obo-all/gene_ontology/gene_ontology.obo file obo-all/gene_ontology/gene_ontology.obo gene_ontology.obo c57a77d3c092e3e737dd9fa551132708 1214338855 1214338878

1.2 23:06:2008 11:12 tanyaberardini OBO-Edit 1.101 goslim_candida Candida GO slim goslim_generic Generic GO slim goslim_goa GOA and proteome slim goslim_pir PIR GO slim goslim_plant Plant GO slim goslim_yeast Yeast GO slim gosubset_prok Prokaryotic GO subset systematic_synonym Systematic synonym EXACT gene_ontology cvs version: $Revision: 1.224 $

GO:0000001 mitochondrion inheritance biological_process The distribution of mitochondria, including the mitochondrial genome, into daughter cells after mitosis or meiosis, mediated by interactions between mitochondria and the cytoskeleton. mcc GOC 10873824 PMID 11389764 PMID mitochondrial inheritance GO:0048308 GO:0048311 GO:0000002 mitochondrial genome maintenance biological_process The maintenance of the structure and integrity of the mitochondrial genome; includes replication and segregation of the mitochondrial chromosome. ai GOC vw GOC GO:0007005 GO:0000003 reproduction biological_process GO:0019952 GO:0050876 The production by an organism of new individuals that contain some portion of their genetic material inherited from that organism. go_curators GOC isa_complete GOC 0198506732 ISBN Oxford Dictionary of Biochemistry and Molecular Biology goslim_generic goslim_pir goslim_plant gosubset_prok reproductive physiological process GO:0008150 GO:0000005 ribosomal chaperone activity molecular_function OBSOLETE. Assists in the correct assembly of ribosomes or ribosomal subunits in vivo, but is not a component of the assembled ribosome when performing its normal biological function. jl GOC 12150913 PMID This term was made obsolete because it refers to a class of gene products and a biological process rather than a molecular function. 1 GO:0042254 GO:0051082 GO:0000006 high affinity zinc uptake transmembrane transporter activity molecular_function Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Zn2+(out) = Zn2+(in), probably powered by proton motive force. In high affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations. 2.A.5.1.1 TC GO:0005385 GO:0000007 low-affinity zinc ion transmembrane transporter activity molecular_function Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Zn2+ = Zn2+, probably powered by proton motive force. In low affinity transport the transporter is able to bind the solute only if it is present at very high concentrations. mtg_transport GOC 0815340729 ISBN GO:0005385 GO:0000008 thioredoxin molecular_function GO:0000013 OBSOLETE. A small disulfide-containing redox protein that serves as a general protein disulfide oxidoreductase. Interacts with a broad range of proteins by a redox mechanism, based on the reversible oxidation of 2 cysteine thiol groups to a disulfide, accompanied by the transfer of 2 electrons and 2 protons. The net result is the covalent interconversion of a disulfide and a dithiol. kd GOC This term was made obsolete because it represents gene products. 1 GO:0006467 GO:0015036 GO:0000009 alpha-1,6-mannosyltransferase activity molecular_function Catalysis of the transfer of a mannose residue from GDP-mannose to an oligosaccharide, forming an alpha-1,6-linkage. mcc GOC 2644248 PMID 2.4.1.- EC GO:0000030 GO:0000010 trans-hexaprenyltranstransferase activity molecular_function Catalysis of the reaction: all-trans-hexaprenyl diphosphate + isopentenyl diphosphate = diphosphate + all-trans-heptaprenyl diphosphate. 2.5.1.30 EC gosubset_prok all-trans-heptaprenyl-diphosphate synthase activity 2.5.1.30 EC all-trans-hexaprenyl-diphosphate:isopentenyl-diphosphate hexaprenyltranstransferase activity 2.5.1.30 EC heptaprenyl diphosphate synthase activity 2.5.1.30 EC heptaprenyl pyrophosphate synthase activity 2.5.1.30 EC heptaprenyl pyrophosphate synthetase activity 2.5.1.30 EC 2.5.1.30 EC TRANS-HEXAPRENYLTRANSTRANSFERASE-RXN MetaCyc GO:0016765 GO:0000011 vacuole inheritance biological_process The distribution of vacuoles into daughter cells after mitosis or meiosis, mediated by interactions between vacuoles and the cytoskeleton. mcc GOC 10873824 PMID 14616069 PMID GO:0007033 GO:0048308 GO:0000012 single strand break repair biological_process The repair of single strand breaks in DNA. Repair of such breaks is mediated by the same enzyme systems as are used in base excision repair. http://www.ultranet.com/~jkimball/BiologyPages/D/DNArepair.html URL gosubset_prok GO:0006281 GO:0000014 single-stranded DNA specific endodeoxyribonuclease activity molecular_function Catalysis of the hydrolysis of ester linkages within a single-stranded deoxyribonucleic acid molecule by creating internal breaks. mah GOC GO:0004520 GO:0000015 phosphopyruvate hydratase complex cellular_component A multimeric enzyme complex, usually a dimer or an octamer, that catalyzes the conversion of 2-phospho-D-glycerate to phosphoenolpyruvate and water. jl GOC 0198506732 ISBN Oxford Dictionary of Biochemistry and Molecular Biology gosubset_prok enolase complex GO:0043234 GO:0044445 GO:0000016 lactase activity molecular_function Catalysis of the reaction: lactose + H2O = D-glucose + D-galactose. 3.2.1.108 EC lactase-phlorizin hydrolase activity 3.2.1.108 EC lactose galactohydrolase activity 3.2.1.108 EC 3.2.1.108 EC LACTASE-RXN MetaCyc 20536 Reactome GO:0004553 GO:0000017 alpha-glucoside transport biological_process The directed movement of alpha-glucosides into, out of, within or between cells. Alpha-glucosides are glycosides in which the sugar moiety is a glucose residue, and the anomeric carbon of the bond is in an alpha configuration. jl GOC http://www.biochem.purdue.edu/ URL 0198506732 ISBN Oxford Dictionary of Biochemistry and Molecular Biology GO:0042946 GO:0000018 regulation of DNA recombination biological_process Any process that modulates the frequency, rate or extent of DNA recombination, a process by which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. go_curators GOC 0198506732 ISBN Oxford Dictionary of Biochemistry and Molecular Biology gosubset_prok GO:0051052 regulates GO:0006310 GO:0000019 regulation of mitotic recombination biological_process Any process that modulates the frequency, rate or extent of DNA recombination during mitosis. go_curators GOC regulation of recombination within rDNA repeats GO:0000018 regulates GO:0006312 GO:0000020 negative regulation of recombination within rDNA repeats biological_process OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of genetic recombination within the DNA of the genes coding for ribosomal RNA. go_curators GOC 0198506732 ISBN Oxford Dictionary of Biochemistry and Molecular Biology This term was made obsolete because it describes a substrate-specific process. 