relationship synonym_type cvterm_property_type anonymous OBO_REL biological_process.obo_xml internal internal comment cvterm_property_type comment internal is_anonymous cvterm_property_type is_anonymous OBO_REL is_a relationship is_a 1 biological_process gene_ontology _default_idspace negatively_regulates negatively_regulates cv__gene_ontology 1 OBO_REL part_of part_of relationship internal is_transitive cvterm_property_type is_transitive 1 1 OBO_REL part_of _default_idspace positively_regulates positively_regulates cv__gene_ontology 1 _default_idspace regulates regulates cv__gene_ontology 1 GO 0000001 mitochondrion inheritance cv__biological_process The distribution of mitochondria, including the mitochondrial genome, into daughter cells after mitosis or meiosis, mediated by interactions between mitochondria and the cytoskeleton. GOC mcc 1 PMID 10873824 1 PMID 11389764 1 mitochondrial inheritance internal exact synonym_type exact GO 0000002 mitochondrial genome maintenance cv__biological_process The maintenance of the structure and integrity of the mitochondrial genome; includes replication and segregation of the mitochondrial chromosome. GOC ai 1 GOC vw 1 GO 0000003 reproduction cv__biological_process The production by an organism of new individuals that contain some portion of their genetic material inherited from that organism. GOC go_curators 1 GOC isa_complete 1 ISBN 0198506732 1 reproductive physiological process internal exact synonym_type exact GO 0019952 GO 0050876 GO 0000011 vacuole inheritance cv__biological_process The distribution of vacuoles into daughter cells after mitosis or meiosis, mediated by interactions between vacuoles and the cytoskeleton. GOC mcc 1 PMID 10873824 1 PMID 14616069 1 GO 0000012 single strand break repair cv__biological_process The repair of single strand breaks in DNA. Repair of such breaks is mediated by the same enzyme systems as are used in base excision repair. URL http://www.ultranet.com/~jkimball/BiologyPages/D/DNArepair.html 1 GO 0000017 alpha-glucoside transport cv__biological_process The directed movement of alpha-glucosides into, out of, within or between cells. Alpha-glucosides are glycosides in which the sugar moiety is a glucose residue, and the anomeric carbon of the bond is in an alpha configuration. GOC jl 1 URL http://www.biochem.purdue.edu/ 1 ISBN 0198506732 1 GO 0000018 regulation of DNA recombination cv__biological_process Any process that modulates the frequency, rate or extent of DNA recombination, a process by which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. GOC go_curators 1 ISBN 0198506732 1 GO 0000019 regulation of mitotic recombination cv__biological_process Any process that modulates the frequency, rate or extent of DNA recombination during mitosis. GOC go_curators 1 regulation of recombination within rDNA repeats internal narrow synonym_type narrow GO 0000020 1 negative regulation of recombination within rDNA repeats (obsolete GO:0000020) cv__biological_process OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of genetic recombination within the DNA of the genes coding for ribosomal RNA. GOC go_curators 1 ISBN 0198506732 1 comment_type This term was made obsolete because it describes a substrate-specific process. 0 GO 0000022 mitotic spindle elongation cv__biological_process Lengthening of the distance between poles of the mitotic spindle. GOC mah 1 spindle elongation during mitosis internal exact synonym_type exact GO 0000023 maltose metabolic process cv__biological_process The chemical reactions and pathways involving the disaccharide maltose (4-O-alpha-D-glucopyranosyl-D-glucopyranose), an intermediate in the catabolism of glycogen and starch. GOC jl 1 ISBN 0198506732 1 malt sugar metabolic process internal exact synonym_type exact malt sugar metabolism internal exact synonym_type exact maltose metabolism internal exact synonym_type exact GO 0000024 maltose biosynthetic process cv__biological_process The chemical reactions and pathways resulting in the formation of the disaccharide maltose (4-O-alpha-D-glucopyranosyl-D-glucopyranose). GOC jl 1 ISBN 0198506732 1 malt sugar biosynthesis internal exact synonym_type exact malt sugar biosynthetic process internal exact synonym_type exact maltose anabolism internal exact synonym_type exact maltose biosynthesis internal exact synonym_type exact maltose formation internal exact synonym_type exact maltose synthesis internal exact synonym_type exact GO 0000025 maltose catabolic process cv__biological_process The chemical reactions and pathways resulting in the breakdown of the disaccharide maltose (4-O-alpha-D-glucopyranosyl-D-glucopyranose). GOC jl 1 ISBN 0198506732 1 malt sugar catabolic process internal exact synonym_type exact malt sugar catabolism internal exact synonym_type exact maltose breakdown internal exact synonym_type exact maltose degradation internal exact synonym_type exact maltose hydrolysis internal narrow synonym_type narrow MetaCyc MALTOSECAT-PWY GO 0000027 ribosomal large subunit assembly and maintenance cv__biological_process The aggregation, arrangement and bonding together of constituent RNAs and proteins to form and maintain the large ribosomal subunit. GOC jl 1 GO 0000028 ribosomal small subunit assembly and maintenance cv__biological_process The aggregation, arrangement and bonding together of constituent RNAs and proteins to form and maintain the small ribosomal subunit. GOC jl 1 GO 0000032 cell wall mannoprotein biosynthetic process cv__biological_process The chemical reactions and pathways resulting in the formation of cell wall mannoproteins, any cell wall protein that contains covalently bound mannose residues other than as a moiety of nucleic acid. GOC ai 1 cell wall mannoprotein anabolism internal exact synonym_type exact cell wall mannoprotein biosynthesis internal exact synonym_type exact cell wall mannoprotein formation internal exact synonym_type exact cell wall mannoprotein synthesis internal exact synonym_type exact GO 0000038 very-long-chain fatty acid metabolic process cv__biological_process The chemical reactions and pathways involving fatty acids with a chain length of C18 or greater. GOC hjd 1 very-long-chain fatty acid metabolism internal exact synonym_type exact GO 0000040 low-affinity iron ion transport cv__biological_process The directed, low-affinity movement of iron (Fe) ions into, out of, within or between cells. In low affinity transport the transporter is able to bind the solute only if it is only present at very low concentrations. GOC mah 1 low affinity iron ion transport internal exact synonym_type exact GO 0000041 transition metal ion transport cv__biological_process The directed movement of transition metal ions into, out of, within or between cells. A transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver. ISBN 0198506732 1 transition metal transport internal exact synonym_type exact GO 0000042 protein targeting to Golgi cv__biological_process The process of directing proteins towards the Golgi using signals contained within the protein. GOC ai 1 protein-Golgi targeting internal exact synonym_type exact GO 0000044 1 ascorbate stabilization (obsolete GO:0000044) cv__biological_process OBSOLETE. The reduction of the ascorbate free radical to a stable form. GOC ai 1 GOC mtg_electron_transport 1 comment_type This term was made obsolete because it is defined as a function term and is in the process ontology. 0 vitamin C stabilization internal exact synonym_type exact GO 0000045 autophagic vacuole formation cv__biological_process The formation of a double membrane-bounded structure, the autophagosome, that occurs when a specialized membrane sac, called the isolation membrane, starts to enclose a portion of the cytoplasm. PMID 9412464 1 autophagosome biosynthesis internal exact synonym_type exact autophagosome formation internal exact synonym_type exact PAS formation internal narrow synonym_type narrow GO 0000046 autophagic vacuole fusion cv__biological_process The fusion of an autophagic vacuole with a vacuole (yeast) or lysosome (e.g. mammals and insects). In the case of yeast, inner membrane-bounded structures (autophagic bodies) appear in the vacuole. PMID 11099404 1 fusion of autophagosome with lysosome internal narrow synonym_type narrow GO 0000050 urea cycle cv__biological_process A cyclic metabolic pathway that converts waste nitrogen in the form of ammonium to urea. ISBN 0198506732 1 ornithine cycle internal exact synonym_type exact urea biosynthesis internal exact synonym_type exact urea biosynthetic process internal exact synonym_type exact GO 0006594 GO 0006871 Reactome 211547 Reactome 221324 Reactome 229964 Reactome 237981 Reactome 244600 Reactome 249543 Reactome 252354 Reactome 255509 Reactome 258881 Reactome 262258 Reactome 265108 Reactome 268232 Reactome 273914 Reactome 280393 Reactome 282778 Reactome 286409 Reactome 288203 Reactome 289764 Reactome 290323 Reactome 291648 Reactome 292335 Reactome 293622 Reactome 70635 GO 0000051 urea cycle intermediate metabolic process cv__biological_process The chemical reactions and pathways involving any of the intermediate compounds involved in the urea cycle, a cyclic metabolic pathway that converts