1.1.1374 19:08:2010 19:52 17:08:2010 15:58 dph gene_ontology cvs version: $Revision: 1.977 $ Candida GO slim Generic GO slim GOA and proteome slim PIR GO slim Plant GO slim Fission yeast GO slim Yeast GO slim Prokaryotic GO subset unvetted gene_ontology This is an OWL translation of an ontology whose native representational form is .obo. The translation was performed using the oboInOwl xslt library. For details, see http://www.berkeleybop.org/obo-conv.cgi ribosomal chaperone activity This term was made obsolete because it refers to a class of gene products and a biological process rather than a molecular function. OBSOLETE. Assists in the correct assembly of ribosomes or ribosomal subunits in vivo, but is not a component of the assembled ribosome when performing its normal biological function. GOC:jl http://purl.org/obo/owl/GOC#GOC_jl PMID:12150913 http://purl.org/obo/owl/PMID#PMID_12150913 molecular_function high affinity zinc uptake transmembrane transporter activity Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Zn2+(out) = Zn2+(in), probably powered by proton motive force. In high affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations. TC:2.A.5.1.1 http://purl.org/obo/owl/TC#TC_2.A.5.1.1 molecular_function low-affinity zinc ion transmembrane transporter activity Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Zn2+ = Zn2+, probably powered by proton motive force. In low affinity transport the transporter is able to bind the solute only if it is present at very high concentrations. GOC:mtg_transport http://purl.org/obo/owl/GOC#GOC_mtg_transport ISBN:0815340729 http://purl.org/obo/owl/ISBN#ISBN_0815340729 molecular_function thioredoxin This term was made obsolete because it represents gene products. OBSOLETE. A small disulfide-containing redox protein that serves as a general protein disulfide oxidoreductase. Interacts with a broad range of proteins by a redox mechanism, based on the reversible oxidation of 2 cysteine thiol groups to a disulfide, accompanied by the transfer of 2 electrons and 2 protons. The net result is the covalent interconversion of a disulfide and a dithiol. GOC:kd http://purl.org/obo/owl/GOC#GOC_kd molecular_function GO:0000013 alpha-1,6-mannosyltransferase activity Catalysis of the transfer of a mannose residue from GDP-mannose to an oligosaccharide, forming an alpha-1,6-linkage. GOC:mcc http://purl.org/obo/owl/GOC#GOC_mcc PMID:2644248 http://purl.org/obo/owl/PMID#PMID_2644248 molecular_function EC:2.4.1.- http://purl.org/obo/owl/EC#EC_2.4.1.- trans-hexaprenyltranstransferase activity Catalysis of the reaction: all-trans-hexaprenyl diphosphate + isopentenyl diphosphate = diphosphate + all-trans-heptaprenyl diphosphate. EC:2.5.1.30 http://purl.org/obo/owl/EC#EC_2.5.1.30 all-trans-heptaprenyl-diphosphate synthase activity EC:2.5.1.30 http://purl.org/obo/owl/EC#EC_2.5.1.30 all-trans-hexaprenyl-diphosphate:isopentenyl-diphosphate hexaprenyltranstransferase activity EC:2.5.1.30 http://purl.org/obo/owl/EC#EC_2.5.1.30 heptaprenyl diphosphate synthase activity EC:2.5.1.30 http://purl.org/obo/owl/EC#EC_2.5.1.30 heptaprenyl pyrophosphate synthase activity EC:2.5.1.30 http://purl.org/obo/owl/EC#EC_2.5.1.30 heptaprenyl pyrophosphate synthetase activity EC:2.5.1.30 http://purl.org/obo/owl/EC#EC_2.5.1.30 molecular_function EC:2.5.1.30 http://purl.org/obo/owl/EC#EC_2.5.1.30 MetaCyc:TRANS-HEXAPRENYLTRANSTRANSFERASE-RXN http://purl.org/obo/owl/MetaCyc#MetaCyc_TRANS-HEXAPRENYLTRANSTRANSFERASE-RXN single-stranded DNA specific endodeoxyribonuclease activity Catalysis of the hydrolysis of ester linkages within a single-stranded deoxyribonucleic acid molecule by creating internal breaks. GOC:mah http://purl.org/obo/owl/GOC#GOC_mah ssDNA-specific endodeoxyribonuclease activity GOC:mah http://purl.org/obo/owl/GOC#GOC_mah molecular_function lactase activity Catalysis of the reaction: lactose + H2O = D-glucose + D-galactose. EC:3.2.1.108 http://purl.org/obo/owl/EC#EC_3.2.1.108 lactase-phlorizin hydrolase activity EC:3.2.1.108 http://purl.org/obo/owl/EC#EC_3.2.1.108 lactose galactohydrolase activity EC:3.2.1.108 http://purl.org/obo/owl/EC#EC_3.2.1.108 molecular_function EC:3.2.1.108 http://purl.org/obo/owl/EC#EC_3.2.1.108 MetaCyc:LACTASE-RXN http://purl.org/obo/owl/MetaCyc#MetaCyc_LACTASE-RXN Reactome:20536 http://purl.org/obo/owl/Reactome#Reactome_20536 alpha-1,2-mannosyltransferase activity Catalysis of the transfer of a mannose residue from GDP-mannose to an oligosaccharide, forming an alpha-1,2-linkage. GOC:mcc http://purl.org/obo/owl/GOC#GOC_mcc PMID:10521541 http://purl.org/obo/owl/PMID#PMID_10521541 molecular_function EC:2.4.1.- http://purl.org/obo/owl/EC#EC_2.4.1.- mannosyltransferase activity Catalysis of the transfer of a mannosyl group to an acceptor molecule, typically another carbohydrate or a lipid. GOC:ai http://purl.org/obo/owl/GOC#GOC_ai molecular_function EC:2.4.1.- http://purl.org/obo/owl/EC#EC_2.4.1.- Reactome:7672 http://purl.org/obo/owl/Reactome#Reactome_7672 mannosylphosphate transferase activity Catalysis of the transfer of a mannosylphosphate group from one compound to another. GOC:jl http://purl.org/obo/owl/GOC#GOC_jl molecular_function alpha-1,3-mannosyltransferase activity Catalysis of the transfer of a mannose residue from GDP-mannose to an oligosaccharide, forming an alpha-1,3-linkage. GOC:mcc http://purl.org/obo/owl/GOC#GOC_mcc PMID:10521541 http://purl.org/obo/owl/PMID#PMID_10521541 molecular_function EC:2.4.1.- http://purl.org/obo/owl/EC#EC_2.4.1.- adenine deaminase activity Catalysis of the reaction: adenine + H2O = hypoxanthine + NH3. EC:3.5.4.2 http://purl.org/obo/owl/EC#EC_3.5.4.2 ADase activity EC:3.5.4.2 http://purl.org/obo/owl/EC#EC_3.5.4.2 adenase activity EC:3.5.4.2 http://purl.org/obo/owl/EC#EC_3.5.4.2 adenine aminase activity EC:3.5.4.2 http://purl.org/obo/owl/EC#EC_3.5.4.2 adenine aminohydrolase activity EC:3.5.4.2 http://purl.org/obo/owl/EC#EC_3.5.4.2 molecular_function EC:3.5.4.2 http://purl.org/obo/owl/EC#EC_3.5.4.2 MetaCyc:ADENINE-DEAMINASE-RXN http://purl.org/obo/owl/MetaCyc#MetaCyc_ADENINE-DEAMINASE-RXN acyl binding Interacting selectively and non-covalently with an acyl group, any group formally derived by removal of the hydroxyl group from the acid function of a carboxylic acid. URL:http://cancerweb.ncl.ac.uk/ http://cancerweb.ncl.ac.uk/ ISBN:0198506732 http://purl.org/obo/owl/ISBN#ISBN_0198506732 acyl-CoA or acyl binding molecular_function acyl carrier activity Enables the directed movement of acyl groups into, out of, within or between cells. ChEBI:22221 http://purl.org/obo/owl/ChEBI#ChEBI_22221 GOC:cb http://purl.org/obo/owl/GOC#GOC_cb molecular_function plasma membrane long-chain fatty acid transporter This term was made obsolete because it describes a gene product and it contains component information. OBSOLETE (was not defined before being made obsolete). GOC:ai http://purl.org/obo/owl/GOC#GOC_ai molecular_function Rieske iron-sulfur protein This term was made obsolete because it represents a gene product. OBSOLETE (was not defined before being made obsolete). GOC:ai http://purl.org/obo/owl/GOC#GOC_ai Rieske iron-sulphur protein molecular_function peptidyltransferase activity Catalysis of the reaction: peptidyl-tRNA(1) + aminoacyl-tRNA(2) = tRNA(1) + peptidylaminoacyl-tRNA(2). EC:2.3.2.12 http://purl.org/obo/owl/EC#EC_2.3.2.12 PMID:11433365 http://purl.org/obo/owl/PMID#PMID_11433365 PMID:9242921 http://purl.org/obo/owl/PMID#PMID_9242921 peptidyl-tRNA:aminoacyl-tRNA N-peptidyltransferase activity EC:2.3.2.12 http://purl.org/obo/owl/EC#EC_2.3.2.12 molecular_function EC:2.3.2.12 http://purl.org/obo/owl/EC#EC_2.3.2.12 MetaCyc:PEPTIDYLTRANSFERASE-RXN http://purl.org/obo/owl/MetaCyc#MetaCyc_PEPTIDYLTRANSFERASE-RXN Reactome:20610 http://purl.org/obo/owl/Reactome#Reactome_20610 tRNA binding Interacting selectively and non-covalently with transfer RNA. GOC:ai http://purl.org/obo/owl/GOC#GOC_ai molecular_function acyl-CoA binding Interacting selectively and non-covalently with acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty acyl group. GOC:jl http://purl.org/obo/owl/GOC#GOC_jl ISBN:0198506732 http://purl.org/obo/owl/ISBN#ISBN_0198506732 acyl-CoA or acyl binding molecular_function L-ornithine transmembrane transporter activity Catalysis of the transfer of L-ornithine from one side of a membrane to the other. L-ornithine is 2,5-diaminopentanoic acid. GOC:ai http://purl.org/obo/owl/GOC#GOC_ai GOC:mtg_transport http://purl.org/obo/owl/GOC#GOC_mtg_transport ISBN:0815340729 http://purl.org/obo/owl/ISBN#ISBN_0815340729 histidine/arginine/lysine/ornithine porter activity L-ornithine transporter activity molecular_function Reactome:20635 http://purl.org/obo/owl/Reactome#Reactome_20635 S-adenosylmethionine transmembrane transporter activity Catalysis of the transfer of S-adenosylmethionine from one side of a membrane to the other. S-adenosylmethionine is S-(5'-adenosyl)-L-methionine, an important intermediate in one-carbon metabolism. GOC:ai http://purl.org/obo/owl/GOC#GOC_ai S-adenosyl methionine permease activity S-adenosyl methionine transporter activity S-adenosylmethionine permease activity S-adenosylmethionine transporter activity molecular_function GO:0015177 sulfur amino acid transmembrane transporter activity Catalysis of the transfer of sulfur amino acids from one side of a membrane to the other. Sulphur amino acids contain sulfur in the form of cystine, methionine or their derivatives. GOC:ai http://purl.org/obo/owl/GOC#GOC_ai GOC:mtg_transport http://purl.org/obo/owl/GOC#GOC_mtg_transport ISBN:0815340729 http://purl.org/obo/owl/ISBN#ISBN_0815340729 sulfur amino acid transporter activity sulphur amino acid transmembrane transporter activity sulphur amino acid transporter activity molecular_function S-methylmethionine transmembrane transporter activity Catalysis of the transfer of S-methylmethionine from one side of a membrane to the other. GOC:ai http://purl.org/obo/owl/GOC#GOC_ai S-methylmethionine permease activity S-methylmethionine transporter activity molecular_function GO:0015178 L-methionine secondary active transmembrane transporter activity Catalysis of the transfer of L-methionine from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport. GOC:mtg_transport http://purl.org/obo/owl/GOC#GOC_mtg_transport L-methionine porter activity molecular_function succinate dehydrogenase activity Catalysis of the reaction: succinate + acceptor = fumarate + reduced acceptor. EC:1.3.99.1 http://purl.org/obo/owl/EC#EC_1.3.99.1 GOC:kd http://purl.org/obo/owl/GOC#GOC_kd fumarate dehydrogenase activity EC:1.3.99.1 http://purl.org/obo/owl/EC#EC_1.3.99.1 fumarate reductase activity EC:1.3.99.1 http://purl.org/obo/owl/EC#EC_1.3.99.1 fumaric hydrogenase activity EC:1.3.99.1 http://purl.org/obo/owl/EC#EC_1.3.99.1 succinate oxidoreductase activity EC:1.3.99.1 http://purl.org/obo/owl/EC#EC_1.3.99.1 succinate:(acceptor) oxidoreductase activity EC:1.3.99.1 http://purl.org/obo/owl/EC#EC_1.3.99.1 succinate:acceptor oxidoreductase activity EC:1.3.99.1 http://purl.org/obo/owl/EC#EC_1.3.99.1 succinic acid dehydrogenase activity EC:1.3.99.1 http://purl.org/obo/owl/EC#EC_1.3.99.1 succinic dehydrogenase activity EC:1.3.99.1 http://purl.org/obo/owl/EC#EC_1.3.99.1 succinodehydrogenase activity EC:1.3.99.1 http://purl.org/obo/owl/EC#EC_1.3.99.1 succinyl dehydrogenase activity EC:1.3.99.1 http://purl.org/obo/owl/EC#EC_1.3.99.1 molecular_function GO:0019739 EC:1.3.99.1 http://purl.org/obo/owl/EC#EC_1.3.99.1 MetaCyc:SUCC-FUM-OXRED-RXN http://purl.org/obo/owl/MetaCyc#MetaCyc_SUCC-FUM-OXRED-RXN Reactome:21566 http://purl.org/obo/owl/Reactome#Reactome_21566 imidazoleglycerol-phosphate synthase activity Catalysis of the reaction: phosphoribulosylformimino-AICAR-P + L-glutamine = D-erythro-imidazole-glycerol-phosphate + AICAR + L-glutamate. MetaCyc:GLUTAMIDOTRANS-RXN http://purl.org/obo/owl/MetaCyc#MetaCyc_GLUTAMIDOTRANS-RXN glutamine amidotransferase:cyclase activity imidazole glycerol phosphate synthase activity imidazole-glycerol-phosphate synthase activity imidazoleglycerol phosphate synthase activity molecular_function EC:2.4.2.- http://purl.org/obo/owl/EC#EC_2.4.2.- MetaCyc:GLUTAMIDOTRANS-RXN http://purl.org/obo/owl/MetaCyc#MetaCyc_GLUTAMIDOTRANS-RXN glycerol-1-phosphatase activity Catalysis of the reaction: glycerol 1-phosphate + H2O = glycerol + phosphate. EC:3.1.3.21 http://purl.org/obo/owl/EC#EC_3.1.3.21 alpha-glycerol phosphatase activity EC:3.1.3.21 http://purl.org/obo/owl/EC#EC_3.1.3.21 alpha-glycerophosphatase activity EC:3.1.3.21 http://purl.org/obo/owl/EC#EC_3.1.3.21 glycerol 3-phosphatase activity EC:3.1.3.21 http://purl.org/obo/owl/EC#EC_3.1.3.21 glycerol 3-phosphate phosphohydrolase activity EC:3.1.3.21 http://purl.org/obo/owl/EC#EC_3.1.3.21 glycerol-1-phosphate phosphohydrolase activity EC:3.1.3.21 http://purl.org/obo/owl/EC#EC_3.1.3.21 glycerol-3-phosphate phosphatase activity EC:3.1.3.21 http://purl.org/obo/owl/EC#EC_3.1.3.21 molecular_function EC:3.1.3.21 http://purl.org/obo/owl/EC#EC_3.1.3.21 MetaCyc:GLYCEROL-1-PHOSPHATASE-RXN http://purl.org/obo/owl/MetaCyc#MetaCyc_GLYCEROL-1-PHOSPHATASE-RXN acylglycerone-phosphate reductase activity Catalysis of the reaction: 1-palmitoylglycerol 3-phosphate + NADP+ = palmitoylglycerone phosphate + NADPH + H+. EC:1.1.1.101 http://purl.org/obo/owl/EC#EC_1.1.1.101 1-acyldihydroxyacetone-phosphate reductase activity 1-palmitoylglycerol-3-phosphate:NADP+ oxidoreductase activity EC:1.1.1.101 http://purl.org/obo/owl/EC#EC_1.1.1.101 acyldihydroxyacetone phosphate reductase activity EC:1.1.1.101 http://purl.org/obo/owl/EC#EC_1.1.1.101 palmitoyl dihydroxyacetone phosphate reductase activity EC:1.1.1.101 http://purl.org/obo/owl/EC#EC_1.1.1.101 palmitoyl-dihydroxyacetone-phosphate reductase activity EC:1.1.1.101 http://purl.org/obo/owl/EC#EC_1.1.1.101 palmitoyldihydroxyacetone-phosphate reductase activity EC:1.1.1.101 http://purl.org/obo/owl/EC#EC_1.1.1.101 molecular_function EC:1.1.1.101 http://purl.org/obo/owl/EC#EC_1.1.1.101 MetaCyc:ACYLGLYCERONE-PHOSPHATE-REDUCTASE-RXN http://purl.org/obo/owl/MetaCyc#MetaCyc_ACYLGLYCERONE-PHOSPHATE-REDUCTASE-RXN Reactome:21659 http://purl.org/obo/owl/Reactome#Reactome_21659 microfilament motor activity Catalysis of movement along a microfilament, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP). GOC:mah http://purl.org/obo/owl/GOC#GOC_mah ISBN:0815316194 http://purl.org/obo/owl/ISBN#ISBN_0815316194 actin filament motor activity GOC:dph http://purl.org/obo/owl/GOC#GOC_dph actin-filament motor activity muscle motor activity myosin ATPase activity molecular_function Reactome:10657 http://purl.org/obo/owl/Reactome#Reactome_10657 SNARE binding Interacting selectively and non-covalently with a SNARE (soluble N-ethylmaleimide-sensitive factor attached protein receptor) protein. PMID:12642621 http://purl.org/obo/owl/PMID#PMID_12642621 SNAP receptor binding molecular_function Reactome:15373 http://purl.org/obo/owl/Reactome#Reactome_15373 recombinase activity Note that this term represents activities that do not break or form phosphodiester bonds, and is therefore not a parent of 'site-specific recombinase activity ; GO:0009009'. Catalysis of the identification and base-pairing of homologous sequences between single-stranded DNA and double-stranded DNA. GOC:elh http://purl.org/obo/owl/GOC#GOC_elh strand transferase molecular_function two-component sensor activity Catalysis of the phosphorylation of a specific transcription regulator in response to the presence of a particular signal substance outside the cell. GOC:mah http://purl.org/obo/owl/GOC#GOC_mah two-component sensor molecule two-component system sensor activity molecular_function EC:2.7.3.