1 GO:0045950 GO:0000022 mitotic spindle elongation biological_process Lengthening of the distance between poles of the mitotic spindle. mah GOC spindle elongation during mitosis GO:0051231 OBO_REL:part_of GO:0007052 GO:0000023 maltose metabolic process biological_process The chemical reactions and pathways involving the disaccharide maltose (4-O-alpha-D-glucopyranosyl-D-glucopyranose), an intermediate in the catabolism of glycogen and starch. jl GOC 0198506732 ISBN Oxford Dictionary of Biochemistry and Molecular Biology gosubset_prok malt sugar metabolic process malt sugar metabolism maltose metabolism GO:0005984 GO:0000024 maltose biosynthetic process biological_process The chemical reactions and pathways resulting in the formation of the disaccharide maltose (4-O-alpha-D-glucopyranosyl-D-glucopyranose). jl GOC 0198506732 ISBN Oxford Dictionary of Biochemistry and Molecular Biology gosubset_prok malt sugar biosynthesis malt sugar biosynthetic process maltose anabolism maltose biosynthesis maltose formation maltose synthesis GO:0000023 GO:0046351 GO:0000025 maltose catabolic process biological_process The chemical reactions and pathways resulting in the breakdown of the disaccharide maltose (4-O-alpha-D-glucopyranosyl-D-glucopyranose). jl GOC 0198506732 ISBN Oxford Dictionary of Biochemistry and Molecular Biology gosubset_prok malt sugar catabolic process malt sugar catabolism maltose breakdown maltose degradation maltose hydrolysis MALTOSECAT-PWY MetaCyc GO:0000023 GO:0046352 GO:0000026 alpha-1,2-mannosyltransferase activity molecular_function Catalysis of the transfer of a mannose residue from GDP-mannose to an oligosaccharide, forming an alpha-1,2-linkage. mcc GOC 10521541 PMID 2.4.1.- EC GO:0000030 GO:0000027 ribosomal large subunit assembly and maintenance biological_process The aggregation, arrangement and bonding together of constituent RNAs and proteins to form and maintain the large ribosomal subunit. jl GOC gosubset_prok GO:0042257 OBO_REL:part_of GO:0042273 GO:0000028 ribosomal small subunit assembly and maintenance biological_process The aggregation, arrangement and bonding together of constituent RNAs and proteins to form and maintain the small ribosomal subunit. jl GOC gosubset_prok GO:0042257 OBO_REL:part_of GO:0042274 GO:0000030 mannosyltransferase activity molecular_function Catalysis of the transfer of a mannosyl group to an acceptor molecule, typically another carbohydrate or a lipid. ai GOC gosubset_prok 2.4.1.- EC 7672 Reactome GO:0016758 GO:0000031 mannosylphosphate transferase activity molecular_function Catalysis of the transfer of an mannosylphosphate group from one compound to another. jl GOC GO:0016740 GO:0000032 cell wall mannoprotein biosynthetic process biological_process The chemical reactions and pathways resulting in the formation of cell wall mannoproteins, any cell wall protein that contains covalently bound mannose residues other than as a moiety of nucleic acid. ai GOC gosubset_prok cell wall mannoprotein anabolism cell wall mannoprotein biosynthesis cell wall mannoprotein formation cell wall mannoprotein synthesis GO:0006057 GO:0031506 GO:0000033 alpha-1,3-mannosyltransferase activity molecular_function Catalysis of the transfer of a mannose residue from GDP-mannose to an oligosaccharide, forming an alpha-1,3-linkage. mcc GOC 10521541 PMID 2.4.1.- EC GO:0000030 GO:0000034 adenine deaminase activity molecular_function Catalysis of the reaction: adenine + H2O = hypoxanthine + NH3. 3.5.4.2 EC gosubset_prok ADase activity 3.5.4.2 EC adenase activity 3.5.4.2 EC adenine aminase activity 3.5.4.2 EC adenine aminohydrolase activity 3.5.4.2 EC 3.5.4.2 EC ADENINE-DEAMINASE-RXN MetaCyc GO:0016814 GO:0019239 GO:0000035 acyl binding molecular_function Interacting selectively with an acyl group, any group formally derived by removal of the hydroxyl group from the acid function of a carboxylic acid. http://cancerweb.ncl.ac.uk/ URL 0198506732 ISBN Oxford Dictionary of Biochemistry and Molecular Biology gosubset_prok acyl-CoA or acyl binding GO:0005488 GO:0000036 acyl carrier activity molecular_function gosubset_prok GO:0022892 GO:0000038 very-long-chain fatty acid metabolic process biological_process The chemical reactions and pathways involving fatty acids with a chain length of C18 or greater. hjd GOC gosubset_prok very-long-chain fatty acid metabolism GO:0006631 GO:0000039 plasma membrane long-chain fatty acid transporter molecular_function OBSOLETE (was not defined before being made obsolete). ai GOC This term was made obsolete because it describes a gene product and it contains component information. 1 GO:0005324 GO:0005886 GO:0000040 low-affinity iron ion transport biological_process The directed, low-affinity movement of iron (Fe) ions into, out of, within or between cells. In low affinity transport the transporter is able to bind the solute only if it is only present at very low concentrations. mah GOC low affinity iron ion transport GO:0006826 GO:0034220 GO:0000041 transition metal ion transport biological_process The directed movement of transition metal ions into, out of, within or between cells. A transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver. 0198506732 ISBN Oxford Dictionary of Biochemistry and Molecular Biology gosubset_prok transition metal transport GO:0030001 GO:0000042 protein targeting to Golgi biological_process The process of directing proteins towards the Golgi using signals contained within the protein. ai GOC protein-Golgi targeting GO:0000301 GO:0006605 GO:0000044 ascorbate stabilization biological_process OBSOLETE. The reduction of the ascorbate free radical to a stable form. ai GOC mtg_electron_transport GOC This term was made obsolete because it is defined as a function term and is in the process ontology. vitamin C stabilization 1 GO:0000045 autophagic vacuole formation biological_process The formation of a double membrane-bounded structure, the autophagosome, that occurs when a specialized membrane sac, called the isolation membrane, starts to enclose a portion of the cytoplasm. 9412464 PMID autophagosome biosynthesis autophagosome formation PAS formation GO:0016050 OBO_REL:part_of GO:0016236 GO:0000046 autophagic vacuole fusion biological_process The fusion of an autophagic vacuole with a vacuole (yeast) or lysosome (e.g. mammals and insects). In the case of yeast, inner membrane-bounded structures (autophagic bodies) appear in the vacuole. 