12:07:2006 10:36 julie mao.obo autogenerated-by: DAG-Edit version 1.418 saved-by: julie date: Fri Jan 07 11:14:23 CET 2005 version: $Revision: 1.30 $ mao.obo This is an OWL translation of an ontology whose native representational form is .obo. The translation was performed using the oboInOwl xslt library. For details, see http://www.berkeleybop.org/obo-conv.cgi multiple_sequence_alignment A representation of a set of sequences, in which structurally or functionally equivalent residues are aligned together. The rows of the multiple alignment represent the different sequences, while the columns represent equivalent residues. Insertions/deletions in the sequences are represented by one or more gap characters. MAO:jt http://purl.org/obo/owl/MAO#MAO_jt msa mao.obo structural_location The location of the residue in the 3D structure. MAO:jt http://purl.org/obo/owl/MAO#MAO_jt mao.obo residue_function Function of the residue, such as catalysis, binding or post-translational modification. A residue may exhibit zero, one or more activities. MAO:jt http://purl.org/obo/owl/MAO#MAO_jt mao.obo column_conservation_level The level of conservation associated with a given column. This may be specified by either a qualitative score or a quantitative score. MAO:jt http://purl.org/obo/owl/MAO#MAO_jt mao.obo conserved_residue_list A user specified list of conserved residues. MAO:jt http://purl.org/obo/owl/MAO#MAO_jt mao.obo biological_process GeneOntology interface GO:0008150 http://purl.org/obo/owl/GO#GO_0008150 mao.obo cellular_component GeneOntology interface GO:0005575 http://purl.org/obo/owl/GO#GO_0005575 mao.obo molecular_function GeneOntology interface GO:0003674 http://purl.org/obo/owl/GO#GO_0003674 mao.obo conserved_small_residue A conserved small residue e.g. PAGST MAO:jt http://purl.org/obo/owl/MAO#MAO_jt mao.obo conserved_negatively_charged_residue A conserved negatively charged residue e.g. DE MAO:jt http://purl.org/obo/owl/MAO#MAO_jt mao.obo conserved_hydrophobic_residue A conserved hydrophobic residue e.g. ACFGLIMVWY MAO:jt http://purl.org/obo/owl/MAO#MAO_jt mao.obo conserved_hydrophilic_residue A conserved hydrophilic residue e.g. DEHKNQRST MAO:jt http://purl.org/obo/owl/MAO#MAO_jt mao.obo quantitative_conservation_level A quantitative score for the conservation associated with a given column. MAO:jt http://purl.org/obo/owl/MAO#MAO_jt mao.obo qualitative_conservation_level A qualitative description of the level of conservation associated with a given column. MAO:jt http://purl.org/obo/owl/MAO#MAO_jt mao.obo low_conservation A low level of conservation associated with a given column. MAO:jt http://purl.org/obo/owl/MAO#MAO_jt mao.obo medium_conservation A medium level of conservation associated with a given column. MAO:jt http://purl.org/obo/owl/MAO#MAO_jt mao.obo high_conservation A high level of conservation associated with a given column. MAO:jt http://purl.org/obo/owl/MAO#MAO_jt mao.obo catalytic_site A residue that is directly involved in some aspect of the reaction catalysed by the enzyme. MAO:jt http://purl.org/obo/owl/MAO#MAO_jt mao.obo domain A discrete portion of a protein assumed to fold independently of the rest of the protein and possessing its own function. [NCBI Bioinformatics] A region of a proteins amino acid sequence that has evolutionary, structural, or functional significance. The amino acid sequence of a domain determines a proteins 3D structure. [CHI Structural proteomics report] MAO:jt http://purl.org/obo/owl/MAO#MAO_jt mao.obo post translational modification A sequence modification that occurs after synthesis of the protein on the ribosome. e.g. cleavage (thus eliminating signal sequences, transit or pro- peptides and initiator