- http://purl.org/obo/owl/EC#EC_2.7.3.- two-component response regulator activity Alters the level of transcription of target genes, usually by binding to a transcription factor, when phosphorylated by a sensor that detects the presence of a particular signal substance outside the cell. GOC:mah http://purl.org/obo/owl/GOC#GOC_mah molecular_function nucleotide binding Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. GOC:mah http://purl.org/obo/owl/GOC#GOC_mah ISBN:0198547684 http://purl.org/obo/owl/ISBN#ISBN_0198547684 molecular_function sphingosine hydroxylase activity Catalysis of the hydroxylation of sphingolipid long chain bases. PMID:9556590 http://purl.org/obo/owl/PMID#PMID_9556590 molecular_function Reactome:21747 http://purl.org/obo/owl/Reactome#Reactome_21747 ribonuclease MRP activity Catalysis of the site-specific cleavage of RNA by a catalytic RNA_mediated mechanism; substrates include the A3 site in the ITS1 of pre-rRNA. PMID:17881380 http://purl.org/obo/owl/PMID#PMID_17881380 RNase MRP molecular_function Wikipedia:RNase_MRP http://purl.org/obo/owl/Wikipedia#Wikipedia_RNase_MRP 3'-5'-exoribonuclease activity Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of an RNA molecule. GOC:mah http://purl.org/obo/owl/GOC#GOC_mah ISBN:0198547684 http://purl.org/obo/owl/ISBN#ISBN_0198547684 3'-5' exoribonuclease activity molecular_function EC:3.1.13.- http://purl.org/obo/owl/EC#EC_3.1.13.- Reactome:21755 http://purl.org/obo/owl/Reactome#Reactome_21755 rRNA (adenine-N6,N6-)-dimethyltransferase activity Catalysis of the dimethylation two adjacent A residues in the loop closing the 3'-terminal stem of the 18S rRNA, using S-adenosyl-L-methionine as a methyl donor. ISBN:1555811337 http://purl.org/obo/owl/ISBN#ISBN_1555811337 PMID:10690410 http://purl.org/obo/owl/PMID#PMID_10690410 18S rRNA dimethylase activity dimethyladenosine transferase activity IMG:02532 http://purl.org/obo/owl/IMG#IMG_02532 S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase activity IMG:02532 http://purl.org/obo/owl/IMG#IMG_02532 molecular_function GO:0043790 EC:2.1.1.- http://purl.org/obo/owl/EC#EC_2.1.1.- rDNA binding Interacting selectively and non-covalently with DNA sequences encoding ribosomal RNA. GOC:mah http://purl.org/obo/owl/GOC#GOC_mah ribosomal DNA binding molecular_function NAD+ diphosphatase activity Catalysis of the reaction: NAD+ + H2O = AMP + NMN. EC:3.6.1.22 http://purl.org/obo/owl/EC#EC_3.6.1.22 NAD diphosphatase activity NAD pyrophosphatase activity NAD(+) pyrophosphatase activity EC:3.6.1.22 http://purl.org/obo/owl/EC#EC_3.6.1.22 NAD+ phosphohydrolase activity EC:3.6.1.22 http://purl.org/obo/owl/EC#EC_3.6.1.22 NAD+ pyrophosphatase activity EC:3.6.1.22 http://purl.org/obo/owl/EC#EC_3.6.1.22 NADH pyrophosphatase activity EC:3.6.1.22 http://purl.org/obo/owl/EC#EC_3.6.1.22 NADP pyrophosphatase activity EC:3.6.1.22 http://purl.org/obo/owl/EC#EC_3.6.1.22 nicotinamide adenine dinucleotide pyrophosphatase activity EC:3.6.1.22 http://purl.org/obo/owl/EC#EC_3.6.1.22 molecular_function EC:3.6.1.22 http://purl.org/obo/owl/EC#EC_3.6.1.22 MetaCyc:NADPYROPHOSPHAT-RXN http://purl.org/obo/owl/MetaCyc#MetaCyc_NADPYROPHOSPHAT-RXN protein degradation tagging activity This term was made obsolete because it represents a biological process and a molecular function. OBSOLETE. Covalent addition of polyubiquitin to another protein, targeting the tagged protein for destruction. GOC:cl http://purl.org/obo/owl/GOC#GOC_cl ISBN:0815316194 http://purl.org/obo/owl/ISBN#ISBN_0815316194 molecular_function tRNA-intron endonuclease activity Catalysis of the endonucleolytic cleavage of pre-tRNA, producing 5'-hydroxyl and 2',3'-cyclic phosphate termini, and specifically removing the intron. EC:3.1.27.9 http://purl.org/obo/owl/EC#EC_3.1.27.9 splicing endonuclease activity EC:3.1.27.9 http://purl.org/obo/owl/EC#EC_3.1.27.9 transfer ribonucleate intron endoribonuclease activity EC:3.1.27.9 http://purl.org/obo/owl/EC#EC_3.1.27.9 transfer splicing endonuclease activity EC:3.1.27.9 http://purl.org/obo/owl/EC#EC_3.1.27.9 tRNA splicing endonuclease activity EC:3.1.27.9 http://purl.org/obo/owl/EC#EC_3.1.27.9 tRNA-intron endoribonuclease activity tRNA-splicing endonuclease activity EC:3.1.27.9 http://purl.org/obo/owl/EC#EC_3.1.27.9 tRNATRPintron endonuclease activity EC:3.1.27.9 http://purl.org/obo/owl/EC#EC_3.1.27.9 molecular_function EC:3.1.27.9 http://purl.org/obo/owl/EC#EC_3.1.27.9 MetaCyc:3.1.27.9-RXN http://purl.org/obo/owl/MetaCyc#MetaCyc_3.1.27.9-RXN tRNA 2'-phosphotransferase activity Catalysis of the reaction: 2'-phospho-[ligated tRNA] + NAD+ = mature tRNA + ADP ribose 1'',2''-phosphate + nicotinamide + H2O; transfers the splice junction 2-phosphate from ligated tRNA to NAD+ to produce ADP-ribose 1'-2' cyclic phosphate. EC:2.7.1.160 http://purl.org/obo/owl/EC#EC_2.7.1.160 PMID:9148937 http://purl.org/obo/owl/PMID#PMID_9148937 2'-phospho-[ligated tRNA]:NAD+ phosphotransferase activity EC:2.7.1.160 http://purl.org/obo/owl/EC#EC_2.7.1.160 2'-phospho-tRNA:NAD+ phosphotransferase activity EC:2.7.1.160 http://purl.org/obo/owl/EC#EC_2.7.1.160 Tpt1 EC:2.7.1.160 http://purl.org/obo/owl/EC#EC_2.7.1.160 Tpt1p EC:2.7.1.160 http://purl.org/obo/owl/EC#EC_2.7.1.160 yeast 2'-phosphotransferase activity EC:2.7.1.160 http://purl.org/obo/owl/EC#EC_2.7.1.160 molecular_function EC:2.7.1.160 http://purl.org/obo/owl/EC#EC_2.7.1.160 MetaCyc:2.7.1.160-RXN http://purl.org/obo/owl/MetaCyc#MetaCyc_2.7.1.160-RXN DNA secondary structure binding Interacting selectively and non-covalently with DNA containing secondary structure elements such as four-way junctions, bubbles, loops, Y-form DNA, or double-strand/single-strand junctions. GOC:krc http://purl.org/obo/owl/GOC#GOC_krc molecular_function peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity Catalysis of the hydrolysis of an N4-(acetyl-beta-D-glucosaminyl)asparagine residue in which the N-acetyl-D-glucosamine residue may be further glycosylated, to yield a (substituted) N-acetyl-beta-D-glucosaminylamine and the peptide containing an aspartic residue. EC:3.5.1.52 http://purl.org/obo/owl/EC#EC_3.5.1.52 glycopeptidase activity EC:3.5.1.52 http://purl.org/obo/owl/EC#EC_3.5.1.52 glycopeptide N-glycosidase activity EC:3.5.1.52 http://purl.org/obo/owl/EC#EC_3.5.1.52 jack-bean glycopeptidase EC:3.5.1.52 http://purl.org/obo/owl/EC#EC_3.5.1.52 N-glycanase activity EC:3.5.1.52 http://purl.org/obo/owl/EC#EC_3.5.1.52 N-linked-glycopeptide-(N-acetyl-beta-D-glucosaminyl)-L-asparagine amidohydrolase activity EC:3.5.1.52 http://purl.org/obo/owl/EC#EC_3.5.1.52 N-oligosaccharide glycopeptidase activity EC:3.5.1.52 http://purl.org/obo/owl/EC#EC_3.5.1.52 peptide:N-glycanase PNGase PNGase A EC:3.5.1.52 http://purl.org/obo/owl/EC#EC_3.5.1.52 PNGase F EC:3.5.1.52 http://purl.org/obo/owl/EC#EC_3.5.1.52 molecular_function EC:3.5.1.52 http://purl.org/obo/owl/EC#EC_3.5.1.52 MetaCyc:3.5.1.52-RXN http://purl.org/obo/owl/MetaCyc#MetaCyc_3.5.1.52-RXN N-acetylglucosaminylphosphatidylinositol deacetylase activity Note that this function was formerly EC:3.1.1.69. Catalysis of the reaction: N-acetyl-D-glucosaminylphosphatidylinositol + H2O = D-glucosaminylphosphatidylinositol + acetate. The second step enzyme catalyzing the biosynthesis of glycosylphosphatidylinositol (GPI), used to anchor various eukaryotic proteins to the cell-surface membrane. Catalyzes the N-deacetylation of GlcNAc-PI to GlcN-PI. EC:3.5.1.89 http://purl.org/obo/owl/EC#EC_3.5.1.89 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol acetylhydrolase activity EC:3.5.1.89 http://purl.org/obo/owl/EC#EC_3.5.1.89 acetylglucosaminylphosphatidylinositol deacetylase activity EC:3.5.1.89 http://purl.org/obo/owl/EC#EC_3.5.1.89 GlcNAc-PI de-N-acetylase activity EC:3.5.1.89 http://purl.org/obo/owl/EC#EC_3.5.1.89 GlcNAc-PI deacetylase activity EC:3.5.1.89 http://purl.org/obo/owl/EC#EC_3.5.1.89 N-acetyl-D-glucosaminylphosphatidylinositol acetylhydrolase activity EC:3.5.1.89 http://purl.org/obo/owl/EC#EC_3.5.1.89 N-acetylglucosaminylphosphatidylinositol de-N-acetylase activity EC:3.5.1.89 http://purl.org/obo/owl/EC#EC_3.5.1.89 molecular_function EC:3.5.1.89 http://purl.org/obo/owl/EC#EC_3.5.1.89 MetaCyc:3.1.1.69-RXN http://purl.org/obo/owl/MetaCyc#MetaCyc_3.1.1.69-RXN Reactome:22619 http://purl.org/obo/owl/Reactome#Reactome_22619 oxaloacetate secondary active transmembrane transporter activity Catalysis of the transfer of oxaloacetate from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport. GOC:mtg_transport http://purl.org/obo/owl/GOC#GOC_mtg_transport oxaloacetate carrier activity molecular_function phosphoethanolamine N-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + ethanolamine phosphate = S-adenosyl-L-homocysteine + N-methylethanolamine phosphate. EC:2.1.1.103 http://purl.org/obo/owl/EC#EC_2.1.1.103 phosphoethanolamine methyltransferase activity EC:2.1.1.103 http://purl.org/obo/owl/EC#EC_2.1.1.103 S-adenosyl-L-methionine:ethanolamine-phosphate N-methyltransferase activity EC:2.1.1.103 http://purl.org/obo/owl/EC#EC_2.1.1.103 molecular_function EC:2.1.1.103 http://purl.org/obo/owl/EC#EC_2.1.1.103 MetaCyc:2.1.1.103-RXN http://purl.org/obo/owl/MetaCyc#MetaCyc_2.1.1.103-RXN delta24(24-1) sterol reductase activity Catalysis of the reaction: ergosterol + NADP+ = ergosta-5,7,22,24(241)-tetraen-3-beta-ol + NADPH + H+. EC:1.3.1.71 http://purl.org/obo/owl/EC#EC_1.3.1.71 PMID:10722850 http://purl.org/obo/owl/PMID#PMID_10722850 C-24(28) sterol reductase activity EC:1.3.1.71 http://purl.org/obo/owl/EC#EC_1.3.1.71 D24(24-1)-sterol reductase activity delta24(241)-sterol reductase activity EC:1.3.1.71 http://purl.org/obo/owl/EC#EC_1.3.1.71 ergosterol:NADP+ delta24(241)-oxidoreductase activity EC:1.3.1.71 http://purl.org/obo/owl/EC#EC_1.3.1.71 sterol Delta(24(28))-methylene reductase activity EC:1.3.1.71 http://purl.org/obo/owl/EC#EC_1.3.1.71 sterol Delta(24(28))-reductase activity EC:1.3.1.71 http://purl.org/obo/owl/EC#EC_1.3.1.71 sterol delta-24(28) methylene reductase activity sterol delta-24(28) reductase activity sterol delta24(28)-methylene reductase activity EC:1.3.1.71 http://purl.org/obo/owl/EC#EC_1.3.1.71 sterol delta24(28)-reductase activity EC:1.3.1.71 http://purl.org/obo/owl/EC#EC_1.3.1.71 molecular_function EC:1.3.1.71 http://purl.org/obo/owl/EC#EC_1.3.1.71 MetaCyc:1.3.1.71-RXN http://purl.org/obo/owl/MetaCyc#MetaCyc_1.3.1.71-RXN C-8 sterol isomerase activity Catalysis of the reaction which results in unsaturation at C-7 in the B ring of sterols. MetaCyc:RXN3O-203 http://purl.org/obo/owl/MetaCyc#MetaCyc_RXN3O-203 PMID:8988026 http://purl.org/obo/owl/PMID#PMID_8988026 delta-8-delta-7 sterol isomerase activity molecular_function EC:5.3.3.- http://purl.org/obo/owl/EC#EC_5.3.3.- C-5 sterol desaturase activity Catalysis of the reaction: 5,7,24(28)-ergostatrienol + O2 + NADPH = 5,7,22,24(28)-ergostatetraenol + 2 H2O + NADP+. MetaCyc:RXN3O-227 http://purl.org/obo/owl/MetaCyc#MetaCyc_RXN3O-227 sterol-C5-desaturase activity molecular_function Reactome:22657 http://purl.org/obo/owl/Reactome#Reactome_22657 C-22 sterol desaturase activity Catalysis of the formation of the C-22(23) double bond in the sterol side chain. An example reaction is 5,7,24(28)-ergostatrienol + O2 + NADPH = 5,7,22,24(28)-ergostatetraenol + 2 H2O + NADP+. MetaCyc:RXN3O-227 http://purl.org/obo/owl/MetaCyc#MetaCyc_RXN3O-227 molecular_function lanosterol synthase activity Catalysis of the reaction: (S)-2,3-epoxysqualene = lanosterol. This is a cyclization reaction that forms the sterol nucleus. EC:5.4.99.7 http://purl.org/obo/owl/EC#EC_5.4.99.7 (S)-2,3-epoxysqualene mutase (cyclizing, lanosterol-forming) EC:5.4.99.7 http://purl.org/obo/owl/EC#EC_5.4.99.7 2,3-epoxysqualene lanosterol cyclase activity EC:5.4.99.7 http://purl.org/obo/owl/EC#EC_5.4.99.7 2,3-epoxysqualene--lanosterol cyclase activity EC:5.4.99.7 http://purl.org/obo/owl/EC#EC_5.4.99.7 2,3-epoxysqualene-lanosterol cyclase activity 2,3-oxidosqualene sterol cyclase activity EC:5.4.99.7 http://purl.org/obo/owl/EC#EC_5.4.99.7 2,3-oxidosqualene-lanosterol cyclase activity EC:5.4.99.7 http://purl.org/obo/owl/EC#EC_5.4.99.7 lanosterol 2,3-oxidosqualene cyclase activity EC:5.4.99.7 http://purl.org/obo/owl/EC#EC_5.4.99.7 OSC oxidosqualene--lanosterol cyclase activity EC:5.4.99.7 http://purl.org/obo/owl/EC#EC_5.4.99.7 oxidosqualene-lanosterol cyclase activity oxidosqualene:lanosterol cyclase activity PMID:18033581 http://purl.org/obo/owl/PMID#PMID_18033581 squalene 2,3-epoxide:lanosterol cyclase activity EC:5.4.99.7 http://purl.org/obo/owl/EC#EC_5.4.99.7 squalene epoxidase-cyclase activity EC:5.4.99.7 http://purl.org/obo/owl/EC#EC_5.4.99.7 squalene-2,3-oxide-lanosterol cyclase activity EC:5.4.99.7 http://purl.org/obo/owl/EC#EC_5.4.99.7 molecular_function EC:5.4.99.7 http://purl.org/obo/owl/EC#EC_5.4.99.7 MetaCyc:LANOSTEROL-SYNTHASE-RXN http://purl.org/obo/owl/MetaCyc#MetaCyc_LANOSTEROL-SYNTHASE-RXN Reactome:22668 http://purl.org/obo/owl/Reactome#Reactome_22668 C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity Note that zymosterol is cholesta-8,24-dien-3-ol. Catalysis of the reaction: 3-beta-hydroxy-4-beta-methyl-5-alpha-cholesta-8,24-dien-4-alpha-carboxylate + NAD(P)+ = 4-alpha-methyl-5-alpha-cholesta-8,24-dien-3-one + CO2 + NAD(P)H. EC:1.1.1.170 http://purl.org/obo/owl/EC#EC_1.1.1.170 PMID:9811880 http://purl.org/obo/owl/PMID#PMID_9811880 3beta-hydroxy-4alpha-methylcholestenecarboxylate 3-dehydrogenase (decarboxylating) EC:1.1.1.170 http://purl.org/obo/owl/EC#EC_1.1.1.170 3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carboxylate:NAD(P)+ 3-oxidoreductase (decarboxylating) 3beta-hydroxy-4beta-methylcholestenecarboxylate 3-dehydrogenase (decarboxylating) 3beta-hydroxy-4beta-methylcholestenoate dehydrogenase activity C-3 sterol dehydrogenase (C-4 decarboxylase) activity C-3 sterol dehydrogenase activity sterol 4alpha-carboxylic decarboxylase activity sterol-4-carboxylate 3-dehydrogenase (decarboxylating) activity sterol-4alpha-carboxylate 3-dehydrogenase (decarboxylating) molecular_function EC:1.1.1.- http://purl.org/obo/owl/EC#EC_1.1.1.