11099404 PMID fusion of autophagosome with lysosome GO:0006944 GO:0048284 OBO_REL:part_of GO:0016236 GO:0000047 Rieske iron-sulfur protein molecular_function OBSOLETE (was not defined before being made obsolete). ai GOC This term was made obsolete because it represents a gene product. Rieske iron-sulphur protein 1 GO:0009055 GO:0000048 peptidyltransferase activity molecular_function Catalysis of the reaction: peptidyl-tRNA(1) + aminoacyl-tRNA(2) = tRNA(1) + peptidylaminoacyl-tRNA(2). 2.3.2.12 EC 11433365 PMID 9242921 PMID peptidyl-tRNA:aminoacyl-tRNA N-peptidyltransferase activity 2.3.2.12 EC 2.3.2.12 EC PEPTIDYLTRANSFERASE-RXN MetaCyc 20610 Reactome GO:0016755 GO:0000049 tRNA binding molecular_function Interacting selectively with transfer RNA. ai GOC gosubset_prok GO:0003723 GO:0000050 urea cycle biological_process GO:0006594 GO:0006871 A cyclic metabolic pathway that converts waste nitrogen in the form of ammonium to urea. 0198506732 ISBN Oxford Dictionary of Biochemistry and Molecular Biology ornithine cycle urea biosynthesis urea biosynthetic process 211547 Reactome 221324 Reactome 229964 Reactome 237981 Reactome 244600 Reactome 249543 Reactome 252354 Reactome 255509 Reactome 258881 Reactome 262258 Reactome 265108 Reactome 268232 Reactome 273914 Reactome 280393 Reactome 282778 Reactome 286409 Reactome 288203 Reactome 289764 Reactome 290323 Reactome 291648 Reactome 292335 Reactome 293622 Reactome 70635 Reactome GO:0019627 GO:0000051 urea cycle intermediate metabolic process biological_process The chemical reactions and pathways involving any of the intermediate compounds involved in the urea cycle, a cyclic metabolic pathway that converts waste nitrogen in the form of ammonium to urea. jl GOC 0198506732 ISBN Oxford Dictionary of Biochemistry and Molecular Biology gosubset_prok urea cycle intermediate metabolism GO:0008152 OBO_REL:part_of GO:0006807 GO:0000052 citrulline metabolic process biological_process The chemical reactions and pathways involving citrulline, N5-carbamoyl-L-ornithine, an alpha amino acid not found in proteins. 0198506732 ISBN Oxford Dictionary of Biochemistry and Molecular Biology gosubset_prok citrulline metabolism GO:0000051 GO:0019794 GO:0000053 argininosuccinate metabolic process biological_process The chemical reactions and pathways involving argininosuccinate, 2-(Nw-arginino)succinate, an intermediate in the ornithine-urea cycle, where it is synthesized from citrulline and aspartate. 0198506732 ISBN Oxford Dictionary of Biochemistry and Molecular Biology argininosuccinate metabolism GO:0000051 GO:0000054 ribosome export from nucleus biological_process The directed movement of a ribosome from the nucleus into the cytoplasm. ai GOC ribosome export out of nucleus ribosome transport from nucleus to cytoplasm ribosome-nucleus export GO:0033753 GO:0051168 OBO_REL:part_of GO:0042254 GO:0000055 ribosomal large subunit export from nucleus biological_process GO:0000057 The directed movement of a ribosomal large subunit from the nucleus into the cytoplasm. mah GOC ribosomal large subunit export out of nucleus ribosomal large subunit transport from nucleus to cytoplasm ribosomal large subunit-nucleus export GO:0000054 GO:0000056 ribosomal small subunit export from nucleus biological_process GO:0000058 The directed movement of a ribosomal small subunit from the nucleus into the cytoplasm. mah GOC ribosomal small subunit export out of nucleus ribosomal small subunit transport from nucleus to cytoplasm ribosomal small subunit-nucleus export GO:0000054 GO:0000059 protein import into nucleus, docking biological_process The aggregation, arrangement and bonding together of the nuclear localization signal of a protein with nuclear envelope proteins such as importins. isa_complete GOC 7878057 PMID protein docking during protein import into nucleus protein docking during protein transport from cytoplasm to nucleus protein docking during protein-nucleus import protein transport from cytoplasm to nucleus, docking protein-nucleus import, docking GO:0043623 OBO_REL:part_of GO:0006606 GO:0000060 protein import into nucleus, translocation biological_process The vectorial transfer of a protein from the cytoplasm into the nucleus, through the nuclear pore and across the nuclear envelope. jl GOC vw GOC 0198506732 ISBN Oxford Dictionary of Biochemistry and Molecular Biology protein translocation during protein import into nucleus protein translocation during protein transport from cytoplasm to nucleus protein translocation during protein-nucleus import protein transport from cytoplasm to nucleus, translocation protein-nucleus import, translocation GO:0006886 OBO_REL:part_of GO:0006606 GO:0000061 protein import into nucleus, substrate release biological_process The disaggregation of a protein complex composed of the nuclear localization sequence and the importin alpha, and importin beta proteins. 9687515 PMID protein substrate release during protein import into nucleus protein substrate release during protein transport from cytoplasm to nucleus protein substrate release during protein-nucleus import protein transport from cytoplasm to nucleus, substrate release protein-nucleus import, substrate release GO:0043624 OBO_REL:part_of GO:0006606 GO:0000062 acyl-CoA binding molecular_function Interacting selectively with acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty acyl group. jl GOC 0198506732 ISBN Oxford Dictionary of Biochemistry and Molecular Biology gosubset_prok acyl-CoA or acyl binding GO:0005504 GO:0050662 GO:0000064 L-ornithine transmembrane transporter activity molecular_function Catalysis of the transfer of L-ornithine from one side of a membrane to the other. L-ornithine is 2,5-diaminopentanoic acid. ai GOC mtg_transport GOC 0815340729 ISBN gosubset_prok histidine/arginine/lysine/ornithine porter activity L-ornithine transporter activity 20635 Reactome GO:0015179 GO:0000066 mitochondrial ornithine transport biological_process The directed movement of ornithine, 2,5-diaminopentanoic acid, into, out of or within a mitochondrion. ai GOC GO:0006839 GO:0015822 GO:0000067 DNA replication and chromosome cycle biological_process OBSOLETE (was not defined before being made obsolete). ai GOC This term was made obsolete because it has been superseded by more accurate terms to represent the biological processes occurring, and it is not clear that this term represents a useful concept. 