methionines) or addition of simple chemical groups or more complex molecules, such as sugars and lipids. (Human Proteomics Initiative) http://www.expasy.ch/sprot/hpi/ n MAO:jt http://purl.org/obo/owl/MAO#MAO_jt ptm mao.obo psi_mutation PSI interface MI:0118 http://purl.org/obo/owl/MI#MI_0118 mao.obo msa_construction_method The method used to construct the multiple sequence alignment. MAO:jt http://purl.org/obo/owl/MAO#MAO_jt mao.obo surface_accessibility Surface area accessible to solvent MAO:jt http://purl.org/obo/owl/MAO#MAO_jt mao.obo N_terminal A residue in a protein chain that has a free amino group. MAO:jt http://purl.org/obo/owl/MAO#MAO_jt amino_terminus mao.obo C_terminal A residue in a protein chain that has a free carboxyl group. MAO:jt http://purl.org/obo/owl/MAO#MAO_jt carboxyl_terminus mao.obo in_domain A residue in a domain i.e. in a discrete portion of a protein assumed to fold independently of the rest of the protein and possessing its own function. [NCBI Bioinformatics] MAO:jt http://purl.org/obo/owl/MAO#MAO_jt mao.obo in_hinge_region A residue in a hinge region i.e. a flexible region of the protein between two globular domains. MAO:jt http://purl.org/obo/owl/MAO#MAO_jt mao.obo in_transmembrane_region A residue in a transmembrane region i.e. in a domain in a amphipathic membrane protein where the hydrophobic regions traverse the lipid bilayers of the membranes, while the hydrophilic regions extend on either side of the membrane and interact with water.[Folding@home glossary, Stanford Univ]. MAO:jt http://purl.org/obo/owl/MAO#MAO_jt mao.obo in_helix A residue in a helical portion of a protein structure i.e. in a frequently highly stable protein chain conformation stabilised by hydrogen bonding between peptide groups and having side chains projecting outwards in a spiral (3.6 residues per turn). [The Biochemical Society Glossary]. MAO:jt http://purl.org/obo/owl/MAO#MAO_jt mao.obo in_strand A residue in a beta_strand i.e. a stable "zig-zag" conformation of protein chain which can align with sections of chain in same conformation and cross-link efficiently via hydrogen bonds between the peptide linkages. [The Biochemical Society Glossary]. MAO:jt http://purl.org/obo/owl/MAO#MAO_jt in_beta_strand mao.obo in_loop A residue in a loop i.e. a section of the protein chain connecting classical secondary structures like helix and sheet. [The Biochemical Society Glossary]. MAO:jt http://purl.org/obo/owl/MAO#MAO_jt mao.obo sub_alignment A subset of sequences in the msa. e.g. a phylogenetic subgroup such as 'mammals', or a sequence cluster calculated by an automatic method such as secator/dpc or any other subset. MAO:jt http://purl.org/obo/owl/MAO#MAO_jt cluster group sub_group mao.obo residue The part of a single sugar that appears in a polysaccharide; of a single amino acid in a protein; of a single nucleotide in a nucleic acid, etc.; usually the monomer minus the elements of water.Glossary of Biochemistry and Molecular Biology, David M. Glick. MAO:jt http://purl.org/obo/owl/MAO#MAO_jt mao.obo gap_character The character used to represent an insertion/deletion. MAO:jt http://purl.org/obo/owl/MAO#MAO_jt mao.obo unknown_residue_function mao.obo unknown_structural_location mao.obo kegg_id KEGG interface KEGG:xref http://purl.org/obo/owl/KEGG#KEGG_xref mao.obo alignment_sequence The order of residues and insertions/deletions represented by gap characters in a single sequence. For proteins, this is known as the primary structure. MAO:jt http://purl.org/obo/owl/MAO#MAO_jt mao.obo sequence_name The name given to the sequence. MAO:jt http://purl.org/obo/owl/MAO#MAO_jt mao.obo column_score A score associated with a given column. MAO:jt