waste nitrogen in the form of ammonium to urea. GOC jl 1 ISBN 0198506732 1 urea cycle intermediate metabolism internal exact synonym_type exact GO 0000052 citrulline metabolic process cv__biological_process The chemical reactions and pathways involving citrulline, N5-carbamoyl-L-ornithine, an alpha amino acid not found in proteins. ISBN 0198506732 1 citrulline metabolism internal exact synonym_type exact GO 0000053 argininosuccinate metabolic process cv__biological_process The chemical reactions and pathways involving argininosuccinate, 2-(Nw-arginino)succinate, an intermediate in the ornithine-urea cycle, where it is synthesized from citrulline and aspartate. ISBN 0198506732 1 argininosuccinate metabolism internal exact synonym_type exact GO 0000054 ribosome export from nucleus cv__biological_process The directed movement of a ribosome from the nucleus into the cytoplasm. GOC ai 1 ribosome export out of nucleus internal exact synonym_type exact ribosome transport from nucleus to cytoplasm internal exact synonym_type exact ribosome-nucleus export internal exact synonym_type exact GO 0000055 ribosomal large subunit export from nucleus cv__biological_process The directed movement of a ribosomal large subunit from the nucleus into the cytoplasm. GOC mah 1 ribosomal large subunit export out of nucleus internal exact synonym_type exact ribosomal large subunit transport from nucleus to cytoplasm internal exact synonym_type exact ribosomal large subunit-nucleus export internal exact synonym_type exact GO 0000057 GO 0000056 ribosomal small subunit export from nucleus cv__biological_process The directed movement of a ribosomal small subunit from the nucleus into the cytoplasm. GOC mah 1 ribosomal small subunit export out of nucleus internal exact synonym_type exact ribosomal small subunit transport from nucleus to cytoplasm internal exact synonym_type exact ribosomal small subunit-nucleus export internal exact synonym_type exact GO 0000058 GO 0000059 protein import into nucleus, docking cv__biological_process The aggregation, arrangement and bonding together of the nuclear localization signal of a protein with nuclear envelope proteins such as importins. GOC isa_complete 1 PMID 7878057 1 protein docking during protein import into nucleus internal exact synonym_type exact protein docking during protein transport from cytoplasm to nucleus internal exact synonym_type exact protein docking during protein-nucleus import internal exact synonym_type exact protein transport from cytoplasm to nucleus, docking internal exact synonym_type exact protein-nucleus import, docking internal exact synonym_type exact GO 0000060 protein import into nucleus, translocation cv__biological_process The vectorial transfer of a protein from the cytoplasm into the nucleus, through the nuclear pore and across the nuclear envelope. GOC jl 1 GOC vw 1 ISBN 0198506732 1 protein translocation during protein import into nucleus internal exact synonym_type exact protein translocation during protein transport from cytoplasm to nucleus internal exact synonym_type exact protein translocation during protein-nucleus import internal exact synonym_type exact protein transport from cytoplasm to nucleus, translocation internal exact synonym_type exact protein-nucleus import, translocation internal exact synonym_type exact GO 0000061 protein import into nucleus, substrate release cv__biological_process The disaggregation of a protein complex composed of the nuclear localization sequence and the importin alpha, and importin beta proteins. PMID 9687515 1 protein substrate release during protein import into nucleus internal exact synonym_type exact protein substrate release during protein transport from cytoplasm to nucleus internal exact synonym_type exact protein substrate release during protein-nucleus import internal exact synonym_type exact protein transport from cytoplasm to nucleus, substrate release internal exact synonym_type exact protein-nucleus import, substrate release internal exact synonym_type exact GO 0000066 mitochondrial ornithine transport cv__biological_process The directed movement of ornithine, 2,5-diaminopentanoic acid, into, out of or within a mitochondrion. GOC ai 1 GO 0000067 1 DNA replication and chromosome cycle (obsolete GO:0000067) cv__biological_process OBSOLETE (was not defined before being made obsolete). GOC ai 1 comment_type This term was made obsolete because it has been superseded by more accurate terms to represent the biological processes occurring, and it is not clear that this term represents a useful concept. 