1 GO:0006260 GO:0007059 GO:0051276 GO:0000070 mitotic sister chromatid segregation biological_process GO:0016359 The cell cycle process whereby replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the mitotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner. One homolog of each morphologic type goes into each of the resulting chromosome sets. ai GOC mitotic chromosome segregation mitotic sister-chromatid adhesion release GO:0000819 OBO_REL:part_of GO:0007067 GO:0000072 M phase specific microtubule process biological_process A microtubule-based process that occurs only during M phase of the cell cycle. mah GOC M-phase specific microtubule process GO:0007017 OBO_REL:part_of GO:0000279 GO:0000073 spindle pole body separation biological_process GO:0030475 A largely uncharacterized process involving the release of duplicated spindle pole bodies (SPBs) and their migration away from each other within the nuclear membrane. Duplicated SPBs are connected by a bridge structure that may be severed in order to release the SPBs from one another. Following liberation, SPBs diffuse through the nuclear membrane until they are across from each other. SPB separation must take place in order for a bipolar mitotic spindle to assemble. sgd_curators GOC spindle pole body separation (sensu Fungi) spindle pole body separation (sensu Saccharomyces) GO:0022402 OBO_REL:part_of GO:0051300 GO:0000075 cell cycle checkpoint biological_process A point in the eukaryotic cell cycle where progress through the cycle can be halted until conditions are suitable for the cell to proceed to the next stage. mah GOC 0815316194 ISBN 212094 Reactome 221853 Reactome 230421 Reactome 238463 Reactome 245004 Reactome 249905 Reactome 252621 Reactome 255806 Reactome 259199 Reactome 262557 Reactome 265381 Reactome 268515 Reactome 274237 Reactome 280705 Reactome 282912 Reactome 286730 Reactome 69620 Reactome GO:0051726 GO:0000076 DNA replication checkpoint biological_process A signal transduction based surveillance mechanism that prevents the initiation of mitosis until DNA replication is complete, thereby ensuring that progeny inherit a full complement of the genome. rn GOC 11728327 PMID 12537518 PMID GO:0031570 GO:0032297 GO:0000077 DNA damage checkpoint biological_process A signal transduction pathway, induced by DNA damage, that blocks cell cycle progression (in G1, G2 or metaphase) or slows the rate at which S phase proceeds. 11891124 PMID DNA damage response, signal transduction resulting in cell cycle arrest GO:0031570 GO:0042770 GO:0000078 cell morphogenesis checkpoint biological_process A cell cycle checkpoint observed when aspects of polarity control are defective, which maintains coordination between the process of cellular morphogenesis and the nuclear events of the cell cycle. For example, in budding yeast cell-cycle delay or arrest is induced when aspects of bud formation are defective. vw GOC 14644188 PMID GO:0007093 OBO_REL:part_of GO:0000902 GO:0000079 regulation of cyclin-dependent protein kinase activity biological_process Any process that modulates the frequency, rate or extent of CDK activity. go_curators GOC regulation of CDK activity GO:0045859 GO:0051726 GO:0000080 G1 phase of mitotic cell cycle biological_process Progression through G1 phase, one of two 'gap' phases in the mitotic cell cycle; G1 is the interval between the completion of mitosis and the beginning of DNA synthesis. 0815316194 ISBN 212033 Reactome 221797 Reactome 230372 Reactome 238411 Reactome 69236 Reactome GO:0051318 OBO_REL:part_of GO:0051329 GO:0000082 G1/S transition of mitotic cell cycle biological_process Progression from G1 phase to S phase of the mitotic cell cycle. mah GOC 212021 Reactome 221784 Reactome 230362 Reactome 238403 Reactome 244953 Reactome 249850 Reactome 252607 Reactome 255745 Reactome 259140 Reactome 262495 Reactome 265325 Reactome 268498 Reactome 274174 Reactome 280647 Reactome 282899 Reactome 286666 Reactome 288375 Reactome 289876 Reactome 290408 Reactome 291794 Reactome 293774 Reactome 69206 Reactome GO:0022402 OBO_REL:part_of GO:0051329 GO:0000083 G1/S-specific transcription in mitotic cell cycle biological_process Any process that regulates transcription such that the target genes are transcribed during the G1/S phase of the mitotic cell cycle. mah GOC 69205 Reactome GO:0006357 GO:0022402 OBO_REL:part_of GO:0000082 GO:0000084 S phase of mitotic cell cycle biological_process Progression through S phase, the part of the mitotic cell cycle during which DNA synthesis takes place. 0815316194 ISBN GO:0051320 OBO_REL:part_of GO:0051329 GO:0000085 G2 phase of mitotic cell cycle biological_process Progression through G2 phase, one of two 'gap' phases in the mitotic cell cycle; G2 is the interval between the completion of DNA synthesis and the beginning of mitosis. 0815316194 ISBN 211891 Reactome 221655 Reactome 230246 Reactome 238281 Reactome 244852 Reactome 249746 Reactome 268392 Reactome 274099 Reactome 280573 Reactome 68911 Reactome GO:0051319 OBO_REL:part_of GO:0051329 GO:0000086 G2/M transition of mitotic cell cycle biological_process Progression from G2 phase to M phase of the mitotic cell cycle. mah GOC 211972 Reactome 221737 Reactome 230316 Reactome 238398 Reactome 244912 Reactome 249804 Reactome 252543 Reactome 255721 Reactome 259114 Reactome 262473 Reactome 265322 Reactome 268466 Reactome 274171 Reactome 280644 Reactome 282855 Reactome 286663 Reactome 69275 Reactome GO:0022402 OBO_REL:part_of GO:0051329 GO:0000087 M phase of mitotic cell cycle biological_process Progression through M phase, the part of the mitotic cell cycle during which mitosis takes place. mah GOC 0815316194 ISBN M-phase of mitotic cell cycle 212043 Reactome 221806 Reactome 230379 Reactome 238418 Reactome 244995 Reactome 249877 Reactome 252596 Reactome 255795 Reactome 259176 Reactome 262532 Reactome 265359 Reactome 268488 Reactome 282892 Reactome 286702 Reactome 68886 Reactome GO:0000279 OBO_REL:part_of GO:0000278 GO:0000088 mitotic prophase biological_process Progression through prophase, the initial stage of mitosis in which the chromosomes are condensed but are not yet attached to a mitotic spindle. 0815316194 ISBN 211977 Reactome 221742 Reactome 230322 Reactome 238359 Reactome 244917 Reactome 249807 Reactome 252546 Reactome 255723 Reactome 259116 Reactome 262475 Reactome 268434 Reactome 286639 Reactome 68875 Reactome GO:0051324 OBO_REL:part_of GO:0007067 GO:0000089 mitotic metaphase biological_process Progression through metaphase, the stage of mitosis at which chromosomes are firmly attached to the mitotic spindle at its equator but have not yet segregated to opposite poles. 0815316194 ISBN 68879 Reactome GO:0051323 OBO_REL:part_of GO:0007067 GO:0000090 mitotic anaphase biological_process Progression through anaphase, the stage of mitosis during which the two sets of chromosomes separate and move away from each other. 0815316194 ISBN 68882 Reactome GO:0051322 OBO_REL:part_of GO:0007067 GO:0000091 mitotic anaphase A biological_process Progression through anaphase A, the part of mitotic anaphase in which the kinetochore microtubules shorten as chromosomes move toward the spindle poles. 