http://purl.org/obo/owl/MAO#MAO_jt mao.obo column_conservation_type The type of residue conserved in a given column. MAO:jt http://purl.org/obo/owl/MAO#MAO_jt mao.obo organism The organism that was the source of the sequence. MAO:jt http://purl.org/obo/owl/MAO#MAO_jt mao.obo sequence_feature A region of the sequence, defined by a start and stop residue, that has a specific property. MAO:jt http://purl.org/obo/owl/MAO#MAO_jt fitem mao.obo feature_start_residue The residue at the beginning of the feature. MAO:jt http://purl.org/obo/owl/MAO#MAO_jt mao.obo feature_stop_residue The residue at the end of the feature. MAO:jt http://purl.org/obo/owl/MAO#MAO_jt mao.obo consensus_sequence A pseudo-sequence that summarises the residue information contained in an aligned set of sequences. MAO:jt http://purl.org/obo/owl/MAO#MAO_jt mao.obo column_weight A weight associated with a given column. MAO:jt http://purl.org/obo/owl/MAO#MAO_jt mao.obo sequence_weight A weight assigned to a sequence. MAO:jt http://purl.org/obo/owl/MAO#MAO_jt mao.obo feature_description A general text description of the feature. MAO:jt http://purl.org/obo/owl/MAO#MAO_jt mao.obo protein:protein interactions PSI interface MI:0000 http://purl.org/obo/owl/MI#MI_0000 mao.obo msa_name The name given to the multiple sequence alignment. MAO:jt http://purl.org/obo/owl/MAO#MAO_jt mao.obo ec_number Enzyme Commission interface EC:xref http://purl.org/obo/owl/EC#EC_xref mao.obo hydrophobicity A measure of how insoluble a given molecule is when in water or other polar liquids. MAO:jt http://purl.org/obo/owl/MAO#MAO_jt mao.obo feature_name The name given to the feature. MAO:jt http://purl.org/obo/owl/MAO#MAO_jt mao.obo sequence_feature_type The type of the sequence feature. MAO:jt http://purl.org/obo/owl/MAO#MAO_jt mao.obo interpro_domain Interpro interface IPR:xref http://purl.org/obo/owl/IPR#IPR_xref mao.obo transmembrane_helix tm mao.obo coiled_coil mao.obo msa_core_block A conserved region in the sub_alignment. MAO:jt http://purl.org/obo/owl/MAO#MAO_jt mao.obo helix A frequently highly stable protein chain conformation stabilised by hydrogen bonding between peptide groups and having side chains projecting outwards in a spiral (3.6 residues per turn). The Biochemical Society Glossary. MAO:jt http://purl.org/obo/owl/MAO#MAO_jt alpha_helix mao.obo strand Stable "zig-zag" conformation of protein chain which can align with sections of chain in same conformation and cross-link efficiently via hydrogen bonds between the peptide linkages. The Biochemical Society Glossary. MAO:jt http://purl.org/obo/owl/MAO#MAO_jt beta_strand mao.obo accession_number A unique identifier in the sequence databases.Accession numbers should remain static between database updates. MAO:jt http://purl.org/obo/owl/MAO#MAO_jt accession mao.obo sequence_description A general description of the sequence. MAO:jt http://purl.org/obo/owl/MAO#MAO_jt mao.obo taxid NCBI taxonomy database interface taxid:xref http://purl.org/obo/owl/taxid#taxid_xref mao.obo sequence_repeat A region which has multiple copies in the sequence. Repeats range from short stretches of adjacent, similar residues to multiple copies of complete domains. MAO:jt http://purl.org/obo/owl/MAO#MAO_jt mao.obo signal Extent of a signal sequence (prepeptide). MAO:jt http://purl.org/obo/owl/MAO#MAO_jt mao.obo sequence_variant A region where an alternative sequence has been observed. MAO:jt http://purl.org/obo/owl/MAO#MAO_jt varsplic mao.obo low_complexity_region A region of biased residue composition, e.g. homopolymeric runs, short repeats, and more subtle overrepresentations of one or a few residues. Low-complexity regions in amino acid sequences typically assume non-globular