- Reactome:22670 http://purl.org/obo/owl/Reactome#Reactome_22670 3-keto sterol reductase activity Note that zymosterol is cholesta-8,24-dien-3-ol. Catalysis of the reaction: a 3-beta-hydroxyl sterol + NADP+ = a 3-keto sterol + NADPH + H+. EC:1.1.1.270 http://purl.org/obo/owl/EC#EC_1.1.1.270 GOC:mah http://purl.org/obo/owl/GOC#GOC_mah MetaCyc:1.1.1.270-RXN http://purl.org/obo/owl/MetaCyc#MetaCyc_1.1.1.270-RXN MetaCyc:RXN3O-4110 http://purl.org/obo/owl/MetaCyc#MetaCyc_RXN3O-4110 MetaCyc:RXN66-19 http://purl.org/obo/owl/MetaCyc#MetaCyc_RXN66-19 MetaCyc:RXN66-24 http://purl.org/obo/owl/MetaCyc#MetaCyc_RXN66-24 MetaCyc:RXN66-314 http://purl.org/obo/owl/MetaCyc#MetaCyc_RXN66-314 MetaCyc:RXN66-319 http://purl.org/obo/owl/MetaCyc#MetaCyc_RXN66-319 PMID:9811880 http://purl.org/obo/owl/PMID#PMID_9811880 3-keto-steroid reductase activity 3-KSR activity EC:1.1.1.270 http://purl.org/obo/owl/EC#EC_1.1.1.270 3beta-hydroxy-steroid:NADP+ 3-oxidoreductase EC:1.1.1.270 http://purl.org/obo/owl/EC#EC_1.1.1.270 molecular_function GO:0050576 EC:1.1.1.270 http://purl.org/obo/owl/EC#EC_1.1.1.270 MetaCyc:1.1.1.270-RXN http://purl.org/obo/owl/MetaCyc#MetaCyc_1.1.1.270-RXN MetaCyc:RXN3O-4110 http://purl.org/obo/owl/MetaCyc#MetaCyc_RXN3O-4110 MetaCyc:RXN66-19 http://purl.org/obo/owl/MetaCyc#MetaCyc_RXN66-19 MetaCyc:RXN66-24 http://purl.org/obo/owl/MetaCyc#MetaCyc_RXN66-24 MetaCyc:RXN66-314 http://purl.org/obo/owl/MetaCyc#MetaCyc_RXN66-314 MetaCyc:RXN66-319 http://purl.org/obo/owl/MetaCyc#MetaCyc_RXN66-319 Reactome:22671 http://purl.org/obo/owl/Reactome#Reactome_22671 C-4 methylsterol oxidase activity Note that zymosterol is cholesta-8,24-dien-3-ol. Catalysis of the reaction: 4,4-dimethyl-5-alpha-cholesta-8,24-dien-3-beta-ol + NAD(P)H + H+ + O2 = 4-beta-hydroxymethyl-4-alpha-methyl-5-alpha-cholesta-8,24-dien-3-beta-ol + NAD(P)+ + H2O. EC:1.14.13.72 http://purl.org/obo/owl/EC#EC_1.14.13.72 PMID:9811880 http://purl.org/obo/owl/PMID#PMID_9811880 4,4-dimethyl-5alpha-cholest-7-en-3beta-ol,hydrogen-donor:oxygen oxidoreductase (hydroxylating) EC:1.14.13.72 http://purl.org/obo/owl/EC#EC_1.14.13.72 4,4-dimethyl-5alpha-cholest-7-en-3beta-ol,NAD(P)H:oxygen oxidoreductase (hydroxylating) EC:1.14.13.72 http://purl.org/obo/owl/EC#EC_1.14.13.72 4-methylsterol oxidase activity methylsterol hydroxylase activity methylsterol monooxygenase activity molecular_function EC:1.14.13.72 http://purl.org/obo/owl/EC#EC_1.14.13.72 MetaCyc:1.14.13.72-RXN http://purl.org/obo/owl/MetaCyc#MetaCyc_1.14.13.72-RXN Reactome:22672 http://purl.org/obo/owl/Reactome#Reactome_22672 nitrilase activity Catalysis of the reaction: a nitrile + H2O = a carboxylate + NH3. Acts on a wide range of aromatic nitriles including (indole-3-yl)-acetonitrile and some aliphatic nitriles, and on the corresponding acid amides. EC:3.5.5.1 http://purl.org/obo/owl/EC#EC_3.5.5.1 GOC:kd http://purl.org/obo/owl/GOC#GOC_kd acetonitrilase activity EC:3.5.5.1 http://purl.org/obo/owl/EC#EC_3.5.5.1 benzonitrilase activity EC:3.5.5.1 http://purl.org/obo/owl/EC#EC_3.5.5.1 nitrile aminohydrolase activity EC:3.5.5.1 http://purl.org/obo/owl/EC#EC_3.5.5.1 molecular_function EC:3.5.5.1 http://purl.org/obo/owl/EC#EC_3.5.5.1 MetaCyc:3.5.5.1-RXN http://purl.org/obo/owl/MetaCyc#MetaCyc_3.5.5.1-RXN UM-BBD_enzymeID:e0283 http://purl.org/obo/owl/UM-BBD_enzymeID#UM-BBD_enzymeID_e0283 isoleucine/valine:sodium symporter activity This term was made obsolete because it represents a multifunctional gene product. OBSOLETE. Catalysis of the reaction: (isoleucine or valine)(out) + Na+(out) = (isoleucine or valine)(in) + Na+(in). TC:2.A.26.1.1 http://purl.org/obo/owl/TC#TC_2.A.26.1.1 molecular_function intracellular nucleoside transmembrane transporter activity This term was made obsolete because it contains component and function information. OBSOLETE. Enables the directed movement of a nucleoside, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose (a deoxyribonucleotide) within a cell. GOC:ai http://purl.org/obo/owl/GOC#GOC_ai molecular_function hydrogen-translocating V-type ATPase activity This term was made obsolete because it represents a gene product. OBSOLETE. Catalysis of the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out). Found in vacuoles of eukaryotes and in bacteria. TC:3.A.2.2.1 http://purl.org/obo/owl/TC#TC_3.A.2.2.1 TC:3.A.2.2.3 http://purl.org/obo/owl/TC#TC_3.A.2.2.3 molecular_function sodium-translocating V-type ATPase activity This term was made obsolete because it represents a gene product. OBSOLETE. Catalysis of the reaction: ATP + H2O + Na+(in) = ADP + phosphate + Na+(out). Found in vacuoles of eukaryotes and in bacteria. TC:3.A.2.2.2 http://purl.org/obo/owl/TC#TC_3.A.2.2.2 molecular_function heterotrimeric G-protein GTPase, alpha-subunit This term was made obsolete because it does not represent a molecular function. OBSOLETE. Subunit of a heterotrimeric G-protein GTPase that contains the guanine nucleotide binding site and possesses GTPase activity. GOC:mah http://purl.org/obo/owl/GOC#GOC_mah ISBN:0198547684 http://purl.org/obo/owl/ISBN#ISBN_0198547684 molecular_function heterotrimeric G-protein GTPase, beta-subunit This term was made obsolete because it does not represent a molecular function. OBSOLETE. Subunit of a heterotrimeric G-protein GTPase; associates tightly with the gamma subunit. GOC:mah http://purl.org/obo/owl/GOC#GOC_mah ISBN:0198547684 http://purl.org/obo/owl/ISBN#ISBN_0198547684 molecular_function heterotrimeric G-protein GTPase, gamma-subunit This term was made obsolete because it does not represent a molecular function. OBSOLETE. Smallest subunit of a heterotrimeric G-protein GTPase; associates tightly with the beta subunit. GOC:mah http://purl.org/obo/owl/GOC#GOC_mah ISBN:0198547684 http://purl.org/obo/owl/ISBN#ISBN_0198547684 molecular_function peroxisome targeting sequence binding Interacting selectively and non-covalently with a peroxisomal targeting sequence, any of several sequences of amino acids within a protein that can act as a signal for the localization of the protein into the peroxisome. GOC:mah http://purl.org/obo/owl/GOC#GOC_mah ISBN:0879693568 http://purl.org/obo/owl/ISBN#ISBN_0879693568 peroxisome targeting signal receptor PTS binding PTS receptor molecular_function GO:0005051 toxin export channel activity Enables the energy independent passage of toxins, sized less than 1000 Da, across a membrane towards the outside of the cell. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria. GOC:mtg_transport http://purl.org/obo/owl/GOC#GOC_mtg_transport molecular_function [cytochrome c]-lysine N-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + cytochrome c L-lysine = S-adenosyl-L-homocysteine + cytochrome c N6-methyl-L-lysine. This is the addition of a methyl group to the N6 atom of a lysine residue in cytochrome c. EC:2.1.1.59 http://purl.org/obo/owl/EC#EC_2.1.1.59 cytochrome c (lysine) methyltransferase activity EC:2.1.1.59 http://purl.org/obo/owl/EC#EC_2.1.1.59 cytochrome c methyltransferase activity EC:2.1.1.59 http://purl.org/obo/owl/EC#EC_2.1.1.59 cytochrome c-lysine N-methyltransferase activity EC:2.1.1.59 http://purl.org/obo/owl/EC#EC_2.1.1.59 cytochrome c-specific protein methylase III activity EC:2.1.1.59 http://purl.org/obo/owl/EC#EC_2.1.1.59 cytochrome c-specific protein-lysine methyltransferase activity EC:2.1.1.59 http://purl.org/obo/owl/EC#EC_2.1.1.59 S-adenosyl-L-methionine:cytochrome c-L-lysine 6-N-methyltransferase activity EC:2.1.1.59 http://purl.org/obo/owl/EC#EC_2.1.1.59 S-adenosyl-L-methionine:cytochrome c-L-lysine N6-methyltransferase activity EC:2.1.1.59 http://purl.org/obo/owl/EC#EC_2.1.1.59 molecular_function EC:2.1.1.59 http://purl.org/obo/owl/EC#EC_2.1.1.59 MetaCyc:2.1.1.59-RXN http://purl.org/obo/owl/MetaCyc#MetaCyc_2.1.1.59-RXN 1-phosphatidylinositol-3-phosphate 5-kinase activity Catalysis of the reaction: ATP + 1-phosphatidyl-1D-myo-inositol 3-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate. EC:2.7.1.150 http://purl.org/obo/owl/EC#EC_2.7.1.150 ATP:1-phosphatidyl-1D-myo-inositol-3-phosphate 5-phosphotransferase activity EC:2.7.1.150 http://purl.org/obo/owl/EC#EC_2.7.1.150 phosphatidylinositol 3-phosphate 5-kinase activity EC:2.7.1.150 http://purl.org/obo/owl/EC#EC_2.7.1.150 phosphatidylinositol-3-phosphate 5-kinase activity type III PIP kinase activity EC:2.7.1.150 http://purl.org/obo/owl/EC#EC_2.7.1.150 molecular_function EC:2.7.1.150 http://purl.org/obo/owl/EC#EC_2.7.1.150 MetaCyc:2.7.1.150-RXN http://purl.org/obo/owl/MetaCyc#MetaCyc_2.7.1.150-RXN alanine dehydrogenase activity Catalysis of the reaction: L-alanine + H2O + NAD+ = pyruvate + NH3 + NADH + H+. EC:1.4.1.1 http://purl.org/obo/owl/EC#EC_1.4.1.1 AlaDH EC:1.4.1.1 http://purl.org/obo/owl/EC#EC_1.4.1.1 alanine oxidoreductase activity EC:1.4.1.1 http://purl.org/obo/owl/EC#EC_1.4.1.1 alpha-alanine dehydrogenase activity EC:1.4.1.1 http://purl.org/obo/owl/EC#EC_1.4.1.1 L-alanine dehydrogenase activity EC:1.4.1.1 http://purl.org/obo/owl/EC#EC_1.4.1.1 L-alanine:NAD+ oxidoreductase (deaminating) EC:1.4.1.1 http://purl.org/obo/owl/EC#EC_1.4.1.1 NAD-dependent alanine dehydrogenase activity EC:1.4.1.1 http://purl.org/obo/owl/EC#EC_1.4.1.1 NAD-linked alanine dehydrogenase activity EC:1.4.1.1 http://purl.org/obo/owl/EC#EC_1.4.1.1 NADH-dependent alanine dehydrogenase activity EC:1.4.1.1 http://purl.org/obo/owl/EC#EC_1.4.1.1 molecular_function EC:1.4.1.1 http://purl.org/obo/owl/EC#EC_1.4.1.1 MetaCyc:ALANINE-DEHYDROGENASE-RXN http://purl.org/obo/owl/MetaCyc#MetaCyc_ALANINE-DEHYDROGENASE-RXN magnesium ion binding Interacting selectively and non-covalently with magnesium (Mg) ions. GOC:ai http://purl.org/obo/owl/GOC#GOC_ai magnesium binding molecular_function ferric-chelate reductase activity Note that this function was formerly EC:1.6.99.13. Catalysis of the reaction: 2 Fe2+ + NAD+ = 2 Fe3+ + NADH + H+. EC:1.16.1.7 http://purl.org/obo/owl/EC#EC_1.16.1.7 Fe(II):NAD+ oxidoreductase activity EC:1.16.1.7 http://purl.org/obo/owl/EC#EC_1.16.1.7 ferric chelate reductase activity EC:1.16.1.7 http://purl.org/obo/owl/EC#EC_1.16.1.7 iron chelate reductase activity EC:1.16.1.7 http://purl.org/obo/owl/EC#EC_1.16.1.7 NADH2:Fe3+ oxidoreductase activity EC:1.16.1.7 http://purl.org/obo/owl/EC#EC_1.16.1.7 NADH:Fe(3+) oxidoreductase activity EC:1.16.1.7 http://purl.org/obo/owl/EC#EC_1.16.1.7 NADH:Fe(3+)-EDTA reductase activity EC:1.16.1.7 http://purl.org/obo/owl/EC#EC_1.16.1.7 NADH:Fe3+ oxidoreductase activity EC:1.16.1.7 http://purl.org/obo/owl/EC#EC_1.16.1.7 NADH:Fe3+-EDTA reductase activity EC:1.16.1.7 http://purl.org/obo/owl/EC#EC_1.16.1.7 molecular_function EC:1.16.1.7 http://purl.org/obo/owl/EC#EC_1.16.1.7 MetaCyc:FERRIC-CHELATE-REDUCTASE-RXN http://purl.org/obo/owl/MetaCyc#MetaCyc_FERRIC-CHELATE-REDUCTASE-RXN adenine nucleotide transmembrane transporter activity Catalysis of the transfer of adenine nucleotides (AMP, ADP, and ATP) from one side of the membrane to the other. PMID:11566870 http://purl.org/obo/owl/PMID#PMID_11566870 molecular_function Reactome:22791 http://purl.org/obo/owl/Reactome#Reactome_22791 spermine transmembrane transporter activity Catalysis of the transfer of spermine from one side of the membrane to the other. Spermine is a polybasic amine found in human sperm, in ribosomes and in some viruses, which is involved in nucleic acid packaging. Synthesis is regulated by ornithine decarboxylase which plays a key role in control of DNA replication. GOC:ai http://purl.org/obo/owl/GOC#GOC_ai molecular_function endopolyphosphatase activity Catalysis of the reaction: polyphosphate + n H2O = (n+1) oligophosphate. The product contains 4 or 5 phosphate residues. EC:3.6.1.10 http://purl.org/obo/owl/EC#EC_3.6.1.10 metaphosphatase activity EC:3.6.1.10 http://purl.org/obo/owl/EC#EC_3.6.1.10 polymetaphosphatase activity EC:3.6.1.10 http://purl.org/obo/owl/EC#EC_3.6.1.10 polyphosphatase activity EC:3.6.1.10 http://purl.org/obo/owl/EC#EC_3.6.1.10 polyphosphate depolymerase activity EC:3.6.1.10 http://purl.org/obo/owl/EC#EC_3.6.1.10 polyphosphate polyphosphohydrolase activity EC:3.6.1.10 http://purl.org/obo/owl/EC#EC_3.6.1.10 molecular_function EC:3.6.1.10 http://purl.org/obo/owl/EC#EC_3.6.1.10 MetaCyc:ENDOPOLYPHOSPHATASE-RXN http://purl.org/obo/owl/MetaCyc#MetaCyc_ENDOPOLYPHOSPHATASE-RXN nicotinamide-nucleotide adenylyltransferase activity Catalysis of the reaction: ATP + nicotinamide nucleotide = diphosphate + NAD+. EC:2.7.7.1 http://purl.org/obo/owl/EC#EC_2.7.7.1 adenosine triphosphate-nicotinamide mononucleotide transadenylase activity EC:2.7.7.1 http://purl.org/obo/owl/EC#EC_2.7.7.1 ATP:nicotinamide-nucleotide adenylyltransferase activity ATP:NMN adenylyltransferase activity EC:2.7.7.1 http://purl.org/obo/owl/EC#EC_2.7.7.1 diphosphopyridine nucleotide pyrophosphorylase activity EC:2.7.7.1 http://purl.org/obo/owl/EC#EC_2.7.7.1 NAD(+) diphosphorylase activity EC:2.7.7.1 http://purl.org/obo/owl/EC#EC_2.7.7.1 NAD(+) pyrophosphorylase activity EC:2.7.7.1 http://purl.org/obo/owl/EC#EC_2.7.7.1 NAD+ diphosphorylase activity EC:2.7.7.1 http://purl.org/obo/owl/EC#EC_2.7.7.1 NAD+ pyrophosphorylase activity EC:2.7.7.1 http://purl.org/obo/owl/EC#EC_2.7.7.1 nicotinamide adenine dinucleotide pyrophosphorylase activity EC:2.7.7.1 http://purl.org/obo/owl/EC#EC_2.7.7.1 nicotinamide mononucleotide adenylyltransferase activity EC:2.7.7.1 http://purl.org/obo/owl/EC#EC_2.7.7.1 NMN adenylyltransferase activity EC:2.7.7.1 http://purl.org/obo/owl/EC#EC_2.7.7.1 NMNAT activity EC:2.7.7.1 http://purl.org/obo/owl/EC#EC_2.7.7.1 molecular_function EC:2.7.7.1 http://purl.org/obo/owl/EC#EC_2.7.7.1 MetaCyc:2.7.7.1-RXN http://purl.org/obo/owl/MetaCyc#MetaCyc_2.7.7.1-RXN Reactome:23250 http://purl.org/obo/owl/Reactome#Reactome_23250 xanthine phosphoribosyltransferase activity Catalysis of the reaction: 5-phospho-alpha-D-ribose 1-diphosphate + xanthine = (9-D-ribosylxanthine)-5'-phosphate + diphosphate; substrate specificity for xanthine. EC:2.4.2.22 http://purl.org/obo/owl/EC#EC_2.4.2.22 GOC:clt http://purl.org/obo/owl/GOC#GOC_clt 5-phospho-alpha-D-ribose-1-diphosphate:xanthine phospho-D-ribosyltransferase activity EC:2.4.2.22 http://purl.org/obo/owl/EC#EC_2.4.2.22 Xan phosphoribosyltransferase activity EC:2.4.2.22 http://purl.org/obo/owl/EC#EC_2.4.2.22 xanthine-guanine phosphoribosyltransferase activity xanthosine 5'-phosphate pyrophosphorylase activity EC:2.4.2.22 http://purl.org/obo/owl/EC#EC_2.4.2.22 xanthylate pyrophosphorylase activity EC:2.4.2.22 http://purl.org/obo/owl/EC#EC_2.4.2.22 xanthylic pyrophosphorylase activity EC:2.4.2.22 http://purl.org/obo/owl/EC#EC_2.4.2.22 XMP pyrophosphorylase activity EC:2.4.2.22 http://purl.org/obo/owl/EC#EC_2.4.2.22 XMP:diphosphate 5-phospho-alpha-D-ribosyltransferase activity EC:2.4.2.22 http://purl.org/obo/owl/EC#EC_2.4.2.22 molecular_function GO:0009043 EC:2.4.2.22 http://purl.org/obo/owl/EC#EC_2.4.2.22 MetaCyc:XANPRIBOSYLTRAN-RXN http://purl.org/obo/owl/MetaCyc#MetaCyc_XANPRIBOSYLTRAN-RXN methionine-S-oxide reductase activity Catalysis of the reaction: L-methionine S-oxide + thioredoxin = L-methionine + thioredoxin disulfide. Thioredoxin disulfide is the oxidized form of thioredoxin. No reaction on oxidized methionine in peptide linkage. PMID:11169920 http://purl.org/obo/owl/PMID#PMID_11169920 methionine sulfoxide reductase activity molecular_function protein-methionine-R-oxide reductase activity Catalysis of the reaction: L-methionine R-oxide + thioredoxin = L-methionine + thioredoxin disulfide; can act on oxidized methionine in peptide linkage with specificity for the R enantiomer. Thioredoxin disulfide is the oxidized form of thioredoxin. EC:1.8.4.