
disjoint_from: OBI:0000146  ! supernatant collection system harvesting frame
disjoint_from: OBI:0000245  ! organization
disjoint_from: OBI:0000318  ! eluate
disjoint_from: OBI:0000390  ! thermostatic circulator
disjoint_from: OBI:0000420  ! trypsinized material
disjoint_from: OBI:0000432  ! polyacrylamide gel
disjoint_from: OBI:0000439  ! agarose gel
disjoint_from: OBI:0000576  ! scattered molecular aggregate
disjoint_from: OBI:0000651  ! urine specimen
disjoint_from: OBI:0000655  ! blood specimen
disjoint_from: OBI:0000680  ! whole organism preparation
disjoint_from: OBI:0000798  ! capsule shell
disjoint_from: OBI:0000814  ! guar gum
disjoint_from: OBI:0100014  ! chimera
disjoint_from: OBI:0100016  ! blood plasma
disjoint_from: OBI:0100017  ! blood serum specimen
disjoint_from: OBI:0100039  ! fragment derived from protein
disjoint_from: OBI:0100055  ! cell line cell
disjoint_from: OBI:0100056  ! immortalized cell line
disjoint_from: OBI:0100060  ! cell culture
disjoint_from: OBI:0100067  ! bronchial alveolar lavage
disjoint_from: OBI:0100069  ! polymer
disjoint_from: OBI:0100086  ! glucose in solution
disjoint_from: OBI:0302714  ! collection (of entities of organismal origin)
disjoint_from: OBI:0400102  ! waste tank
disjoint_from: OBI:1000023  ! cell culture supernatant
disjoint_from: OBI:1000024  ! cell pellet
disjoint_from: OBI:1000036  ! cell lysate
disjoint_from: OBI:1000042  ! peptide construct
disjoint_from: OBI:1000048  ! transgenic organism

[Term]
id: OBI:0100060
name: cell culture
def: "a cell culture is a material entity consisting of a population of cells that is maintained in vitro" []
is_a: OBI:0000047  ! processed material
relationship: OBI:0000312 OBI:0600036 ! establishing cell culture
relationship: OBI:0000643 CL:0000000 ! cell
disjoint_from: OBI:0000050  ! platform
disjoint_from: OBI:0000146  ! supernatant collection system harvesting frame
disjoint_from: OBI:0000245  ! organization
disjoint_from: OBI:0000318  ! eluate
disjoint_from: OBI:0000390  ! thermostatic circulator
disjoint_from: OBI:0000420  ! trypsinized material
disjoint_from: OBI:0000432  ! polyacrylamide gel
disjoint_from: OBI:0000439  ! agarose gel
disjoint_from: OBI:0000576  ! scattered molecular aggregate
disjoint_from: OBI:0000651  ! urine specimen
disjoint_from: OBI:0000655  ! blood specimen
disjoint_from: OBI:0000680  ! whole organism preparation
disjoint_from: OBI:0000798  ! capsule shell
disjoint_from: OBI:0000814  ! guar gum
disjoint_from: OBI:0100014  ! chimera
disjoint_from: OBI:0100016  ! blood plasma
disjoint_from: OBI:0100017  ! blood serum specimen
disjoint_from: OBI:0100039  ! fragment derived from protein
disjoint_from: OBI:0100055  ! cell line cell
disjoint_from: OBI:0100056  ! immortalized cell line
disjoint_from: OBI:0100058  ! xenograft
disjoint_from: OBI:0100067  ! bronchial alveolar lavage
disjoint_from: OBI:0100069  ! polymer
disjoint_from: OBI:0100086  ! glucose in solution
disjoint_from: OBI:0302714  ! collection (of entities of organismal origin)
disjoint_from: OBI:0400102  ! waste tank
disjoint_from: OBI:1000023  ! cell culture supernatant
disjoint_from: OBI:1000024  ! cell pellet
disjoint_from: OBI:1000036  ! cell lysate
disjoint_from: OBI:1000042  ! peptide construct
disjoint_from: OBI:1000048  ! transgenic organism

[Term]
id: OBI:0100061
name: primary cell culture
def: "a primary cell culture is a cell culture where the cells derive from a fresh tissue source." []
is_a: OBI:0100060  ! cell culture
disjoint_from: OBI:0100062  ! cell line culture
disjoint_from: OBI:0100063  ! clonal cell culture

[Term]
id: OBI:0100062
name: cell line culture
def: "a cell line culture is a cell culture where the cells grown are from a cell line, long term culture of cells that are replicating continuously. The cell population is homogenous but not clonal" []
is_a: OBI:0100060  ! cell culture
disjoint_from: OBI:0100061  ! primary cell culture
disjoint_from: OBI:0100063  ! clonal cell culture

[Term]
id: OBI:0100063
name: clonal cell culture
def: "a clonal cell culture is a cell culture in which all cells can be assumed to be identical, tracking back to a single ancestor cell." []
is_a: OBI:0100060  ! cell culture
disjoint_from: OBI:0100061  ! primary cell culture
disjoint_from: OBI:0100062  ! cell line culture

[Term]
id: OBI:0100064
name: screening library
def: "a screening library is a collection of materials engineered to identify qualities of a subset of its members during a screening process?" []
is_a: OBI:0302714  ! collection (of entities of organismal origin)
disjoint_from: OBI:0000164  ! cDNA library
disjoint_from: OBI:0000181  ! population
disjoint_from: OBI:0000722  ! paired-end library
disjoint_from: OBI:0000736  ! single fragment library
disjoint_from: OBI:1000029  ! phage display library

[Term]
id: OBI:0100065
name: synthetic p