structure in proteins. [NCBI sef.glossary). MAO:jt http://purl.org/obo/owl/MAO#MAO_jt mao.obo site A generic term for the extent of a user-specified site. MAO:jt http://purl.org/obo/owl/MAO#MAO_jt mao.obo sequence_keyword_list A list of keywords that provide information that can be used to generate indexes of the sequence entries based on functional, structural, or other categories. MAO:jt http://purl.org/obo/owl/MAO#MAO_jt mao.obo buried A residue in the core of the protein that has no surface area accessible to solvent. MAO:jt http://purl.org/obo/owl/MAO#MAO_jt core_residue mao.obo residue_hydrogen_bond A type of attractive intermolecular force that exists between two partial electric charges of opposite polarity. MAO:jt http://purl.org/obo/owl/MAO#MAO_jt mao.obo conserved_aliphatic_residue A conserved aliphatic residue e.g. AGLIV MAO:jt http://purl.org/obo/owl/MAO#MAO_jt mao.obo conserved_aromatic_residue A conserved aromatic residue e.g. YWFH MAO:jt http://purl.org/obo/owl/MAO#MAO_jt mao.obo conserved_basic_residue A conserved basic residue e.g. HKR MAO:jt http://purl.org/obo/owl/MAO#MAO_jt mao.obo conserved_hydroxyl_residue A conserved hydroxyl residue e.g. STY MAO:jt http://purl.org/obo/owl/MAO#MAO_jt mao.obo dna_binding_site A residue that is directly involved in binding to dna. MAO:jt http://purl.org/obo/owl/MAO#MAO_jt mao.obo column_conservation The conservation associated with a given column in the msa. MAO:jt http://purl.org/obo/owl/MAO#MAO_jt mao.obo residue_function_detection_method The method used to detect the activity or function of the residue. MAO:jt http://purl.org/obo/owl/MAO#MAO_jt mao.obo column_conservation_construction_method The method used to construct the conservation score associated with a given column. MAO:jt http://purl.org/obo/owl/MAO#MAO_jt mao.obo user_conservation_value A user defined conservation term e.g. mixed conservation from different methods MAO:jt http://purl.org/obo/owl/MAO#MAO_jt mao.obo strict_conservation A strictly conserved column. MAO:jt http://purl.org/obo/owl/MAO#MAO_jt mao.obo no_conservation An unconserved column. MAO:jt http://purl.org/obo/owl/MAO#MAO_jt mao.obo in_cavity The residue is touching a cavity. MAO:pk http://purl.org/obo/owl/MAO#MAO_pk in_pocket mao.obo alignment_column The alignment_column contains one residue (or a gap character) from each sequence. The residues in the column are considered to be equivalent. If no equivalent residue exists for a given sequence, a gap character is inserted. MAO:jt http://purl.org/obo/owl/MAO#MAO_jt mao.obo sub_alignment_construction_method The method used to determine the sub_alignment or sub_families. MAO:jt http://purl.org/obo/owl/MAO#MAO_jt cluster_construction_method group_construction_method sub_group_construction_method mao.obo loop A section of the protein chain connecting classical secondary structures like helix and sheet. Often of irregular structure, surface exposed and containing hydrophilic residues. The Biochemical Society Glossary. MAO:jt http://purl.org/obo/owl/MAO#MAO_jt mao.obo interresidue_contact_list List of spatial contacts between two residues MAO:jt http://purl.org/obo/owl/MAO#MAO_jt residue_contact_list mao.obo contact_residue1 First residue involved in contact MAO:jt http://purl.org/obo/owl/MAO#MAO_jt mao.obo interresidue_contact Spatial contact between two residues MAO:jt http://purl.org/obo/owl/MAO#MAO_jt residue_contact mao.obo differential_conservation A column that is conserved differently in the different sub_families. e.g. a residue that is conserved in mammals, but is divergent in the other organisms. MAO:jt http://purl.org/obo/owl/MAO#MAO_jt mao.obo conserved_gap_character A conserved insertion/deletion. MAO:jt