0815316194 ISBN GO:0000090 GO:0000092 mitotic anaphase B biological_process Progression through anaphase B, the part of mitotic anaphase in which the polar microtubules elongate and the two poles of the spindle move farther apart. 0815316194 ISBN GO:0000090 GO:0000093 mitotic telophase biological_process Progression through telophase, the last of the stages of mitosis; in the canonical cell cycle, telophase begins when the chromosomes arrive at the poles of the cell and the division of the cytoplasm starts. 0721662544 ISBN Dorland's Illustrated Medical Dictionary GO:0051326 OBO_REL:part_of GO:0007067 GO:0000094 septin assembly and septum formation biological_process OBSOLETE (was not defined before being made obsolete). go_curators GOC This term was made obsolete because it was not defined and the string name implied two separate processes. 1 GO:0000917 GO:0000918 GO:0000921 GO:0000095 S-adenosylmethionine transmembrane transporter activity molecular_function GO:0015177 Catalysis of the transfer of S-adenosylmethionine from one side of a membrane to the other. S-adenosylmethionine is S-(5'-adenosyl)-L-methionine, an important intermediate in one-carbon metabolism. ai GOC S-adenosyl methionine permease activity S-adenosyl methionine transporter activity S-adenosylmethionine permease activity S-adenosylmethionine transporter activity GO:0000099 GO:0051184 GO:0000096 sulfur amino acid metabolic process biological_process The chemical reactions and pathways involving amino acids containing sulfur, comprising cysteine, homocysteine, methionine and selenocysteine. ai GOC gosubset_prok sulfur amino acid metabolism sulphur amino acid metabolic process sulphur amino acid metabolism GO:0006520 GO:0006790 GO:0000097 sulfur amino acid biosynthetic process biological_process The chemical reactions and pathways resulting in the formation of amino acids containing sulfur, comprising cysteine, methionine and selenocysteine. ai GOC gosubset_prok sulfur amino acid anabolism sulfur amino acid biosynthesis sulfur amino acid formation sulfur amino acid synthesis sulphur amino acid biosynthesis sulphur amino acid biosynthetic process GO:0000096 GO:0008652 GO:0044272 GO:0000098 sulfur amino acid catabolic process biological_process The chemical reactions and pathways resulting in the breakdown of amino acids containing sulfur, comprising cysteine, methionine and selenocysteine. ai GOC gosubset_prok sulfur amino acid breakdown sulfur amino acid catabolism sulfur amino acid degradation sulphur amino acid catabolic process sulphur amino acid catabolism GO:0000096 GO:0009063 GO:0044273 GO:0000099 sulfur amino acid transmembrane transporter activity molecular_function Catalysis of the transfer of sulfur amino acids from one side of a membrane to the other. Sulphur amino acids contain sulfur in the form of cystine, methionine or their derivatives. ai GOC mtg_transport GOC 0815340729 ISBN gosubset_prok sulfur amino acid transporter activity sulphur amino acid transmembrane transporter activity sulphur amino acid transporter activity GO:0015171 GO:0000100 S-methylmethionine transmembrane transporter activity molecular_function GO:0015178 Catalysis of the transfer of S-methylmethionine from one side of a membrane to the other. ai GOC gosubset_prok S-methylmethionine permease activity S-methylmethionine transporter activity GO:0000099 GO:0000101 sulfur amino acid transport biological_process The directed movement of amino acids containing sulfur (cystine, methionine and their derivatives) into, out of, within or between cells. ai GOC gosubset_prok sulphur amino acid transport GO:0006865 GO:0000102 L-methionine secondary active transmembrane transporter activity molecular_function Catalysis of the transfer of L-methionine from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport. mtg_transport GOC L-methionine porter activity GO:0005294 GO:0015191 GO:0000103 sulfate assimilation biological_process The pathways by which inorganic sulfate is processed and incorporated into sulfated compounds. jl GOC gosubset_prok sulphate assimilation GO:0006791 GO:0000104 succinate dehydrogenase activity molecular_function GO:0019739 Catalysis of the reaction: succinate + acceptor = fumarate + reduced acceptor. No reaction with quinols. 1.3.99.1 EC kd GOC gosubset_prok fumarate dehydrogenase activity 1.3.99.1 EC fumarate reductase activity 1.3.99.1 EC fumaric hydrogenase activity 1.3.99.1 EC succinate oxidoreductase activity 1.3.99.1 EC succinate:(acceptor) oxidoreductase activity 1.3.99.1 EC succinate:acceptor oxidoreductase activity 1.3.99.1 EC succinic acid dehydrogenase activity 1.3.99.1 EC succinic dehydrogenase activity 1.3.99.1 EC succinodehydrogenase activity 1.3.99.1 EC succinyl dehydrogenase activity 1.3.99.1 EC 1.3.99.1 EC SUCC-FUM-OXRED-RXN MetaCyc 21566 Reactome GO:0016627 GO:0000105 histidine biosynthetic process biological_process The chemical reactions and pathways resulting in the formation of histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid. go_curators GOC gosubset_prok histidine anabolism histidine biosynthesis histidine formation histidine synthesis HISTSYN-PWY MetaCyc GO:0006547 GO:0009076 GO:0000107 imidazoleglycerol-phosphate synthase activity molecular_function Catalysis of the reaction: phosphoribulosylformimino-AICAR-P + L-glutamine = D-erythro-imidazole-glycerol-phosphate + AICAR + L-glutamate. GLUTAMIDOTRANS-RXN MetaCyc gosubset_prok glutamine amidotransferase:cyclase activity imidazole glycerol phosphate synthase activity imidazole-glycerol-phosphate synthase activity imidazoleglycerol phosphate synthase activity 2.4.2.- EC GLUTAMIDOTRANS-RXN MetaCyc GO:0016763 GO:0000108 repairosome cellular_component A stable complex of proteins that carry out the DNA damage recognition and incision reactions characteristic of nucleotide excision repair (NER), such as DNA damage recognition, DNA helix unwinding, and endonucleolytic cleavage at sites flanking damaged DNA; includes TFIIH subunits and additional polypeptides; may form in the absence of DNA damage. 10681587 PMID 9852079 PMID GO:0000109 GO:0000109 nucleotide-excision repair complex cellular_component Any complex formed of proteins that act in nucleotide-excision repair. 