/tmp/pl_owl_6017_0 file /tmp/pl_owl_6017_0 pl_owl_6017_0 3f0f1e37ae8c278eece36134523ea514 1268238307 1268238308

1.2

PW:0000001 Pathway Ontology pathway 1 PW:0000013 disease pathway pathway Complex human diseases encompass a spectrum of genetic and environmental attributes that together affect the normal functioning of several molecular and cellular pathways. Their combined and accumulated effect is manifested in the anomalous phenotype of the complex condition. InHouse_PW_dictionary InHouse complex human diseases PW:0000001 PW:0000605 cancer pathway pathway Cancer, or malignant neoplasm, represents a category of diseases characterized by uncontrolled cell growth and avoidance of apoptosis, invasion and metastasis. Deregulation of many pathways - signaling, regulatory, metabolic and combination of them, have been implicated in susceptibility to or development of these conditions. Generally, cancer is classified according to the tissue or organ affected. PMID:_10647931 PubMed neoplasm pathway PW:0000013 PW:0000606 urogenital cancer pathway pathway Urogenital cancer groups those malignancies that affect the urinary system and reproductive organs. Deregulation of several pathways along with genetic damage accumulated over time can lead to the development of these conditions. InHouse_PW_dictionary InHouse genitourinary cancer pathway urinogenital cancer pathway PW:0000605 PW:0000607 ovarian cancer pathway pathway Ovarian cancer is a leading cause of cancer deaths in women. Several susceptibility genes have been identified and they have a role to play in pathways involved in or regulating proliferation, DNA repair and apoptosis. PMID:12413930;_PMID:12886939;_PMID:15111296 PubMed ovarian neoplasm pathway PW:0000606