http://purl.org/obo/owl/MAO#MAO_jt mao.obo structural_location_detection_method The method used to determine the location of the residue in the 3d structure. MAO:jt http://purl.org/obo/owl/MAO#MAO_jt mao.obo 3d_atomic_coordinates The coordinates of the atom in 3-dimensional space. MAO:jt http://purl.org/obo/owl/MAO#MAO_jt mao.obo atom The fundamental building blocks of chemistry, which cannot be broken by any chemical means. MAO:jt http://purl.org/obo/owl/MAO#MAO_jt mao.obo other_residue_function A user specified activity or function associated with a residue. MAO:jt http://purl.org/obo/owl/MAO#MAO_jt mao.obo pdb_name mao.obo msa_3d_superposition mao.obo msa_reference_structure_name mao.obo msa_superposed_regions mao.obo msa_symmetry_operator mao.obo msa_rmsd mao.obo tissue_type The tissue from which the sequence was extracted. MAO:jt http://purl.org/obo/owl/MAO#MAO_jt mao.obo developmental_stage The developmental stage of the organism's life cycle during which the sequence was extracted nMGED Interface MAO:jt http://purl.org/obo/owl/MAO#MAO_jt mao.obo exposed A residue on the surface of the protein that is accessible to solvent. MAO:jt http://purl.org/obo/owl/MAO#MAO_jt surface_residue mao.obo residue_salt_bridge An interaction between positive and negative charges on side chains of a protein. MAO:jt http://purl.org/obo/owl/MAO#MAO_jt mao.obo ramanchandran_plot The Ramachandran plot is a graph of the protein backbone torsional angles psi (Calpha-C bond) versus phi (N-Calpha bond). The psi and phi angles cover the ranges from -180 to +180. MAO:pk http://purl.org/obo/owl/MAO#MAO_pk mao.obo phi_angle The phi (N-Calpha bond) protein backbone torsional angles of the Ramachandran plot. The phi angle cover the range from -180 to +180. MAO:pk http://purl.org/obo/owl/MAO#MAO_pk mao.obo 3d_coordinate_x mao.obo psi_angle The psi (C-Calpha bond) protein backbone torsional angles of the Ramachandran plot. The phi angle cover the range from -180 to +180. MAO:pk http://purl.org/obo/owl/MAO#MAO_pk mao.obo 3d_coordinate_y mao.obo 3d_coordinate_z mao.obo bonded_residue The other residue bonded to the reference residue. MAO:jt http://purl.org/obo/owl/MAO#MAO_jt mao.obo msa_freetext_line A line of free text in the msa, containing annotation associated with a sequence or group of sequences. MAO:jt http://purl.org/obo/owl/MAO#MAO_jt aln_text mao.obo msa_freetext_owner The alignment_sequence or sub_family that the msa_freetext is attached to. MAO:jt http://purl.org/obo/owl/MAO#MAO_jt aln_text_owner mao.obo msa_freetext_type The type of text supplied in the msa_freetext. MAO:jt http://purl.org/obo/owl/MAO#MAO_jt aln_text_type mao.obo consensus_sequence_construction_method The method used to determine the consensus sequence. MAO:jt http://purl.org/obo/owl/MAO#MAO_jt mao.obo sequence_type The type of sequence e.g. protein or dna. MAO:jt http://purl.org/obo/owl/MAO#MAO_jt mao.obo column_score_calculation_method The method used to calculate the score associated with a given column. MAO:jt http://purl.org/obo/owl/MAO#MAO_jt mao.obo column_weight_calculation_method The method used to calculate the weight associated with a given column. MAO:jt http://purl.org/obo/owl/MAO#MAO_jt mao.obo amino_acid_residue An organic compound that generally contains an amino (-NH2) and a carboxyl (-COOH) group. There are 20 different kinds of amino acids. A protein consists of a specific sequence of amino acids. MAO:jt http://purl.org/obo/owl/MAO#MAO_jt aa aa_residue amino_acid mao.obo nucleotide_residue A DNA sequence consists of a specific sequence of nucleotides. A nucleotide is made of a molecule of sugar, a molecule of phosphoric acid, and a molecule called a base. The bases are