- http://purl.org/obo/owl/EC#EC_1.8.4.- PMID:11929995 http://purl.org/obo/owl/PMID#PMID_11929995 molecular_function EC:1.8.4.- http://purl.org/obo/owl/EC#EC_1.8.4.- sulfite transmembrane transporter activity Catalysis of the transfer of sulfite ions from one side of a membrane to the other. GOC:as http://purl.org/obo/owl/GOC#GOC_as sulphite transporter activity molecular_function template for synthesis of G-rich strand of telomere DNA activity Note that this term describes the activity of an RNA gene product that interacts with other nucleic acid molecules via base pairing; it should not be used to annotate proteins. Provision of the template used by reverse transcriptase to synthesize the G-rich strand of telomeric DNA. PMID:11812242 http://purl.org/obo/owl/PMID#PMID_11812242 telomerase RNA telomerase, template molecular_function 3-hydroxyanthranilate 3,4-dioxygenase activity Catalysis of the reaction: 3-hydroxyanthranilate + O2 = 2-amino-3-carboxymuconate semialdehyde. EC:1.13.11.6 http://purl.org/obo/owl/EC#EC_1.13.11.6 3-hydroxyanthranilate oxygenase activity EC:1.13.11.6 http://purl.org/obo/owl/EC#EC_1.13.11.6 3-hydroxyanthranilate:oxygen 3,4-oxidoreductase (decyclizing) EC:1.13.11.6 http://purl.org/obo/owl/EC#EC_1.13.11.6 3-hydroxyanthranilic acid dioxygenase activity EC:1.13.11.6 http://purl.org/obo/owl/EC#EC_1.13.11.6 3-hydroxyanthranilic acid oxygenase activity EC:1.13.11.6 http://purl.org/obo/owl/EC#EC_1.13.11.6 3-hydroxyanthranilic oxygenase activity EC:1.13.11.6 http://purl.org/obo/owl/EC#EC_1.13.11.6 3HAO EC:1.13.11.6 http://purl.org/obo/owl/EC#EC_1.13.11.6 molecular_function EC:1.13.11.6 http://purl.org/obo/owl/EC#EC_1.13.11.6 MetaCyc:1.13.11.6-RXN http://purl.org/obo/owl/MetaCyc#MetaCyc_1.13.11.6-RXN Reactome:23302 http://purl.org/obo/owl/Reactome#Reactome_23302 UM-BBD_enzymeID:e0633 http://purl.org/obo/owl/UM-BBD_enzymeID#UM-BBD_enzymeID_e0633 RNA cap binding Interacting selectively and non-covalently with a 7-methylguanosine (m7G) moiety or derivative located at the 5' end of an RNA molecule. GOC:krc http://purl.org/obo/owl/GOC#GOC_krc binding to mRNA cap mRNA cap binding snRNA cap binding molecular_function RNA 7-methylguanosine cap binding Interacting selectively and non-covalently with the 7-methylguanosine moiety added cotranscriptionally to the 5' end of RNA molecules transcribed by polymerase II. GOC:krc http://purl.org/obo/owl/GOC#GOC_krc RNA m7G cap binding molecular_function RNA trimethylguanosine cap binding Interacting selectively and non-covalently with the trimethylguanosine (m(3)(2,2,7)-GTP) moiety located at the 5' end of some RNA molecules. Such trimethylated cap structures, generally produced by posttranscriptional modification of a 7-methylguanosine cap, are often found on snRNAs and snoRNAs transcribed by RNA polymerase II, but have also be found on snRNAs transcribed by RNA polymerase III. They have also been found on a subset of the mRNA population in some species, e.g. C. elegans. GOC:krc http://purl.org/obo/owl/GOC#GOC_krc RNA m2,2,7G cap binding molecular_function RNA cap 4 binding Interacting selectively and non-covalently with a hypermethylated cap structure consisting of 7-methylguanosine (m(7)G) followed by four methylated nucleotides (cap 4): 7-methylguanosine-ppp-N6, N6, 2'-O-trimethyladenosine-p-2'-O-methyladenosine-p-2'-O-methylcytosine-p-N3, 2'-O-dimethyluridine Such caps are known to be found at the 5' ends of SL RNAs of trypanosomatid protozoa. GOC:krc http://purl.org/obo/owl/GOC#GOC_krc PMID:10880518 http://purl.org/obo/owl/PMID#PMID_10880518 PMID:12121975 http://purl.org/obo/owl/PMID#PMID_12121975 molecular_function first U2-type spliceosomal transesterification activity This term was made obsolete because the activities used in the U2- and U12-type complexes are the same. The cellular component ontology should (and does) represent the two different complexes, but the molecular function ontology should not. OBSOLETE. Catalysis of the first transesterification reaction of U2-type spliceosomal mRNA splicing. The intron branch site adenosine is the nucleophile attacking the 5' splice site, resulting in cleavage at this position. In cis splicing, this is the step that forms a lariat structure of the intron RNA, which is still joined to the 3' exon. The catalytic site is thought to be formed by U6 and/or U2 snRNA, and/or associated proteins. GOC:krc http://purl.org/obo/owl/GOC#GOC_krc ISBN:0879695897 http://purl.org/obo/owl/ISBN#ISBN_0879695897 lariat formation, 5'-splice site cleavage molecular_function first U12-type spliceosomal transesterification activity This term was made obsolete because the activities used in the U2- and U12-type complexes are the same. The cellular component ontology should (and does) represent the two different complexes, but the molecular function ontology should not. OBSOLETE. Catalysis of the first transesterification reaction of U12-type spliceosomal mRNA splicing. The intron branch site adenosine is the nucleophile attacking the 5' splice site, resulting in cleavage at this position. In cis splicing, this is the step that forms a lariat structure of the intron RNA, which is still joined to the 3' exon. The catalytic site is thought to be formed by U6atac snRNA and/or U2atac snRNA, and/or associated proteins. GOC:krc http://purl.org/obo/owl/GOC#GOC_krc ISBN:0879695897 http://purl.org/obo/owl/ISBN#ISBN_0879695897 lariat formation, 5'-splice site cleavage molecular_function second U2-type spliceosomal transesterification activity This term was made obsolete because the activities used in the U2- and U12-type complexes are the same. The cellular component ontology should (and does) represent the two different complexes, but the molecular function ontology should not. OBSOLETE. Catalysis of the second transesterification reaction of U2-type spliceosomal mRNA splicing. Ligation of the two exons occurs via a transesterification reaction where the free 3'-hydroxyl group of the 5' exon is the nucleophile attacking the 3' splice site. Non-expressed sequences are now detached from the exons. In cis splicing, the intron is in a lariat structure. The catalytic site is thought to be formed by U6 and/or U2 snRNAs and/or associated proteins. GOC:krc http://purl.org/obo/owl/GOC#GOC_krc ISBN:0879695897 http://purl.org/obo/owl/ISBN#ISBN_0879695897 3'-splice site cleavage, exon ligation molecular_function second U12-type spliceosomal transesterification activity This term was made obsolete because the activities used in the U2- and U12-type complexes are the same. The cellular component ontology should (and does) represent the two different complexes, but the molecular function ontology should not. OBSOLETE. Catalysis of the second transesterification reaction of U12-type spliceosomal mRNA splicing. Ligation of the two exons occurs via a transesterification reaction where the free 3'-hydroxyl group of the 5' exon is the nucleophile attacking the 3' splice site. Non-expressed sequences are now detached from the exons. In cis splicing, the intron is in a lariat structure. The catalytic site is thought to be formed by U6 and/or U2 snRNAs and/or associated proteins. GOC:krc http://purl.org/obo/owl/GOC#GOC_krc ISBN:0879695897 http://purl.org/obo/owl/ISBN#ISBN_0879695897 3'-splice site cleavage, exon ligation molecular_function first spliceosomal transesterification activity Catalysis of the first transesterification reaction of spliceosomal mRNA splicing. The intron branch site adenosine is the nucleophile attacking the 5' splice site, resulting in cleavage at this position. In cis splicing, this is the step that forms a lariat structure of the intron RNA, while it is still joined to the 3' exon. GOC:krc http://purl.org/obo/owl/GOC#GOC_krc ISBN:0879695897 http://purl.org/obo/owl/ISBN#ISBN_0879695897 lariat formation, 5'-splice site cleavage molecular_function second spliceosomal transesterification activity Catalysis of the second transesterification reaction of spliceosomal mRNA splicing. Ligation of the two exons occurs via a transesterification reaction where the free 3'-hydroxyl group of the 5' exon is the nucleophile attacking the 3' splice site. Non-expressed sequences are now detached from the exons. In cis splicing, the intron is in a lariat structure. GOC:krc http://purl.org/obo/owl/GOC#GOC_krc ISBN:0879695897 http://purl.org/obo/owl/ISBN#ISBN_0879695897 3'-splice site cleavage, exon ligation lariat formation, 5'-splice site cleavage molecular_function four-way junction DNA binding Interacting selectively and non-covalently with DNA containing four-way junctions, also known as Holliday junctions, a structure where two DNA double strands are held together by reciprocal exchange of two of the four strands, one strand each from the two original helices. GOC:krc http://purl.org/obo/owl/GOC#GOC_krc ISBN:0815332181 http://purl.org/obo/owl/ISBN#ISBN_0815332181 PMID:15563464 http://purl.org/obo/owl/PMID#PMID_15563464 forked DNA binding Holliday junction binding molecular_function open form four-way junction DNA binding Interacting selectively and non-covalently with DNA containing the open form of a four-way junction, also known as a Holliday junction, a structure where two DNA double strands are held together by reciprocal exchange of two of the four strands, one strand each from the two original helices. The open form of a four-way junction can be diagrammed without any of the strands crossing over. GOC:krc http://purl.org/obo/owl/GOC#GOC_krc ISBN:0815332181 http://purl.org/obo/owl/ISBN#ISBN_0815332181 PMID:15563464 http://purl.org/obo/owl/PMID#PMID_15563464 open form Holliday junction binding molecular_function crossed form four-way junction DNA binding Interacting selectively and non-covalently with DNA containing the crossed form of a four-way junction, also known as a Holliday junction, a structure where two DNA double strands are held together by reciprocal exchange of two of the four strands, one strand each from the two original helices. The crossed form of a four-way junction cannot be diagrammed without any of the strands crossing over, and instead contains a single crossover between two of the strands. GOC:krc http://purl.org/obo/owl/GOC#GOC_krc ISBN:0815332181 http://purl.org/obo/owl/ISBN#ISBN_0815332181 PMID:15563464 http://purl.org/obo/owl/PMID#PMID_15563464 crossed form Holliday junction binding molecular_function Y-form DNA binding Interacting selectively and non-covalently with segment of DNA shaped like a Y. This shape occurs when DNA contains a region of paired double-stranded DNA on one end and a region of unpaired DNA strands on the opposite end. GOC:elh http://purl.org/obo/owl/GOC#GOC_elh PMID:16781730 http://purl.org/obo/owl/PMID#PMID_16781730 forked DNA binding splayed Y-form DNA binding molecular_function loop DNA binding Interacting selectively and non-covalently with DNA containing a loop. A loop occurs when DNA contains a large insertion or deletion that causes a region of unpaired single-stranded DNA to loop out, while the rest of the DNA is in a paired double-stranded configuration. GOC:elh http://purl.org/obo/owl/GOC#GOC_elh PMID:16781730 http://purl.org/obo/owl/PMID#PMID_16781730 molecular_function bubble DNA binding Interacting selective with DNA that contains a bubble. A bubble occurs when DNA contains a region of unpaired, single-stranded DNA flanked on both sides by regions of paired, double-stranded DNA. GOC:elh http://purl.org/obo/owl/GOC#GOC_elh PMID:16781730 http://purl.org/obo/owl/PMID#PMID_16781730 molecular_function double-strand/single-strand DNA junction binding Interacting selectively and non-covalently with a region of DNA that contains double-stranded DNA flanked by a region of single-stranded DNA. GOC:elh http://purl.org/obo/owl/GOC#GOC_elh PMID:16781730 http://purl.org/obo/owl/PMID#PMID_16781730 molecular_function base pairing Note that with respect to annotation, "base pairing" and its child terms are intended to be used to annotate the activity of gene products composed of nucleic acid, presumably RNA, to interact with other nucleic acid molecules via base pairing. Internal base pairing with itself is considered part of the secondary structure of the molecule and is not within the scope of GO function. Interacting selectively and non-covalently with nucleic acid via hydrogen bonds between the bases of a gene product molecule and the bases of a target nucleic acid molecule. GOC:krc http://purl.org/obo/owl/GOC#GOC_krc molecular_function Wikipedia:Base_pair http://purl.org/obo/owl/Wikipedia#Wikipedia_Base_pair base pairing with DNA Note that with respect to annotation, "base pairing" and its child terms are intended to be used to annotate the activity of gene products composed of nucleic acid, presumably RNA, to interact with DNA molecules via base pairing. Internal base pairing with itself is considered part of the secondary structure of the molecule and is not within the scope of GO function. Interacting selectively and non-covalently with nucleic acid via hydrogen bonds between the bases of a gene product molecule and the bases of a target DNA molecule. GOC:krc http://purl.org/obo/owl/GOC#GOC_krc molecular_function base pairing with RNA Note that with respect to annotation, "base pairing with RNA" and its child terms are intended to be used to annotate the activity of gene products composed of nucleic acid, presumably RNA, to interact with other RNA molecules via base pairing. Internal base pairing with itself is considered part of the secondary structure of the molecule and is not within the scope of GO function. Interacting selectively and non-covalently with ribonucleic acid (RNA) via hydrogen bonds between the bases of a gene product molecule and the bases of a target RNA molecule. GOC:krc http://purl.org/obo/owl/GOC#GOC_krc molecular_function base pairing with mRNA Note that with respect to annotation, "base pairing with RNA" and its child terms are intended to be used to annotate the activity of gene products composed of nucleic acid, presumably RNA, to interact with other RNA molecules via base pairing. Internal base pairing with itself is considered part of the secondary structure of the molecule and is not within the scope of GO function. Interacting selectively and non-covalently with messenger ribonucleic acid (mRNA) via hydrogen bonds between the bases of a gene product molecule and the bases of a target mRNA molecule. GOC:krc http://purl.org/obo/owl/GOC#GOC_krc molecular_function mismatch base pair DNA N-glycosylase activity Catalysis of the removal of single bases present in mismatches by the cleavage the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic/apyrimidinic (AP) site. GOC:elh http://purl.org/obo/owl/GOC#GOC_elh PMID:9224623 http://purl.org/obo/owl/PMID#PMID_9224623 molecular_function purine-specific mismatch base pair DNA N-glycosylase activity Catalysis of the removal of purines present in mismatches, especially opposite oxidized purines, by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic (AP) site. GOC:elh http://purl.org/obo/owl/GOC#GOC_elh PMID:9224623 http://purl.org/obo/owl/PMID#PMID_9224623 A/G-specific adenine DNA glycosylase activity molecular_function EC:3.2.2.