0 GO 0000070 mitotic sister chromatid segregation cv__biological_process The cell cycle process whereby replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the mitotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner. One homolog of each morphologic type goes into each of the resulting chromosome sets. GOC ai 1 mitotic chromosome segregation internal exact synonym_type exact mitotic sister-chromatid adhesion release internal narrow synonym_type narrow GO 0016359 GO 0000072 M phase specific microtubule process cv__biological_process A microtubule-based process that occurs only during M phase of the cell cycle. GOC mah 1 M-phase specific microtubule process internal exact synonym_type exact GO 0000073 spindle pole body separation cv__biological_process A largely uncharacterized process involving the release of duplicated spindle pole bodies (SPBs) and their migration away from each other within the nuclear membrane. Duplicated SPBs are connected by a bridge structure that may be severed in order to release the SPBs from one another. Following liberation, SPBs diffuse through the nuclear membrane until they are across from each other. SPB separation must take place in order for a bipolar mitotic spindle to assemble. GOC sgd_curators 1 spindle pole body separation (sensu Fungi) internal exact synonym_type exact spindle pole body separation (sensu Saccharomyces) internal narrow synonym_type narrow GO 0030475 GO 0000075 cell cycle checkpoint cv__biological_process A point in the eukaryotic cell cycle where progress through the cycle can be halted until conditions are suitable for the cell to proceed to the next stage. GOC mah 1 ISBN 0815316194 1 Reactome 212094 Reactome 221853 Reactome 230421 Reactome 238463 Reactome 245004 Reactome 249905 Reactome 252621 Reactome 255806 Reactome 259199 Reactome 262557 Reactome 265381 Reactome 268515 Reactome 274237 Reactome 280705 Reactome 282912 Reactome 286730 Reactome 69620 GO 0000076 DNA replication checkpoint cv__biological_process A signal transduction based surveillance mechanism that prevents the initiation of mitosis until DNA replication is complete, thereby ensuring that progeny inherit a full complement of the genome. GOC rn 1 PMID 11728327 1 PMID 12537518 1 GO 0000077 DNA damage checkpoint cv__biological_process A signal transduction pathway, induced by DNA damage, that blocks cell cycle progression (in G1, G2 or metaphase) or slows the rate at which S phase proceeds. PMID 11891124 1 DNA damage response, signal transduction resulting in cell cycle arrest internal narrow synonym_type narrow GO 0000078 cell morphogenesis checkpoint cv__biological_process A cell cycle checkpoint observed when aspects of polarity control are defective, which maintains coordination between the process of cellular morphogenesis and the nuclear events of the cell cycle. For example, in budding yeast cell-cycle delay or arrest is induced when aspects of bud formation are defective. GOC vw 1 PMID 14644188 1 GO 0000079 regulation of cyclin-dependent protein kinase activity cv__biological_process Any process that modulates the frequency, rate or extent of CDK activity. GOC go_curators 1 regulation of CDK activity internal exact synonym_type exact GO 0000080 G1 phase of mitotic cell cycle cv__biological_process Progression through G1 phase, one of two 'gap' phases in the mitotic cell cycle; G1 is the interval between the completion of mitosis and the beginning of DNA synthesis. ISBN 0815316194 1 Reactome 212033 Reactome 221797 Reactome 230372 Reactome 238411 Reactome 69236 GO 0000082 G1/S transition of mitotic cell cycle cv__biological_process Progression from G1 phase to S phase of the mitotic cell cycle. GOC mah 1 Reactome 212021 Reactome 221784 Reactome 230362 Reactome 238403 Reactome 244953 Reactome 249850 Reactome 252607 Reactome 255745 Reactome 259140 Reactome 262495 Reactome 265325 Reactome 268498 Reactome 274174 Reactome 280647 Reactome 282899 Reactome 286666 Reactome 288375 Reactome 289876 Reactome 290408 Reactome 291794 Reactome 293774 Reactome 69206 GO 0000083 G1/S-specific transcription in mitotic cell cycle cv__biological_process Any process that regulates transcription such that the target genes are transcribed during the G1/S phase of the mitotic cell cycle. GOC mah 1 Reactome 69205 GO 0000084 S phase of mitotic cell cycle cv__biological_process Progression through S phase, the part of the mitotic cell cycle during which DNA synthesis takes place. ISBN 0815316194 1 GO 0000085 G2 phase of mitotic cell cycle cv__biological_process Progression through G2 phase, one of two 'gap' phases in the mitotic cell