the "letters" that spell out the genetic code. In DNA, the code letters are A, T, G, and C, which stand for the chemicals adenine, thymine, guanine, and cytosine, respectively. In base pairing, adenine always pairs with thymine, and guanine always pairs with cytosine. [NHGRI] A DNA sequence consists of a specific sequence of nucleotides. MAO:jt http://purl.org/obo/owl/MAO#MAO_jt base base_pair nucleotide mao.obo atom_name mao.obo motif A pattern of conserved residues in a sequence that are located within a certain distance from each other in the sequence. MAO:jt http://purl.org/obo/owl/MAO#MAO_jt mao.obo enzyme_active_site The active site of an enzyme is the binding site where catalysis occurs. The structure and chemical properties of the active site allow the recognition and binding of the substrate. The active site consists of the catalytic amino acids and one or more binding sites that bind the substrate(s). MAO:jt http://purl.org/obo/owl/MAO#MAO_jt mao.obo substrate_binding_site A residue that is directly involved in the binding of a specific substrate. MAO:jt http://purl.org/obo/owl/MAO#MAO_jt mao.obo mutation A mutation is a permanent, transmissible change to the genetic material (usually DNA or RNA) of a cell. MAO:jt http://purl.org/obo/owl/MAO#MAO_jt mao.obo point_mutation A point mutation is usually caused by chemicals or malfunction of DNA replication and exchanges a single nucleotide for another. Most common is the transition that exchanges a purine for a purine or a pyrimidine for a pyrimidine (A ? G, C ? T). Less common is a transversion, which exchanges a purine for a pyrimidine or a pyrimidine for a purine (C/T ? A/G). MAO:jt http://purl.org/obo/owl/MAO#MAO_jt mao.obo insertion_mutation The addition of one or more extra nucleotides into the DNA. They are usually caused by transposable elements, or errors during replication of repeating elements (e.g. AT repeats). Insertions in a gene can cause a shift in the reading frame (frameshift) or alter splicing of the mRNA, both of which can significantly alter the gene product. MAO:jt http://purl.org/obo/owl/MAO#MAO_jt mao.obo deletion_mutation Deletions remove one or more nucleotides from the DNA. Like insertions, these mutations can alter the reading frame of the gene. Deletions in a gene can cause a shift in the reading frame (frameshift) or alter splicing of the mRNA, both of which can significantly alter the gene product. MAO:jt http://purl.org/obo/owl/MAO#MAO_jt mao.obo silent_mutation A silent mutation is a DNA mutation that does not alter the final amino acid, and hence does not affect the final protein. Anaylsis of mutations in genes causing genetic disorders has shown that silent mutations can affect gene transcription, leading to the formation of truncated protein with reduced or no function. MAO:jt http://purl.org/obo/owl/MAO#MAO_jt synonymous_mutation mao.obo missense_mutation A missense mutations is a type of point mutation where a nucleotide is changed which results in a different amino acid. This in turn can render the resulting protein nonfunctional. MAO:jt http://purl.org/obo/owl/MAO#MAO_jt nonsynonymous_mutation mao.obo nonsense_mutation A nonsense mutation is a point mutation that results in a premature stop codon in the transcribed mRNA, and possibly a truncated (and often nonfunctional) protein product. MAO:jt http://purl.org/obo/owl/MAO#MAO_jt mao.obo mutation_type The type fo mutation. e.g. germline mutation, which can be passed on to progeny or somatic mutation, which often leads to the malfunction or death of a cell and can cause cancer. MAO:jt http://purl.org/obo/owl/MAO#MAO_jt mao.obo metal_binding_site A residue that is directly involved in the binding of