- http://purl.org/obo/owl/EC#EC_3.2.2.- oxidized base lesion DNA N-glycosylase activity Catalysis of the removal of oxidized bases by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic/apyrimidinic (AP) site. GOC:elh http://purl.org/obo/owl/GOC#GOC_elh PMID:11554296 http://purl.org/obo/owl/PMID#PMID_11554296 molecular_function oxidized pyrimidine base lesion DNA N-glycosylase activity Consider also annotating to the molecular function term 'DNA-(apurinic or apyrimidinic site) lyase activity ; GO:0003906'. Catalysis of the removal oxidized pyrimidine bases by cleaving the N-C1' glycosidic bond between the oxidized pyrimidine and the deoxyribose sugar. The reaction involves formation of a covalent enzyme-pyrimidine base intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apyrimidinic (AP) site. GOC:elh http://purl.org/obo/owl/GOC#GOC_elh PMID:11554296 http://purl.org/obo/owl/PMID#PMID_11554296 bifunctional DNA glycosylase DNA glycosylase/AP-lyase DNA glycosylase/beta-lyase endodeoxyribonuclease III endonuclease III endonuclease VIII activity pyrimidine-specific oxidized base lesion DNA N-glycosylase activity molecular_function GO:0019004 Reactome:25087 http://purl.org/obo/owl/Reactome#Reactome_25087 pyrimidine dimer DNA N-glycosylase activity Catalysis of the removal of pyrimidine dimers by removing the 5' pyrimidine of the dimer by cleaving the N-C1' glycosidic bond between the 5' pyrimidine of the dimer and the deoxyribose sugar. The reaction releases the 5' pyrimidine of the dimer and leaves an apurinic (AP) site. The reaction involves the formation of a covalent enzyme substrate intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apyrimidinic (AP) site. GOC:elh http://purl.org/obo/owl/GOC#GOC_elh PMID:9224623 http://purl.org/obo/owl/PMID#PMID_9224623 molecular_function (R,R)-butanediol dehydrogenase activity Catalysis of the reversible reaction: (R,R)-butane-2,3-diol + NAD+ = (R)-acetoin + NADH + H+. EC:1.1.1.4 http://purl.org/obo/owl/EC#EC_1.1.1.4 (R)-2,3-butanediol dehydrogenase activity EC:1.1.1.4 http://purl.org/obo/owl/EC#EC_1.1.1.4 (R)-diacetyl reductase activity EC:1.1.1.4 http://purl.org/obo/owl/EC#EC_1.1.1.4 1-amino-2-propanol dehydrogenase activity EC:1.1.1.4 http://purl.org/obo/owl/EC#EC_1.1.1.4 1-amino-2-propanol oxidoreductase activity EC:1.1.1.4 http://purl.org/obo/owl/EC#EC_1.1.1.4 2,3-butanediol dehydrogenase activity EC:1.1.1.4 http://purl.org/obo/owl/EC#EC_1.1.1.4 aminopropanol oxidoreductase activity EC:1.1.1.4 http://purl.org/obo/owl/EC#EC_1.1.1.4 butylene glycol dehydrogenase activity EC:1.1.1.4 http://purl.org/obo/owl/EC#EC_1.1.1.4 butyleneglycol dehydrogenase activity EC:1.1.1.4 http://purl.org/obo/owl/EC#EC_1.1.1.4 D-(-)-butanediol dehydrogenase activity EC:1.1.1.4 http://purl.org/obo/owl/EC#EC_1.1.1.4 D-1-amino-2-propanol dehydrogenase activity EC:1.1.1.4 http://purl.org/obo/owl/EC#EC_1.1.1.4 D-1-amino-2-propanol:NAD(2) oxidoreductase activity EC:1.1.1.4 http://purl.org/obo/owl/EC#EC_1.1.1.4 D-aminopropanol dehydrogenase activity EC:1.1.1.4 http://purl.org/obo/owl/EC#EC_1.1.1.4 D-butanediol dehydrogenase activity EC:1.1.1.4 http://purl.org/obo/owl/EC#EC_1.1.1.4 diacetyl (acetoin) reductase activity EC:1.1.1.4 http://purl.org/obo/owl/EC#EC_1.1.1.4 molecular_function EC:1.1.1.4 http://purl.org/obo/owl/EC#EC_1.1.1.4 MetaCyc:RR-BUTANEDIOL-DEHYDROGENASE-RXN http://purl.org/obo/owl/MetaCyc#MetaCyc_RR-BUTANEDIOL-DEHYDROGENASE-RXN DNA strand annealing activity Facilitates the base-pairing of complementary single-stranded DNA. GOC:elh http://purl.org/obo/owl/GOC#GOC_elh molecular_function mating pheromone activity The activity of binding to and activating specific cell surface receptors, thereby inducing a behavioral or physiological response(s) from a responding organism or cell that leads to the transfer or union of genetic material between organisms or cells. The mating pheromone can either be retained on the cell surface or secreted. GOC:clt http://purl.org/obo/owl/GOC#GOC_clt GOC:elh http://purl.org/obo/owl/GOC#GOC_elh molecular_function phosphatidyl-N-methylethanolamine N-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + phosphatidyl-N-methylethanolamine = S-adenosyl-L-homocysteine + phosphatidyl-N-dimethylethanolamine. EC:2.1.1.71 http://purl.org/obo/owl/EC#EC_2.1.1.71 methyltransferase II EC:2.1.1.71 http://purl.org/obo/owl/EC#EC_2.1.1.71 phosphatidyl-N-methylethanolamine methyltransferase activity EC:2.1.1.71 http://purl.org/obo/owl/EC#EC_2.1.1.71 phosphatidyl-N-monomethylethanolamine methyltransferase activity EC:2.1.1.71 http://purl.org/obo/owl/EC#EC_2.1.1.71 phosphatidylethanolamine methyltransferase I EC:2.1.1.71 http://purl.org/obo/owl/EC#EC_2.1.1.71 phosphatidylmonomethylethanolamine methyltransferase activity EC:2.1.1.71 http://purl.org/obo/owl/EC#EC_2.1.1.71 phospholipid methyltransferase activity EC:2.1.1.71 http://purl.org/obo/owl/EC#EC_2.1.1.71 PLMT S-adenosyl-L-methionine:phosphatidyl-N-methylethanolamine N-methyltransferase activity EC:2.1.1.71 http://purl.org/obo/owl/EC#EC_2.1.1.71 molecular_function EC:2.1.1.71 http://purl.org/obo/owl/EC#EC_2.1.1.71 MetaCyc:2.1.1.71-RXN http://purl.org/obo/owl/MetaCyc#MetaCyc_2.1.1.71-RXN adenyl-nucleotide exchange factor activity Stimulates the hydrolysis and exchange of adenyl nucleotides by other proteins. GOC:kd http://purl.org/obo/owl/GOC#GOC_kd molecular_function diacylglycerol pyrophosphate phosphatase activity Catalysis of the reaction: diacylglycerol pyrophosphate + H20 = 3-sn-phosphatidate + phosphate. EC:3.6.1.- http://purl.org/obo/owl/EC#EC_3.6.1.- PMID:8567632 http://purl.org/obo/owl/PMID#PMID_8567632 PMID:9452443 http://purl.org/obo/owl/PMID#PMID_9452443 DGPP phosphatase activity DGPP phosphohydrolase activity molecular_function nicotinamide riboside kinase activity Catalysis of the reaction: ATP + nicotinamide riboside = ADP + nicotinamide nucleotide (NMN). PMID:15137942 http://purl.org/obo/owl/PMID#PMID_15137942 molecular_function inositol hexakisphosphate binding Interacting selectively and non-covalently with inositol hexakisphosphate. GOC:go_curators http://purl.org/obo/owl/GOC#GOC_go_curators InsP6 binding IP6 binding molecular_function inositol trisphosphate 6-kinase activity Catalysis of the reaction: ATP + 1D-myo-inositol 1,4,5-trisphosphate = ADP + 1D-myo-inositol 1,4,5,6-tetrakisphosphate. GOC:elh http://purl.org/obo/owl/GOC#GOC_elh ATP:1D-myo-inositol-1,4,5-trisphosphate 6-phosphotransferase activity EC:2.7.1.151 inositol polyphosphate multikinase activity IpmK molecular_function inositol tetrakisphosphate 3-kinase activity Catalysis of the reaction: ATP + 1D-myo-inositol 1,4,5,6-tetrakisphosphate = ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate. GOC:elh http://purl.org/obo/owl/GOC#GOC_elh 1D-myo-inositol-tetrakisphosphate 3-kinase activity EC:2.7.1.151 inositol 1,4,5,6-tetrakisphosphate 3-kinase activity inositol polyphosphate multikinase activity IpmK molecular_function inositol tetrakisphosphate 6-kinase activity Catalysis of the reaction: 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ATP = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP. GOC:elh http://purl.org/obo/owl/GOC#GOC_elh 1D-myo-inositol-tetrakisphosphate 6-kinase activity inositol 1,3,4,5-tetrakisphosphate 6-kinase activity molecular_function inositol pyrophosphate synthase activity Catalysis of the phosphorylation of inositol phosphates which possess pyrophosphate bonds. GOC:elh http://purl.org/obo/owl/GOC#GOC_elh PMID:16429326 http://purl.org/obo/owl/PMID#PMID_16429326 inositol diphosphate synthase activity molecular_function inositol 1,3,4,5,6-pentakisphosphate kinase activity Catalysis of the reaction: ATP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate = ADP + diphospho-1D-myo-inositol tetrakisphosphate (isomeric configuration unknown). GOC:elh http://purl.org/obo/owl/GOC#GOC_elh PMID:11311242 http://purl.org/obo/owl/PMID#PMID_11311242 EC:2.7.4.21 molecular_function inositol hexakisphosphate kinase activity Catalysis of the reaction: ATP + 1D-myo-inositol hexakisphosphate (IP6) = ADP + diphospho-1D-myo-inositol-pentakisphosphate (PP-IP5; isomer unknown). GOC:elh http://purl.org/obo/owl/GOC#GOC_elh PMID:16429326 http://purl.org/obo/owl/PMID#PMID_16429326 molecular_function MetaCyc:2.7.1.152-RXN http://purl.org/obo/owl/MetaCyc#MetaCyc_2.7.1.152-RXN inositol heptakisphosphate kinase activity Catalysis of the reaction: ATP + diphospho-1D-myo-inositol-pentakisphosphate (PP-IP5; isomer unknown) = ADP + bis(diphospho)-1D-myo-inositol-tetrakisphosphate (bis-PP-IP4; isomer unknown). GOC:elh http://purl.org/obo/owl/GOC#GOC_elh PMID:16429326 http://purl.org/obo/owl/PMID#PMID_16429326 molecular_function inositol hexakisphosphate 4-kinase activity Catalysis of the reaction: ATP + 1D-myo-inositol hexakisphosphate = ADP + 4-diphospho-1D-myo-inositol (1,2,3,5,6)pentakisphosphate. GOC:elh http://purl.org/obo/owl/GOC#GOC_elh PMID:16429326 http://purl.org/obo/owl/PMID#PMID_16429326 molecular_function inositol hexakisphosphate 6-kinase activity Catalysis of the reaction: ATP + 1D-myo-inositol hexakisphosphate = ADP + 6-diphospho-1D-myo-inositol (1,2,3,4,5)pentakisphosphate. GOC:elh http://purl.org/obo/owl/GOC#GOC_elh PMID:16429326 http://purl.org/obo/owl/PMID#PMID_16429326 molecular_function inositol hexakisphosphate 5-kinase activity Catalysis of the reaction: ATP + 1D-myo-inositol hexakisphosphate = ADP + 5-diphospho-1D-myo-inositol (1,2,3,4,6)pentakisphosphate. GOC:elh http://purl.org/obo/owl/GOC#GOC_elh PMID:16429326 http://purl.org/obo/owl/PMID#PMID_16429326 ATP:1D-myo-inositol-hexakisphosphate 5-phosphotransferase activity EC:2.7.4.21 molecular_function inositol heptakisphosphate 4-kinase activity Catalysis of the reaction: ATP + 5-diphospho-1D-myo-inositol (1,2,3,4,6)pentakisphosphate = 4,5-bisdiphosphoinositol-1D-myoinositol (1,2,3,6)tetrakisphosphate. GOC:elh http://purl.org/obo/owl/GOC#GOC_elh PMID:16429326 http://purl.org/obo/owl/PMID#PMID_16429326 diphosphoinositol-pentakisphosphate 4-kinase activity IP7 4-kinase activity molecular_function inositol heptakisphosphate 6-kinase activity Catalysis of the reaction: ATP + 5-diphospho-1D-myo-inositol (1,2,3,4,6)pentakisphosphate = 5,6-bisdiphosphoinositol-1D-myoinositol (1,2,3,4)tetrakisphosphate. GOC:elh http://purl.org/obo/owl/GOC#GOC_elh PMID:16429326 http://purl.org/obo/owl/PMID#PMID_16429326 molecular_function translation repressor activity, nucleic acid binding Antagonizes the ribosome-mediated translation of mRNA into a polypeptide via direct binding to nucleic acid. GOC:clt http://purl.org/obo/owl/GOC#GOC_clt molecular_function translation repressor activity, non-nucleic acid binding Antagonizes the ribosome-mediated translation of mRNA into a polypeptide but does not bind directly to nucleic acid. GOC:clt http://purl.org/obo/owl/GOC#GOC_clt molecular_function 6,7-dimethyl-8-ribityllumazine synthase activity Catalysis of the reaction: 3,4-dihydroxy-2-butanone 4-phosphate + 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione = 6,7-dimethyl-8-ribityllumazine + phosphate. EC:5.4.-.- http://purl.org/obo/owl/EC#EC_5.4.-.- PMID:7559556 http://purl.org/obo/owl/PMID#PMID_7559556 lumazine synthase activity MetaCyc:LUMAZINESYN-CPLX http://purl.org/obo/owl/MetaCyc#MetaCyc_LUMAZINESYN-CPLX molecular_function EC:5.4.-.- http://purl.org/obo/owl/EC#EC_5.4.-.- sulfonate dioxygenase activity Catalysis of the reaction: sulfonate + 2-oxoglutarate + O2 = SO3(2-) (sulfite) + aminoacetaldehyde + succinate + CO2. EC:1.14.11.- http://purl.org/obo/owl/EC#EC_1.14.11.- GOC:clt http://purl.org/obo/owl/GOC#GOC_clt PMID:10482536 http://purl.org/obo/owl/PMID#PMID_10482536 sulfonate/alpha-ketoglutarate dioxygenase activity sulphonate dioxygenase activity molecular_function EC:1.14.11.- http://purl.org/obo/owl/EC#EC_1.14.11.- taurine dioxygenase activity Catalysis of the reaction: taurine + 2-oxoglutarate + O2 = SO3(2-) (sulfite) + aminoacetaldehyde + succinate + CO2. EC:1.14.11.17 http://purl.org/obo/owl/EC#EC_1.14.11.17 MetaCyc:RXN0-299 http://purl.org/obo/owl/MetaCyc#MetaCyc_RXN0-299 2-aminoethanesulfonate dioxygenase activity EC:1.14.11.17 http://purl.org/obo/owl/EC#EC_1.14.11.17 alpha-ketoglutarate-dependent taurine dioxygenase activity EC:1.14.11.17 http://purl.org/obo/owl/EC#EC_1.14.11.17 taurine, 2-oxoglutarate:O2 oxidoreductase (sulfite-forming) EC:1.14.11.17 http://purl.org/obo/owl/EC#EC_1.14.11.17 molecular_function EC:1.14.11.17 http://purl.org/obo/owl/EC#EC_1.14.11.17 MetaCyc:RXN0-299 http://purl.org/obo/owl/MetaCyc#MetaCyc_RXN0-299 base pairing with rRNA Note that with respect to annotation, "base pairing with RNA" and its child terms are intended to be used to annotate the activity of gene products composed of nucleic acid, presumably RNA, to interact with other RNA molecules via base pairing. Internal base pairing with itself is considered part of the secondary structure of the molecule and is not within the scope of GO function. Interacting selectively and non-covalently with ribosomal ribonucleic acid (rRNA) via hydrogen bonds between the bases of a gene product molecule and the bases of a target rRNA molecule. GOC:krc http://purl.org/obo/owl/GOC#GOC_krc molecular_function base pairing with snRNA Note that with respect to annotation, "base pairing with RNA" and its child terms are intended to be used to annotate the activity of gene products composed of nucleic acid, presumably RNA, to interact with other RNA molecules via base pairing. Internal base pairing with itself is considered part of the secondary structure of the molecule and is not within the scope of GO function. Interacting selectively and non-covalently with small nuclear ribonucleic acid (snRNA) via hydrogen bonds between the bases of a gene product molecule and the bases of a target snRNA molecule. GOC:krc http://purl.org/obo/owl/GOC#GOC_krc molecular_function base pairing with tRNA Note that with respect to annotation, "base pairing with RNA" and its child terms are intended to be used to annotate the activity of gene products composed of nucleic acid, presumably RNA, to interact with other RNA molecules via base pairing. Internal base pairing with itself is considered part of the secondary structure of the molecule and is not within the scope of GO function. Interacting selectively and non-covalently with transfer ribonucleic acid (mRNA) via hydrogen bonds between the bases of a gene product molecule and the bases of a target tRNA molecule. GOC:krc http://purl.org/obo/owl/GOC#GOC_krc molecular_function glycerophosphodiester transmembrane transporter activity Catalysis of the transfer of glycerophosphodiesters from one side of a membrane to the other. Glycerophosphodiesters are small molecules composed of glycerol-3-phosphate