10915862 PMID Note that process information is included in the term and definition for the purpose of describing and distinguishing the complex. goslim_pir GO:0043234 GO:0044428 GO:0000110 nucleotide-excision repair factor 1 complex cellular_component One of several protein complexes involved in nucleotide-excision repair; possesses DNA damage recognition and endodeoxynuclease activities. In S. cerevisiae, it is composed of Rad1p, Rad10p, and Rad14p. 10915862 PMID Note that process and function information are included in the term and definition for the purpose of describing and distinguishing the complex. NEF1 complex GO:0000109 GO:0000111 nucleotide-excision repair factor 2 complex cellular_component One of several protein complexes involved in nucleotide-excision repair; possesses damaged DNA binding activity. In S. cerevisiae, it is composed of Rad4p and Rad23p. 10915862 PMID Note that process and function information are included in the term and definition for the purpose of describing and distinguishing the complex. NEF2 complex GO:0000109 GO:0000112 nucleotide-excision repair factor 3 complex cellular_component One of several protein complexes involved in nucleotide-excision repair; possesses endodeoxynuclease and DNA helicase activities. In S. cerevisiae, it is composed of Rad2p and the core TFIIH-Ssl2p complex (Core TFIIH is composed of Rad3p, Tfb1p, Tfb2p, Ssl1p, and Tfb4p. Note that Ssl2p is also called Rad25p). 10915862 PMID 14500720 PMID 7813015 PMID Note that process and function information are included in the term and definition for the purpose of describing and distinguishing the complex. NEF3 complex GO:0000109 GO:0000113 nucleotide-excision repair factor 4 complex cellular_component One of several protein complexes involved in nucleotide-excision repair; possesses DNA damage recognition and DNA-dependent ATPase activities. In S. cerevisiae, it is composed of Rad7p and Rad16p. 10915862 PMID Note that process and function information are included in the term and definition for the purpose of describing and distinguishing the complex. NEF4 complex GO:0000109 GO:0000114 G1-specific transcription in mitotic cell cycle biological_process Any process that regulates transcription such that the target genes are transcribed during the G1 phase of the mitotic cell cycle. mah GOC GO:0006357 GO:0022402 OBO_REL:part_of GO:0000080 GO:0000115 S-phase-specific transcription in mitotic cell cycle biological_process A cell cycle process that regulates transcription such that the target genes are transcribed during the S phase of the mitotic cell cycle. mah GOC S-specific transcription in mitotic cell cycle 69241 Reactome GO:0006357 GO:0022402 OBO_REL:part_of GO:0000084 GO:0000116 G2-specific transcription in mitotic cell cycle biological_process Any process that regulates transcription such that the target genes are transcribed during the G2 phase of the mitotic cell cycle. mah GOC GO:0006357 GO:0022402 OBO_REL:part_of GO:0000085 GO:0000117 G2/M-specific transcription in mitotic cell cycle biological_process Any process that regulates transcription such that the target genes are transcribed during the G2/M phase of the mitotic cell cycle. mah GOC 69274 Reactome GO:0006357 GO:0022402 OBO_REL:part_of GO:0000086 GO:0000118 histone deacetylase complex cellular_component A protein complex that possesses histone deacetylase activity. mah GOC Note that this term represents a location, not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex. The function of this complex is represented by the molecular function term 'histone deacetylase activity ; GO:0004407'. HDAC complex GO:0043234 GO:0044451 GO:0000119 mediator complex cellular_component A protein complex that enables the RNA polymerase II-general RNA polymerase II transcription factor complex to react to transcriptional activator proteins; also enhances the level of basal transcription. 10384286 PMID 11114191 PMID 8187178 PMID 9396788 PMID 9774831 PMID S mediator complex TRAP complex GO:0043234 GO:0044451 OBO_REL:part_of GO:0016591 GO:0000120 RNA polymerase I transcription factor complex cellular_component A transcription factor complex that acts at promoters of genes transcribed by RNA polymerase I. mah GOC GO:0005667 GO:0044452 GO:0000121 glycerol-1-phosphatase activity molecular_function Catalysis of the reaction: glycerol 1-phosphate + H2O = glycerol + phosphate. 3.1.3.21 EC alpha-glycerol phosphatase activity 3.1.3.21 EC alpha-glycerophosphatase activity 3.1.3.21 EC glycerol 3-phosphatase activity 3.1.3.21 EC glycerol 3-phosphate phosphohydrolase activity 3.1.3.21 EC glycerol-1-phosphate phosphohydrolase activity 3.1.3.21 EC glycerol-3-phosphate phosphatase activity 3.1.3.21 EC 3.1.3.21 EC GLYCEROL-1-PHOSPHATASE-RXN MetaCyc GO:0016791 GO:0000122 negative regulation of transcription from RNA polymerase II promoter biological_process Any process that stops, prevents or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter. go_curators GOC down regulation of transcription from RNA polymerase II promoter down-regulation of transcription from RNA polymerase II promoter downregulation of transcription from RNA polymerase II promoter inhibition of transcription from RNA polymerase II promoter negative regulation of transcription from Pol II promoter GO:0006357 GO:0045892 negatively_regulates GO:0006366 GO:0000123 histone acetyltransferase complex cellular_component A protein complex that possesses histone acetyltransferase activity. mah GOC Note that this term represents a location, not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex. The function of this complex is represented by the molecular function term 'histone acetyltransferase activity ; GO:0004402'. histone acetylase complex GO:0043234 GO:0044451 GO:0000124 SAGA complex cellular_component A large multiprotein complex that possesses histone acetyltransferase activity and is involved in regulation of transcription. The budding yeast complex includes Gcn5p, several proteins of the Spt and Ada families, and several TBP-associate proteins (TAFs); analogous complexes in other species have analogous compositions, and usually contain homologs of the yeast proteins. 