a metal ion. MAO:jt http://purl.org/obo/owl/MAO#MAO_jt mao.obo CSA_catalytic_site CSA Interface MAO:jt http://purl.org/obo/owl/MAO#MAO_jt mao.obo ligand_binding_site A residue that is directly involved in the binding of a specific ligand. MAO:jt http://purl.org/obo/owl/MAO#MAO_jt mao.obo mutation_phenotypic_manifestation OBO_phenotype_ontology interface MAO:jt http://purl.org/obo/owl/MAO#MAO_jt mao.obo resid_ptm RESID database interface MAO:jt http://purl.org/obo/owl/MAO#MAO_jt mao.obo acetylation N-terminal of some residues and side chain of lysine or cysteine MAO:jt http://purl.org/obo/owl/MAO#MAO_jt mao.obo amidation Generally at the C-terminal of a mature active peptide after oxidative cleavage of last glycine MAO:jt http://purl.org/obo/owl/MAO#MAO_jt mao.obo blocked Unidentified N- or C-terminal blocking group MAO:jt http://purl.org/obo/owl/MAO#MAO_jt mao.obo formylation Of the N-terminal methionine MAO:jt http://purl.org/obo/owl/MAO#MAO_jt mao.obo gamma_carboygluamic_acid Of glutamate MAO:jt http://purl.org/obo/owl/MAO#MAO_jt mao.obo hydroxylation Generally of asparagine, aspartate, proline or lysine MAO:jt http://purl.org/obo/owl/MAO#MAO_jt mao.obo methylation Generally of N-terminal phenylalanine, side chain of lysine, arginine, histidine, asparagine or glutamate, and C-terminal cysteine MAO:jt http://purl.org/obo/owl/MAO#MAO_jt mao.obo phosphorylation Of serine, threonine, tyrosine, aspartate, histidine or cysteine MAO:jt http://purl.org/obo/owl/MAO#MAO_jt mao.obo pyrrolidone_carboxylic_acid N-terminal glutamine which has formed an internal cyclic lactam. This is also called 'pyro-Glu'. Very rarely, pyro-Glu can be produced by modification of a N-terminal glutamate MAO:jt http://purl.org/obo/owl/MAO#MAO_jt mao.obo sulfation Of tyrosine, serine or threonine MAO:jt http://purl.org/obo/owl/MAO#MAO_jt mao.obo carbohydrate_binding_site mao.obo lipid_binding_site A residue that is directly involved in the binding of a lipid. MAO:jt http://purl.org/obo/owl/MAO#MAO_jt mao.obo residue_disulfide_bond A strong covalent bond between two sulfhydryl groups. This bond is very important to the folding, structure, and function of proteins. MAO:jt http://purl.org/obo/owl/MAO#MAO_jt disulfide_bridge mao.obo residue_structural_bond mao.obo contact_residue2 Second residue involved in spatial contact MAO:jt http://purl.org/obo/owl/MAO#MAO_jt mao.obo n_terminal_extension mao.obo c_terminal_extension mao.obo sequence_weight_calculation_method mao.obo sequence_insertion mao.obo column_consensus A consensus character that summarises the residue information contained in an alignment_column. MAO:jt http://purl.org/obo/owl/MAO#MAO_jt mao.obo feature_calculation_method The method used to determine the feature. MAO:jt http://purl.org/obo/owl/MAO#MAO_jt mao.obo column_consensus_calculation_method The method used to determine the consensus character associated with a column. MAO:jt http://purl.org/obo/owl/MAO#MAO_jt mao.obo so_mutation SO interface MAO:jt http://purl.org/obo/owl/MAO#MAO_jt mao.obo sequence_keyword A keyword provides information that can be used to generate indexes of the sequence entries based on functional, structural, or other categories. MAO:jt http://purl.org/obo/owl/MAO#MAO_jt mao.obo hydrophobicity_calculation_method The method used to calculate the hydrophobicity measure. MAO:jt http://purl.org/obo/owl/MAO#MAO_jt mao.obo contact_distance Distance between two residues in spatial contact MAO:jt http://purl.org/obo/owl/MAO#MAO_jt mao.obo contact_description Textual comment describing spatial contact between two residues MAO:jt http://purl.org/obo/owl/MAO#MAO_jt mao.obo is_annotation mao.obo is_attribute mao.obo is_name mao.obo part_of mao.obo