and an alcohol, for example, glycerophosphoinositol. GOC:mcc http://purl.org/obo/owl/GOC#GOC_mcc PMID:12912892 http://purl.org/obo/owl/PMID#PMID_12912892 molecular_function guanine nucleotide transmembrane transporter activity Catalysis of the transfer of guanine nucleotides (GMP, GDP, and GTP) from one side of the membrane to the other. GOC:mcc http://purl.org/obo/owl/GOC#GOC_mcc molecular_function legumain activity This term was made obsolete because it represents a gene product. OBSOLETE. Catalysis of the hydrolysis of proteins and small-molecule substrates at Asn-Xaa bonds. EC:3.4.22.34 http://purl.org/obo/owl/EC#EC_3.4.22.34 asparaginyl endopeptidase activity EC:3.4.22.34 http://purl.org/obo/owl/EC#EC_3.4.22.34 bean endopeptidase activity EC:3.4.22.34 http://purl.org/obo/owl/EC#EC_3.4.22.34 citvac EC:3.4.22.34 http://purl.org/obo/owl/EC#EC_3.4.22.34 hemoglobinase activity EC:3.4.22.34 http://purl.org/obo/owl/EC#EC_3.4.22.34 phaseolin activity EC:3.4.22.34 http://purl.org/obo/owl/EC#EC_3.4.22.34 proteinase B EC:3.4.22.34 http://purl.org/obo/owl/EC#EC_3.4.22.34 PRSC1 gene product (Homo sapiens) EC:3.4.22.34 http://purl.org/obo/owl/EC#EC_3.4.22.34 vicilin peptidohydrolase activity EC:3.4.22.34 http://purl.org/obo/owl/EC#EC_3.4.22.34 molecular_function EC:3.4.22.34 http://purl.org/obo/owl/EC#EC_3.4.22.34 MetaCyc:3.4.22.34-RXN http://purl.org/obo/owl/MetaCyc#MetaCyc_3.4.22.34-RXN fibrillin This term was made obsolete because it represents a gene product. OBSOLETE. Large glycoprotein that is a calcium binding component of connective tissue microfibrils containing 34 six-cysteine (EGF-like) repeats and five eight-cysteine (TGFbeta-1 binding protein-like) repeats. Defects associated with Marfan syndrome. ISBN:0198506732 http://purl.org/obo/owl/ISBN#ISBN_0198506732 molecular_function dihydronicotinamide riboside quinone reductase activity Catalysis of the reaction: 1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide + a quinone = 1-(beta-D-ribofuranosyl)nicotinamide + a hydroquinone. EC:1.10.99.2 http://purl.org/obo/owl/EC#EC_1.10.99.2 1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide:quinone oxidoreductase activity EC:1.10.99.2 http://purl.org/obo/owl/EC#EC_1.10.99.2 N-ribosyldihydronicotinamide dehydrogenase (quinone) activity EC:1.10.99.2 http://purl.org/obo/owl/EC#EC_1.10.99.2 NAD(P)H:quinone oxidoreductase 2 activity EC:1.10.99.2 http://purl.org/obo/owl/EC#EC_1.10.99.2 NAD(P)H:quinone oxidoreductase-2 EC:1.10.99.2 http://purl.org/obo/owl/EC#EC_1.10.99.2 NAD(P)H:quinone oxidoreductase2 EC:1.10.99.2 http://purl.org/obo/owl/EC#EC_1.10.99.2 NQO(2) activity EC:1.10.99.2 http://purl.org/obo/owl/EC#EC_1.10.99.2 NQO2 EC:1.10.99.2 http://purl.org/obo/owl/EC#EC_1.10.99.2 NRH:quinone oxidoreductase 2 activity EC:1.10.99.2 http://purl.org/obo/owl/EC#EC_1.10.99.2 QR2 activity EC:1.10.99.2 http://purl.org/obo/owl/EC#EC_1.10.99.2 quinone reductase 2 activity EC:1.10.99.2 http://purl.org/obo/owl/EC#EC_1.10.99.2 ribosyldihydronicotinamide dehydrogenase (quinone) activity molecular_function EC:1.10.99.2 http://purl.org/obo/owl/EC#EC_1.10.99.2 MetaCyc:1.10.99.2-RXN http://purl.org/obo/owl/MetaCyc#MetaCyc_1.10.99.2-RXN opioid peptide activity Naturally occurring peptide that is an opioid (any non-alkaloid having an opiate-like effect that can be reversed by naloxone or other recognized morphine antagonist). These include Leu- and Met-enkephalin, dynorphin and neoendorphin, alpha, beta, gamma and delta endorphins formed from beta-lipotropin, various pronase-resistant peptides such as beta casamorphin, and other peptides whose opiate-like action seems to be indirect. ISBN:0198506732 http://purl.org/obo/owl/ISBN#ISBN_0198506732 molecular_function N-acetylglucosamine 6-O-sulfotransferase activity Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + N-acetyl-D-glucosamine = adenosine 3',5'-bisphosphate + N-acetyl-D-glucosamine 6-sulfate. GOC:ai http://purl.org/obo/owl/GOC#GOC_ai GOC:hjd http://purl.org/obo/owl/GOC#GOC_hjd N-acetylglucosamine 6-O-sulphotransferase activity molecular_function EC:2.8.2.- http://purl.org/obo/owl/EC#EC_2.8.2.- globin This term was made obsolete because it represents a gene product. OBSOLETE. The colorless and basic protein moiety of hemoglobin and myoglobins. GOC:ai http://purl.org/obo/owl/GOC#GOC_ai ISBN:0198506732 http://purl.org/obo/owl/ISBN#ISBN_0198506732 molecular_function elastin This term was made obsolete because it represents a gene product. OBSOLETE. A major structural protein of mammalian connective tissues; composed of one third glycine, and also rich in proline, alanine, and valine. Chains are cross-linked together via lysine residues. ISBN:0198506732 http://purl.org/obo/owl/ISBN#ISBN_0198506732 molecular_function lipopolysaccharide binding Interacting selectively and non-covalently with lipopolysaccharide. PMID:11079463 http://purl.org/obo/owl/PMID#PMID_11079463 endotoxin binding LPS binding molecular_function interleukin-21 receptor binding Interacting selectively and non-covalently with the interleukin-21 receptor. GOC:ai http://purl.org/obo/owl/GOC#GOC_ai IL-21 interleukin-21 receptor ligand molecular_function interleukin-21 receptor activity Combining with interleukin-21 to initiate a change in cell activity. GOC:jl http://purl.org/obo/owl/GOC#GOC_jl IL-21 receptor activity GOC:mah http://purl.org/obo/owl/GOC#GOC_mah IL-21R molecular_function N-acetylgalactosamine 4-O-sulfotransferase activity Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + N-acetyl-D-galactosamine = adenosine 3',5'-bisphosphate + N-acetyl-D-galactosamine 4-sulfate. EC:2.8.2.- http://purl.org/obo/owl/EC#EC_2.8.2.- GOC:ai http://purl.org/obo/owl/GOC#GOC_ai N-acetylgalactosamine 4-O-sulphotransferase activity molecular_function EC:2.8.2.- http://purl.org/obo/owl/EC#EC_2.8.2.- beta-amyloid binding Interacting selectively and non-covalently with beta-amyloid peptide/protein and/or its precursor. GOC:hjd http://purl.org/obo/owl/GOC#GOC_hjd molecular_function phorbol ester receptor activity Combining with a phorbol ester to initiate a change in cell activity. GOC:ai http://purl.org/obo/owl/GOC#GOC_ai PMID:10506570 http://purl.org/obo/owl/PMID#PMID_10506570 molecular_function non-kinase phorbol ester receptor activity Phorbol ester/diacylglycerol binding proteins that do not have intrinsic kinase activity. PMID:10506570 http://purl.org/obo/owl/PMID#PMID_10506570 molecular_function cholesterol 25-hydroxylase activity Catalysis of the reaction: cholesterol + AH2 + O2 = 25-hydroxycholesterol + A + H2O. EC:1.14.99.38 http://purl.org/obo/owl/EC#EC_1.14.99.38 cholesterol 25-monooxygenase activity EC:1.14.99.38 http://purl.org/obo/owl/EC#EC_1.14.99.38 cholesterol,hydrogen-donor:oxygen oxidoreductase (25-hydroxylating) activity EC:1.14.99.38 http://purl.org/obo/owl/EC#EC_1.14.99.38 molecular_function EC:1.14.99.38 http://purl.org/obo/owl/EC#EC_1.14.99.38 MetaCyc:1.14.99.38-RXN http://purl.org/obo/owl/MetaCyc#MetaCyc_1.14.99.38-RXN non-tyrosine kinase fibroblast growth factor receptor activity A receptor belonging to the FGFR family but lacking the tyrosine kinase domain. PMID:11418238 http://purl.org/obo/owl/PMID#PMID_11418238 non-tyrosine kinase FGF receptor activity non-tyrosine kinase FGFR activity molecular_function galectin This term was made obsolete because it refers to a class of gene products. OBSOLETE. A lectin that exhibits calcium independent binding of beta-galactoside sugars. PMID:9786891 http://purl.org/obo/owl/PMID#PMID_9786891 S-type lectin molecular_function rhodopsin-like receptor activity This term was made obsolete because it represents a gene product and is named based on protein features. OBSOLETE. A G-protein coupled receptor that is structurally/functionally related to the rhodopsin receptor. GOC:dph http://purl.org/obo/owl/GOC#GOC_dph GOC:mah http://purl.org/obo/owl/GOC#GOC_mah GOC:tb http://purl.org/obo/owl/GOC#GOC_tb IUPHAR_GPCR:1505 http://purl.org/obo/owl/IUPHAR_GPCR#IUPHAR_GPCR_1505 Class A G protein coupled receptor Class A G-protein coupled receptor Class A GPCR class A orphan receptor activity molecular_function GO:0001620 5-HT1 receptor activity molecular_function 5-HT2 receptor activity molecular_function dopamine receptor activity, coupled via Gs Combining with the neurotransmitter dopamine and activating adenylate cyclase via coupling to Gs to initiate a change in cell activity. GOC:mah http://purl.org/obo/owl/GOC#GOC_mah ISBN:0953351033 http://purl.org/obo/owl/ISBN#ISBN_0953351033 molecular_function dopamine D5 receptor activity A G-protein coupled receptor that binds dopamine and has the pharmacological characteristics of classic D5 receptors. IUPHAR_RECEPTOR:2260 http://purl.org/obo/owl/IUPHAR_RECEPTOR#IUPHAR_RECEPTOR_2260 molecular_function dopamine D1 receptor activity A G-protein coupled receptor that binds dopamine and has the pharmacological characteristics of classic D1 receptors. IUPHAR_RECEPTOR:2252 http://purl.org/obo/owl/IUPHAR_RECEPTOR#IUPHAR_RECEPTOR_2252 molecular_function dopamine receptor activity, coupled via Gi/Go Combining with the neurotransmitter dopamine and activating adenylate cyclase via coupling to Gi/Go to initiate a change in cell activity. GOC:mah http://purl.org/obo/owl/GOC#GOC_mah ISBN:0953351033 http://purl.org/obo/owl/ISBN#ISBN_0953351033 molecular_function dopamine D3 receptor activity A G-protein coupled receptor that binds dopamine and has the pharmacological characteristics of classic D3 receptors. IUPHAR_RECEPTOR:2256 http://purl.org/obo/owl/IUPHAR_RECEPTOR#IUPHAR_RECEPTOR_2256 molecular_function dopamine D4 receptor activity A G-protein coupled receptor that binds dopamine and has the pharmacological characteristics of classic D4 receptors. IUPHAR_RECEPTOR:2258 http://purl.org/obo/owl/IUPHAR_RECEPTOR#IUPHAR_RECEPTOR_2258 molecular_function trace-amine receptor activity molecular_function angiotensin receptor activity Combining with angiotensin to initiate a change in cell activity. GOC:ai http://purl.org/obo/owl/GOC#GOC_ai molecular_function angiotensin type I receptor activity molecular_function apelin-like receptor This term was made obsolete because the function it represents does not exist. OBSOLETE (was not defined before being made obsolete). GOC:jl http://purl.org/obo/owl/GOC#GOC_jl APJ-like receptor molecular_function chemokine receptor-like receptor activity This term was made obsolete because it represents a gene product, was not defined, and is named based on protein features. OBSOLETE (was not defined before being made obsolete). GOC:mah http://purl.org/obo/owl/GOC#GOC_mah molecular_function endothelin-A receptor activity A G-protein coupled receptor that preferentially binds endothelin 1. IUPHAR_RECEPTOR:2263 http://purl.org/obo/owl/IUPHAR_RECEPTOR#IUPHAR_RECEPTOR_2263 PMID:8582288 http://purl.org/obo/owl/PMID#PMID_8582288 molecular_function endothelin-B receptor activity A G-protein coupled receptor that binds all endothelin molecules with approximately equal affinity. IUPHAR_RECEPTOR:2265 http://purl.org/obo/owl/IUPHAR_RECEPTOR#IUPHAR_RECEPTOR_2265 PMID:8582288 http://purl.org/obo/owl/PMID#PMID_8582288 molecular_function peptide YY receptor activity Combining with gut peptide YY to initiate a change in cell activity. PMID:9315606 http://purl.org/obo/owl/PMID#PMID_9315606 molecular_function pancreatic polypeptide receptor activity Combining with pancreatic polypeptide PP to initiate a change in cell activity. PMID:9315606 http://purl.org/obo/owl/PMID#PMID_9315606 molecular_function vasopressin-like receptor activity molecular_function urotensin II receptor activity molecular_function adrenomedullin receptor activity Combining with adrenomedullin to initiate a change in cell activity. GOC:ai http://purl.org/obo/owl/GOC#GOC_ai G10D receptor molecular_function GPR37/endothelin B-like receptor activity This term was made obsolete because it represents a gene product, was not defined, and is named based on protein features. OBSOLETE (was not defined before being made obsolete). GOC:mah http://purl.org/obo/owl/GOC#GOC_mah molecular_function neuromedin U receptor activity Combining with neuromedin U to initiate a change in cell activity. GOC:ai http://purl.org/obo/owl/GOC#GOC_ai NMUR activity molecular_function nucleotide receptor activity, G-protein coupled A GPCR that binds a nucleotide or nucleotide derivative as its ligand. GOC:dph http://purl.org/obo/owl/GOC#GOC_dph IUPHAR_GPCR:1294 http://purl.org/obo/owl/IUPHAR_GPCR#IUPHAR_GPCR_1294 G protein coupled nucleotide receptor activity G-protein-coupled nucleotide receptor activity nucleotide receptor activity, G protein coupled molecular_function adenosine receptor activity, G-protein coupled Combining with adenosine and transmitting the signal to a heterotrimeric G-protein complex to initiate a change in cell activity. GOC:mah http://purl.org/obo/owl/GOC#GOC_mah PMID:9755289 http://purl.org/obo/owl/PMID#PMID_9755289 A1 adenosine receptor activity, G protein coupled A1 adenosine receptor activity, G-protein coupled A2A adenosine receptor activity, G protein coupled A2A adenosine receptor activity, G-protein coupled A2B adenosine receptor activity, G protein coupled A2B adenosine receptor activity, G-protein coupled A3 adenosine receptor activity, G protein coupled A3 adenosine receptor activity, G-protein coupled adenosine nucleotide receptor adenosine receptor activity, G protein coupled G protein coupled A1 adenosine receptor activity G protein coupled A2A adenosine receptor activity G protein coupled A2B adenosine receptor activity G protein coupled A3 adenosine receptor activity G protein coupled adenosine receptor activity G-protein-coupled A1 adenosine receptor activity G-protein-coupled A2A adenosine receptor activity G-protein-coupled A2B adenosine receptor activity G-protein-coupled A3 adenosine receptor activity G-protein-coupled adenosine receptor activity molecular_function GO:0001610 GO:0001611 GO:0001612 GO:0001613 GO:0008501 Reactome:71 http://purl.org/obo/owl/Reactome#Reactome_71 purinergic nucleotide receptor activity Combining with a purine nucleotide to initiate a change in cell activity. GOC:mah http://purl.org/obo/owl/GOC#GOC_mah P2Y receptor purinoceptor purinoreceptor molecular_function thyrotropin releasing hormone and secretagogue-like receptors activity This term was made obsolete because it represents a gene product, was not defined, and is named based on protein features. OBSOLETE (was not defined before being made obsolete). GOC:mah http://purl.org/obo/owl/GOC#GOC_mah molecular_function growth hormone secretagogue receptor activity molecular_function growth hormone secretagogue-like receptor activity This term was made obsolete because it represents a gene product, was not defined, and is named based on protein features. OBSOLETE (was not defined before being made obsolete). GOC:mah http://purl.org/obo/owl/GOC#GOC_mah molecular_function viral receptor activity Combining with a virus component to initiate a change in cell activity. GOC:dph http://purl.org/obo/owl/GOC#GOC_dph molecular_function