10637607 PMID Spt-Ada-Gcn5-acetyltransferase complex GO:0000123 GO:0000125 PCAF complex cellular_component A large multiprotein complex that possesses histone acetyltransferase and is involved in regulation of transcription. The composition is similar to that of the SAGA complex, but includes fewer Spt and Ada proteins, and more TAFs. 10637607 PMID See also the cellular component term 'SAGA complex ; GO:0000124'. GO:0000123 GO:0000126 transcription factor TFIIIB complex cellular_component A transcription factor for eukaryotic RNA polymerase III promoters that is an RNA polymerase binding protein. mah GOC 0198547684 ISBN GO:0005667 GO:0000127 transcription factor TFIIIC complex cellular_component A heterotrimeric transcription factor for eukaryotic RNA polymerase III promoters. mah GOC 0198547684 ISBN GO:0005667 GO:0000128 flocculation biological_process The non-sexual aggregation of single-celled organisms. jl GOC goslim_pir gosubset_prok GO:0051704 GO:0000131 incipient cellular bud site cellular_component The portion of the budding yeast plasma membrane where a daughter cell will emerge. The yeast marks this spot with bud-site selection proteins before bud emergence occurs. Actin is polarized to this spot just prior to and during bud emergence. clt GOC GO:0044424 GO:0000132 establishment of mitotic spindle orientation biological_process GO:0030607 GO:0030609 A cell cycle process that sets the alignment of mitotic spindle relative to other cellular structures. ems GOC establishment of spindle orientation during mitosis mitotic spindle orientation mitotic spindle orientation (sensu Fungi) mitotic spindle orientation (sensu Saccharomyces) orienting of mitotic spindle GO:0040001 GO:0051294 GO:0000133 polarisome cellular_component Protein complex that plays a role in determining cell polarity by directing the localized assembly of actin filaments at polarization sites; in Saccharomyces the polarisome includes Bni1p, Spa2p, Pea2p, and Bud6p. 14734532 PMID 14998522 PMID 9632790 PMID goslim_pir GO:0043234 GO:0044448 OBO_REL:part_of GO:0030427 GO:0000135 septin checkpoint biological_process A cell cycle checkpoint that detects septin defects and responds by inhibiting the mitotic CDK. In Saccharomyces cerevisiae, correct formation of a functional septin cytoskeleton permits the cell to switch to isotropic bud growth and the onset of mitotic chromosome segregation. In the presence of septin defects, the mitotic CDK is inhibited and both the switch to isotropic bud growth and the onset of mitotic chromosome segregation is delayed. 9925642 PMID GO:0031565 GO:0000136 alpha-1,6-mannosyltransferase complex cellular_component A large, multiprotein complex with alpha-1,6 mannosyltransferase activity, located in the cis Golgi membrane; adds mannan to N-linked glycans on proteins. mcc GOC 10037752 PMID 11095735 PMID GO:0031501 GO:0044431 OBO_REL:part_of GO:0000137 GO:0000137 Golgi cis cisterna cellular_component The Golgi cisterna closest to the endoplasmic reticulum; the first processing compartment through which proteins pass after export from the ER. 0815316194 ISBN GO:0031985 GO:0000138 Golgi trans cisterna cellular_component The Golgi cisterna farthest from the endoplasmic reticulum; the final processing compartment through which proteins pass before exiting the Golgi apparatus; the compartment in which N-linked protein glycosylation is completed. 0815316194 ISBN GO:0031985 GO:0000139 Golgi membrane cellular_component The lipid bilayer surrounding any of the compartments of the Golgi apparatus. mah GOC GO:0031090 GO:0044431 OBO_REL:part_of GO:0012505 GO:0000140 acylglycerone-phosphate reductase activity molecular_function Catalysis of the reaction: 1-palmitoylglycerol 3-phosphate + NADP+ = palmitoylglycerone phosphate + NADPH + H+. 1.1.1.101 EC 1-acyldihydroxyacetone-phosphate reductase activity 1-palmitoylglycerol-3-phosphate:NADP+ oxidoreductase activity 1.1.1.101 EC acyldihydroxyacetone phosphate reductase activity 1.1.1.101 EC palmitoyl dihydroxyacetone phosphate reductase activity 1.1.1.101 EC palmitoyl-dihydroxyacetone-phosphate reductase activity 1.1.1.101 EC palmitoyldihydroxyacetone-phosphate reductase activity 1.1.1.101 EC 1.1.1.101 EC ACYLGLYCERONE-PHOSPHATE-REDUCTASE-RXN MetaCyc 21659 Reactome GO:0016616 GO:0000142 cellular bud neck contractile ring cellular_component A contractile ring, i.e. a cytoskeletal structure composed of actin filaments and myosin, that forms beneath the plasma membrane at the mother-bud neck in mitotic cells that divide by budding in preparation for completing cytokinesis. krc GOC 16009555 PMID actomyosin ring (sensu Saccharomyces) contractile ring (sensu Saccharomyces) cytokinetic ring (sensu Saccharomyces) neck ring GO:0005826 OBO_REL:part_of GO:0005935 GO:0000144 cellular bud neck septin ring cellular_component A ring-shaped structure that forms at the site of cytokinesis; composed of members of the conserved family of filament forming proteins called septins as well as septin-associated proteins. In S. cerevisiae, this structure forms at the time of bud emergence and the septins show a high rate of exchange. krc GOC 16009555 PMID septin ring (sensu Saccharomyces) GO:0000399 GO:0005940 GO:0032161 GO:0000145 exocyst cellular_component Protein complex peripherally associated with the plasma membrane that determines where secretory vesicles dock and fuse. At least eight complex components are conserved between yeast and mammals. 9700152 PMID GO:0043234 GO:0044448 GO:0000146 microfilament motor activity molecular_function Catalysis of movement along a microfilament, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP). mah GOC 0815316194 ISBN actin filament motor activity dph GOC actin-filament motor activity muscle motor activity myosin ATPase activity GO:0003774 GO:0000147 actin cortical patch assembly biological_process Assembly of an actin cortical patch, a discrete actin-containing structure found at the plasma membrane of fungal cells. mah GOC GO:0022607 GO:0030866 GO:0000148 1,3-beta-glucan synthase complex cellular_component A protein complex that catalyzes the transfer of a glucose moiety from UDP-glucose to a 1,3-beta-D-glucan chain. 2.4.1.34 EC GO:0043234 GO:0044459 GO:0000149 SNARE binding molecular_function Interacting selectively with a SNARE (soluble N-ethylmaleimide-sensitive factor attached protein receptor) protein. 12642621 PMID SNAP receptor binding GO:0005515 GO:0000150 recombinase activity molecular_function Catalysis of the identification and base-pairing of homologous sequences between single-stranded DNA and double-stranded DNA. elh GOC Consider also annotating to the molecular function terms 'double-stranded DNA binding ; GO:0003690' and 'single-stranded DNA binding ; GO:0003697'. Note that this term represents activities that do not break or form phosphodiester bonds, and is therefore not a parent of 'site-specific recombinase activity ; GO:0009009'. gosubset_prok strand transferase GO:0003824 GO:0000151 ubiquitin ligase complex cellular_component A protein complex that includes a ubiquitin-protein ligase (E3) and other proteins that may confer substrate specificity on the complex. 