cycle; G2 is the interval between the completion of DNA synthesis and the beginning of mitosis. ISBN 0815316194 1 Reactome 211891 Reactome 221655 Reactome 230246 Reactome 238281 Reactome 244852 Reactome 249746 Reactome 268392 Reactome 274099 Reactome 280573 Reactome 68911 GO 0000086 G2/M transition of mitotic cell cycle cv__biological_process Progression from G2 phase to M phase of the mitotic cell cycle. GOC mah 1 Reactome 211972 Reactome 221737 Reactome 230316 Reactome 238398 Reactome 244912 Reactome 249804 Reactome 252543 Reactome 255721 Reactome 259114 Reactome 262473 Reactome 265322 Reactome 268466 Reactome 274171 Reactome 280644 Reactome 282855 Reactome 286663 Reactome 69275 GO 0000087 M phase of mitotic cell cycle cv__biological_process Progression through M phase, the part of the mitotic cell cycle during which mitosis takes place. GOC mah 1 ISBN 0815316194 1 M-phase of mitotic cell cycle internal exact synonym_type exact Reactome 212043 Reactome 221806 Reactome 230379 Reactome 238418 Reactome 244995 Reactome 249877 Reactome 252596 Reactome 255795 Reactome 259176 Reactome 262532 Reactome 265359 Reactome 268488 Reactome 282892 Reactome 286702 Reactome 68886 GO 0000088 mitotic prophase cv__biological_process Progression through prophase, the initial stage of mitosis in which the chromosomes are condensed but are not yet attached to a mitotic spindle. ISBN 0815316194 1 Reactome 211977 Reactome 221742 Reactome 230322 Reactome 238359 Reactome 244917 Reactome 249807 Reactome 252546 Reactome 255723 Reactome 259116 Reactome 262475 Reactome 268434 Reactome 286639 Reactome 68875 GO 0000089 mitotic metaphase cv__biological_process Progression through metaphase, the stage of mitosis at which chromosomes are firmly attached to the mitotic spindle at its equator but have not yet segregated to opposite poles. ISBN 0815316194 1 Reactome 68879 GO 0000090 mitotic anaphase cv__biological_process Progression through anaphase, the stage of mitosis during which the two sets of chromosomes separate and move away from each other. ISBN 0815316194 1 Reactome 68882 GO 0000091 mitotic anaphase A cv__biological_process Progression through anaphase A, the part of mitotic anaphase in which the kinetochore microtubules shorten as chromosomes move toward the spindle poles. ISBN 0815316194 1 GO 0000092 mitotic anaphase B cv__biological_process Progression through anaphase B, the part of mitotic anaphase in which the polar microtubules elongate and the two poles of the spindle move farther apart. ISBN 0815316194 1 GO 0000093 mitotic telophase cv__biological_process Progression through telophase, the last of the stages of mitosis; in the canonical cell cycle, telophase begins when the chromosomes arrive at the poles of the cell and the division of the cytoplasm starts. ISBN 0721662544 1 GO 0000094 1 septin assembly and septum formation (obsolete GO:0000094) cv__biological_process OBSOLETE (was not defined before being made obsolete). GOC go_curators 1 comment_type This term was made obsolete because it was not defined and the string name implied two separate processes. 0 GO 0000096 sulfur amino acid metabolic process cv__biological_process The chemical reactions and pathways involving amino acids containing sulfur, comprising cysteine, homocysteine, methionine and selenocysteine. GOC ai 1 sulfur amino acid metabolism internal exact synonym_type exact sulphur amino acid metabolic process internal exact synonym_type exact sulphur amino acid metabolism internal exact synonym_type exact GO 0000097 sulfur amino acid biosynthetic process cv__biological_process The chemical reactions and pathways resulting in the formation of amino acids containing sulfur, comprising cysteine, methionine and selenocysteine. GOC ai 1 sulfur amino acid anabolism internal exact synonym_type exact sulfur amino acid biosynthesis internal exact synonym_type exact sulfur amino acid formation internal exact synonym_type exact sulfur amino acid synthesis internal exact synonym_type exact sulphur amino acid biosynthesis internal exact synonym_type exact sulphur amino acid biosynthetic process internal exact synonym_type exact GO 0000098 sulfur amino acid catabolic process cv__biological_process The chemical reactions and pathways resulting in the breakdown of amino acids containing sulfur, comprising cysteine, methionine and selenocysteine. GOC ai 1 sulfur amino acid breakdown internal exact synonym_type exact sulfur amino acid catabolism internal exact synonym_type exact sulfur amino acid degradation internal exact synonym_type exact sulphur amino acid catabolic process internal