format-version: 1.2

[Term]
id: PW:0000001
name: Pathway Ontology
namespace: pathway

[Term]
id: PW:0000013
name: disease pathway
namespace: pathway
def: "Complex human diseases encompass a spectrum of genetic and environmental attributes that together affect the normal functioning of several molecular and cellular pathways. Their combined and accumulated effect is manifested in the anomalous phenotype of the complex condition." [InHouse:InHouse_PW_dictionary]
synonym: "complex human diseases" RELATED []
is_a: PW:0000001  ! Pathway Ontology

[Term]
id: PW:0000605
name: cancer pathway
namespace: pathway
def: "Cancer, or malignant neoplasm, represents a category of diseases characterized by uncontrolled cell growth and avoidance of apoptosis, invasion and metastasis.  Deregulation of many pathways - signaling, regulatory, metabolic and combination of them, have been implicated in susceptibility to or development of these conditions. Generally, cancer is classified according to the tissue or organ affected." [PubMed:PMID:_10647931]
synonym: "neoplasm pathway" RELATED []
is_a: PW:0000013  ! disease pathway

[Term]
id: PW:0000606
name: urogenital cancer pathway
namespace: pathway
def: "Urogenital cancer groups those malignancies that affect the urinary system and reproductive organs. Deregulation of several pathways along with genetic damage accumulated over time can lead to the development of these conditions." [InHouse:InHouse_PW_dictionary]
synonym: "genitourinary cancer pathway" RELATED []
synonym: "urinogenital cancer pathway" RELATED []
is_a: PW:0000605  ! cancer pathway

[Term]
id: PW:0000607
name: ovarian cancer pathway
namespace: pathway
def: "Ovarian cancer is a leading cause of cancer deaths in women. Several susceptibility genes have been identified and they have a role to play in pathways involved in or regulating proliferation, DNA repair and apoptosis." [PubMed:PMID:12413930;_PMID:12886939;_PMID:15111296]
synonym: "ovarian neoplasm pathway" RELATED []
is_a: PW:0000606  ! urogenital cancer pathway