9529603 PMID goslim_pir gosubset_prok GO:0043234 GO:0044424 GO:0000152 nuclear ubiquitin ligase complex cellular_component A ubiquitin ligase complex found in the nucleus. mah GOC GO:0000151 GO:0044428 GO:0000153 cytoplasmic ubiquitin ligase complex cellular_component A ubiquitin ligase complex found in the cytoplasm. mah GOC GO:0000151 GO:0044444 GO:0000154 rRNA modification biological_process GO:0016548 The covalent alteration of one or more nucleotides within an rRNA molecule to produce an rRNA molecule with a sequence that differs from that coded genetically. curators GOC The term 'RNA editing' (GO:0016547) was merged into 'RNA modification' (GO:0009451) on the basis of statements in the preface of Modification and Editing of RNA (ISBN:1555811337) that there is no clear distinction between modification and editing. Parallel changes were made for substrate (e.g. tRNA, rRNA, etc.) specific child terms of 'RNA editing'. gosubset_prok rRNA editing GO:0006364 GO:0009451 GO:0000155 two-component sensor activity molecular_function Catalysis of the phosphorylation of a specific transcription regulator in response to the presence of a particular signal substance outside the cell. mah GOC gosubset_prok two-component sensor molecule two-component system sensor activity 2.7.3.- EC GO:0004673 GO:0004871 GO:0000156 two-component response regulator activity molecular_function Alters the level of transcription of target genes, usually by binding to a transcription factor, when phosphorylated by a sensor that detects the presence of a particular signal substance outside the cell. mah GOC gosubset_prok GO:0004871 GO:0030528 GO:0000159 protein phosphatase type 2A complex cellular_component A heterodimer with protein serine/threonine phosphatase activity that is polycation-stimulated (PCS), being directly stimulated by protamine, polylysine, or histone H1; it constitutes a subclass of several enzymes activated by different histones and polylysine, and consists of catalytic and regulatory subunits. mah GOC 0198547684 ISBN GO:0008287 GO:0044424 GO:0000160 two-component signal transduction system (phosphorelay) biological_process A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. 9191038 PMID gosubset_prok histidyl-aspartyl phosphorelay GO:0007165 GO:0000161 MAPKKK cascade during osmolarity sensing biological_process MAPKKK cascade involved in signal transduction in response to change in osmotic conditions. 9561267 PMID osmolarity sensing, MAPKKK cascade GO:0000165 OBO_REL:part_of GO:0007231 GO:0000162 tryptophan biosynthetic process biological_process GO:0009096 The chemical reactions and pathways resulting in the formation of tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid; tryptophan is synthesized from chorismate via anthranilate. mah GOC 0471331309 ISBN Biochemical Pathways TRPSYN-PWY MetaCyc gosubset_prok aromatic amino acid family biosynthetic process, anthranilate pathway tryptophan anabolism tryptophan biosynthesis tryptophan formation tryptophan synthesis TRPSYN-PWY MetaCyc GO:0006568 GO:0009073 GO:0046219 GO:0000164 protein phosphatase type 1 complex cellular_component A protein complex that possesses magnesium-dependent protein serine/threonine phosphatase (AMD phosphatase) activity, and consists of a catalytic subunit and one or more regulatory subunits that dictates the phosphatase's substrate specificity, function, and activity. mah GOC ssd GOC GO:0008287 GO:0044444 GO:0000165 MAPKKK cascade biological_process Cascade of at least three protein kinase activities culminating in the phosphorylation and activation of a MAP kinase. MAPKKK cascades lie downstream of numerous signaling pathways. mah GOC 9561267 PMID ERK/MAPK cascade MAP kinase cascade MAP kinase kinase kinase cascade MAPK cascade MAPK signaling MAPK signalling MAPKKK cascade during sporulation (sensu Fungi) MAPKKK cascade during sporulation (sensu Saccharomyces) 109869 Reactome 211967 Reactome 221732 Reactome 230313 Reactome 238351 Reactome 244909 Reactome 249802 Reactome 252619 Reactome 255804 Reactome 259197 Reactome 262555 Reactome 268509 Reactome 274234 Reactome 280703 Reactome 286727 Reactome GO:0007243 GO:0000166 nucleotide binding molecular_function Interacting selectively with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. mah GOC 0198547684 ISBN goslim_generic goslim_pir goslim_plant gosubset_prok GO:0005488 GO:0000167 activation of MAPKKK activity during osmolarity sensing biological_process Any process that initiates the activity of the inactive enzyme MAP kinase kinase kinase during osmolarity sensing. 9561267 PMID activation of MAP kinase kinase kinase activity during osmolarity sensing osmolarity sensing, activation of MAP kinase kinase kinase activity osmolarity sensing, activation of MAPKKK activity GO:0000185 OBO_REL:part_of GO:0000161 GO:0000168 activation of MAPKK activity during osmolarity sensing biological_process GO:0007233 Any process that initiates the activity of the inactive enzyme MAP kinase kinase during osmolarity sensing. 9561267 PMID activation of MAP kinase kinase activity during osmolarity sensing activation of Pbs2 kinase osmolarity sensing, activation of MAP kinase kinase activity osmolarity sensing, activation of MAPKK activity GO:0000186 OBO_REL:part_of GO:0000161 GO:0000169 activation of MAPK activity during osmolarity sensing biological_process Any process that initiates the activity of the inactive enzyme MAP kinase activity during osmolarity sensing. 9561267 PMID osmolarity sensing, activation of MAPK activity GO:0000187 OBO_REL:part_of GO:0000161 GO:0000170 sphingosine hydroxylase activity molecular_function Catalysis of the hydroxylation of sphingolipid long chain bases. 9556590 PMID GO:0016491 GO:0000171 ribonuclease MRP activity molecular_function Catalysis of the site-specific cleavage of RNA by a catalytic RNA_mediated mechanism; substrates include the A3 site in the ITS1 of pre-rRNA. 17881380 PMID RNase MRP GO:0004540 GO:0000172 ribonuclease MRP complex cellular_component A ribonucleoprotein complex that performs the first cleavage in rRNA transcript processing and is also involved in mitochondrial RNA processing. 10690410 PMID ribonuclease mitochondrial RNA processing complex RNase MRP complex GO:0030529 GO:0000173 inactivation of MAPK activity during osmolarity sensing biological_process Any process that terminates the activity of the active enzyme MAP kinase during osmolarity sensing. 9561267 PMID osmolarity sensing, inactivation of MAPK osmolarity sensing, termination of MAPK activity termination of MAPK activity during osmolarity sensing GO:0000188 OBO_REL:part_of GO:0000161 GO:0000174 inactivation of MAPK (mating sensu Saccharomyces) biological_process OBSOLETE. Downregulation of MAP kinase activity in the context of transduction of mating pheromone signal, as described for Saccharomyces. 9561267 PMID This term was made obsolete because it is a gene product specific term. 1