lysosphingolipid and lysophosphatidic acid receptor activity Combining with lysosphingolipid or lysophosphatidic acid to initiate a change in cell activity. GOC:dph http://purl.org/obo/owl/GOC#GOC_dph molecular_function platelet ADP receptor activity K101 receptor molecular_function super conserved receptor expressed in brain receptor activity SREB receptor molecular_function Mas proto-oncogene receptor activity molecular_function RDC1 receptor activity molecular_function Epstein-Barr Virus-induced receptor activity EBV-induced receptor molecular_function nociceptin/orphanin-FQ receptor activity ORPH receptor molecular_function leucine-rich G-protein receptor-like receptor activity This term was made obsolete because it represents a gene product, was not defined, and is named based on protein features. OBSOLETE (was not defined before being made obsolete). GOC:mah http://purl.org/obo/owl/GOC#GOC_mah leucine-rich G protein receptor-like receptor activity LGR-like receptor molecular_function gastropyloric receptor activity GPR receptor molecular_function G-protein receptor 45-like receptor activity This term was made obsolete because it represents a gene product, was not defined, and is named based on protein features. OBSOLETE (was not defined before being made obsolete). GOC:mah http://purl.org/obo/owl/GOC#GOC_mah G protein receptor 45-like receptor activity GPR45-like receptor molecular_function GP40-like receptor activity This term was made obsolete because it represents a gene product, was not defined, and is named based on protein features. OBSOLETE (was not defined before being made obsolete). GOC:mah http://purl.org/obo/owl/GOC#GOC_mah molecular_function cysteinyl leukotriene receptor activity Combining with a cysteinyl leukotriene to initiate a change in cell activity. Cysteinyl leukotrienes are leukotrienes that contain a peptide moiety based on cysteine. GOC:ai http://purl.org/obo/owl/GOC#GOC_ai ISBN:0198506732 http://purl.org/obo/owl/ISBN#ISBN_0198506732 CysLT receptor molecular_function leukotriene B4 receptor activity Combining with leukotriene B4, LTB4, to initiate a change in cell activity. Leukotriene B4 is also known as (6Z, 8E, 10E, 14Z)-(5S, 12R)-5,12-dihydroxyicosa-6,8,10,14-tetraen-1-oate. GOC:ai http://purl.org/obo/owl/GOC#GOC_ai ISBN:0198506732 http://purl.org/obo/owl/ISBN#ISBN_0198506732 BLT receptor molecular_function secretin-like receptor activity This term was made obsolete because it represents a gene product and is named based on protein features. OBSOLETE. A G-protein coupled receptor that is structurally/functionally related to the secretin receptor. GOC:mah http://purl.org/obo/owl/GOC#GOC_mah IUPHAR_GPCR:1506 http://purl.org/obo/owl/IUPHAR_GPCR#IUPHAR_GPCR_1506 class B G protein coupled receptor class B G-protein coupled receptor class B GPCR class B orphan receptor activity molecular_function GO:0001638 pituitary adenylate cyclase-activating polypeptide receptor activity A G-protein coupled receptor that interacts with pituitary adenylate cyclase-activating polypeptide. GOC:dph http://purl.org/obo/owl/GOC#GOC_dph GOC:tb http://purl.org/obo/owl/GOC#GOC_tb PACAP receptor pituitary adenylate cyclase activating polypeptide receptor pituitary adenylate cyclase activating protein receptor activity GOC:dph http://purl.org/obo/owl/GOC#GOC_dph GOC:tb http://purl.org/obo/owl/GOC#GOC_tb pituitary adenylate cyclase-activating peptide receptor activity pituitary adenylate cyclase-activating polypeptide receptor activity pituitary adenylyl cyclase activating protein receptor activity molecular_function GO:0016522 Reactome:272 http://purl.org/obo/owl/Reactome#Reactome_272 calcitonin gene-related polypeptide receptor activity CGRP receptor molecular_function Wikipedia:CALCRL http://purl.org/obo/owl/Wikipedia#Wikipedia_CALCRL corticotrophin-releasing factor gastric inhibitory peptide-like receptor activity This term was made obsolete because it represents a gene product, was not defined, and is named based on protein features. OBSOLETE (was not defined before being made obsolete). GOC:mah http://purl.org/obo/owl/GOC#GOC_mah molecular_function G-protein chemoattractant receptor activity G protein chemoattractant receptor activity molecular_function PLC activating metabotropic glutamate receptor activity A G-protein coupled receptor that binds glutamate and is linked to the inositol 1,4,5-trisphosphate/calcium signaling system. PMID:9016303 http://purl.org/obo/owl/PMID#PMID_9016303 Group I metabotropic glutamate receptor group I metabotropic glutamate receptor activity phospholipase C activating metabotropic glutamate receptor activity molecular_function adenylate cyclase inhibiting metabotropic glutamate receptor activity A G-protein coupled receptor that binds glutamate and inhibits adenylate cyclase activity. GOC:dph http://purl.org/obo/owl/GOC#GOC_dph adenylyl cyclase inhibiting metabotropic glutamate receptor activity molecular_function group II metabotropic glutamate receptor activity A G-protein coupled receptor that is activated by trans-1-aminocyclopentane-1,3-dicarboxylic acid (t-ACPD) and inhibits adenylate cyclase activity. GOC:dph http://purl.org/obo/owl/GOC#GOC_dph molecular_function group III metabotropic glutamate receptor activity A G-protein coupled receptor that is activated by L-AP-4 and inhibits adenylate cyclase activity. PMID:9016303 http://purl.org/obo/owl/PMID#PMID_9016303 molecular_function cAMP receptor activity Combining with cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate) to initiate a change in cell activity. GOC:pg http://purl.org/obo/owl/GOC#GOC_pg 3',5' cAMP receptor activity 3',5'-cAMP receptor activity adenosine 3',5'-cyclophosphate receptor activity class E G protein coupled receptor class E G-protein coupled receptor class E GPCR cyclic AMP receptor activity molecular_function GO:0001644 G-protein coupled cytokinin receptor activity Combining with a cytokinin to initiate a change in cell activity. The receptor is G-protein coupled. GOC:dph http://purl.org/obo/owl/GOC#GOC_dph G protein coupled cytokinin receptor activity G-protein-coupled cytokinin receptor activity molecular_function proteinase activated receptor activity molecular_function peptide receptor activity Combining with an extracellular or intracellular peptide to initiate a change in cell activity. GOC:jl http://purl.org/obo/owl/GOC#GOC_jl endogenous peptide receptor activity exogenous peptide receptor activity molecular_function G-protein-coupled receptor binding Interacting selectively and non-covalently with a G-protein-coupled receptor. GOC:ceb http://purl.org/obo/owl/GOC#GOC_ceb GOC:dph http://purl.org/obo/owl/GOC#GOC_dph G protein coupled receptor binding G protein coupled receptor ligand G-protein-coupled receptor ligand molecular_function Reactome:260 http://purl.org/obo/owl/Reactome#Reactome_260 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity Catalysis of the reaction: CMP-N-acetylneuraminate + glycano-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein = CMP + glycano-(2,6-alpha-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)-glycoprotein. EC:2.4.99.3 http://purl.org/obo/owl/EC#EC_2.4.99.3 CMP-N-acetylneuraminate:glycano-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein alpha-2,6-N-acetylneuraminyltransferase activity EC:2.4.99.3 http://purl.org/obo/owl/EC#EC_2.4.99.3 GalNAc alpha-2,6-sialyltransferase I activity EC:2.4.99.3 http://purl.org/obo/owl/EC#EC_2.4.99.3 molecular_function EC:2.4.99.3 http://purl.org/obo/owl/EC#EC_2.4.99.3 MetaCyc:2.4.99.3-RXN http://purl.org/obo/owl/MetaCyc#MetaCyc_2.4.99.3-RXN dopamine D2 receptor activity A G-protein coupled receptor that binds dopamine and has the pharmacological characteristics of classic D2 receptors. IUPHAR_RECEPTOR:2254 http://purl.org/obo/owl/IUPHAR_RECEPTOR#IUPHAR_RECEPTOR_2254 molecular_function ATPase activator activity Functions to increase the rate of ATP hydrolysis. GOC:ajp http://purl.org/obo/owl/GOC#GOC_ajp ATPase stimulator activity molecular_function sialate O-acetylesterase activity Catalysis of the reaction: N-acetyl-O-acetylneuraminate (free or glycosidically bound) + H2O = N-acetylneuraminate + acetate. EC:3.1.1.53 http://purl.org/obo/owl/EC#EC_3.1.1.53 PMID:1991039 http://purl.org/obo/owl/PMID#PMID_1991039 N-acetylneuraminate acetyltransferase activity EC:3.1.1.53 http://purl.org/obo/owl/EC#EC_3.1.1.53 N-acyl-O-acetylneuraminate O-acetylhydrolase activity EC:3.1.1.53 http://purl.org/obo/owl/EC#EC_3.1.1.53 sialate 9(4)-O-acetylesterase activity molecular_function EC:3.1.1.53 http://purl.org/obo/owl/EC#EC_3.1.1.53 MetaCyc:SIALATE-O-ACETYLESTERASE-RXN http://purl.org/obo/owl/MetaCyc#MetaCyc_SIALATE-O-ACETYLESTERASE-RXN pseudophosphatase activity Maintains the phosphorylation state of certain molecules by associating with them and preventing them from associating with active phosphatases, and thus inhibiting the enzyme activity without interacting with the enzyme. Often pertains to proteins belonging to dual-specificity phosphatase family but lacking critical active site residues. GOC:ajp http://purl.org/obo/owl/GOC#GOC_ajp molecular_function L-amino-acid oxidase activity Catalysis of the reaction: a L-amino acid + H2O + O2 = a 2-oxo acid + NH3 + H2O2. EC:1.4.3.2 http://purl.org/obo/owl/EC#EC_1.4.3.2 L-amino-acid:oxygen oxidoreductase (deaminating) EC:1.4.3.2 http://purl.org/obo/owl/EC#EC_1.4.3.2 ophio-amino-acid oxidase activity EC:1.4.3.2 http://purl.org/obo/owl/EC#EC_1.4.3.2 molecular_function EC:1.4.3.2 http://purl.org/obo/owl/EC#EC_1.4.3.2 MetaCyc:L-AMINO-ACID-OXIDASE-RXN http://purl.org/obo/owl/MetaCyc#MetaCyc_L-AMINO-ACID-OXIDASE-RXN lipid kinase activity Catalysis of the phosphorylation of a simple or complex lipid. GOC:hjd http://purl.org/obo/owl/GOC#GOC_hjd molecular_function ceramide kinase activity Catalysis of the reaction: ATP + ceramide = ADP + ceramide 1-phosphate. EC:2.7.1.138 http://purl.org/obo/owl/EC#EC_2.7.1.138 acylsphingosine kinase activity EC:2.7.1.138 http://purl.org/obo/owl/EC#EC_2.7.1.138 ATP:ceramide 1-phosphotransferase activity EC:2.7.1.138 http://purl.org/obo/owl/EC#EC_2.7.1.138 molecular_function EC:2.7.1.138 http://purl.org/obo/owl/EC#EC_2.7.1.138 MetaCyc:CERAMIDE-KINASE-RXN http://purl.org/obo/owl/MetaCyc#MetaCyc_CERAMIDE-KINASE-RXN 2'-5'-oligoadenylate synthetase activity Catalysis of the reaction: ATP = pppA(2'p5'A)n oligomers. Requires binding of double-stranded RNA. ISBN:0198506732 http://purl.org/obo/owl/ISBN#ISBN_0198506732 (2-5')oligo(A) synthetase activity 2'-5' oligoadenylate synthetase activity 2-5A synthetase activity oligo-2',5'-adenylate synthetase activity molecular_function galactosylceramide sulfotransferase activity Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + a galactosylceramide = adenosine 3',5'-bisphosphate + a galactosylceramidesulfate. EC:2.8.2.11 http://purl.org/obo/owl/EC#EC_2.8.2.11 PMID:10727929 http://purl.org/obo/owl/PMID#PMID_10727929 3'-phosphoadenosine-5'-phosphosulfate-cerebroside sulfotransferase activity EC:2.8.2.11 http://purl.org/obo/owl/EC#EC_2.8.2.11 3'-phosphoadenylyl-sulfate:galactosylceramide 3'-sulfotransferase activity EC:2.8.2.11 http://purl.org/obo/owl/EC#EC_2.8.2.11 cerebroside sulfotransferase activity galactocerebroside sulfotransferase activity EC:2.8.2.11 http://purl.org/obo/owl/EC#EC_2.8.2.11 galactolipid sulfotransferase activity EC:2.8.2.11 http://purl.org/obo/owl/EC#EC_2.8.2.11 galactosylceramide sulphotransferase activity glycolipid sulfotransferase activity EC:2.8.2.11 http://purl.org/obo/owl/EC#EC_2.8.2.11 glycosphingolipid sulfotransferase activity EC:2.8.2.11 http://purl.org/obo/owl/EC#EC_2.8.2.11 GSase EC:2.8.2.11 http://purl.org/obo/owl/EC#EC_2.8.2.11 molecular_function EC:2.8.2.11 http://purl.org/obo/owl/EC#EC_2.8.2.11 MetaCyc:GALACTOSYLCERAMIDE-SULFOTRANSFERASE-RXN http://purl.org/obo/owl/MetaCyc#MetaCyc_GALACTOSYLCERAMIDE-SULFOTRANSFERASE-RXN mRNA (N6-adenosine)-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + RRACH = S-adenosyl-L-homocysteine + RRm6ACH; R = purine, and H = C, A, or U. GOC:hjd http://purl.org/obo/owl/GOC#GOC_hjd molecular_function Reactome:2399 http://purl.org/obo/owl/Reactome#Reactome_2399 prenylcysteine oxidase activity Catalysis of the reaction: S-prenyl-L-cysteine + O2 + H20 = a prenal + L-cysteine + H202. GOC:hjd http://purl.org/obo/owl/GOC#GOC_hjd prenylcysteine lyase activity EC:1.8.3.5 http://purl.org/obo/owl/EC#EC_1.8.3.5 S-prenyl-L-cysteine:oxygen oxidoreductase activity EC:1.8.3.5 http://purl.org/obo/owl/EC#EC_1.8.3.5 molecular_function EC:1.8.3.5 http://purl.org/obo/owl/EC#EC_1.8.3.5 MetaCyc:1.8.3.5-RXN http://purl.org/obo/owl/MetaCyc#MetaCyc_1.8.3.5-RXN retinal dehydrogenase activity Catalysis of the reaction: retinal + NAD+ + H2O = retinoate + NADH. Acts on both 11-trans and 13-cis forms of retinal. EC:1.2.1.36 http://purl.org/obo/owl/EC#EC_1.2.1.36 cytosolic retinal dehydrogenase activity EC:1.2.1.36 http://purl.org/obo/owl/EC#EC_1.2.1.36 retinal:NAD+ oxidoreductase activity EC:1.2.1.36 http://purl.org/obo/owl/EC#EC_1.2.1.36 molecular_function EC:1.2.1.36 http://purl.org/obo/owl/EC#EC_1.2.1.36 MetaCyc:RETINAL-DEHYDROGENASE-RXN http://purl.org/obo/owl/MetaCyc#MetaCyc_RETINAL-DEHYDROGENASE-RXN aminocarboxymuconate-semialdehyde decarboxylase activity Catalysis of the reaction: 2-amino-3-(3-oxoprop-2-enyl)-but-2-enedioate = 2-aminomuconate semialdehyde + CO2. EC:4.1.1.45 http://purl.org/obo/owl/EC#EC_4.1.1.45 2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate carboxy-lyase (2-aminomuconate-semialdehyde-forming) EC:4.1.1.45 http://purl.org/obo/owl/EC#EC_4.1.1.45 2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate carboxy-lyase activity EC:4.1.1.45 http://purl.org/obo/owl/EC#EC_4.1.1.45 2-amino-3-(3-oxoprop-2-enyl)but-2-enedioate carboxy-lyase activity EC:4.1.1.45 http://purl.org/obo/owl/EC#EC_4.1.1.45 alpha-amino-beta-carboxymuconate-epsilon-semialdehade decarboxylase activity EC:4.1.1.45 http://purl.org/obo/owl/EC#EC_4.1.1.45 alpha-amino-beta-carboxymuconate-epsilon-semialdehyde beta-decarboxylase activity EC:4.1.1.45 http://purl.org/obo/owl/EC#EC_4.1.1.45 picolinic acid carboxylase activity EC:4.1.1.45 http://purl.org/obo/owl/EC#EC_4.1.1.45 picolinic acid decarboxylase activity EC:4.1.1.45 http://purl.org/obo/owl/EC#EC_4.1.1.45 molecular_function EC:4.1.1.45 http://purl.org/obo/owl/EC#EC_4.1.1.45 MetaCyc:AMINO-CARBOXYMUCONATE-SEMIALDEHYDE-RXN http://purl.org/obo/owl/MetaCyc#MetaCyc_AMINO-CARBOXYMUCONATE-SEMIALDEHYDE-RXN beta-alanine transmembrane transporter activity Catalysis of the transfer of beta-alanine from one side of a membrane to the other. Beta-alanine is 3-aminopropanoic acid. GOC:hjd http://purl.org/obo/owl/GOC#GOC_hjd beta-alanine transporter activity molecular_function phosphotyrosine binding Interacting selectively and non-covalently with a phosphorylated tyrosine residue within a protein. PMID:14636584 http://purl.org/obo/owl/PMID#PMID_14636584 molecular_function prostaglandin J receptor activity Combining with prostaglandin J (PGJ(2)), a metabolite of prostaglandin D (PGD(2)) to initiate a change in cell activity. PMID:12878180 http://purl.org/obo/owl/PMID#PMID_12878180 PGJ receptor activity PGJ(2) receptor activity molecular_function phosphatidylserine binding Interacting selectively and non-covalently with phosphatidylserine, a class of glycophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of L-serine. ISBN:0198506732 http://purl.org/obo/owl/ISBN#ISBN_0198506732 PMID:12000961 http://purl.org/obo/owl/PMID#PMID_12000961 molecular_function polymeric immunoglobulin binding Interacting selectively and non-covalently with a J-chain-containing polymeric immunoglobulin of the IgA or IgM isotypes. GOC:add http://purl.org/obo/owl/GOC#GOC_add ISBN:0781735149 http://purl.org/obo/owl/ISBN#ISBN_0781735149 molecular_function IgM binding Interacting selectively and non-covalently with an immunoglobulin of the IgM isotype. GOC:add http://purl.org/obo/owl/GOC#GOC_add ISBN:0781735149 http://purl.org/obo/owl/ISBN#ISBN_0781735149 molecular_function polymeric immunoglobulin receptor activity Combining with a J-chain-containing polymeric immunoglobulin of the IgA or IgM isotypes via the Fc region to initiate a change in cell activity. GOC:add http://purl.org/obo/owl/GOC#GOC_add ISBN:0781735149 http://purl.org/obo/owl/ISBN#ISBN_0781735149 molecular_function IgM receptor activity Combining with an immunoglobulin of the IgM isotype via the Fc region to initiate a change in cell activity. GOC:add http://purl.org/obo/owl/GOC#GOC_add ISBN:0781735149 http://purl.org/obo/owl/ISBN#ISBN_0781735149 molecular_function opsonin binding Note that an opsonin is a blood serum protein or fragment which when deposited on the surface of a bacteria, virus, immune complex, or other particulate material acts a signal for phagocytosis to cells bearing the appropriate receptors. Not all complement components or fragments and not all antibodies have opsonic properties. Interacting selectively and non-covalently with an opsonin, such as a complement component or antibody, deposited on the surface of a bacteria, virus, immune complex, or other particulate material. GOC:add http://purl.org/obo/owl/GOC#GOC_add ISBN:0781735149 http://purl.org/obo/owl/ISBN#ISBN_0781735149 molecular_function opsonin receptor activity Combining with an opsonin to initiate a change in cell activity. GOC:add http://purl.org/obo/owl/GOC#GOC_add ISBN:0781735149 http://purl.org/obo/owl/ISBN#ISBN_0781735149 molecular_function complement binding Note that the complement cascade includes all of the components involved in the classical complement pathway, the alternative complement pathway, and the lectin complement pathway, as well as the common components of all three pathways. Interacting selectively and non-covalently with any component or product of the complement cascade. GOC:add http://purl.org/obo/owl/GOC#GOC_add ISBN:0781735149 http://purl.org/obo/owl/ISBN#ISBN_0781735149 molecular_function complement component C1q binding Interacting selectively and non-covalently with the C1q component of the classical complement cascade. GOC:add http://purl.org/obo/owl/GOC#GOC_add ISBN:0781735149 http://purl.org/obo/owl/ISBN#ISBN_0781735149 molecular_function complement component C3a binding Interacting selectively and non-covalently with the C3a product of the complement cascade. GOC:add http://purl.org/obo/owl/GOC#GOC_add ISBN:0781735149 http://purl.org/obo/owl/ISBN#ISBN_0781735149 molecular_function complement component C3b binding Interacting selectively and non-covalently with the C3b product of the complement cascade. GOC:add http://purl.org/obo/owl/GOC#GOC_add ISBN:0781735149 http://purl.org/obo/owl/ISBN#ISBN_0781735149 molecular_function complement component iC3b binding Interacting selectively and non-covalently with the iC3b product of the complement cascade. GOC:add http://purl.org/obo/owl/GOC#GOC_add ISBN:0781735149 http://purl.org/obo/owl/ISBN#ISBN_0781735149 molecular_function complement component C3dg binding Interacting selectively and non-covalently with the C3dg product of the complement cascade. GOC:add http://purl.org/obo/owl/GOC#GOC_add ISBN:0781735149 http://purl.org/obo/owl/ISBN#ISBN_0781735149 molecular_function complement component C3d binding Interacting selectively and non-covalently with the C3d product of the complement cascade. GOC:add http://purl.org/obo/owl/GOC#GOC_add ISBN:0781735149 http://purl.org/obo/owl/ISBN#ISBN_0781735149 molecular_function complement component C4b binding Interacting selectively and non-covalently with the C4b product of the classical complement cascade. GOC:add http://purl.org/obo/owl/GOC#GOC_add ISBN:0781735149 http://purl.org/obo/owl/ISBN#ISBN_0781735149 molecular_function complement component C5a binding Interacting selectively and non-covalently with the C5a product of the complement cascade. GOC:add http://purl.org/obo/owl/GOC#GOC_add ISBN:0781735149 http://purl.org/obo/owl/ISBN#ISBN_0781735149 molecular_function complement component C1q receptor activity Combining with the C1q component of the classical complement cascade to initiate a change in cell activity. GOC:add http://purl.org/obo/owl/GOC#GOC_add ISBN:0781735149 http://purl.org/obo/owl/ISBN#ISBN_0781735149 molecular_function complement component iC3b receptor activity Combining with the iC3b product of the complement cascade to initiate a change in cell activity. GOC:add http://purl.org/obo/owl/GOC#GOC_add ISBN:0781735149 http://purl.org/obo/owl/ISBN#ISBN_0781735149 molecular_function complement component C3dg receptor activity Combining with the C3dg product of the complement cascade to initiate a change in cell activity. GOC:add http://purl.org/obo/owl/GOC#GOC_add ISBN:0781735149 http://purl.org/obo/owl/ISBN#ISBN_0781735149 molecular_function complement component C3d receptor activity Combining with the C3d product of the complement cascade to initiate a change in cell activity. GOC:add http://purl.org/obo/owl/GOC#GOC_add ISBN:0781735149 http://purl.org/obo/owl/ISBN#ISBN_0781735149 molecular_function complement component C4b receptor activity Combining with the C4b product of the classical complement cascade to initiate a change in cell activity. GOC:add http://purl.org/obo/owl/GOC#GOC_add ISBN:0781735149 http://purl.org/obo/owl/ISBN#ISBN_0781735149 molecular_function collectin binding Note that collectins include such proteins as mannose-binding lectins (MBL) and surfactant proteins A and D (SP-A and SP-D). Interacting selectively and non-covalently with a collectin, a member of a group of structurally related pattern recognition molecules characterized by having a carbohydrate recognition domain of the C-type lectin family at the C-terminus and a collagenous domain at the N-terminus. GOC:add http://purl.org/obo/owl/GOC#GOC_add ISBN:0781735149 http://purl.org/obo/owl/ISBN#ISBN_0781735149 molecular_function collectin receptor activity Note that collectins include such proteins as mannose-binding lectin (MBL) and surfactant proteins A and D (SP-A and SP-D). Combining with a collectin to initiate a change in cell activity. GOC:add http://purl.org/obo/owl/GOC#GOC_add ISBN:0781735149 http://purl.org/obo/owl/ISBN#ISBN_0781735149 molecular_function pentraxin binding Note that pentraxins include such proteins as serum amyloid P component (SAP) and C-reactive protein (CRP). Interacting selectively and non-covalently with a pentraxin, a member of a family of inflammatory proteins with a radially symmetric arrangement of five identical, noncovalently linked chains in a pentagonal array. GOC:add http://purl.org/obo/owl/GOC#GOC_add ISBN:0781735149 http://purl.org/obo/owl/ISBN#ISBN_0781735149 molecular_function pattern binding Note that this term and its child terms are intended for annotation of gene products which function to recognize (bind) the repeating structural units such as polysaccharides or peptidoglycans commonly found in microbial cell walls and virions. If such binding is coupled to signal transduction, use 'pattern recognition receptor activity ; GO:0008329' instead. Interacting selectively and non-covalently with a repeating or polymeric structure, such as a polysaccharide or peptidoglycan. PMID:12072369 http://purl.org/obo/owl/PMID#PMID_12072369 PMID:12225919 http://purl.org/obo/owl/PMID#PMID_12225919 PMID:12507420 http://purl.org/obo/owl/PMID#PMID_12507420 PMID:12925128 http://purl.org/obo/owl/PMID#PMID_12925128 PMID:14523544 http://purl.org/obo/owl/PMID#PMID_14523544 pattern recognition activity molecular_function zymosan binding Interacting selectively and non-covalently with zymosan. PMID:14707091 http://purl.org/obo/owl/PMID#PMID_14707091 molecular_function polysaccharide receptor activity Combining with a polysaccharide to initiate a change in cell activity. PMID:14707091 http://purl.org/obo/owl/PMID#PMID_14707091 molecular_function zymosan receptor activity Combining with zymosan to initiate a change in cell activity. PMID:14707091 http://purl.org/obo/owl/PMID#PMID_14707091 molecular_function lipopolysaccharide receptor activity Combining with a lipopolysaccharide to initiate a change in cell activity. Lipopolysaccharides (LPS) are major components of the outer membrane of Gram-negative bacteria, making them prime targets for recognition by the immune system. PMID:14609719 http://purl.org/obo/owl/PMID#PMID_14609719 PMID:15379975 http://purl.org/obo/owl/PMID#PMID_15379975 endotoxin receptor activity LPS receptor activity molecular_function lipoarabinomannan binding Interacting selectively and non-covalently with lipoarabinomannan. PMID:10586073 http://purl.org/obo/owl/PMID#PMID_10586073 LAM binding molecular_function lipoarabinomannan receptor activity Combining with lipoarabinomannan to initiate a change in cell activity. PMID:10586073 http://purl.org/obo/owl/PMID#PMID_10586073 LAM receptor activity molecular_function nucleoside binding Interacting selectively and non-covalently with a nucleoside, a compound consisting of a purine or pyrimidine nitrogenous base linked either to ribose or deoxyribose. GOC:hjd http://purl.org/obo/owl/GOC#GOC_hjd molecular_function purine nucleoside binding Interacting selectively and non-covalently with a purine nucleoside, a compound consisting of a purine base linked either to ribose or deoxyribose. GOC:hjd http://purl.org/obo/owl/GOC#GOC_hjd molecular_function pyrimidine nucleoside binding Interacting selectively and non-covalently with a pyrimidine nucleoside, a compound consisting of a pyrimidine base linked either to ribose or deoxyribose. GOC:hjd http://purl.org/obo/owl/GOC#GOC_hjd molecular_function glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-glucuronosyl-(1,3)-beta-D-galactosyl-(1,3)-beta-D-galactosyl-(1,4)-beta-D-xylosyl-proteoglycan = UDP + alpha-N-acetyl-D-glucosaminyl-(1,4)-beta-D-glucuronosyl-(1,3)-beta-D-galactosyl-(1,3)-beta-D-galactosyl-(1,4)-beta-D-xylosyl-proteoglycan. EC:2.4.1.223 http://purl.org/obo/owl/EC#EC_2.4.1.223 alpha-1,4-N-acetylglucosaminyltransferase activity EC:2.4.1.223 http://purl.org/obo/owl/EC#EC_2.4.1.223 alpha-N-acetylglucosaminyltransferase I activity EC:2.4.1.223 http://purl.org/obo/owl/EC#EC_2.4.1.223 alpha1,4-N-acetylglucosaminyltransferase activity EC:2.4.1.223 http://purl.org/obo/owl/EC#EC_2.4.1.223 glucuronosylgalactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity EC:2.4.1.223 http://purl.org/obo/owl/EC#EC_2.4.1.223 UDP-N-acetyl-D-glucosamine:beta-D-glucuronosyl-(1->3)-beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl-proteoglycan 4IV-alpha-N-acetyl-D-glucosaminyltransferase activity EC:2.4.1.223 http://purl.org/obo/owl/EC#EC_2.4.1.223 molecular_function EC:2.4.1.223 http://purl.org/obo/owl/EC#EC_2.4.1.223 MetaCyc:2.4.1.223-RXN http://purl.org/obo/owl/MetaCyc#MetaCyc_2.4.1.223-RXN farnesylated protein binding Interacting selectively and non-covalently with a farnesylated protein. GOC:add http://purl.org/obo/owl/GOC#GOC_add PMID:14555765 http://purl.org/obo/owl/PMID#PMID_14555765 molecular_function glycoprotein binding Interacting selectively and non-covalently with a glycoprotein, a protein that contains covalently bound glycose (monosaccharide) residues. These also include proteoglycans. GOC:hjd http://purl.org/obo/owl/GOC#GOC_hjd ISBN:0198506732 http://purl.org/obo/owl/ISBN#ISBN_0198506732 molecular_function alpha-1,3-galactosyltransferase activity Catalysis of the transfer of a galactose residue from a donor molecule, such as GDP-galactose or UDP-galactose, to an oligosaccharide, forming an alpha-1,3-linkage. GOC:hjd http://purl.org/obo/owl/GOC#GOC_hjd PMID:10854427 http://purl.org/obo/owl/PMID#PMID_10854427 isoglobotriaosylceramide synthase molecular_function EC:2.4.1.- http://purl.org/obo/owl/EC#EC_2.4.1.- G-protein alpha-subunit binding Interacting selectively and non-covalently with a G-protein alpha subunit. The alpha subunit binds a guanine nucleotide. GOC:hjd http://purl.org/obo/owl/GOC#GOC_hjd G-alpha protein subunit binding molecular_function fibronectin binding Interacting selectively and non-covalently with a fibronectin, a group of related adhesive glycoproteins of high molecular weight found on the surface of animal cells, connective tissue matrices, and in extracellular fluids. GOC:hjd http://purl.org/obo/owl/GOC#GOC_hjd molecular_function retinoic acid binding Interacting selectively and non-covalently with retinoic acid, 3,7-dimethyl-9-(2,6,-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acid. GOC:hjd http://purl.org/obo/owl/GOC#GOC_hjd molecular_function protease binding Interacting selectively and non-covalently with any protease or peptidase. GOC:hjd http://purl.org/obo/owl/GOC#GOC_hjd molecular_function p53 binding Interacting selectively and non-covalently with one of the p53 family of proteins. GOC:hjd http://purl.org/obo/owl/GOC#GOC_hjd molecular_function opsin binding Interacting selectively and non-covalently with an opsin, any of a group of hydrophobic, integral membrane glycoproteins located primarily in the disc membrane of rods or cones, involved in photoreception. GOC:hjd http://purl.org/obo/owl/GOC#GOC_hjd molecular_function nucleobase binding Interacting selectively and non-covalently with a nucleobase, any of a class of pyrmidines or purines, organic nitrogenous bases. GOC:hjd http://purl.org/obo/owl/GOC#GOC_hjd molecular_function adenine binding Interacting selectively and non-covalently with adenine, a purine base. GOC:hjd http://purl.org/obo/owl/GOC#GOC_hjd 6-aminopurine binding molecular_function cytosine binding Interactiing selectively with cytosine. GOC:hjd http://purl.org/obo/owl/GOC#GOC_hjd molecular_function guanine binding Interacting selectively and non-covalently with guanine. GOC:hjd http://purl.org/obo/owl/GOC#GOC_hjd molecular_function uracil binding Interacting selectively and non-covalently with uracil. GOC:hjd http://purl.org/obo/owl/GOC#GOC_hjd molecular_function thymine binding Interacting selectively and non-covalently with thymine. GOC:hjd http://purl.org/obo/owl/GOC#GOC_hjd molecular_function purine binding Interacting selectively and non-covalently with a purine, an organic nitrogenous base. GOC:hjd